민-군 갈등 관련 민·관·군 협의체 운영에 관한 연구 : 군 훈련장 갈등관리 사례를 중심으로

심재정(Shim, Jae Jeong) 한국부동산학회 2021 不動産學報 Vol.85 No.-

군에서는 정상적인 전투력을 유지하기 위해 전후방 각지에 훈련장을 운영하고 있다. 군 훈련장은 주변지역의 안전을 위협하고 군사규제를 수반함으로써 갈등의 요인이 되고 있다. 군은 갈등을 해소하기 위해 주요 군사시설 및 훈련장이 위치한 지자체에 민·관·군 협의체를 운영하고 있다. 연구의 목적은 군 훈련장에 대한 민·관·군 협의체 운영 실태를 분석하여 효율적인 운영 방법 및 과제를 도출함으로써 국방정책에 기여하려는 것이다. 연구의 방법은 한국군 및 주한미군 훈련장 2개소를 선정하여 협의체의 운영실태를 분석하였으며, 문헌조사 및 관계자 면담방법을 병행하였다. 연구 결과, 민-군 갈등 상황에서 협의체의 운영은 갈등을 효과적으로 관리하는데 매우 유용하였다. 그러나 협의체 구성의 적시성과 구성원의 대표성, 적절한 중앙정부의 지원은 협의체 운영의 성과를 높이는 관건이 되었다. 따라서 군에서는 협의체 운영이 민-군갈등 해소에 기여할 수 있도록 운영절차 및 방법을 보완해야 한다. 아울러 협의체에서 협의된 안건들이 적절하게 반영될 수 있게 법·제도 개선 노력을 지속해야 한다. 1. CONTENTS (1) RESEARCH OBJECTIVESThe purpose of this study is to analyze the current operation status of the civil-local government-military councils related to the military training centers and to derive efficient operation methods and suggestions. (2) RESEARCH METHOD Two of the major training centers of the ROK and the US Armed Forces in Korea, were selected as the study subject. Then, the operation cases were investigated through literature review and interview. (3) RESEARCH FINDINGS The operation of a council in a civil-military conflict is useful in addressing the conflict effectively. the timeliness of council organization, the representativeness of council members, and the proper support from the central government were found to be the key to enhancing the achievement of each council’s operation. 2. RESULTS The armed forces should be devoted to improving the procedures and methods for each council’s operation in a way to be helpful in resolving the ongoing conflicts. Furthermore, a consistent commitment to ensuring the reform of the relevant law and system is also required so that the agendas discussed in the councils will be applied.

산화질소 ( Nitric Oxide ) 의 기도내 신경성 염증 조절에 관한 연구

심재정(Jae Jeong Shim),박상면(Sang Myun Park),이진구(Jin Goo Lee),조재연(Jae Yeun Cho),인광호(Kwang Ho In),유세화(Se Hwa Yoo),강경호(Kyung Ho Kang),김철환(Chul Hwan Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.4

N/A Baekground: Asthma is classified as an inflammatory disease because there are inflammatory changes in the asthmatic airways. There are many evidences that sensory neuropeptides are involved in these inflammatory responses. Neurogenic inflammation is caused by the antidromic nonadrenergic noncholinergic (NANC) release of neuropeptides from vagal nerves. Recently nitric oxide (NO) has received considerable attention as a messenger molecule in the peripheral nervous system and relaxes airway smooth muscle. Also NO is a potent vasodilator and involved in plasma exudation from airway vessels, To investigate the role of nitric oxide in neurogenic inflammation, neurogenic inflammatory responses in rat airways according to duration of NANC stimuation and effects of NO were evaluated, Method: Neurogenic inflammation was produced in rat airways of 2 experimental groups of 1 min and 2 min stimulation with 5V, 1mSec, 5Hz after cholinergic and adrenergic blockade and compared with sham NANC, The magnitude of airway microvascular leakages was checked in the trachea, main bronchus, peripheral bronchus, and lung parenchyme and the leakeage was measured by Evans blue dye extravasation. NW-nitro-L-arginine (L-NNA, 5 mg/kg iv), L-NNA and L-arginine (50 mg/kg iv) were given 15 min before 2 min stimulation on 3 separate groups for evaluation of NO effects, and microvascular leakage was compared with 2 min NANC stimulation group. Results: 1) Vascular permeability of 1 min NANC stimulation group was increased trachea (208.2%, p<0.05), main bronchus (169.4%, p<0.05), and peripheral bronchus (123.6, p=0.18) compared with sham NANC group. 2) There was about l.5 times increase of vascular permeability in 2 min stimulation group compared with 1 min stimulation group (p<0,05), but not significantly increased permeability of lung parenchyme in both groups. 3) In L-NNA pretreated stimulation oup, there was increased vascular permeability of the trachea (133.3%, p<0.05), main bronchus (167.4%, p<0.05), and peripheral bronchus (197.1%, p<0.05) compared with 2 min stimulation group. 4) L-NNA and L-arginine pretreated stimulation group revealed suppressed vascular permeability com- pared with L-NNA pretreated stimulation group. Conclusion: These results revealed that neurogenic inflammation in the rat airway increases inflammatory responses according to duration of stimulation and blocking of NO synthetase increases neurogenic inflammation. These results provide that nitric oxide modulates inflammatory response of NANC stimulation of the vagal nerves in the rat airways.

Amiodarone에 의해 유발된 폐 독성

심재정 ( Jae Jeong Shim ),이상화 ( Sang Hwa Lee ),유재명 ( Jae Myung Yoo ),서홍석 ( Hong Suk Suh ),오동주 ( Dong Joo Oh ),조재연 ( Jae Youn Joh ),인광호 ( Kwang Ho In ),유세화 ( Se Hwa Yoo ),강경호 ( Kyung Ho Kang ),강은영 ( Eun Y 대한결핵 및 호흡기학회 1994 Tuberculosis and Respiratory Diseases Vol.41 No.1

기관지 천식 환자에서 천식 증상의 정도에 따른 β2 교감신경 수용체의 유전자 다형성

심재정 ( Jae Jeong Shim ),김제형 ( Jei Hyung Kim ),이승룡 ( Seung Yong Lee ),권영환 ( Young Hwan Kwan ),이소라 ( So Ra Lee ),이상엽 ( Sang Youb Lee ),강세용 ( Se Yong Kang ),강용구 ( Yong Koo Kang ),조재연 ( Jae Youn Cho ),인광호 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.1

기관지 천식 환자에서 천식 증상의 정도에 따른 $\beta_2$ 교감신경 수용체의 유전자 다형성

심재정,김제형,이승룡,권영환,이소라,이상엽,강세용,강용구,조재연,인광호,원남희,유세화,강경호,Shim, Jae-Jeong,Kim, Jei-Hyung,Lee, Seung-Yong,Kwan, Young-Hwan,Lee, So-Ra,Lee, Sang-Youb,Kang, Se-Yong,Kang, Yong-Koo,Cho, Jae-Youn,In, Kwang-Ho,Wo 대한결핵및호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.1

서 론: $\beta_2$ 교감신경 수용체 유전자에는 여러 종류의 다형성(polymorphism)가 존재하며, 천식 환자에서 $\beta_2$ 교감신경 수용체의 대표적인 변이는 $\beta_2$ 교감신경 수용체의 아미노산이 대치된 부분으로 Arg16-Gly, Gln27-Glu, Val34-Met 및 Thr164-Ile 등인 것으로 알려져 있다. 지속적인 $\beta_2$ 교감신경 유도체의 자극에 대하여 세포표면으로 부터 세포내의 전달과정이 둔화되어 점차 세포전달이 없어질 수도 있는 desensitization 또는 수용체와 수가 감소하는 downregulation이 존재하는 것으로 알려져 있다. 천식환자에서 $\beta_2$ 교감신경 수용체의 desensitization 또는 downregulation 뿐만 아니라 천식 표현형과 $\beta_2$ 교감신경 수용체 유전자 다형성의 상관 관계에 대한 연구가 이루어지고 있으나 논란이 많다. 이에 본 연구는 기관지 천식환자에서 $\beta_2$ 교감신경 수용체의 가장 흔한 16, 27, 34 및 164 의 아미노산에 해당하는 유전자의 다형성을 MASA (Mutated Allele Specific Amplification)법으로 시행하여 각각의 다형성의 발생 빈도와 천식의 심한 정도와 연관이 있는 가를 확인하였다. 대상 및 방법: 대상 환자는 천식 환자 103명이었으며, 이중 남자는 54명, 여자는 49명으로 평균 연령은 46.6세 (19~80세)였고 이환 기간은 4.7년이었다. 대상 환자는 경미하고 간헐적 증상을 보인 30명, 지속적인 경미한 천식 환자는 32명으로 경미한 천식은 모두 62명이었으며, 중등증의 천식 증상은 17명 및 중종의 천식증상을 보인 환자는 24명이었다. 이중 1년 중에 6개월 이상 전신적 스테로이드를 투여하는 환자는 39명이었으며, 투약 중에도 야간 발작이나 야간 기침이 발생되었던 환자는 44명이었다. 대상 환자로부터 10cc의 전혈구를 체취 하여 분리된 림파구에서 분리된 DNA를 이용하여 MASA 방법으로 $\beta_2$ 교감신경 수용체 16번, 27번, 34번 및 164번째 아미노산의 다형성을 검색하였고, 천식의 심한 정도 따른 $\beta_2$ 교감신경 수용체 유전자의 다형성의 분포와 야간 천식의 발작이나 증상의 유무에 따른 $\beta_2$ 교감신경 수용체 유전자의 다형성의 분포를 확인하였다. 결 과: 16 번째 Arginine이 Glycine으로 변이는 heterozygous 변이가 67명, homozygous 변이가 13명으로 heterozygous 변이가 65.1%로 가장 많았다. 27번째 Glutamine이 Glutamate로 변이는 heterozygous만 11명으로 10.7%였으며, 34번째 Valine이 Methionine으로 변이를 일으키는 100번째 핵산의 경우도 heterozygous만 6명으로 5.8%였다. 27 번째와 34번째 아미노산의 변이를 일으키는 homozygous 변이와 164번째 아미노산의 변이는 대상 환자 중에는 없었다. 천식 증상의 심한 정도를 경종 및 중등증, 중중으로 2 구분하여 $\beta_2$ 교감신경 수용체 다형성의 발생빈도를 관찰한 결과 중증의 천식환자에서 16번째 아미노산의 변이의 빈도는 많았으나 (p=0.015), 27번, 34번 및 164번째의 아미노산의 변이는 천식 증상의 정도와는 연관성이 없었다. 야간 천식 증상의 유무에 따른 $\beta_2$ 교감신경 수용체 다형성은 16, 27, 34 및 164번째 아미노산의 핵산의 변이와 연관성이 없었다. 결 론: 이상의 결과로 기관지 천식 환자에서 $\beta_2$ 교감신경 수용체 다형성은 Arg 16, Gln 27 및 Val 34의 변이가 존재하고, Arg 16이 가장 많았으며, Thr 164는 없었다. 기관지 천식 환자에서 증상이 심한 중증 천식은 $\beta_2$ 교감 신경 수용체의 다형성중 Arg 16의 변이는 중증 천 Background: Genetic and environmental factors are known to affect the incidence and severity of asthma. Stimulation of $\beta_2$-Adrenergic Receptor ($\beta_2$AR) results in smooth muscle relaxation, leading to decrease in resistance of airflow. The gene encoding the $\beta_2$AR has recently been seguenced. The $\beta_2$AR genotype at the polymorphic loci of codons 16, 27, 34, and 164 was known to cause changes in the amino acids. The relationships between the structure of the $\beta_2$AR and its functions are being elucidated. Purpose : The gene encoding the $\beta_2$AR was carried out to assess the frequency of polymorphisms in bronchial asthma, to determine wheather these polymorphisms have any relation to the severity, or nocturnal symptoms in bronchial asthma. Methods: The subjects studied were 103 patients with bronchial asthma, which consisted of 30 mild episodic, 32 mild persistent, 17 moderate, and 24 severe asthma patients. The polymorphisms of the $\beta_2$AR gene were detected by mutated allele specific amplification (MASA) method at the codons 16,27,34, and 164. Results: The most frequent polymorphism was arginine 16 to glycine. The other two polymorphisms, valine 34 to methionine and glutamine 27 to glutamic acid occured in 11 and 6 patients respectively. The polymorphism of threonine 164 to isoleucine was not found in our enrolled patients. The homozygous polymorphism of $\beta_2$AR gene was found in only arginine 16 to glycine (12.6%). The heterozygous polymorphisms of $\beta_2$AR gene were in arginine 16 to glycine, valine 34 to methionine, and glutamine 27 to glutamic acid, as 65.1 %,10.7%, and 5.8% respectively in asthma patients. The presence of agrginine 16 to glycine heterozygous or/and homozygous polymorphism was associated in severe asthma (p=0.015), but there was no association between the other three polymorphisms and the severity of asthma. The frequency of the $\beta_2$AR gene polymorphisms was no relation in nocturnal asthma as compared with non-nocturnal asthma. Conclusion: The arginine 16 to glycine polymorphism of the $\beta_2$AR gene is the most frequently found in asthma patients and association with severe asthma. But there was no association between the polymorphism of the $\beta_2$AR gene and nocturnal asthma.

학술논문 7 : 규제 정책 갈등과 제3자의 역할 - 군사시설보호구역 관련 갈등 조정사례를 중심으로 -

심재정 ( Jae Jeong Shim ) 한국군사학회 2015 군사논단 Vol.82 No.-

Designating and managmg military installation protection zones 1S one of the representative regulatory policies by the military. Such policy could depress local economy and infringe property rights of the individuals. As a result, civil-military conflict is escalating. Since various interested parties are involved in issues concerning military installations, conflict over the issues is complicated. Therefore, higher level of conflict management is required. This study focuses on the third party mediation, one of the typical means of dispute settlement and a very useful one. The central government, national assembly, local government, and citizen association could be the third party to mediate policy conflict. This study addresses the role of the mediator that could be used to settle civil-military conflict through case studies. First, the central government manages dispute settlement organization stipulated by relevant ordinance and is very helpful in mediating the conflict. Second, dispute settlement by the political community including the national assembly has been done mainly by the national defense committee and local members of the national assembly made strong opinions. Third, the local government became an active mediator or spoke for the local community depending on the interest of the community. Fourth, citizen association showed negative attitude towards the regulatory policy, aggravating the conflict rather than mediating it. Therefore, the military has to devise preventive dispute management system and consider a dispute settlement strategy through proper intervention of third party in case of conflict.

군사시설보호구역 규제의 개선방안에 관한 연구

심재정(Shim, Jae Jeong) 한국부동산학회 2020 不動産學報 Vol.82 No.-

군은 안정적인 군사 활동을 보장하고 주민 안전을 위해 군사시설 주변지역에 보호구역을 지정하여 일정한 규제를 하고 있으며, 지역사회 불이익 최소화를 위해 완화 조치를 하고 있다. 그러나 군사시설보호구역이 다수 지정된 일부 지방자치단체는 규제완화를 지속적으로 요구하고 있다. 본 연구의 목적은 군사시설보호구역 규제개선 정책의 실태와 효과를 분석하여 효율적인 규제개선 방안을 제시함으로써 관련 정책 수행에 기여하기 위한 것이다. 본 연구는 2015년 이후부터 현재까지 경기도 및 강원도 북부 지역의 군사시설보호구역을 대상으로 한정하여 군사규제 실태와 군사규제 환경변화, 규제완화 정책의 효과 등에 대해 문헌연구 방법으로 수행하였다. 연구 결과, 군은 급속하게 변하는 규제 환경에 맞게 지속적으로 규제 완화 조치를 하고 있으나 규제 대상자들의 정책체감도는 낮았으며, 규제로 인한 실질적인 피해 보상의 대책도 미약하였다. 따라서 군에서는 군사시설보호구역을 지정 목적에 맞게 적절한 수준으로 관리하고, 민원은 주민편익 차원에서 적극적이고 투명하게 처리하며, 지역사회와 상생할 수 있는 협력시스템 체계화 등의 효과적 군사규제 개선전략이 필요하다. 1. CONTENTS (1) RESEARCH OBJECTIVES The purpose of this study is to contribute to the enforcement of relevant policies by analyzing the actual conditions and the effectiveness of policies to improve the regulation on protection zone of military installations by the military. (2) RESEARCH METHOD This study was conducted using methods including literature reviews for the current condition of military regulation, changes in the military regulation environment, measures to mitigate the regulation, targeting the protection zone of military installations in Gyeonggi-do and Gangwon-do Province. (3) RESEARCH FINDINGS The results showed that the military has continuously taken measures to mitigate the regulation. However, those subject to such regulation were not satisfied with the measures and the measures for actual damage compensation due to such regulation were also insignificant. 2. RESULTS An effective military regulation improvement strategy for managing the protection zone of military installations at a proper level in accordance with its purpose, handling relevant civil complaints actively and transparently in terms of local residents’ benefit, and systematizing the cooperation system to coexist with local communities is necessary for the military.

백서의 기도 신경성 염증에서 산화질소 합성효소(Nitric Oxide Synthase)의 역할과 분포

심재정 ( Jae Jeong Shim ),이상엽 ( Sang Yub Lee ),이상화 ( Sang Hwa Lee ),서정경 ( Jung Kyung Suh ),김철환 ( Chul Hwan Kim ),조재연 ( Jae Youn Cho ),인광호 ( Kwang Ho In ),유세화 ( Seo Hwa Yoo ),강경호 ( Kyung Ho Kang ) 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.3

Web 양상으로 발현한 외상성 기관지 파열

심재정 ( Jae Jeong Shim ),한승환 ( Seung Hwan Han ),이진구 ( Jin Goo Lee ),조재연 ( Jae Yeun Cho ),인광호 ( Kwang Ho In ),김광택 ( Kwang Taek Kim ),유세화 ( Sae Hwa Yoo ),강경호 ( Kyung Ho Kang ) 대한결핵 및 호흡기학회 1994 Tuberculosis and Respiratory Diseases Vol.41 No.5

고립성 폐결절의 감별진단에서 결핵균에 대한 Nested PCR 의 유용성

심재정(Jae Jeong Shim),이소라(So Ra Lee),이상엽(Sang Youb Lee),이상화(Sang Hwa Lee),서정경(Jung Kyung Suh),정희진(Hee Jin Cheong),조재연(Jae Yun Cho),김우주(Woo Joo Kim),강은영(Eun Young Kang),인광호(Kwang Ho In),유세화(Se Hwa Yoo),강 대한내과학회 1997 대한내과학회지 Vol.52 No.6

N/A Objectives: The evaluation and management of a patient with solitary pulmonary nodule(SPN) are guided by principles that were derived from earlier surgical studies. SPN has a relatively good prognosis even if it is a malignant lesion. In Korea, where there is a high incidence of pulmonary tuberculosis, approximately 40% to 70% of clinically encountered solitary pulmonary nodules are tuberculous lesions. SPNs can be diagnosed by clinical findings and chest imaging techniques, but confirmed only by pathologic or cytologic studies. Transthoracic needle aspiration biopsy(TNAB) or cytology will be diagnostic in 80% to 95% of malignant nodules, but will identify the benign nature in 50% to 90% of benign nodules; such results imply lower accuracy of TNBA or cytology in diagnosing benign nodules. Differential diagnosis of SPNs can be difficult in tuberculosis endemic areas, such as in Korea, Nested polymerase chain reaction(PCB) is the widely used method to test very small amount of pathogene and to detect M, tuberculosis in fine needle aspirates. Methods: 33 patients with SPN found on chest radiographs were evaluated by chest CT, mycobacteriologic and cytologic studies from sputum, bronchial washing fluids, and transthoracic fine needle aspirates, 17 cases were malignant SPNs(51.5%), consisting af 14 primary lung cancers and 3 metastatic SPNs, 18 cases were benign SPNs(48.5%), consisting of 8 tuberculous, 4 localized pneumonia, 1 pulmonary sequestration, and 3 radiologically suspected tuberculous lesions without response to anti-TB drugs. Nested PCR for detecting M. tuberculosis using TB-1, TB-2, TB-28, and TB-29C was carried out on fine needle aspirates from 33 patients with SPN. Results: Among the pathologically proven 17 malignant SFNs, 15(88.5%) cases were detected as cancer on chest CT. 15(88.5%) cases were confirmed by transthoracic needle aspiration cytology, among which 3(17.7%) cases showed positive on sputum cytology, and other 3(17.7%) cases yielded positive on bronchial washing cytology as well. Two cases of malignant nodules were confirmed by open resection. In 8 tuberculous SPNs, Neither AFB stain of sputum, bronchial washings, nor transthoracic needle aspirates showed positive. However, mycobacterium was cultured in 1 (9.l%) case from sputum, in 3 (27.3%) cases from bronchial washing fluids, and in 2 (18.2%) cases from transthoracic needle aspirates. Thus, five cases were confirmed bacteriologically; one case had positive culture results on both bronchial washing and transthoracic needle aspirates. Three out of 8 tuberculous cases were radiologically suspected and showed response to anti-TB drugs, but were not bacteriologically confirmed. Chest CT could detect 72.7% of tuberculous nodules. Aspirates from malignancy, pneumonia, and sequestration were negative on nested PCR for tuberculosis, One of the 3 radiologically suspected tuberculous nadules with- out response to anti-TB drugs yielded positive results on nested PCR for M, tuberculosis. In contrast, 7 out of 8(87.5%) aspirates from proven tuberculous nodules showed positive results on nested PCR for M. tuberculous, which included 4 bacteriologically proven tuberculous nodules and 3 radiologically suspected tuberculous nodules with response to anti-TB drugs. Conclusion: Nested PCR could be used to detect M. tuberculosis in fine needle aspirates from tuberculous SPN with good sensitivity (87.5%) and specificity(96.0%). Therefore, nested PCR for detecting M. tuberculosis in fine needle aspirates may be useful in the differential diagnosis of solitary pulmonary nodules.