MTHFR 677유전자형과 복합운동이 남자 대학생들의 호모시스테인 농도에 미치는 영향

신윤아 ( Yun A Shin ) 한국스포츠정책과학원(구 한국스포츠개발원) 2010 체육과학연구 Vol.21 No.3

이 연구의 목적은 심폐체력, 심혈관질환 위험요인과 식이섭취가 호모시스테인의 농도에 미치는 영향을 알아보고, MTHFR 유전자 다형성과 복합운동에 따른 호모시스테인의 농도변화를 알아보는 데 있다. 이 연구는 62명의 건강한 남자 대학생(24.50 ± 1.84세)을 대상으로 실시하였으며, 12주간 주 4회의 중,고강도의 유산소운동 (70%VO2R)과 저항운동(8~12RM)을 병행한 복합운동을 실시하였다. 심폐체력, 심혈관질환 위험요인과 식이 섭취는 호모시스테인의 농도에 유의한 영향을 주지 않는 것으로 나타났다. 반면, MTHFR 유전자 다형성에 따른 호모시스테인 농도는 운동 전 유의한 차이를 나타내었으며, TT 유전자형 집단이 CC 유전자형( p<.001)과 CT 유전자형 집단( p<.001)보다 유의하게 높은 혈중 호모시스테인 농도를 나타내었다. 12주간 운동훈련 후체질량지수의 변화가 측정시기와 유전자형 집단의 상호작용 효과를 나타내었으며( p<.05), 호모시스테인의 농도도 유전자형 집단( p<.05) 및 측정시기와 유전자형 집단의 상호작용 효과를 나타내었다( p<.01). 따라서 건강한 남자 대학생들의 경우 심폐체력, 심혈관질환 위험요인 및 식이섭취는 호모시스테인 농도에 유의한 영향을 주지않는 것으로 나타났다. 또한, 호모시스테인 농도는 MTHFR 유전자형에 따라 차이를 나타내는 것으로 나타났으며, 운동훈련에 따른 변화에도 영향을 주는 것으로 나타났다. The purpose of this study was to investigate the association between cardiorespiratory fitness, cardiovascular risk factors, dietary habits and homocysteine level in male college students. Also, this study was to investigate the combined training effects on homocysteine levels in male college students according to MTHFR 677 polymorphism. The subjects who participated in this study were 62 healthy male college students(24.50 ± 1.84yrs). All subjects participated in the supervised training program for 12 weeks(4days a week) consisting of aerobic exercise(70% VO2R, 50minutes a day) and resistance training(8~12 RM, 3sets). We did not find any association among cardiorespiratory fitness, cardiovascular risk factors, dietary habits and homocysteine level. Mean values of plasma homocysteine level were significantly higher in the TT genotype group compared to the CC and CT genotype in baseline(p<.001). After exercise training, it was shown that body mass index(p<.05) and plasma homocysteine levels(p<.001) significantly interaction effect between time and group. No change occurred in total cholesterol, high density lipoprotein cholesterol, or triglycerides. Consequently, there were no significant relationships among plasma homocysteine and cardiovascular risk factor, dietary habits and cariorespiratory fitness. However, our results indicate that MTHFR 677 gene affected plasma homocysteine level at baseline and the changes of homocysteine level after combined exercise training.

유산소와 근력운동으로 구성된 복합트레이닝이 뇌졸중 환자의 등속성 하지근력에 미치는 영향

신윤아 ( Yun A Shin ),유연주 ( Yeon Joo Yu ),이한준 ( Han Joon Lee ),진영수 ( Young Soo Jin ) 대한스포츠의학회 2006 대한스포츠의학회지 Vol.24 No.1

척수장애인과 비장애인의 최대운동 검사 시 최대 생리적 반응 비교

신윤아 ( Yun A Shin ),이근호 ( Gun Ho Lee ),김일영 ( Il Young Kim ),( Robert R Wolfe ) 한국특수체육학회 2016 한국특수체육학회지 Vol.24 No.2

이 연구의 목적은 비장애인(AB), 척수손상 운동선수(SCIA), 척수손상 좌업생활인SCIS)을 대상으로 트레드밀과 암 에르고미터를 이용한 최대운동검사 시 생리적 최대 반응과 최고산소섭취량의 차이를 알아보는 것이다. 36명의 척수장애인(23-36세)과 동일한 연령대의 비장애인 40명이 연구에 참여하였으며, 신체 조성과 점증적 트레드밀과 암 에르고미터 검사 동안의 VEpeak, HEpeak, RERpeak , 및 V O2peak가 측정되었다. 암 에르고미터 검사 시 VEpeak는 SCIA와 AB집단이 AB 집단의 트레드밀 검사보다 높게 나타났다. 또한, 암 에르고미터 검사 시 SCIS 집단의 VEpeak는 AB집단의 암 에르고미터 검사와 트레드밀 검사 시보다 낮게 나타났다. SCIA와 AB 집단의 HEpeak는 SCIS와 AB집단의 암 에르고미터 검사 시보다 높게 나타났다. 암 에르고미터 검사 시 RERpeak는 SCIA와 AB집단의 암 에르고미터 검사와 AB집단의 트레드밀 검사보다 높게 나타났다. 암 에르고미터 검사 시 SCIS집단의 체중 당 VO2peak는 SCIA와 AB집단의 암 에르고미터 검사 시와 AB집단의 트레드밀 검사 시보다 낮게 나타났다. 또한 AB집단의 암 에르고미터 검사 시 체중 당 VO2peak는 AB집단의 트레드밀 검사 시보다 낮게 나타났다. 암 에르고미터 검사 시 SCIA집단의 상지근육량 당 VO2peak는 SCIS집단과 AB집단의 암 에르고미터 검사와 AB집단의 트레드밀 검사 시보다 높게 나타났다. 또한 암 에르고미터 검사 시 SCIS집단의 상지근육량 당 VO2peak는 AB집단보다 낮게 나타났다. 총 제지방량 당 VO2peak는 암 에르고미터 검사 시 SCIA집단이 SCIS집단과 AB집단보다, 그리고 AB집단의 트레드밀 검사보다 높게 나타났다. 특히 트레드밀 검사 시 AB집단의 총 체지방량 당 VO2peak는AB집단의 암 에르고미터 검사 시보다 낮게 나타났다. 따라서 하지의 근육량이 감소된 척수장애인들의 VO2peak는 근육량을 고려한 측정이 더 적절할 것으로 사료된다. The purpose of this study was to compare differences in physiological peak variables and peakoxygen uptake (VO2peak) during a maximal exercise test by using a treadmill and an arm ergometer inan able-bodied group (AB), a spinal cord injured athlete group (SCIA), and spinal cord injured sedentary group (SCIS). Thirty-six men with spinal cord injuries (age range, 23-36y) and 40 age-matched AB controls participated in this study. Body composition and VEpeak, HEpeak, RERpeak, and V O2peak were measured during an incremental treadmill and arm ergometer test. The VEpeak during the arm ergometer test for SCIA and AB groups was significantly higher than that in AB group during the treadmill test. In addition, the VEpeak of the SCIS group during the arm ergometer test was significantly lower than that in the AB group and during the treadmill test in the AB group. The HRpeak during the arm ergometer test in the SCIA and AB groups was significantly higher than that in the SCIS and AB groups during the arm ergometer test. RERpeak during the arm ergometer test was significantly higher than that in the SCIA and AB groups; and in the AB group during the treadmill test. For V O2peak per body weight, the SCIS group during the arm ergometer test was significantly lower than that in the SCIA and AB groups, and in the AB group during the treadmill test. Additionally, V O2peak in the AB group during the arm ergometer test was significantly lower than that in the AB group during the treadmill test. V O2peak per upper lean body mass in the SCIA group during the arm ergometer test was significantly higher than that in the SCIS and AB groups; and in the AB group during the treadmill test. Moreover, the SCIS group during the arm ergometer test had a significantly lower V O2peak than the AB group. V O2peak per total lean body mass, in the SCIA group during the arm ergometer test was significantly higher than that in the SCIS and AB groups; and in the AB group during the treadmill test. Further, the V O2peak per total lean body mass in the AB group during the treadmill test was significantly lower than that in the AB group during the arm ergometer test. Therefore, analyzing V O2peak in consideration of muscle mass may be more appropriate for persons with SCI whose lower extremity muscles are paralyzed and are therefore reduced in mass.

중년 남성의 흡연습관과 신체활동이 백혈구 텔로미어 길이에 미치는 영향

신윤아(Yun-A Shin),박동호(Dong-Ho Park),김창선(Changsun Kim) 한국생활환경학회 2020 한국생활환경학회지 Vol.27 No.4

This study was to investigate the effects of smoking habits and physical activity on telomere length in middle aged men. This study was conducted on 106 middle aged men. We examined smoking habites such as smoking period and amount per week, physical activity inflammation markers including c-reactive protein (CRP) and lactate dehycrogenase (LDH), oxidative stress marker (8-OHG), and telomere length. Waist circumference were significant difference between smoking and non-smoking groups (p<.05). Physical activity (PA) were not difference between smoking and non-smoking groups. LDH levels significant difference between smoking and non-smoking groups (p<.05). High-intensity PA has shown a negative association with LDH levels (r=-.117, p<.05) and 8-OHdG (r=-.234, p<.05). Moderate-intensity PA frequency has shown a negative association with 8-OHdG (r=-.223, p<.05). Telomere length has shown a negative association with smoking period (r=-.340, p<.05) and LDH levels (r=-.239, p<.01). These results suggested that smoking and PA affected inflammation and oxidative stress, but did not affect telomere because it was not clinically meaningful. Therefore, it is considered that further research is needed to analyze the chnages according to observation at various time points in the long period.

운동훈련에 따른 심폐체력의 상승이 백혈구수와 대사증후군 위험요인 변화에 미치는 영향

신윤아(Shin, Yun-A),홍지영(Hong, Jee-Young),임미영(Yim, Mee-Young) 대한운동학회 2008 아시아 운동학 학술지 Vol.10 No.1

본 연구는 폐경 후 여성들을 대상으로 염증반응의 지표로서 백혈구수와 심폐체력 및 대사증후군 위험요인의 상관관계를 알아보고, 12주간 유산소 운동을 실시하여 염증반응지표인 백혈구 수와 심폐체력 및 대사증후군 요인의 변화와 관련성을 알아보기 위해 실시되었다. 본 연구는 116명의 중년여성(56.09±4.71yrs)들을 대상으로 실시되었다. 심폐체력은 체질량지수(r=-.503, p<.001), 허리둘레(r=-.592, p<.001), 수축기혈압(r=-.307, p<.05), 이완기혈압(r=-.506, p<.001), 고밀도지단백 콜레스테롤(r=-.429, p<.001), 중성지방(r=-.336, p<.01), 공복시혈당(r=-.369, p<.01), 백혈구 수(r=-.278, p<.05)와 유의한 음의 상관관계를 나타내었으며, 심폐체력이 높을수록 대사증후군 발병 위험이 감소하는 것으로 나타났다. 또한 백혈구수의 증가는 체질량지수, 허리둘레, 수축기혈압, 이완기혈압, 중성지방, 공복 시 혈당 및 대사증후군 위험요인수의 증가와 관련이 있는 것으로 나타났다(p<.01). 12주간의 유산소 운동은 대사증후군의 위험을 감소시키는 것으로 나타났다. 따라서 규칙적인 운동과 심폐체력의 상승은 염증반응의 지표인 백혈구수를 감소시키고, 대사증후군 위험 감소와 관련이 있는 것으로 나타났다. The purpose of this study is to investigated the association between cardiorespiratory fitness, inflammation marker(WBC) and metabolic syndrome factors and the effects of WBC, cardiorespiratory fitness, and metabolic syndrome risk factors after 12 weeks exercise training. The subjects were 116 postmenopausal women(56.09±4.71yrs) participated in this study. Cardiorepitatory fitness were negatively correlated with BMI(r=-.503, p<.001), WC(r=-.592, p<.001), systolic blood pressure(r=-.307, p<.05), diastolic blood press(r=-.506, p<.001), HDL-C(r=-.429, p<.001, TG(r=-.336, p<.01), fasting glucose levels(r=-.369, p<.01) and WBC(r=-.278, p<.05). The high levels of cardiorespratory fitness were associated with the lower risk of metabolic syndrome. Additionally, the risk for clustered metabolic syndrome risk factors including BMI, WC, SBP, DBP, TG, FBG, and Mets was increased along with increasing WBC counts(p<.01). Furthermore, following 12weeks aerobic exercise, the metabolic syndrome risk factors significantly decreased. Therefore, this results suggested that regular exercise and up-regulated cardiorespiratory fitness decreased the inflammatory index(WBC) and metabolic syndrome.

비만인의 체중감량을 위한 운동중재 방법에 대한 고찰

신윤아 ( Yun-a Shin ),최명동 ( Myung-dong Choi ),김일영 ( Il-young Kim ) 한국운동생리학회(구 한국운동과학회) 2016 운동과학 Vol.25 No.4

PURPOSE: The prevalence of obesity in South Korea has been greatly increased over the past decades despite increases in one`s participation in weight reduction programs including exercise intervention. While it has been repeatedly shown that exercise has positive impacts on many health outcomes including lean body mass, fat mass, and insulin sensitivity, its effect on weight reduction is largely unclear. The purpose of this review was to summarize available data on the effect of exercise intervention on weight reduction and provide guidelines for developing effective exercise intervention, applicable to clinical practice. METHODS: In this review, we reviewed currently available data mainly from meta-analytic studies and other available literature on the effect of therapeutic exercise intervention on weight loss. RESULTS: Studies have generally shown that exercise intervention alone may not be effective in weight reduction due in part to insufficient exercise volume, compensatory increases in food intake, and so on. CONCLUSIONS: It seems that exercise, especially when combined with other interventions such as diet, may enhance effectiveness of the weight loss intervention through increases in lean body mass and/or decreases in fat mass in an exercise volume dependent manner.

뇌병변 장애인의 심폐체력과 염증반응 지표 및 뇌졸중 위험요인의 관련성

신윤아 ( Yun A Shin ),김효중 ( Hyou Jung Kim ),임강일 ( Kang Il Lim ) 한국특수체육학회 2009 한국특수체육학회지 Vol.17 No.4

본 연구의 목적은 뇌병변 장애인 중 뇌졸중 환자들을 대상으로 심폐체력과 염증반응 지표 및 뇌졸중 위험요인과의 관련성을 분석하는데 있다. 본 연구는 80명의 뇌졸중 환자를 대상으로 실시하였다. 여성 뇌졸중 환자는 남성보다 체지방량(p<.001), 총콜레스테롤(p<.05), 고밀도지단백질 콜레스테롤(p<.05)이 높은 것으로 나타났으며, 남성 뇌졸중 환자는 호모시스테인 농도(p<.001)과 hsCRP 수준(p<.05)이 여성보다 높은 것으로 나타났다. 전체적으로 백혈구 수는 체질량지수(p<.05) 및 공복 시 혈당(p<.01)과 유의한 양의 상관관계를 나타내었으며, 고밀도지단백질 콜레스테롤(p<.01)과 유의한 음의 상관관계를 나타내었다. Fibrinogen은 체지방률(p<.01)과 유의한 양의 상관관계를 나타내었다. oxLDL은 총콜레스테롤(p<.01) 및 호모시스테인(p<.05)과 유의한 양의 관련성을 나타내었다. 심폐체력은 체질량지수(p<.05), 체지방량(p=.01)과 음의 관련성을 나타내었다. 이상의 결과를 종합 해보면 본 연구의 뇌졸중 환자들은 염증반응 지표 중 백혈구 수와 혈중 oxLDL 수준이 증가되어 있으며, 이러한 염증지표가 뇌졸중 위험과 관련이 높은 것으로 나타나 염증반응 개선을 통한 뇌졸중 위험요인의 관리가 필요한 것으로 고려된다. The purpose of this study was to investigate the association between cardiorespiratory fitness, inflammation marker and stroke risk factors. The subjects who participated in this study were 80 stroke patients. There was showed that body percent fat(p<.001), total cholesterol(p<.05), and high lipoprotein cholesterol(p<.05) in women were higher than men. On the other hand, homocystein(p<.001) and hsCRP(p<.05) in men were higher than women. White blood cell(WBC) was positively correlated with body mass index(BMI)(p<.05) and fasting blood glucose(FBG) level(p<.01) and negatively correlated with high lipoprotein cholesterol(HDL-C)(p<.01). Fibrinogen was positively correlated with percent body fat(p<.01). OxLDL(oxidative low-density lipoprotein) was positively correlated with total cholesterol(TC)(p<.01) and homocystein(p<.05). Moreover, the cariorespratory fitness was negatively correlated with BMI(p<.05) and body percent fat(p<.01) and positively correlated with HDL-C(p<.05). Consequently, the results of this study demonstrated that the inflammation indices, especially WBC and plasma oxLDL, were up-regulated in stroke patients and these factors have significant relationship with the recurrent stroke events. Therefore, stroke patients in this study were need to manage and treat for the prevention of recurrent stroke events.

노인의 사회적 지지 및 자아존중감이 구강건강행위에 미치는 영향

신윤아 ( Yuna Shin ),홍진실 ( Jinsil Hong ),김영삼 ( Youngsam Kim ),장기완 ( Kee-wan Chang ) 대한예방치과·구강보건학회 2017 大韓口腔保健學會誌 Vol.41 No.4

Objectives: This study aimed to determine the oral health behaviors and the relationships between social support, self-esteem, and oral health behaviors. Methods: The institutions were selected based on the “2016 Elderly Welfare Facilities Status.” A total of 195 people participated in interviews conducted using a 39-item questionnaire. It included information on the following topics: a) sociodemographic and health-related characteristics (11 items), b) oral health behaviors (6), c) social support (12), and d) self-esteem (10). Statistical analyses included descriptive statistics, a reliability test, a t-test, an ANOVA, a Pearson’s correlation test, and a stepwise multiple regression, conducted using the SPSS 23.0 program. Results: Of the 195 participants, 165 (84.6%) brushed their teeth twice a day; however only 74 (38.0%) participants used oral care products. Although many (64.6%) elderly people visited a dentist at least once a year, only a few (24.6%) visited the dentist for preventive purposes. Oral health behaviors had a positive correlation with self-esteem, significant others’ support, and friends’ support (.337, .270, and .254, respectively; P<.01). According to the multiple regression analysis, self-esteem, significant others’ support, perceived health status, number of existing permanent teeth, friends’ support, degree of exercise, gender, and average monthly expenditure had a significant effect on the participants’ oral health behaviors. Conclusions: We demonstrated that social support and self-esteem might be major predictors of oral health behaviors. These results suggest that psychosocial factors need to be taken into account in the oral health education provided for elderly people.

비만여성들의 C-Reactive Protein과 염증반응지표에 미치는 유산소훈련의 효과

신윤아(Yun A Shin),임강일(Kang Il Lim),석민화(Min Hwa Suk) 한국사회체육학회 2007 한국사회체육학회지 Vol.0 No.30

The purpose of this study was investigate the effect of aerobic exercise on high sensitivity C-reactive protein(hs=CRP), inflammatory markers, and cardiovascular risk factors in obese women. Nineteen obese women(body mass indexs≥25) aged 40 to 53 years were randomly assigned to either a training or control group. The training program consisted of 12 weeks of supervised aerobic exercise(60%VO2R, 60min) three times a week on treadmill. Body weight, BMI, percent of body fat, and waist circumference were significantly decreased after training. Aerobic exercise significantly decreased cardiovascular risk factors and inflammatory markers, including fibrinogen, leptin and IL-6 whereas CRP and adiponectin did not change. The reduction of weight after training was positively associated with the decrease of SBP, TC, TC/HDL-C, TG, CRP, leptin, and IL-6. The change of CRP was positively associated with that of fibrinogen and leptin(p<.05), and also a positive correlation between the changes of leptin and IL-6 was observed(p<.01). As a results, a 12-week aerobic exercise intervention improved cardiovascular risk factors as well as inflammatory markers including fibrinogen, IL-6 and leptin, but had no effect on the modification of CRP despite the improvement of body composition in obese women.

장애유무, 선수경력 유무에 따른 백혈구 텔로미어 길이와 미토콘드리아 DNA 농도에 대한 비교분석

신윤아 ( Yun-a Shin ) 한국체육학회 2020 한국체육학회지 Vol.59 No.3

이 연구는 장애유무와 선수경력이 심폐능력, 세포노화지표인 텔로미어와 미토콘드리아 DNA 농도에 미치는 영향을 알아보기 위한 목적으로 수행되었다. 연구의 대상은 유산소 종목의 선수경력을 가진 척수장애인과 비장애인 운동경력자와 규칙적인 운동을 하지 않는 동일한 연령대의 척수장애인과 비장애인을 대상으로 심폐능력, 텔로미어 길이 및 미토콘드리아 DNA(mtDNA)농도를 측정하여 분석하였다. 심폐능력은 장애유무(p <.01), 선수경력(p <.001), 및 장애유무와 선수경력에 따른 상호작용 효과를 나타내었다(p <.05). 텔로미어는 장애유무(p <.01), 선수경력(p <.001), 및 장애유무와 선수경력에 따른 상호작용 효과를 나타내었다(p <.05). mtDNA 농도는 선수경력에 따른 유의한 차이가 나타났다(p <.001). 장애유무에 따른 변인들 간의 관련성은 척수장애인의 경우 심폐능력이 텔로미어 길이(r=.431, p <.05)와 mtDNA 농도(r=.354, p <.05)와 유의한 양의 상관관계를 나타내었다. 비장애인의 경우 심폐능력은 텔로미어 길이(r=.629, p <.001)와 mtDNA 농도(r=.571, p <.001)와 유의한 양의 상관관계를 나타내었다. 이러한 결과를 종합해보면, 규칙적인 운동은 척수장애인의 심폐능력을 향상시키고 세포노화를 지연시키는 것으로 나타났다. This study aimed to comparison of white blood cell markers of cellular aging, namely telomere length (TL) and mitochondrial DNA (mtDNA) concentration with or withour disability and athletics experience. We measured cardiorepiratory fitness (CRF), white blood cell TL, and mtDNA concentration in former aerobic athletes with and without SCI as well as their counterparts of similar ages who do not exercise regularly. CRF showed a significant difference with or without disability(p<.01), athletics experience(p <.001), and the effect of interaction between disability and athletics experience(p <.05). Telomere length showed a significant difference with or without disability(p<.01), athletics experience(p<.001), and the effect of interaction between disability and athletics experience(p <.001). mtDNA concentration showed a significant difference according to athletics experience(p <.001). Association according to disability between factors, CRF showed significant positive correlation with TL (r=.431, p <.05) and mtDNA concentration (r=.354, p <.05) in people with SCI. Also, CRF showed significant positive correlation with TL (r=.629, p <.001) and mtDNA concentration (r=.571, p <.001) in people without SCI. In summary, the study concluded that regular exercise could improve cardiopulmonary function and delay cellular aging in people with SCI.