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김종수(Jong-Soo Kim),안병권(Byeong-Kwon Ahn),최현숙(Hyun-Suk Choi),최두복(Du-Bok Choi),염정민(Jung-Min Yeom),김숭평(Soong-Pyung Kim),이인성(In-Sung Lee),조미자(Mi-Ja Cho),차월석(Wol-Suk Cha) 한국생물공학회 2015 KSBB Journal Vol.30 No.1
Radiation causes various pathophysiological alterations in living animals, and it causes death at high doses by multiple mechanisms, including direct DNA damage and indirect oxidative stress. The search for useful radioprotectors has been an important issue in the field of radiation biology. Ideal radioprotectors should have low toxicity and an extended window of protection. As many synthetic compounds have toxic side effects, the natural products have attracted scientific attention as radioprotectors. Natural products that have been recently shown to be effective with various biological activities were found to have radioprotective effect. The aim of this review is to summary the recent research of the radioprotective effects of natural foods, especially focused on the glycobiological properties of mushrooms.
김연순 ( Youn Soon Kim ),안병권 ( Byeong Kwon Ahn ),김란 ( Ran Kim ),최두복 ( Du Bok Choi ) 한국공업화학회 2011 공업화학 Vol.22 No.1
본 연구는 함초를 이용하여 기능성 화장품 개발을 위한 기초자료를 얻기 위해 추출용매에 따른 함초 추출물의 항산화 활성, tyrosinase 저해활성, elastase 저해활성, collagenase 저해활성을 검토 하였다. 여러 아미노산 중에서 glutamic acid이 가장 높았고, 그 다음으로는 proline, alanine, y-amino-n-butyric acid, arginine 순이였다. 폴리페놀 함량 및 항산화 효과는 ethyl acetate extract>n-butanol extract>hexane extract>hot water extract>ethanol extract 순이였다. 특히 ethyl acetate를 추출용매로 사용 할 경우 폴리페놀 함량이 31.6mg/mL였고, 항산화 활성은 82.6%였다. Tyrosinase활성 저해도는 ethyl acetate 추출물의 농도에 의존적으로 증가하였다. 특히 추출물 농도가 20에서 100mg/mL로 증가 할 경우 ty-rosinase활성 저해도는 15.2에서 98.2%로 증가 했다. Ethylacetate 추출물 농도가 20에서 100ug/mL 증가 할 경우 elastase 저해활성은 2.9에서 32.5%로 증가 되었고, collagenase 저해 활성은 3.8에서 29.7%로 증가 하였다. 이상의 결과는 함초 ethylacetate추출물이 화장품 기능성 소재로서 응용 가능성을 나타내었다. This study investigates the effect of Salicornia bigelovii extract on the activities of antioxidant, anti-wrinkle and whitening. Among amino acids, the glutamic acid concentration was the highest with an order of proline>alanine>y-amino-n-butyric acid>arginine. The total polyphenol concentration and antioxidant activity were an order of ethyl acetate extract>n-butanol extract>hexane extract>hot water extract>ethanol extract. Especially, when ethylacetate was used as extractant, the total polyphenol concentration and antioxidant activity were 31.6mg/mL and 82.6%, respectively. The inhibition activity of tyrosinase was increased with the increase concentration of ethylacetate extract. Especially, when the extract concentration was increased from 20 to 100mg/mL, it was raised from 15.2 to 98.2%. In the case of inhibition activities of elastase, and collagenase, they were also increased with the increase concentration of ethylacetate extract. When the extract concentrations were increased from 20 to 100ug/mL, they were enhanced from 2.9 to 32.5% and from 3.8 to 29.7%, respectively. The results show that the ethyl acetate extract of Salicornia bigelovii can be applied as sources for functional cosmetics and pharmaceuticals.
조숙정(Suk-Jung Cho),김윤수(Yoon-Soo Kim),남형근(Hyung-Gun Nam),신현재(Hyun-Jae Shin),류은미(Eun-Mi Ryu),나명순(Myung-Soon Na),안병권(Byeong-Kwon Ahn),최두복(Du-Bok Choi),차월석(Wol-Suk Cha) 한국생물공학회 2011 KSBB Journal Vol.26 No.3
This study was to suggest the method for wrinkle improvement using Mugil cephalus extract. In order to evaluate the cosmetic product made of M. cephalus extract, the experiments were conducted with subjects and skin states for 4 weeks. Effect of cosmetics containing M. cephalus extract on the water holding capacity and evaporation of the women skin were investigated. The water holding capacity was increased after 1 h of application. But after 2 h, it was decreased. In the case of the water evaporation, it was increased with the increase of time. On the clinical trial, it was also found that water, oil, and rough level on the women skin were increased and wrinkles were improved. Side effects were also not detected during the application and treatment of cosmetics. Based on this result, the application of M. cephalus extract had positive effects on the improvement of wrinkles and skin in women. Therefore, it will be used to develop the wrinkle improvement therapy for women.
고주파요법과 갯장어 추출물 병행처리가 남성피부에 미치는 영향
노현주(Hyun-Ju No),김윤수(Yoon-Soo Kim),남형근(Hyung-Gun Nam),신현재(Hyun-Jae Shin),류은미(Eun-Mi Ryu),나명순(Myung-Soon Na),안병권(Byeong-Kwon Ahn),최두복(Du-Bok Choi),차월석(Wol-Suk Cha) 한국생물공학회 2011 KSBB Journal Vol.26 No.3
This study aimed to examine the treatment effect of Muraenesox cinereus extract product combined with high frequency on men’s damaged skin. The subjects were treated by a product containing M. cinereus extract combined with high frequency therapy for six weeks and tested in skin condition. First, for moisture level change, there was no significant difference between the control group treated only by high frequency therapy and the experimental group treated by a M. cinereus extract product combined with high frequency therapy. But the subjects who increased consistently in moisture level in the cheek and chin were more common in the experimental group. Second, for an oil level, prominently high increase was found in both the control group and the experimental group. Finally, for a rough level, while there was little difference in the control group between immediately after peeling and after six weeks, high improvement effect on a curve was found in the experimental group. Based on this result, cosmetics using M. cinereus extract may have a positive effect on men’s skin which is exposed to several stress factors. Accordingly, this result will contribute to developing men’s functional cosmetics.