참외추출물이 스코폴라민 유도 기억상실 흰쥐의 인지능 회복에 미치는 효과

박상신(Sang-Shin Park),박나오미(Naomi Park),강주억(Ju-Uk Kang),신석철(Suk-Chul Shin),이동웅(Dong-Ung Lee) 한국생명과학회 2009 생명과학회지 Vol.19 No.5

The methanol extract of muskmelon (Cucumis melo) has been investigated for its cognition enhancing effects by evaluation of inhibitory activities on acetylcholinesterase, a degrading enzyme of acetylcholine, a brain neurotransmitter, and β-secretase, which forms the β-amyloid toxic protein from its precursor protein. A passive avoidance task, one of the animal model experiments for learning and memory, was also performed. As a result, the melon extract showed 15.8% and 35.3% inhibition on acetylcholinesterase and β-secretase, respectively, with a final concentration of 100 ㎎/ml. In the animal model test, melon extract significantly (p<0.05) lengthened the step-through latency time by 22.7% compared to the control group, suggesting that melon extract has, indeed, an effect on cognition enhancement.

화학수소화합물을 이용한 소형 무인항공기용 연료전지 시스템 연구

홍지석(Ji-Seok Hong),정원철(Won-chul Jung),김현진(Hyeon-jin Kim),이민재(Min-Jae Lee),정대성(Dae-Seong Jeong),전창수(Chang-Soo Jeon),성홍계(Hong-Gye Sung),신석재(Seock-Jae Shin),남석우(Suk-Woo Nam) 한국항공우주학회 2013 韓國航空宇宙學會誌 Vol.41 No.3

소형 무인항공기의 동력장치로 연료전지 시스템을 적용하기 위해 화학수소화합물 수소 저장방법을 이용한 소형 수소 발생 제어장치를 설계하였다. 효율이 높은 소형/경량 수소 발생 제어장치를 설계하기 위하여 NaBH4 수용액 공급 유량에 따른 Co-B 촉매의 수소 전환율을 확인하였고, 100W 스택의 최대 수소 발생량에 적합한 Co-B 촉매양을 제안하였다. 효율적인 연료 소모를 위해 Dead-end 방식의 스택을 선택하였고, 수소 발생 제어장치 내부 압력을 이용한 펌프 on/off 제어로 수소 생성량을 제어하였다. 소형 수소 발생 제어장치를 이용한 연료전지 시스템의 각 작동구간에서 안정된 운전을 확인하였다. 장시간 운전 실험을 통하여 최대 7시간 운전이 가능하며, 임의의 비행 프로화일에 요구되는 추력 프로화일은 최소 4시간 이상 조정 가능함을 확인하였다. A compact hydrogen generation device of fuel cell system using chemical hydride storage technique was designed to fit the propulsion device requirement of a small unmanned aerial vehicle(SUAV). For high efficient, compact, and lightweight hydrogen generation control device, the Co-B catalyst hydrogen conversion rate by NaBH4 aqueous solution flux is measured so that the proper amount of Co-B catalyst for maximum hydrogen generation of 100W stack was proposed. A compact hydrogen generation device is controlled by pumps on/off using its own internal pressure and consumes fuel in high efficiency through a dead-end type fuel cell. The fuel cell system has stable operation for a planed flight profile. The system operates up to maximum 7 hours and at least 4 hours for tough flight profiles.

치매환자의 다면적 평가와 평가척도간의 상관성

신용재(Yong-Jae Shin),정성수(Seong-Su Jung),왕성근(Sung-Kuen Wang),신석철(Suk-Chul Shin) 대한노인정신의학회 2000 노인정신의학 Vol.4 No.2

목 적: 치매는 인지기능의 손상 외에도 행동장애, 기능수행의 장애 등을 초래하고, 자주 신체질환이 공존한다. 따라서 치매환자의 관리를 위해서는 이들 영역에 대한 평가가 필요하다. 본 연구는 이들 모든 영역을 실질적이면서도 간편하게 평가할 수 있는 방법을 제시하고, 평가결과를 분석하고자 한다. 방 법: 이 다면적평가방법은 하나의 전반적단계 평가도구(GDS)와 네가지 영역들;인지, 일상생활동작, 행동과 동반신체질환에 대한 평가도구들(MMSE, B-ADL, BEHAVE-AD, GMHR)로 구성되었다. 이것을 한 치매 요양원에 재원중인 29명의 치매환자들(알쯔하이머형 치매 21명, 혈관성 혹은 혼합형 치매 9명)에게 실시하였고, 평가척도간의 상관성을 Pearson 상관계수로, 치매유형, 성별, 나이에 의한 차이를 independent t-test를 이용하여 분석하였다. 결과.결론: 알쯔하이머형 치매군에서 MMSE와 B-ADL간에 유의한 상관성이 있었다. 알쯔하이머형 치매군이 기타 군(혈관성 혹은 혼합형 치매군)보다 B-ADL의 점수가 유의하게 높았고, GMHR의 점수가 높았으나 통계학적으로 유의하지는 않았다. 성별과 나이(80세 미만과 이상)에 따른 유의한 차이는 없었다. 공존신체질환에 대한 평가가 포함된 본 다면적 평가방법은 치매요양원에서 간편하게 사용될 수 있고, 환자관리에 실질적인 도움이 될 수 있다고 생각된다. Objectives:Behavioral problem and functional impairment in addition to cognitive impairment are induced, and the medical comorbidity is common in dementia patients. Thus the evaluation of these domains is needed for the management of dementia patients. This study presents a method practically and easily assessing above all dimensions, and analyzes the results. Methods:The multidimensional evaluating method consists of one general staging measure (GDS) and four measures(MMSE, B-ADL, BEHAVE-AD, GMHR) evaluating four domains; cognition, activities of daily living, behavior, and medical comorbidity. These measures are administered to 29 dementia patients(Alzheimer's dementia 21, mixed or vascular dementia 9) admitted in a long-term care residence of dementia patients. The correlation of measures and the difference of the type of dementia, sex, and age are analysed by Pearson correlation coefficient and independent t-test respectively. Results & Conclusions:In the correlation of scales, the score of MMSE was significantly correlated to the score of B-ADL in Alzheimer's dementia patient group(p<0.05). The score of B-ADL was significantly higher(p<0.05) and the score of GMHR was statistically insignificantly higher in Alzheimer's dementia patient group than mixed or vascular dementia patient group. The sex and age was unrelated to cognitive or functional ability. This multidimensional evaluating method, including the assessment of the medical comorbidity, is thought to be convenient to apply in the long-term care residence of dementia patients, and be of practical help to the management of dementia patients.

치매 환자에 대한 신체건강척도의 한국판 표준화

정성수(Seong-Su Jeong),신용재(Yong-Jae Shin),안정애(Jung-Ae Ahn),여경희(Kyoung-Hee Yeo),신석철(Suk-Chul Shin) 대한노인정신의학회 2000 노인정신의학 Vol.4 No.2

치매 환자에 대한 동반질환 및 예후에 대한 평가는 적절한 환자관리를 위해 필요하나 그동안 만족할 만한 평가도구가 없었다. 최근에 치매 환자에 대해 동반질환 및 예후에 대해 신뢰도가 높은 평가도구인 GMHR이 계발되어 본 저자들은 이를 신체건강척도로 번안하여 표준화하였다. 연구대상은 치매 환자 35명으로 내과의사 1명, 간호사 2명에 의해 평가되었다. 신체건강척도의 신뢰도를 검증한 결과 kappa 값이 0.001 이하로 매우 신뢰도가 높았다(reliability coefficient α=0.9121). 복용중인 약물의 수 및 불안정 질환의 수와의 상관은 각각 r=-0.487(p<0.01), r=-0.542(p<0.01)로 만족스러웠다. 3점 이하로 측정된 환자는 71.5%이었고 40%의 환자에서 불안정 질환이 동반되어 동반질환의 중요성을 인식 할 수 있었다. 결론적으로 신체건강척도는 치매 환자에 대해 쉽게 평가할 수 있는 도구로 평가자 사이의 신뢰도가 높고 불 안정 질환의 수와 투여 약물의 수와도 상관성이 높은 평가도구이었다. 향후 이 신체건강척도의 신뢰도 및 예후적 가치가 검증되기 위해 더 많은 환자를 대상으로 하여 평가 및 장기간의 추적관찰이 요구된다. Concurrent medical problem is common in dementia patients and critical to their care. Despite its importance, there was no bedside global rating scale for the seriousness of medical comorbidity. Lykestos et al. newly developed a reliable bedside scale, the General Medical Health Rating(GMHR). The objective of this study was to standardize the GMHR in form of Korean version(KGMHR). The study population consisted of 35 dementia patients in nursing home. Rating was performed by 1 physician and 2 nurses. Forty percent(14/35) of patients had one or more unstable medical illnesses. KGMHR ratings no more than 3 were 71.5%(25/35) of patients. The value of interrater reliability coefficient αwas 0.9121. Correlations between KGMHR ratings and number of unstable medi-cal illnesses were high(r=-0.487, p<0.01). KGMHR ratings were also correlated with number of medications being taken for comorbid conditions(r=-0.542, p<0.01). In conclusion, KGMHR is a very reliable and simple rating scale for medical comorbidity in dementia patients. So the KGMHR could be a useful tool for evaluation of comorbidity in dementia patients. To verify the prognostic value of KGMHR, further large sized long-term study are needed.

Usefulness of three parameters models in engineering plasticity and sheet metal forming research

Quoc-Tuan Pham(팜쿽투완),Seok-Chul Shin(신석철),Young-Suk Kim(김영석) 한국소성가공학회 2015 금형가공 심포지엄 Vol.2015 No.8

From an overview of mechanical engineering, it is accepted that the plasticity of metals is a strongly nonlinear problem in which many nonlinear curves are required to describe important characteristics of plasticity such as flow curve, yield locus and ductile fracture. Much effort has been made to capture these characteristics by introducing many parameters to precisely express the experimental results. For example, to describe the stress-strain relation of materials, Swift and Voce models are widely used, and Hill non-quadratic and Hosford yield functions are usually applied in modeling the yield locus, because of their simple expression with only two parameters. Similarly, the most ductile failure models with a few parameters are Clift and Oyane models. However, the above-mentioned models have at most two parameters in their equations and intrinsically have limited accuracy. Of course, introduction of more parameters in plasticity models may yield more accurate solutions, such as the Barlat (2003) yield function which has eight parameters. Nevertheless, these proposed models significantly increase the computational cost and may introduce inevitable errors in estimating their parameters. To overcome this disadvantage, this study proposes three-parameter models to describe the governing equation of the above mentioned topics. These models achieve a balance between accuracy and computational cost in engineering.

정상 성인에서 Haloperidol이 정신생리적 기능에 미치는 영향

이진영(Jin-Young Lee),이선우(Sun-Woo Lee),신석철(Suk-Chul Shin) 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

To investigate the effects of haloperidol on psychophysiologic function in normal adults, author applied reaction time for attention and visual analogue scale for daytime fatigue, mood and sleepiness to normal volunteers before and after administration of haloperidol 2.5㎎. The subjects were 8 healthy young adults, aged from 20 to 24 years old. The results were summarized as follows : 1. Compared with baseline, haloperidol increased subjective feeling of sleepiness and dysphonc mood significantly in the morning after haloperidol administration. 2. Compared with baseline, haloperidol delayed reaction time significantly on the day after haloperidol administration. 3. In the baseline, daytime sleepiness was positively correlated with feeling of fatigue and dysphoric mood. 4. On the day after haloperidol administration, daytime sleepiness was negatively correlated with reaction time, and positively correlated with feeling of fatigue and dysphoric mood.

뇌경색후에 발생한 이차성 조증

신석철,이충숙,지익성,이선우 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Mania is a rare complication of stoke. The clinical features and response to treatment are usually the same as mania without brain injury. Post-stroke mania strongly associated with both a right hemisphere lesion in a limbic-connected area and a second predisposing factor, such as genetic loading for a affective disorder, pre-existing subcortical atrophy or seizure disorder. It may be mediated through frontal lobe dysfunction. We report a case of secondary mania in 65-year old man who showed multiple lacunar infarction left thalamus and right periventricular area.

年齡階層에 따른 憂鬱症의 變化에 關한 硏究

申石澈 충남대학교 의과대학 지역사회의학연구소 1978 충남의대잡지 Vol.5 No.2

The author studied the self-rating depression scale(SDS) for 953 persons of the nomal control group and 330 depressive neurotics whose diagnosis were conformed by psychiatrists at the psychiatric out patient clinic of the Chungnam National University Hospital. Results of comparison with 20 items of the SDS among 3 age groups, under 19, 20 t 39, and 40 to 64 age group, are as follows: 1. In the normal control group, the most depressive symptoms are accentuated according to aging progress. Particularly in the 40 to 64 age group, somatic symptoms are significantly remarkable among depressive syndromes. 2. In the depressive neurotics, depressive symptoms of diurnal variation, personal devaluation, sleep disturbance, emptiness, psychomotor retardation, and indecisiveness are also significantly remarkable particularly in the 40 to 64 age group.

기질성 정신장애환자에서 불안과 우울

신석철,왕성근,강민희,신윤오 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

Atuhors applied the self-rating anxiety scale(SAS) and the self-rating depression scale(SDS) devised by Zung to 95 psychiatric outpatients with organic mental disorder in order to investigate about anxiety and depression manifest in organic mental disorder and tried factor ananlysis using both test scores. 1. In SAS, 4 factors were extracted as paresthesia & facial flushing, fear & dizziness, palpitation & urinary frequency, and nervousness & fatigability. 2. In SDS, 4 factors were extracted as depressed affect & suicidal rumination, dissatisfaction & indecisiveness, fatigability & sleep distrubance, and emptiness & hopelessness.

MMPI에 依한 靑少年 性格에 關한 硏究

申石澈,曺守鎬,李泰淑 충남대학교 의과대학 지역사회의학연구소 1975 충남의대잡지 Vol.2 No.1

The author has attempt to study the personality of the adolescent by utilize the MMPI. One thousand and two hundred normal, male student, aged between 13 through 19 were selected randomly for this study. Summaries are made as follow: 1. T score of the validity scales is higher in the younger than in elder age group. 2. In the T score of the clinical scores, there are higher of the psychotic and behavior disorder scales in the younger group, but there are higher score of standard deviation, standard error and coefficient of variance in the elder age group. 3. The value of anxiety index and internalized ratio is higher in the elder age group. 4. The value of active hostility index is higher in the younger age group, but passive aggressive index is higher in the elder age group.