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대퇴골에 발생한 Bizarre Parosteal Osteochondromatous Proliferation of the Femur (Nora 병변) - 증례 보고 -
신봉경,조현득,염범우,최종상,김철환,Shin, Bong-Kyung,Cho, Hyun-Deuk,Yum, Bum-Woo,Choi, Jong-Sang,Kim, Chul-Hwan The Korean Musculoskeletal Tumor Society 1999 대한골관절종양학회지 Vol.5 No.3
저자들은 18세 남자 환자의 우측 대퇴골에 발생한 bizarre parosteal osteochondromatous proliferation (Nora 병변) 1례를 보고하고자 한다. 방사선 소견상 비교적 경계가 좋은 석회화 병변이 하부 대퇴골의 피질 표면에 붙어 있었으며 병변은 넓은 기저면을 갖고 있었다. 대퇴골의 변형은 없었고, 병변과 대퇴골간의 골수강의 연결은 관찰되지 않았다. 조직학적으로 병변은 연골, 골 및 섬유조직으로 구성되어 있었고 연골은 세포밀도가 증가되어 있었으나, 과염색증이나 다형성세포는 없었다. 불규칙한 골과 연골간의 경계와 연골내 골화를 보였다. 골소주는 불규칙한 형태를 보이고 배경 기질에서 방추형 세포들을 관찰할 수 있었다. 세포학적 비정형은 관찰되지 않았다. 본 병변은 일종의 이소성 골화로써 반응성 병변으로 간주되며, 임상적으로나 병리학적으로 골육종이나 연골육종과 같은 악성 병변과 혼동하지 않는 것이 중요하다. We report a case of bizarre parosteal osteochondromatous proliferation of the right femur in an 18-year-old man. Roentgenograms showed a calcific mass attached to the underlying cortex with a broad base. Histologically, the lesion showed hypercellular cartilaginous tissue with maturation into trabecular bone, which contained spindle cells and lymphocytes in the intertrabecular spaces. Bizarre parosteal osteochondromatous proliferations are a form of heterotopic ossification and should not be mistaken for osteosarcoma or chondrosarcoma.
신봉경,이영석,정회선,이상호,김현철,김애리,김인선,김한겸,Shin, Bong-Kyung,Lee, Young-Suk,Jeong, Hoi-Seon,Lee, Sang-Ho,Kim, Hyun-Chul,Kim, A-Ree,Kim, In-Sun,Kim, Han-Kyeom The Korean Society for Cytopathology 2008 대한세포병리학회지 Vol.19 No.2
Urothelial carcinoma accounts for 90% of all the cases of bladder cancer. Although many cases can be easily managed by local excision, urothelial carcinoma rather frequently recurs, tends to progress to muscle invasion, and requires regular follow-ups. Urine cytology is a main approach for the follow-up of bladder tumors. It is noninvasive, but it has low sensitivity of around 50% with using the conventional cytospin preparation. Liquid-based cytology (LBC) has been developed as a replacement for the conventional technique. We compared the cytomorphometric parameters of $ThinPrep^{(R)}$ and cytospin preparation urine cytology to see whether there are definite differences between the two methods and which technique allows malignant cells to be more effectively discriminated from benign cells. The nuclear-to-cytoplasmic ratio value, as measured by digital image analysis, was efficient for differentiating malignant and benign urothelial cells, and this was irrespective of the preparation method and the tumor grade. Neither the $ThinPrep^{(R)}$ nor the conventional preparation cytology was definitely superior for distinguishing malignant cells from benign cells by cytomorphometric analysis of the adequately preserved cells. However, the $ThinPrep^{(R)}$ preparation showed significant advantages when considering the better preservation and cellularity with a clear background.
원발성 시신경교차 주위 종양으로부터 전이한 비장의 생식세포종 - 1예 보고 -
신봉경,김민경,김한겸,채양석,원남희,김인선,Shin, Bong-Kyuug,Kim, Min-Kyung,Kim, Han-Kyeom,Chae, Yang-Seok,Won, Nam-Hee,Kim, In-Sun 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1
A 20-year-old young man who had undergone treatment for a suprasellar/perichiasmal tumor 2 years before, was presented with a huge palpable splenic mass. A fine needle aspiration cytology from the splenic mass showed dissociated large pleomorphic tumor cells having irregular nuclear outline, coarse chromatin, and one or two macronucleoli, and scattered small lymphocytes in fine granular background. Above cytologic findings were regarded as the characteristics of germinoma. Differential diagnosis from the large cell lymphoma of spleen was emphasized.
위에 발생한 염증성 근섬유모세포성 종양의 세침흡인 세포학적 소견 -1 예 보고-
이지혜,신봉경,김정렬,조성진,김한겸,김인선,Lee, Ji-Hye,Shin, Bong-Kyung,Kim, Chung-Yeul,Cho, Seong-Jin,Kim, Han-Kyeom,Kim, In-Sun 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.2
Inflammatory myofibroblastic tumor, histologically characterized by the presence of bland-locking spindle cells and infiltration of chronic inflammatory cells, is extremely rare in the gastric wall. We report a case of gastric inflammatory myofibroblastic tumor In a 27-month-old boy. The fine needle aspiration biopsy from the mass showed loose clusters or scattered spindle cells and inflammatory cells, predominantly of lymphocytes and plasma cells. The spindle cells resembled fibroblasts or myofibroblasts. Differential diagnosis from benign and malignant diseases involving abdominal cavity was discussed.
위 선암종에서의 E-cadherin, $\beta$-catenin 및 c-Met 단백 발현에 대한 연구
조성진,김민경,신봉경,민연기,조민영,서성옥,원남희,채양석,Cho Seong Jin,Kim Min Kyung,Shin Bong Kyung,Min Youn Ki,Cho Min Young,Suh Sung Ock,Won Nam Hee,Chae Yang Seok 대한위암학회 2001 대한위암학회지 Vol.1 No.2
Purpose: E-cadherin is an adhesion molecule essential for tight connection between cells, forming the cadherin/catenin complex. Truncated $\beta$-catenin disrupts the interaction between E-cadherin and $\alpha$-catenin, leading to the loss of intercellular adhesion. Met protein, the hepatocyte growth factor receptor, plays important roles in signal transduction. We investigated the relationships between the expressions of E-cadherin, $\beta$-catenin, and c-met protein and the clinicopathological and prognostic parameters in gastric adenocarcinomas. Materials and Methods: The patterns of E-cadherin, $\beta$-catenin, and c-met protein expression were studied using immunohistochemistry in formalin-fixed, paraffin-embedded archival tissues from 76 surgically resected gastric adenocarcinomas. Results: Increased expressions of E-cadherin, $\beta$-catenin, and c-met were more significantly correlated in early gastric cancers (EGC) than in advanced gastric cancers (AGC) (P=0.002, P=0.003 and P=0.026). The positive immunoreactivities of all three markers were markedly lower in signet ring-cell type and poorly differentiated type lesions than in intestinal-type lesions. Decreased expression of the $\beta$-catenin protein correlated well with increased tumor invasion depth (P=0.039), and increased lymph node metastasis correlated well with reduced expression of c-met (P=0.046). Conclusion: In gastric cancers, reduced expressions of the E-cadherin, $\beta$-catenin, and c-met proteins may play some role in poorer tumor differentiation, deeper tumor invasion, and increased lymph node metastasis. Also, the c-met gene is thought to play a specific role in the mechanism of the yet unknown catenin action.
방광의 미세유두형 요로상피암종의 세포소견 -1예 보고-
이영석,이현주,최정우,신봉경,김한겸,김인선,김애리,Lee, Young-Seok,Lee, Hyun-Joo,Choi, Jung-Woo,Shin, Bong-Kyung,Kim, Han-Kyem,Kim, In-Sun,Kim, Ae-Ree 대한세포병리학회 2006 대한세포병리학회지 Vol.17 No.1
A micropapillary variant of urothelial carcinoma (MPC) is a distinct entity with an aggressive clinical course. It has a micropapillary configuration resembling that of ovarian papillary serous carcinoma. Its cytologic features have rarely been reported. We report a case of MPC detected by urine cytology. A woman aged 93 years presented with a chief complaint of macroscopic hematuria. Cytology of her voided urine showed clusters of malignant cells in a micropapillary configuration. Each tumor cell had a vacuolated cytoplasm, a high nuclear:cytoplasmic ratio, and irregular hyperchromatic nuclei. An ureteroscopic examination revealed exophytic sessile papillary masses extending from the left lateral wall to the anterolateral wall of the urinary bladder. A transurethral resection of the tumor was carried out. The tumor was characterized by delicate papillae with a thin, well-developed fibrovascular stromal core and numerous secondary micropapillae lined with small cuboidal cells containing uniform low- to intermediate-grade nuclei and occasional intracytoplasmic mucinous inclusions. These tumor cells infiltrated the muscle layers of the bladder, and lymphatic tumor emboli were frequently seen. Recognizing that the presence of MPC components in urinary cytology is important for distinguishing this lesion from low-grade papillary lesions and high-grade urothelial carcinomas can result in early detection and earlier treatment for an improved treatment outcome.
Ticlopidine에 의해 유발된 담즙정체간염과 진정적혈구계무형성증 1예
이지연 ( Ji Yeon Lee ),박은범 ( Eun Bum Park ),안재홍 ( Jae Hong Ahn ),서상준 ( Sang Jun Suh ),정영걸 ( Young Kul Jung ),김지훈 ( Ji Hoon Kim ),신봉경 ( Bong Kyung Shin ),양진혁 ( Jin Hyuk Yang ),연종은 ( Jong Eun Yeon ),변관수 ( 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.1