물리 효과 기반 서비스 디스커버리

신용진 ( Yong-jin Shin ),김도현 ( Do-hyun Kim ),이영희 ( Young-hee Lee ),최우진 ( Woo-jin Choi ) 한국정보처리학회 2008 한국정보처리학회 학술대회논문집 Vol.15 No.2

본 논문은 대체 서비스 디스커버리를 위한 효과 기반 명세 모델과 매칭 방식을 제안한다. 효과 기반이라 함은 시맨틱 웹의 IOPE 모델에서 효과(effect)를 재 정의 하여 서비스 및 디바이스를 명세 하는데 사용한다는 말이다. 여기서 효과는 인간이 인지할 수 있는 오감을 사용하며, 오감의 인지는 센서를 통하여 한다. 오감을 이용하여 서비스를 탐색 함으로써, 우리는 서비스의 가용성을 높일 수 있다. 매칭은 서비스를 세 가지의 타입으로 나눈 후 각 타입에 해당하는 항목별로 유사도를 계산하고 각 항목들의 합으로 최종 유사도를 도출해 낸다. 본 연구에서 제안한 효과 기반 서비스 디스커버리는 기존의 시맨틱 서비스 디스커버리보다 서비스의 가용성을 높여 줄 것으로 기대한다.

정신병원 입원 환자들의 휴대 전화 사용에 대한 고찰

최영숙(Young Sook Choi),신경철(KyoungChul Shin),박한선(Han Sun Park),임미래(Mee Rae Lim),신용진(Yong Jin Shin),이호선(Ho Sun Lee),이건석(Kounseok Lee),오규수(Kyu Soo Oh) 대한사회정신의학회 2016 사회정신의학 Vol.21 No.2

디지털 테크놀로지(Digital Technology)는 모든 현대인의 일상 생활과 의료 환경에 막대한 영향을 주고 있다. 정신병원 입원 환자들에게 휴대 전화 사용을 제한하지 않았을 때 환자들의 사생활의 자유, 표현의 자유, 알 권리 등의 기본권이 보장되어 인권이 보호된다고 볼 수 있는 측면이 있다. 한편으로 휴대 전화 사용이 타 환자뿐만 아니라 휴대 전화를 이용하는 환자 자신의 사생활의 보호, 진료 정보의 비밀유지와 안전하고 치료적인 환경 조성에 미치는 영향을 고려해야 한다. 그러므로 환자의 기본권 보호와 안전한 치료 환경 형성과 사생활 보호의 효과를 얻기 위해서, 개별 기관은 환자뿐만 아니라 직원, 방문자의 휴대전화, 녹음기기, 무선 전자기기 사용에 대한 구체적인 정책과 절차를 마련해야 한다. 환자의 휴대 전화 사용을 허용할 때, 기관은 환자에게 올바른 휴대 전화, 스마트폰 사용에 대한 교육을 제공하고, 문제성 인터넷 사용 및 비디오 게임 사용 등에 대해 사전 평가를 하는 것이 필요할 것으로 보인다. 또한 향후 정신질환을 가진 사람들의 휴대 전화·모바일 전자기기(Mobile Device)·인터넷·소셜 네크워킹 서비스(Social Net-working Service)사용 양상 및 치료재활 서비스에 모바일 전자기기의 이용 등, 디지털 테크놀로지와 정신 건강에 대한 연구가 필요할 것으로 보인다. Digital technology has a great effect on a daily life and medical environment of human. In mental hospital, many things thus should be considered when deciding a restriction of use of mobile phone by patients. There is positive effect of use of mobile phone on protecting human rights such as freedom of private life and expression, and right-to-know. However, Unchecked used of mobile phone can make the other person distracted and uncomfortable and can disturb treatment. Therefore, mental hospitals should establish their policy for the use of recording devices, mobile phone and other electronic wireless devices. Prior to the permission of mobile phone, mental hospital should provide an education of proper use of mobile phone for patients and should evaluate their risk for misuse of it.

3-NP에 의해 유발된 신경교세포의 산화적 손상에 대한 남성(南星)의 보호효과

이정섭,신용진,전지영,설재균,최철원,신선호,이인,남상규,Lee, Jung-Sup,Shin, Yong-Jin,Jeon, Ji-Young,Seol, Jae-Gyun,Choi, Chul-Won,Shin, Sun-Ho,Lee, In,Nam, Sang-Kyu 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.3

Objectives : This study aimed to investigate the underlying protective mechanism of Rhizoma Arisaematis(RA) on 3-NP-induced Cytotoxicity in rat C6 glial cells. Methods : We investigated treatment ofC6 cells with 20mM 3-NP and pretreatment with RA to cause loss of cell viability. and morphological change. which was associated with elevation of ROS level. increase in Bax/Bcl2 ratio and HIF-a protein expression Results : RA inhibited 3-NP-induced cell death in C6 glial cells and inhibited the changes of the : MMPT (mitochondria membrane potential transition) and inhibited the decrease of mitochondria complex II activity and 3-NP-induced ROS generation in C6 cells. And RA decreased the activity of HIF-a and Bax. and increased the activity of $Bcl_2$ in C6 glial cells Conclusions : RA markedly protects C6 glial cells from 3-NP-induced oxidative injury.

$CoCl_2$로 유도된 C6 신경교세포의 사멸에 대한 억간산(抑肝散)의 보호 효과

조문영,신용진,하예진,우찬,김태정,유주연,최용석,최정훈,신선호,Cho, Mun-Young,Shin, Yong-Jeen,Ha, Ye-Jin,Woo, Chan,Kim, Ta-Jung,You, Ju-Yeon,Choi, Yong-Seok,Choi, Jung-Hoon,Shin, Sun-Ho 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.2

Objectives : In this study, we made an effort to investigate the protective mechanism of Ukgan-san (UGS) extracts on hypoxia-induced C6 glial cell death. Methods : The cell viability was assessed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MMT) assay and cell morphological changes were analysed with microscope after staining with crystal violet (CV). Reactive oxygen species (ROS) formation was assessed by flow cytometer after staining with 2'7'-dichlorofluorescein diacetate (DCF-DA). We also analyzed expression of hypoxia-inducible factor-1 alpha (HIF-$1{\alpha}$) and p53, processing of procaspase-3 and procyclic acidic repetitive protein (PARP) by western blot method. Results : We estimated the elevated cell viability by UGS extract on $CoCl_2$-induced C6 glial cells. UGS attenuated $CoCl_2$-induced ROS formation in C6 glial cells and also showed a protective activity compared to antioxidants and exhibited abrogation of LDH-released by $CoCl_2$. UGS suppressed the typical apoptotic cell death markers, caspase-3 and PARP activation. UGS inhibited $CoCl_2$-induced HIF-1${\alpha}$ expression which is known as a major regulator for hypoxia-induced cell death, and suppressed p53 expression. Conclusions : These results suggest that UGS extract contains protective constituents for hypoxia-induced C6 glial cell death.

진무탕(眞武湯)이 $H_2O_2$로 유도된 C6 Glial 세포사에 미치는 영향

최정훈,신용진,하예진,조문영,유주연,이숭인,신선호,Choi, Jung-Hoon,Shin, Yong-Jeen,Ha, Ye-Jin,Cho, Mun-Young,You, Ju-Yeon,Lee, Soong-In,Shin, Sun-Ho 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.3

Objectives : The purpose of this study was to investigate the mechanism of protective effect of Jinmu-tang (JMT, Zhenwu-tang) extract on $H_2O_2$-induced cell death in C6 glial cells. Methods : Cultured C6 glial cells of white mice were pretreated with JMT extract and exposed to $H_2O_2$ for inducing cell death. We measure the cell viability by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and investigate the cell morphology using a light microscope after crystal violet (CV) staining. Reactive oxygen species (ROS) formation was analyzed using a flow cytometer and a fluorescent microscope after staining with 2'7'-dichlorofluorescein diacetate (DCF-DA). DNA fragmentation was analyzed using a flow cytometer after propidium iodide (PI) staining and nuclei morphology was investigated using a fluorescent microscope after 2-[4-amidinophenyl]-6-indo-lecarbamidine dihydrochloride (DAPI) staining. We analyzed expression of Bax, processing of procaspase-3 and poly (ADP-ribose) polymerase (PARP), and activation of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) by western blot method. Tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) secretion was analyzed using Quantikine kit. Results : We determined the elevated cell viability by JMT extract on $H_2O_2$-induced C6 glial cell death. ROS formation, DNA fragmentation, $I{\kappa}B{\alpha}$ phosphorylation, NF-${\kappa}B$ activation, and secretion of TNF-${\alpha}$ induced by $H_2O_2$ are inhibited by JMT extract pre-treatment. JMT extract inhibits Bax expression, processing of caspase-3 and PARP that are critical biochemical markers of apoptotic cell death. Conclusions : These results suggest that JMT extract has a protective effect on $H_2O_2$-induced C6 glial cell death in various pathways.

육군자탕(六君子湯)이 Glutamate에 의한 C6 신경교세포의 Apoptosis에 미치는 영향

장원석,신용진,고석재,하예진,권영미,신선호,Jang, Won-Seok,Shin, Yong-Jeen,Ko, Seok-Jae,Ha, Ye-Jin,Kwon, Young-Mi,Shin, Sun-Ho 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3

Objective : The water extract of Yukgunja-tang(YGJT) has been traditionally used in treatment of qi deficiency and phlegm in Oriental medicine. However, little is known about the mechanism by which YGJT protects neuronal cells from injury damages. Therefore, this study was designed to evaluate the protective effects of YGJT on C6 glial cells by glutamate-induced cell death. Methods : The present study describes glutamate, which is known as an excitatory neurotransmitter, related with oxidative damages, and YGJT, which shows protective effects against glutamate-induced C6 glial cell death. One of the main mediators of glutamate-induced cytotoxicity was known on the generation of reactive oxygen species(ROS) via activation of NADPH oxidase (NOX). The protective effects of antioxidant(NAC) and NOX inhibitor(apocynin) on the glutamate-induced C6 glial cells were determined by a MTT reduction assay. Result : YGJT inhibited glutamate-induced ROS generation via inhibition of NOX expression on glutamate-stimulated C6 glial cells. Furthermore, YGJT attenuated glutamate-induced caspase activation. These results suggest that YGJT could be a new potential candidate against glutamate-induced oxidative stress and cell death. Conclusion : These findings indicate that in C6 glial cells, ROS plays an important role of glutamate-induced cell death and that YGJT may prevent cell death from glutamate-induced cell death by inhibiting the ROS generation.

인터넷 도박의 잠재적 문제점

최영숙(Young Sook Choi),신경철(Kyoung Chul Shin),최용성(Yong-Sung Choi),박한선(Han Sun Park),임미래(Mee Rae Lim),신용진(Yong Jin Shin),이호선(Ho Sun Lee) 대한사회정신의학회 2014 사회정신의학 Vol.19 No.1

병적 도박은 지속적이고 반복적으로 나타나는 부적응적인 도박행위로 개인, 가족, 혹은 직업적 기능을 붕괴시키는 질환으로 개인 수준의 병리적 문제를 일으킬 수 있을 뿐만 아니라 가족과 사회 전반에까지 부정적인 문제를 양산할 수 있다. 인터넷 도박은 오프라인 도박이 인터넷을 매개로 한 가상공간에서 이루어지는 도박이다. 도박 환경은 최근 수 년 동안 변해왔고 인터넷을 이용한 도박은 도박에 더 접근 가능하게 만들고 언제 어디서든 도박을 할 수 있는 기회를 제공하며 인터넷 도박 사이트 수와 매출액이 세계적 으로 매년 증가하고 있다. 인터넷 환경과 도박과 관련 문제의 발생 혹은 악화 사이의 연관성에 있어서 방향성을 단정할 수는 없음에도 인터넷이라는 매개체가 오프라인에서 보다 문제 도박에 더 기여하고, 문제 인터넷 도박자는 문제 오프라인 도박자들에 비해 더 젊고 더 심각한 도박 문제를 가지고 있는 등의 유의한 차이를 보고하는 연구 결과들이 있다. 그리고 문제 인터넷 도박자는 문제 비인터넷 도박자에 비해 도움을 구하는 행동을 적게 하는 경향을 나타냈다. 그리고 청소년들 사이에서 인터넷 사용이 확산되면서 인터넷 도박 행동이 급격히 증가하고 있고 인터넷 도박을 하는 청소년들은 문제성 인터넷 사용과 인터넷 중독적 행동을 발전시킬 잠재적 위험에 처해있다. 인터넷 도박과 연관된 위험성에 대한 관심이 아직 부족한 실정이다. 인터넷 도박의 잠재적 문제점에 대한 대중의 인식을 증가시키려는 노력이 필요하며 문제 인터넷 도박자들에게 특화된 치료 및 예방적 계획이 요구된다. Pathological gambling is persistent and recurrent maladaptive gambling behavior that disrupts personal, family, and vocational pursuits, and causes not only problems of personal level but also of family up to the society at large. Internet gambling is gambling mediated by internet in the cyberspace. Environment for gambling has been changed for several years. Internet gambling enabled people starting gambling more easily, and provided greater chance for being addicted to gambling via gambling websites. Thereby, total market and websites for internet gambling has been grown up in recent years. Although there is no clear relationship between the gambling environment and development of problems related to gambling, gambling behavior tends to be more problematic by internet gambling than by offline gambling. In addition, internet gamblers are younger and have more serious gambling problems than offline gamblers. Problem internet gamblers less tend to seek help than offline gamblers. As the adolescents more popularly use internet, internet gambling behavior has been abruptly increased, and adolescent internet gamblers are at the risk of developing internet use problem and internet addictive behaviors. There is little attention to the risks related to internet gambling. Works for increasing public awareness about potential problems of internet gambling and special treatment and preventive plans for problem internet gambling are necessary.

로마 가톨릭에서 본 영성과 정신의학

강석진(Seok-Jin Kang),박한선(Hanson Park),신용진(Yong Jin Shin),이호선(Ho Seon Lee),임미래(Meerae Lim),고석만(Seok-Man Ko),최영숙(Young-Sook Choi),신경철(Kyung-Chul Shin),최용성(Yong-Sung Choi) 대한사회정신의학회 2014 사회정신의학 Vol.19 No.1

인간의 몸과 마음이 분리될 수 없는 것처럼 인간의 영성과 마음도 분리될 수 없는 속성을 가진 실체이다. 로마 가톨릭 교회에서는 수 천년 전부터 여러 가지 형태와 이름으로 인간의 영성에 대한 신학적 이론 아래에서 정신장애인을 바라보고, 또한 실천적인 치료를 해오고 있다. 본고에서는 영성 정신치료의 역사적 연원을 다루어 보고, 로마 가톨릭의 입장에서 이에 대한 이론적 배경을 다루고 자 한다. 또한 임상적인 측면에서 가톨릭 영성 정신치료의 역할과 한계, 가능성을 간략하게 검토한다. It is human mind that has inseparable relation from the spirit, like the relation of body and mind. Roman Catholic Church has a long history of theory and practice about mental illness and mentally disabled people by a variety of therapeutic forms in the view of theological virtues. In this article, we overview the historical roots of spiritual psychotherapy and deal with the theological background in the terms of Roman Catholic Church. In addition, we review the role, limitation and possibility of Catholic spiritual psychotherapy in clinical psychiatric aspects in brief.

자금정(紫金錠)이 간암세포주 HepG2의 세포고사 및 세포주기에 미치는 영향

조영기,전지영,신용진,설재균,이재화,원진희,문구,Cho, Young-Kee,Jeon, Ji-Young,Shin, Yong-Jeen,Seol, Jae-Kyun,Rhee, Jae-Hwa,Won, Jin-Hee,Moon, Goo 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4

Objectives : Jageum-Jung is used as an anti-cancer agent in oriental medicine, but the mechanism by which it induces cell death in cancer cells is still unclear. The purpose of this study was to investigate the effects of Jageum-Jung on apoptosis and cell cycle arrest in HepG2 hepatoma cells. Methods : Various cancer cell lines including HepG2, C6 glioma, SH-SY5Y, PANC-1, and MCF-7 cells, were used. Apoptosis was determined by DAPI nuclei staining and flow cytometry in HepG2 cells treated with various concentrations (from 25 to 200 ${\mu}g/ml$) of $H_2O$ extract of Jageum-Jung (JGJ) for 48 hrs. Expression of cell cycle arrest mediators including Rb, p53, p21, cyclin B1, cdk4, and cyclin E proteins were measured by Western blot analysis. To estimate intracellular hydrogen peroxide levels and intracellular nitric oxide levels, HepG2 cells were stained with DCFH-DA dye and DAF dye, subjected on flow cytometric analysis. Results : 1. Jageum-Jung decreased the viability of HepG2 cells in a dose-dependent manner. 2. Jageum-Jung induced the catalytic activation of caspase-3 in HepG2 cells. 3. Jageum-Jung increased the intracellular hydrogen peroxide and NO in HepG2 cells. 4. Jageum-Jung increased the expression of Rb, p53 and p21 in HepG2 cells. 5. Jageum-Jung induced the expression of cyclin B1, cdk4, and cyclin E in HepG2 cells. Conclusions : Taken together, we suggest that Jageum-Jung exhibits cytotoxic effects on HepG2 cells, causing apoptosis and cell cycle arrest. The results showed that Jageum-Jung may do so by regulating the expression of specific target molecules that promote efficient apoptotic cell death following $G_2$/M phase arrest in a dose-dependent manner.

右歸飮加味方 투여로 호전된 레이노 병 환자 1례

하예진(Ye Jin Ha),조문영(Mun Young Cho),장원석(Won Seok Jang),은선혜(Seon Hye Eun),신용진(Yong Jeen Shin),신선호(Sun Ho Shin) 한의병리학회 2011 동의생리병리학회지 Vol.25 No.5