http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Salmonella typhi Group D로 인한 장티푸스에 병발된 접형동염의
안득수(Deuk Soo Ahn),이창환(Chang Hwan Lee),이수택(Soo Taek Lee),서재석(Jae Seok Seo),김대곤(Dae Gon Kim),최수미(Su Mi Choi) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3
Typhoid fever is bacterial disease caused by Salmonella typhi. It is characterized by prolonged fever, abdominal pain, diarrhea, delirium, rose spot, and splenomgaly, and occasionally complicated with intestinal bleeding and perforation. We experienced a case of peculier type of typhoid fever associated with sphenoid sinusitis.
위장관 ( 胃腸管 ) : 백서에서 알콜 유도성 위점막 병변에 대한 Somatostatin의 보호 효과
안득수(Deuk Soo Ahn),이준학(Joon Hak Lee),이수택(Soo Taek Lee) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
N/A The purpose of this study was investigate mucosal protective effect of somatostain, which is known to inhibit stimulated gastric acid secretion and basal gastrin release and reduce splanchnic blood flow. Fifteen minutes after treatment with somatostatin at various doses (10,100,1,000 u/kg), absolute ethanol was administrated orally, therafter mucosal lesions were evaluated grossly and histopathologically. To understand the mechanism involved in the protective effect of somatostatin against ethanol-induced gastric mucosal lesions, we were doing pretreatment with indomethacin (50 ug/kg) intraperitoneally, prostaglandin E2 or somatostatin was administrated, followed by ethanol administration in rats. Thereafter the mucosal lesions were evaluated. These results provided evidence that 1) treatment of rats with somatostatin before ethanol administration significantly (p<0.01) reduced the mean number of the red stria, the damaged area of the glandular stomach and the severity fo lesions, but no effect on the incidence of ethanol-incuced gastric lesios, 2) treatment with PGE, or somatostatin after indomethacin pretreatment, also significantly reduced ethanol-induced gastric lesions, but had no effect on the incidence, 3) the mucosal protective effect of somatostatin against ethanol-induced gastric lesions was suggested to be independent that of PGE.
만성 활동성 간염 환자에서 Inosiplex 및 Adenine Arabinoside Monophosphate ( Vidarabine Phosphate ) 의 치료효과
안득수(Deuk Soo Ahn),송석현(Seock Hyun Song),이승호(Seung Ho Lee),장현철(Hyun Cheol Jang),박태선(Tae Sun Park),김대곤(Dae Ghon Kim) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2
N/A Serologically chronic active hepatitis is divided into HBsAg-positive chronic active hepatitis and HBsAg-negative chronic active hepatitis. The treatment of HBsAg-positive chronic active hepatitis is very difficult and has been tried with steroid, immunosuppressive drugs and supportive care which are more effective in HBsAg-negative chronic active hepatitis. Inosiplex (Isoprinosine), a combination of the natural nucleoside inosine with the P-acetaminobenzoic acid salt of N-N-dimethylamino -propanolol in a molar ratio of 1:3 has been reported to have an anti-virus activity by stimulating cell-mediated immunity. Adenine arabinoside (Ara-A, Vidarabine) is a synthetic purine nucleotide and is reported to have an antiviral activity against DNA virus by inhibition of DNA polymerase activity. This study was attempted to evaluate the therapeutic effects of inosiplex in 17 cases and those of vidarabine in 11 cases of HBsAg-positive chronic active hepatitis by measuring the pre-and post treatment serum transaminase levels and seroconversion of hepatitis B virus (HBV) serologic markers, and by measuring skin reaction against several antigens in 17 cases administered by inosiplex. From two drugs comparative study, following results were obtained. 1) In groups treated with inosiplex (17 cases), the mean AST and ALT levels were reduced significantly within 3 months of treatment (p<0.001). In groups treated with vidarabine (11 cases), the mean AST and ALT levels were reduced si- gnificantly within 3 months (p<0.01). 2) In groups treated with inosiplex, each 3 cases with HBsAg, HBeAg and antiHBc negatively seroconverted and one case was positively seroconverted to antiHBs. In groups treated with vidarabine, only 3 cases with HBeAg were negatively seroconverted. 3) In groups treated with inosiplex, DTH (delayed type hypersensitivity) to tetanus toxoid and Candida albicans antigens during 10th day and 20th day of treatment was significantly increased (p< 0,05). 4) In groups treated with vidarabine, 4 cases experienced nausea and vomiting and one case went through with systemic eruption and generalized seizure while, in groups treated with inosiplex, none of them experienced side effects such as hyperuricemea. These results suggest that inosiplex and vidarabine might be recommended in the treatment of HRsAg-positive chronic active hepatitis and further studies on dosage, duration and combination with other drugs will be necessary.
안득수(Deuk Soo Ahn),김원호(Won Ho Kim),이수택(Soo Taek Lee),서재석(Jae Seok Seo),김대곤(Dae Gon Kim) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3
N/A Hepatocellular carcinama (HCC) has an estimated annual incidance of 1,000,000 worldwise, and two0thirds are patients from Asia, the south Pacific and subsaharan Africa. In Korea, there is evidence that incidance of HCC may be increasing like other country. This study was sone to investigate clinical feature of HCC. 87 patients that was siagnosed Hcc, underwnet laboratory study, ultrasonography, computed tomography and transhepatic arterial embolization(TAE) form July 1989 to June 1992. These patients included 75 men (83.3%) and 12 women (16.7%) whose ages ranged from 32 to 79 years with average of 54.9 years. Underlying cirrhosis of the liver was found in 53.4% of patient, alcohoh abuse was present in 65.2% heavy smoking was present in 69.2%. Hepatitis Bsurface antigen was positive in 81%, IgG Hepatitis Bcore antibody was positive in 92.2%, and alpha-fetoprotein showed a high diagnostic sensitivity (values above 500 ng/mm3 in 73.2% ) . TAE is the relatively effective method of mangement of HCC. The patients who recieved TAE had better prohnosis. HCC that have male predominant occurrance are successive sequale of chronic hetatitis B and C virus infection, and the quantitation of alpha-fetoprotein and advent of ultrasonography have made detection of hepatin mass possible. Therefore, we have suggested study using both alpha-fetoprotein and ultrasonography to screen for asymtomatic HCC in patients with chronic hepatitis.
Retinoic Acid가 Bromodeoxyuridine 표지 PLC / PRF / 5 간암 세포주의 역동성에 미치는 효과
안득수(Deuk Soo Ahn),김대곤(Dae Ghon Kim),송석현(Suck Hyun Song),김이엽(Ee Yup Kim),장동석(Dong Suck Jang),이수택(Soo Taeck Lee) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
N/A Retinoie acid (RA) has been reported to show antiproliferative and differentiation-inducing effects on human tumor cells. In this report, we examined the antiproliferative effect and the influence on the cell cycle in PLC/PRF/5 hepatocelluar carcinoma cells, secreting hepatitis B surface antigen (HBs Ag). MTT assay was conducted to prove the antiproliferative effect of RA, and the univariate and the bivariate distribution of BrdU/DNA were analyzed using FACScan, to evaluate the influence of RA on tumor cell kinetics in the labelled cells with the 5-bromodeoxyuridine (BrdU). Following 6 days of exposure, 1uM and 0 1 uM RA containing nontoxic DMSO level showed antiproliferative effect on the cells. The analysis from the tumor cell kinetics showed that actual doubling time (Td) is 69 hrs, potential doubling time (Tpot) is 42 hrs, the mean DNA synthesis time (T5) is 17.4 hrs, and the labelling index is 35.2%. The changes of the tumor cell kinetics in the cells treated with RA were investigated. Early stage of culture (day 2, 4) showed increase in S phase percentage of cells and decrease in G0/G1 phase. But ]ate stage of culture (day 6) show decrease in S phase percentage of cells to minimum and increase in G0/G1 phase at either 1 uM or 0.1 uM concentration of RA as compared with that of control. The influence on cell cyclc was rnore pronounced at 1 uM than at 0.luM concentration. These results demonstrated that RA inhibits the growth of PLC/PRF/5 cells and its antiproliferative effect is suggested to be driven from arresting cell cycle progression from G0/G1 to S phase in tumor cell kinetics.