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심은보,Shim, E.B. 대한의용생체공학회 2009 의공학회지 Vol.30 No.5
Mitochondria play a key role in maintaining life by producing ATP and heat. Recent researches have demonstrated that degenerative diseases such as heart failure, obesity/diabetes, cardiovascular disease, and psychiatric diseases are accompanied by mitochondria dysfunction. In this sense, mitochondria medicine considers the significance of mitochondria in human pathology and tries to explain degenerative diseases as a fatal consequence of mitochondria dysfunction. Here, I introduce the fundamentals of mitochondria physiology and present examples showing the relationship between mitochondria dysfunction and chronic complex diseases. Although mitochondria medicine uses a molecular biological approach predominantly, a biomedical engineering approach might play a critical role in unveiling the complexity of mitochondria medicine and in its application to the diagnosis and treatment of chronic diseases. Thus, I also briefly review the prospects of research using biomedical engineering methods.
심은보(E. B. Shim),김헌영(H. Y. Kim),임채헌(C. H. Leem) 한국정밀공학회 2004 한국정밀공학회 학술발표대회 논문집 Vol.2004 No.10월
A new cell-cross bridge mechanics model is proposed to analyze the mechanics of heart muscle. Electrophysiology of a cardiac cell is numerically approximated using the previous model of human ventricular myocyte. Ion transports across cell membrane initiated by action potential induce excitation-contraction mechanism in the cell via cross bridge dynamics. Negroni and Lascano model (NL model) is employed to compute the tension of cross bridge closely related to ion dynamics in cytoplasm.
심은보(E.B. Shim),고형종(H.J. Ko),윤찬현(C.H. Youn),민병구(B.G. Min) 한국전산유체공학회 2002 한국전산유체공학회 학술대회논문집 Vol.2002 No.-
Flow in the blood sac of the Korean artificial heart is numerically simulated by finite element method. Fluid-structure interaction algorithm is employed to compute the 3D blood flow interacting with the sac material. The motion of the actuator is simplified by a time-varying pressure boundary condition imposed on the outer surface of the sac. Numerical solutions show that there are a strong flow into the outlet and a stagnation flow near the inlet during systole. Shear stress distribution is also delineated to assess the possibility of thrombus formation.
Navier-Stokes 점성유동의 전속도 영역 해석을 위한 새로운 압력기반 PISO-유한요소법
심은보(E. B. Shim),장근식(K. S. Chang) 한국전산유체공학회 1996 한국전산유체공학회지 Vol.1 No.1
A finite element scheme using the concept of PISO method has been developed to solve the Navier-Stokes viscous flows in all speed range. This scheme includes development of new pressure equation that retains both the hyperbolic term related with the density variation and the elliptic term reflecting the incompressibility constraint. The present method is applied. to the incompressible two-dimensional driven cavity flow problems(Re=100, 400 and 1,000). For compressible flows, the Carter plate problem(M=3 and Re=1,000) is computed. Finally, we have simulated the shock-boundary layer interaction(M=2 and Re=2.96×10 5), a more difficult problem, and compared its results with the experiment to demonstrate the shock capturing capability of the present solution algorithm.
Butterfly Valve주위의 3차원 유동에 대한 유한요소해
심은보(E.B.Shim),장근식(K.S.Chang) 한국자동차공학회 1995 한국자동차공학회 춘 추계 학술대회 논문집 Vol.1995 No.6_1
The three-dimensional vortical flow around a half-open butterfly valve is numerically solved using a segregated finite element method developed by the authors. The present finite element scheme uses the well-known finite difference concept PISO. Computational result shows that flow is seperated along the forward part of circular edge of the valve and reattached at the middle of its back face, forming a recirculation region. Vortex tubes are consequently generated in the wake of the valve, the strength of which depends on the Reynolds number. It is shown that in the confined duct flow the secondary vortex tubes are also induced and there arises axial velocity overshoot in the symmetric midplane of the duct flow.<br/>
우주비행 직후 인체 심혈관계의 혈류역학적 변화에 대한 수치적 연구
심은보(E. B. Shim),고형종(H. J. Ko),T. Heldt,R. D. Kamm,R. G. Mark 한국전산유체공학회 2000 한국전산유체공학회 학술대회논문집 Vol.2000 No.10
Orthostatic stress in human cardiovascular system following spaceflight remains a critical problem in the current lifescience space program. The study presented in this paper is part of an<br/> ongoing effort to use mathematical models to investigate the effects of gravitational stresses on the cardiovascular system of normals and microgravity adapted individuals. We employ a twelve compartment lumped parameter representation of the hemodynamic system coupled to setpoint models of the arterial baroreflex and the cardiopulmonary reflex to investigate the transient response of heart rate to orthostatic stress. We simulate current hypotheses concerning the mechanisms underlying postspaceflight orthostatic intolerance over a range of physiologically reasonable values and compare the simulations to astronaut stand test data pre-and postflight.
암의 비대칭적 성장, 혈관생성 및 혈류역학에 대한 수치적 연구
김유석(Y. S. Kim),심은보(E. B. Shim) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
Tumor hemodynamics in vascular state is numerically simulated using pressure node solution. The tumor angiogenesis pattern in our previous study is used for the geometry of vessel networks. For tumor angiogenesis, the equation that governed angiogenesis comprises a tumor angiogenesis factor (TAF) conservation equation in time and space, which is solved numerically using the Galerkin finite element method. A stochastic process model is used to simulate vessel formation and vessel. In this study, we use a two-dimensional model with planar vessel structure. Hemodynamics in vessel is assumed as incompressible steady flow with Newtonian fluid properties. In parent vessel, arterial pressure is assigned as a boundary condition whereas a constant terminal pressure is specified in tumor inside. Kirchhoff’s law is applied to each pressure node to simulate the pressure distribution in vessel networks. Transient pressure distribution along with angiogenesis pattern is presented to investigate the effect of tumor growth in tumor hemodynamics.