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성인 천식 환자들에서 Cytokeratin 18 단백에 대한 IgG 자가항체와 천식의 임상적 중증도 간의 연관성
신지영 ( Jee Young Shin ),권별 ( Byul Kwon ),신호수 ( Ho Su Sin ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ),남동호 ( Dong Ho Nahm ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.3
Background: Cytokeratin 18 (CK18) protein was identified as an airway epithelial cell antigen associated with nonallergic asthma. Objective: We evaluated an association between IgG autoantibodies to CK18 protein and clinical severity of asthma in this study. Method: Severe asthma was defined as when patients had experienced at least one severe asthmatic exacerbation requiring an emergency room visit or admission in the last year despite continuous typical therapies. Moderate asthma was defined as when patients had been controlled by typical therapies without severe asthmatic exacerbation in the last year. Mild asthma was defined as when patients experienced intermittent asthmatic symptoms and did not need continuous anti-asthmatic treatments in the last year. IgG autoantibodies to CK18 protein were detected in serum samples by immunoblot analysis Result: IgG autoantibodies to CK18 protein were detected in 48 of 161 asthmatic patients (29.8%) and 5 of 58 healthy controls (8.6%) (P=0.002). IgG autoantibodies to CK18 protein were detected in 1 of 20 patients with mild asthma (5.0%), 22 of 63 patients with moderate asthma (34.9%), and 25 of 78 patients with severe asthma (32.1%)(P<0.001). Conclusion: These findings suggest that IgG autoantibodies to CK18 protein could be a biological marker for moderate-to-severe asthma requiring continuous medical treatment. (Korean J Asthma Allergy Clin Immunol 2006;26:219-224)
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