http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
류마티스 관절염환자와 골관절염환자의 요중 Hydroxypyridinium Crosslinks 의 측정과 임상적 유용성에 관하 연구
정성광(Sung Kwang Jung),이윤우(Yun Woo Lee),신보문(Bo Moon Shin),김종원(Jong Won Kim) 대한내과학회 1997 대한내과학회지 Vol.53 No.2
N/A Objectives: To evaluate the urinary concentrations of hydroxyridinium crosslinks of collagen in patients with osteoarthritis(OA) or rheumatoid arthritis(RA), and to compare its clinical correlation with the classic indices of the disease activity of RA. Methods: Concentrations of urinary pyridinoline (Pyd) and deoxypyridinoline(Dpd) were measured in urinary samples collected from 18 control patients, 35 patients with OA, 45 patients with RA by competitive enzyme immunoassay using microplate coated with monoclonal antibody. Results: 1) Mean urinary concentrations of Pyd in OA patients were 33.5nmol/mmol creatinine, in RA patients were 50.0nmol/mmol creatinine which were higher than the values in controls (25.1 nmol/mmol creatinine). Also, mean concentrations of Dpd in OA patients were 9.2nmol/mmol creatinine, in RA patients were 10.1nmol/mmol creatinine which were higher than the values in controls(5.6nmol/mmol creatinine)(p<0.01). 2) Mean urinary concentration of Pyd was 50.0 nmol/mmol creatinine in RA patients, which was significantly higher than the values in OA(33.5 nnmol/mmol creatinine)(p<0.05), but the mean Dpd concentratians were not significantly different between the two groups. 3) The concentrations of urinary Pyd in RA patients was significantly correlated with the biologic markers indicating inflammatory activity such as ESR(r=0.68, p<0.001), CRP(r=0.72, p<0.001) and the number of tender joint(r=0.66, p<0.01) Conclusion : Urinary concentrations of Pyd and Dpd were significantly higher in OA and RA patients than in controls, Especially urinary Pyd concentrations were significantly increased in RA patients than in OA patients, and strongly correlated with disease activity index of rheumatoid arthritis. The mean Dpd concentration, bone specific analogue, in RA patients was not significantly different from that of OA patients and it was not correlated with disease activity index Thus measurement of urinary Pyd might provide a sensitive, noninvasive biochemical marker for studying activity of RA.
영유아천식 악화시 Eosinophil-derived Neurotoxin 및 Eosinophil Cationic Protein 농도와 기도벽 비후 사이의 연관성
김효빈 ( Hyo Bin Kim ),최준기 ( Jun Gi Choi ),윤운기 ( Un Ki Youn ),마영수 ( Young Soo Ma ),신보문 ( Bo Moon Shin ),김정숙 ( Joung Sook Kim ),김창근 ( Chang Keun Kim ),Rachel Fletcher 대한소아알레르기 및 호흡기학회 2007 소아알레르기 및 호흡기학회지 Vol.17 No.2
류마티스 관절염 양상으로 발현한 다발성 골수종에 의한 아밀로이드 관절병증
한성훈 ( Seong Hoon Han ),양대원 ( Dae Won Yang ),김동욱 ( Dong Yook Kim ),김준희 ( Joon Hee Kim ),신보문 ( Bo Moon Shin ),이윤우 ( Yun Woo Lee ),김예희 ( Re Hwe Kim ) 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.2
Amyloid arthropathies in patients with multiple myeloma have been reported rarely in the world. In Korea, only one case of amyloid arthropathy with multiple myeloma was reported, but there had been no report of multiple myeloma which was initially manifested as a polyarthritis simulating rheumatoid arthritis. We report a case of multiple myeloma with amyloid arthropathy. The patient was 62 years old man, who had had progressive bilateral shoulder pain for one year. Since 6 months prior to admission, progressive painful swelling developed in bilateral hips, shoulders, wrists and hands. Simple X-rays and MRI of shoulders and hips showed huge osteolytic mass, and the amyloid was found in the biopsy of the mass in hip. The diagnosis of multiple myeloma was made after bone marrow biopsy and biochemical studies, but X-rays of skeletal survey didn`t show typical osteolytic lesions of multiple myeloma at the time of diagnosis.
건강했던 영아의 Respiratory Syncytial Virus 세기관지염에 대한 조기, 저용량 리바비린 투여의 효과
고지연 ( Ji Yeon Koh ),이현숙 ( Hyun Suk Lee ),김동욱 ( Dong Wook Kim ),김병의 ( Byung Eui Kim ),김창근 ( Chang Keun Kim ),최명재 ( Myoung Jae Chey ),김상우 ( Sang Woo Kim ),신보문 ( Bo Moon Shin ),김성준 ( Sung Jun Kim ) 대한소아알레르기 및 호흡기학회 2007 소아알레르기 및 호흡기학회지 Vol.17 No.1
임상검체에서의 분리된 대장균과 녹농균의 항생제 감수성 양상
신보문,김의종,정혜림 대한화학요법학회 1987 대한화학요법학회지 Vol.5 No.2
E. coli and P. aeruginosa are most frequently isolated organisms from clinical specimens and especially, P. aerutinosa is important organism of hospital infection. Currently, multi-resistant strains of P. aeruginosa to antibiotics are developed. So, we report some data of susceptibility patterns of 30 antibiotics against clinical strains of E. coli and 16 antibiotics against P. aruginosa isolated from Seoul National University Hospital using rapid ATB system®(API SYSTEM S.A.) The results are as follow ; 1) E. coli are highly susceptible to ceftazidime, cefotaxime, cefoxitin, netilmicin, amikacin, tobramycin, gentamicin and quinolone, and resistant to penicillin derivatives. 2) P. aeruginosa are highly susceptible to ceftazidime and colistin, moderately susceptible to cefsulodin, amikancin, azlocillin, piperacillin, ticacillin, and resistant to cefotaxime, latamoxef, cefoperazone, gentamicin, fosfomycin, mezlocillin and pefloxacin.