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신동현 ( Dong Hyun Sinn ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Hepatitis B virus and hepatitis C virus-associated liver disease is a major indication for liver transplantation. There has been major advance in antiviral agents that can be used in Hepatitis B virus and hepatitis C virus patients. Recently, tenofovir alafenamide has been introduced to treat Hepatitis B virus patients. There are several oral antiviral regimens that can be used to treat hepatitis C virus in pre- or post-liver transplanting setting. Here, we will briefly discuss recent update of antiviral agents that can be used in liver transplantation for and hepatitis C virus.
신동현 ( Dong Hyun Sinn ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Alcoholic hepatitis includes a broad spectrum of pathological process. In case of severe alcoholic hepatitis, the prognosis is worse with a 1-month mortality of 40%. Drink excessively, may induce recurrent episodes of alcoholic hepatitis in patients with alcoholic liver disease, and if this is severe or associated with liver cirrhosis, complications occur due to liver failure and portal hypertension, leading to a high short-term mortality. Recently, liver transplantation (LT) has shown improved outcome for patients with severe alcoholic hepatitis who were not abstinence for 6 months. In Korea, there is no limitation to enlist patients into waiting-list for patients with severe alcoholic hepatitis who presented to hospital while drinking. This brings a several questions that needs critical evaluations. Is it justifiable to transplant severe alcoholic hepatitis patient who were not abstinence? If so, when is optimal time to list patients into waiting-list?
신동현 ( Sinn Dong Hyun ),임성우 ( Lim Seong Woo ),김경묵 ( Kim Kyung Mook ),유호열 ( You Ho Yeol ),최종권 ( Choi Jong Kown ) 국군의무사령부 2010 대한군진의학학술지 Vol.41 No.1
Objectives: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) is commonly diagnosed disease among military soldiers. We investigated the role of smoking in young military soldiers in GERD and FD. Methods: A survey was conducted to the random sample of military soldiers who visited Armed Forces Daejeon Hospital during March 2009 to April 2009. A total of 374 responded and completed the survey. Results: GERD and FD were diagnosed in 7.5% and 5.6% of participants, respectively. GERD was diagnosed more frequently among smokers (13.7%) compared to non-smoker (4.8%, p = 0.008). FD was diagnosed more frequently among smokers (12.6%) compared to past smoker (4.4%, p = 0.045) or non-smoker (2.7%, p = 0.001). Compared to smokers, non smoking was a protective factor for GERD (odds ratio: 0.34, 95% Confidence interval (CI): 0.13 - 0.83, p = 0.018) and FD (odd ratio: 0.20, 95% CI: 0.07 - 0.59, p = 0.004). Conclusions: Smoking is a factor associated with GERD and FD in the young military soldiers. Smoking cessation should be recommended for patients with GERD and FD, and anti-smoking campaign can be effective strategy to reduce GERD and FD in the military.
신동현 ( Dong Hyun Sinn ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Liver transplantation saves life and is sometime the only option for the patients suffering from various liver disease. The organ shortage has encouraged the development of living liver donation, and provides the only realistic chance of survival in some cases. However, living donation is not complication-free in donors. Herein, we will discuss evaluation process in living donor evaluation and long-term health outcome of donor, to seek a way to minimize living donor’s damage and maximize living donor’s safety.
마우스 소장에서 배양한 카할간질세포 군집에서의 박동 조율성 칼슘 변화에 대한 세로토닌에 의한 조절효과
신동현 ( Dong Hyun Sinn ),이풍렬 ( Poong Lyul Rhee ),손희정 ( Hee Jung Son ),김재준 ( Jae J. Kim ),이지연 ( Ji Yeon Lee ),서인석 ( In Suk So ) 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.2
Background/Aims: Interstitial cells of Cajal (ICCs) are considered to be pacemaker cells in the gastrointestinal tracts and Ca(2+) oscillation in ICCs is intimately linked to the pacemaker function. Although serotonin is one of most importance substance involved in gastrointestinal motility, it`s effects on the ICCs are not known. We wanted to study the effect of serotonin on Ca(2+) oscillation in ICCs. Methods: Using cultured cell clusters isolated from the mouse ileum, we measured spontaneous Ca(2+) oscillation as an index of pacemaker activity in the ICCs. The cultured cell clusters showed spontaneous contraction and they contained c-Kit immunopositive cells. We visualized the changes in intracellular Ca2 concentration in the ICCs within the cultured cell clusters that were loaded with a fluorescent Ca2 indicator, fura-2. Results: There was no significant change in the fluorescence emission intensity and spike frequency between the baseline and after the addition of TTX. The addition of serotonin in the buffer solution caused an increase in the fluorescence emission intensity and the spike frequency per minute of Ca(2+) oscillations. The addition of serotonin in the presence of TTX caused increases in the spike frequency per minute of the calcium oscillation. Conclusions: These results suggest that serotonin may modulate the pacemaker Ca(2+) activity in ICCs by the TTX-resistant, direct serotonergic pathway. (Kor J Neurogastroenterol Motil 2006;12:151-156)
B형간염 바이러스: 변화하는 항바이러스 치료 전략: 간경변 동반된 낮은 바이러스 혈중 농도를 보이는 환자
신동현 ( Dong Hyun Sinn ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Unfortunately, there are no effective cures for hepatitis B virus (HBV); currently available treatments, such as interferons and nucleoside/nucleotide analogues (NUCs), can suppress viral replication but cannot eradicate the virus. Therefore, decision to treat should be individualized based on balancing the risk (i.e., un-treated natural course, side effects from treatments, cost) and benefit of the treatment. Generally, patients with low viral load (< 2,000 IU/mL) are considered as a group at low risk for developing hepatic complications. Therefore treatment are usually recommended for those who shows elevated HBV DNA levels (≥ 2,000 IU/mL). Yet, recent studies suggest treatment strategy should also consider the severity of liver disease. Herein, we will discuss recent evidences for the risk and benefit of antiviral therapy in cirrhotic patients who shows low level viremia.