패혈증 쇼크에서 단삼 추출물의 억제 효과와 그 기전에 관한 연구

신상호,윤정민,고우신,윤화정,Shin, Sang-Ho,Yun, Jeong-Min,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.3

Objectives : This study was performed to investigate the protective effects and mechanisms of Salvia miltiorrhizae Radix extract (SME) on endotoxin shock.Methods : We used two models; LPS-induced sepsis model for in vivo model, and murine peritoneal macrophages responses for in vitro. SME was administrated orally to mice. After 1 hr, LPS was injected intraperitoneally. Survival rate was checked each time per 12 hr for 5 days. Mice were sacrificed 3 hr after LPS injection, then blood samples and organs were harvested. Cytokines secretion was measured by ELISA. Organs tissues were observed with microscope. Murine peritoneal macrophages were cultured for 1 hr either in a medium alone or in a medium that contained SME, as indicated. Then, the cells were treated with LPS for 24 hr. mRNA levels of cytokines were measured by real-time RT-PCR. Cytokine levels in the supernatants were measured by ELISA. The amount of nitrite was measured by using the Griess method to evaluate NO production. The cell lysates were analysed by Western blotting using antibodies for iNOS and β-actin was used as an internal control to monitor equal protein loading.Results : SME improverd the survival rate of mice model. SME inhibited the secretion of inflammatory cytokines and organs damages on Endotoxin Shock model. SME suppressed cytokine expression, cytokine secretion,NO production, iNOS expression in LPS-induced murine peritoneal macrophages.Conclusions : The results suggest that SME has protective effects on endotoxin shock through suppression of inflammatory cytokines, organ damages, NO production and so on.

일 병원 정신건강의학과로 자문의뢰 된 HIV 감염/후천성면역결핍증 환자의 임상적 특성과 향정신약물 사용

신상호,김현정,유소영,신형식,원성두,이소희,Shin, Sang-Ho,Kim, Hyun-Chung,Yoo, So-Young,Shin, Hyoung Shik,Won, Sung-Doo,Lee, So Hee 한국정신신체의학회 2014 정신신체의학 Vol.22 No.1

Objectives : This study aimed to investigate the psychiatric status of HIV-infected/AIDS inpatients in a general hospital over the past 2.5 years. Methods : A retrospective chart review was conducted of psychiatric consultations performed between January 1, 2011, and July 30, 2013. The records of 97 HIV-infected/AIDS patients were analyzed. These included a total of 282 psychiatric consultations. Results : Of the 97 patients, 91(93.8%) were male, the mean age was 48 years, and mean number of consultations was 2.8. Depressed mood was reported in 102 consultations(23.8%), insomnia in 60(14.0%), and anxiety in 31(7.2%). Psychiatric disorders diagnosed on initial consultation included depressive disorder(37 patients ; 37.0%), cognitive disorder(11 ; 11.0%), and delirium(9 ; 9.0%). Recommended psychotropic medication included Lorazepam(99 ; 17.2%), Escitalopram(90 ; 15.7%), and Quetiapine(84 ; 14.6%). Conclusions : The main complaints of HIV-infected/AIDS patients were depressed mood, insomnia, and suicidal ideation(including suicide attempts). In total, 85(93.3%) patients of those consulted were diagnosed as meeting the criteria for a psychiatric condition. However, considering that only 16.9% of patients consulted received follow-up treatment, longitudinal research is needed to examine the influence of psychiatric disorders on the transmission of HIV-infection/AIDS, as well as on prognosis and treatment adherence. 연구목적 이 연구는 2년 6개월 동안 일 병원에 입원 중인 HIV감염/AIDS환자에 대한 정신건강의학과 자문 의뢰를 분석하였다. 방법 일 병원에서 2011년 1월 1일부터 2013년 6월 30일까지 자문 의뢰된 97명의 HIV감염/AIDS 환자와 282개의 자문 의뢰를 대상으로 후향적 의무기록 연구를 수행하였다. 결과 97명의 HIV감염/AIDS 환자 중 91명(93.8%)이 남자였으며, 평균연령은 48세, 연구 기간 동안 평균 1인당 자문건수는 2.8건이었다. 주로 호소한 증상으로는 우울 102건(55.3%), 불면 60건(14.0%), 불안감 31건(7.2%) 등이었으며, 최초 자문의뢰 시 진단된 정신과적 질환은 우울장애 37명(37.0%), 인지장애 11명(11.0%), 섬망 9명(9.0%) 등 이었고 투약 권고된 향정신병 약물은 Lorazepam 99건(17.2%), Escitalopram 90건(15.7%), Quetiapine 84건(14.6%) 순이었다. 결론 HIV감염/AIDS 입원 환자들은 '우울감', '불면', '자살사고/시도' 등을 주문제로 정신건강의학과로 자문의뢰 되었고, 자문의뢰 환자의 85명(93.3%)에서 정신장애로 진단을 받았다 그러나 자문의뢰 환자의 16.9%만 퇴원 후 본원 정신건강의학과로 외래 추적 진료가 이루어져, 향후, 정신건강문제가 HIV감염 및 AIDS의 치료 순응도, 예후, 전파에 미치는 영향에 대한 장기적 연구가 필요할 것으로 보인다.

안과질환 외래환자에 관한 임상적 분석

신상호,김자혜,김민희,고우신,윤화정,Shin, Sang-Ho,Kim, Ja-Hye,Kim, Min-Hee,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.3

Objective : The purpose of this study is to investigate outpatients of ophthalmologic disease who had visited to Hospital of Oriental Medicine. Method : We analyzed statistics study in 590 patients, who had visited to the Dept. of dermatology, ophthalmology & otorhinolayngology Hospital of Oriental Medicine Dongeui University from January, 1998 to July , 2006. Result : The results were as follows. 1. Distributions of sex : male 45.42%, female 54.58%. 2. The age distributions of patients showed highest in 51-60 years, followed by 41-50 years, 61-70 years in order. 3. The yearly distributions of patients showed highest in 2004, followed by 2005, 2002 in order. The seasonal distributions of patients showed highest in summer, followed by spring, winter, autumn in order. The monthly distributions of patients showed highest in August, followed by June, March in order. 4. The frequency of chief complaint showed highest in visual disorder, followed by dry eye, blepharospasm, squint in arch order. Visual disorder and dry eye were the most common ophthalmologic disease, irrespective of age. 5. The Distribution of past history showed highest in ophthalmologic disease, followed by circulatory disease, digestive disease in order. The Distribution of ophthalmologic diseases showed highest in retinal disease, followed by lens-induced ocular disease, disease of the optic nerve in order. 6. The number of times in treatment : 1-20 times(84.07%), 21-40 times(7.97%). 7. In the treatment method, a major portion of treatment methods was acupuncture & herbal medicine treatment, followed by acupuncture, consulting, herbal medicine treatment in order.

냉동치료 경험이 있는 손과 발의 난치성 사마귀에 대한 한방치료의 효과

신상호,윤정민,허정은,고우신,윤화정,Shin, Sang-Ho,Yun, Jeong-Min,Heo, Jeong-Eun,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.2

Objective : The purpose of this study is to know the efficacy of Korean medical treatment for recalcitrant hand and foot warts with an experience of cryotherapy. Methods : Twenty-two patients(male 12, female 10) with recalcitrant warts visited Amar Korean Medicine Clinic and were treated with herbal medicine, herbal acupuncture, acupuncture, moxibustion and bloodletting for at least 3 months. After treatment, a clearance rate was divided into 4 scales such as; complete clearance / partial clearance-good / partial clearance-poor / no change. Results : Mean age of patients was 23.4 years and mean period of disease was 43.6 months. Mean duration of treatment was 3.0 months and mean dosage(貼) of herbal medicine was 89.1. Nineteen patients(86.4%) showed complete clearance, one(4.5%) partial clearance-good, and two(9.1%) partial clearance-poor. Conclusion : This data demonstrates that Korean medical treatment could be an effective treatment for recalcitrant warts.

승갈탕(升葛湯)을 사용한 아토피 피부염 환자에 대한 임상시험

신상호,김자혜,김미보,윤화정,유선애,이승연,이미연,김규곤,고우신,Shin, Sang-Ho,Kim, Ja-Hye,Kim, Mi,Yoon, Hwa-Jung,Lyu, Sun-Ae,Lee, Seung-Yeon,Lee, Mi-Yeon,Kim, Kyu-Kon,Ko, Woo-Shin 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.2

Objective : The purpose of this clinical research was to investigate the effects of Seunggaltang on patients with atopic dermatitis. Methods : Thirteen patients were treated with Seunggaltang and ten patients were treated with placebo for 8 weeks. We observed skin humidity, skin sebum,, transepidermal water loss, skin melanin, skin erythema, total IgE class and number of allergen. And Clinic Index of Atopic Dermatitis(Extent, Intensity, Subjective symptoms, Total score) was used to evaluate the effects of Seunggaltang. Statistical analysis was performed by using paired sample T-test. Statistical significance was achieved if the probability was less than 5%(P<0.05). The result were as follows : 1. Statistically, Seunggaltang didn't showed significant effect on skin humidity, skin sebum, skin transepidermal water loss, skin melanin and skin erythema. 2. Statistically, Seunggaltang showed significant effect on Clinic Index of atopic dermatitis. 3. Statistically, Seunggaltang didn't showed significant effect on total IgE class and number of allergen. 4. Before and after treatment, the results of blood test and urinalysis were normal. Conclusion : We speculate that Seunggaltang has some therapeutic effects in mitigating the symptoms of atopic dermatitis.

알레르기 비염을 포함하는 과민성 비염 환자 580례에 대한 임상적 고찰sdf

신상호,김자혜,김미보,고우신,윤화정,Shin, Sang-Ho,Kim, Ja-Hye,Kim, Mi-Bo,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1

Objective : The purpose of this study is to investigate outpatients of hypersensitive rhinitis including allergic rhinitis who had visited to Hospital of Oriental Medicine. Method : We analyzed statistics study in 580 patients, who had visited to the Dept. of dermatology, ophthalmology & otorhinolayngology Hospital of Oriental Medicine Dongeui University from March, 1998 to December, 2006. Results : The results were as follows. 1. There is more male(53.28%) than femal(46.72%). The age distributions of patients showed highest in 20-29 years, followed by 10-19 years, 30-39 years in order. 2. The yearly distributions of patients showed highest in 2004, followed by 2001, 2005 in order. The seasonal distributions of patients showed highest in fall, followed by winter, summer, spring in order. The monthly distributions of patients showed highest in September, followed by August, October in order. 3. The distributions of number of times in treatment showed highest in 1-5 times. The distributions of duration of treatment showed highest in 1 week. In the treatment method, a major portion of treatment methods was acupuncture, followed by herbal medicine treatment, aroma therapy in order. 4. The Frequency of use of Prescriptions showed highest in Bojungikgi-Tanggami. The Frequency of use of Extract showed highest in Sochungryong-Tang. 5. The distribution of past history showed highest in Atopic dermatitis. The distribution of Rhinologic Complication showed highest in Paranasal sinusitis.

폐쇄형 해양온도차발전 사이클에 관한 연구

신상호,정동수,김종보,서태범,천원기,오정무,Shin, Sang-Ho,Jung, Dong-Soo,Kim, Chong-Bo,Seo, Tae-Beom,Chun, Won-Gee,Auh, P. Chung-Moo 한국태양에너지학회 1997 한국태양에너지학회 논문집 Vol.18 No.4

본 연구에서는 Rankine 사이클을 이용한 해양 온도차 발전 시스템을 컴퓨터로 모사했고 작동유체를 변화시켜 가면서 그 성능을 비교하였다. 증발기와 응축기는 UA(총괄열전달계수$\times$전열면적)와 LMTD(대수평균온도차) 방법으로 모사하였으며 터빈과 펌프는 등엔트로피 효율로 모사하였다. 작동유체로는 R22, R290, R1270, R134a, R125, R143a, R32, R410A 그리고 암모니아 등을 사용하였다. 모사 결과 OTEC 발전 시스템의 효율은 작동유체에 상관없이 거의 일정한 것으로 드러났다. 한편 증발기 출구에서의 과열도와 응축기 출구에서의 과냉도는 시스템의 성능에 거의 영향을 미치지 않는 것으로 나타났지만 터빈의 효율과 열교환기의 크기는 시스템 성능에 큰 영향을 미치는 것으로 나타났다. 마지막으로 따뜻한 표층수와 차가운 심해수 사이의 온도차가 $20^{\circ}C$이상일 때 실제로 전기를 생산할 수 있다는 사실을 확인했다. In this paper, performance of various working fluids is evaluated for the closed Ocean Thermal Energy Conversion(OTEC) power plant operating on Rankine cycle. The evaporator and condenser are modeled via UA and LMTD method while turbine and pump are modeled by specifying isentropic efficiencies. R22, Propane, Propylene, R134a, R125, R143a, R32, R410A and Ammonia are used as working fluids. Results show that newly developed fluids such as R410A and R32 that do not cause stratospheric ozone layer depletion perform as well as R22 and ammonia. The superheat at the evaporator exit and subcooling at the condenser exit do not affect the performance of the simple OTEC power cycle. Turbine efficiency and heat exchanger size influence greatly the performance of the Rankine cycle. Finally, it was shown that closed OTEC power plants can practically generate electricity when the difference in warm and cold sea water inlet temperatures is greater than $20^{\circ}C$.

스테로이드 치료후 리바운드 현상이 발생한 한포진 치험 1례

신상호,윤정민,허정은,고우신,윤화정,Shin, Sang-Ho,Yun, Jeong-Min,Heo, Jeong-Eun,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objectives : The purpose of this study is to know the effect of Korean medical treatment on pompholyx including steroid rebound phenomenon. Methods : We experienced one case of pompholyx treated with herbal medicine, pharmacupuncture and acupuncture. To evaluate the results of this treatment, we categorized symptoms into four items which are vesicles, itching, erythema and erosions. Results & Conclusions : After treatment we observed the improvement. Based on this experience, it is considered that the Korean medicine can be applied to the treatment of pompholyx.

아토피 피부염의 외치법에 대한 고찰;국내 논문을 중심으로

신상호,김미보,변석미,이호섭,박선규,고우신,윤화정,Shin, Sang-Ho,Kim, Mi-Bo,Byun, Seok-Mi,Lee, Ho-Sub,Park, Sun-Gyoo,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.2

Objective : The purpose of this study is to investigate the results of preceding research related external treatment for Atopic dermatitis(AD). Methods : We studied the 13 research papers that had been published in The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology, The Journal of Korean Oriental Pediatrics, The Journal of Korean Oriental Internal Medicine, The Journal of Korean Oriental Medicine, Korean Journal of Oriental Physiology & Pathology and so on. Results : About 13 treatises, 3 treatises were for the literatual study, I treatise was for the clinical research about the effects of external therapy, 3 treatises were for the effects of herbal medicine along with external treatment on AD development in NC/Nga mice, 6 treatises were for the case of AD. Conclusion : These treatises showed that external treatment is effective method to improve AD. To develop the better external treatment on AD, we have need of studies on the well used prescriptions and herbs through double-blind, randomized, placebo-controlled methods, clinic research and so on.

보튤리늄 독소를 이용한 보상성 다한증의 치료경험

신상호 ( Sang Ho Shin ),신은영 ( Eun Young Shin ),김두환 ( Du Hwan Kim ),서정훈 ( Jeong Hun Suh ),임정길 ( Jung Gil Leem ),신진우 ( Jin Woo Shin ) 대한통증학회 2009 The Korean Journal of Pain Vol.22 No.3