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Objectives: The two criteria to clarify the toxicity of a herbal diet are well known. Although mechanical analysis of effective ingredients, a western approach, is widely used, the toxicity presence classification through the herbal analysis from a viewpoint of a theory of the herbal medicine properties has been disregarded. This study is for the safe use of a herbal diet through classification and study of toxicity presence in the herbal diet from the view of a theory of herbal medicine properties, one of the methods of Oriental Medicine. Methods: We classified and studied the toxicity presence in four kinds of herbal diets, waters and grains, animals groups, fruits and vegetables, and herbs and trees, excluding mineral natural drugs, of 1,400 kinds of medicines in 16 chapters of Tang-aec-pyeon, Dong-ui-bo-gam, for which the herbal analysis from a viewpoint of the theory of the herbal medicine properties has been used. The criteria of the toxicity presence in the herbal diet have been largely classified into the toxicant and the non-toxicant, and the toxicant is in turn classified into the insignificant, the medium and the significant. The category to clarify herbal diet has been limited to simultaneous utilization of food and natural drugs. The main text is Dong-ui-bo-gam, although diverse other references have also been used. Results: There are toxicant diets: a kind of tortoise meat of animals groups; five kinds of grains part in fruits and vegetables: aengdo, peach, oyat, small apple and gingko nut; and 12 kinds of vegetables part in fruits and vegetables: ginger, oriental cabbage, lettuce, chongbaek, onion, garlic, leek, fern, houttuynia cordata (myeol), pyeongji, geundae, and spinach, which should be prohibited from long-term use both as food and medicine. Conclusion: If herbal diet is used as health food supplements or food, the toxicity presence should be considered on the grounds of an Oriental Medicine theory of the herbal medicine properties.
Objectives : To evaluate effect of allergy by Radix Scutellariae Water Extract(RS), the biochemical changes associated with allergy were measured in Broncho Alveola Lavage Fluid(BALF), serum, splenocyte and lung of mice. Methods : After induction of allergic inflammation asthma by treatment of Ovalbumine(OVA), RS were taken orally for five successive days on mice, respectively. Results : In the total cell of BALF , the RS(1000mg/kg) treated group was significantly reduced compared to control level, and the reduction of eosinophil showed significantly at concentration of RS(300, 1000 mg/kg). Substantial decrease IgE antibody formation was significantly observed by administration with RS(300, 1000mg/kg), whereas IgGl, IgG2a antibody formation was not affected in serum from RS treated mice. The content of IL-4 exhibited physiological role in lung, splenocyte was not significantly reduced compared to control group after treatment of RS, but IL-5 was significantly reduced at concentration of RS (300, 1000mg/kg). Conclusions : From the above result, it could be concluded that Radix Scutellariae Water Extract showed beneficial effect on the allergic asthma.
Objectives : Asthma is characterized by acute and chronic airway inflammation, and the severity of the airway hyperreactivity correlates with the degree of inflammation. The goal of this study was to investigate the effects of the Radix Platicodi(RP) used to treat allergic asthma, on a well-characterized mouse model of allergic asthma. Methods : Mice sensitized intraperitoneally and challenged intratracheally with conalbumin were treated with RP 24hr after the first intratracheal challenge. The effects of RP on allergic airway hyperreactivity, inflammation, antigenspecific antibody production, cytokine profiles were evaluated. Results RP treatment virtually eliminated airway hyperreactivity and markedly reduced the total number of cells and the percent eosinophils in bronchoalveolar lavage fluids compared with the control group. RP treatment decreased antigen- specific IgE, IgG2a, IL-4, IL.-5, and IL-13 levels, but IFN-γ synthesis increased as compared with control group. Conclusions : From the above results, RP exhibits anti-airway hyperresponsiveness, anti-airway inflammation, and immunoregulatory effects on Thl/Th2 response, which may be useful for treatment of allergic asthma.