기상청 디지털예보 개발 및 운영 계획

신경섭(Kyung-Sub Shin) 한국기상학회 2005 한국기상학회 학술대회 논문집 Vol.2005 No.-

운동강도가 고지방식 후 정상인의 식후 지혈증과 혈중 지질에 미치는 영향

변재경 ( Jae Kyung Byeon ),김용인 ( Yong In Kim ),신경섭 ( Kyeong Sub Shin ) 한국운동생리학회(구-한국운동과학회) 2007 운동과학 Vol.16 No.1

소아 기능성 시력저하 환자의 임상양상과 예후

이수현(Soo Hyun Lee),신경섭(Kyung Sub Shin),이연희(Yeon Hee Lee) 대한안과학회 2016 대한안과학회지 Vol.57 No.9

목적: 기능성 시력저하를 보이는 환아의 임상양상과 예후를 알아보고자 하였다. 대상과 방법: 2006년 4월부터 2014년 2월까지 기능성 시력저하로 진단된 4세 이상, 16세 미만의 환자 53명을 대상으로 후향적으로 의무기록을 검토하여 임상양상 및 각종 검사결과, 최종 상태에 대하여 조사하였다. 결과: 남자가 20명(37.8%), 여자가 33명(62.2%)으로 여아의 비율이 높았다. 평균 나이는 9.69 ± 2.76세였고 8세에서 12세 사이에서 높은 발병률을 보였다. 내원 시 평균 교정시력은 0.43 ± 0.23이었고 88.7%에서 중등도 혹은 경도의 시력저하를 보였다. 96.2%에서 양안성이었고 이 중 94.1%에서 양안 간에 한 줄 이하의 시력차이를 보였다. 정신과적인 치료 없이 안심과 격려만으로 59.5%에서 1.77 ± 0.98개월 이내에 증상이 소실되었고 최종 경과관찰 시 51명(96.2%)에서 자연적으로 증상이 소실되었으나 2명의 환자에서는 최종관찰 시까지 증상이 지속되었다. 결론: 소아의 기능성 시력저하는 대부분 중등도나 경도의 시력저하를 보이며 양안성으로 나타났다. 이 질환은 예후가 좋아 정신과적인 치료 없이 안심과 격려만으로 대부분 자연회복되나 소수의 환자에서는 증상이 장기간 지속되었다. Purpose: To evaluate the clinical characteristics and prognoses of children with functional visual loss. Methods: Retrospective medical record review was performed in 53 patients 4 to 16 years of age diagnosed with functional visual loss between April 2006 and February 2014. We investigated the clinical features and results of clinical tests and the final status of the patients. Results: Twenty male (37.8%) and 33 female (62.2%) patients were included in the study. The mean age was 9.69 ± 2.76 years. The incidence was highest between 8 to 12 years. The mean best corrected visual acuity at baseline was 0.43 ± 0.23, and 88.7% of patients had mild to moderate visual loss. The symptoms were bilateral in 96.2% of patients, and the difference of corrected visual acuity between two eyes was 1 line or less on Snellen chart in 94.1% of bilateral cases. The symptoms were resolved by 1.8 ± 1.0 months in 59.5% of patients and resolved by the final follow-up visit in 51 (96.2%). However, the symptoms persisted through the final follow-up in 2 patients. Conclusions: Most children with functional visual loss have bilateral and mild to moderate visual loss. The prognosis of functional visual loss in children was excellent. Most patients recovered from the disease with reassurance supportive care without psychiatric treatment, although a few patients had persistent symptoms.

Comparison of Image Quality of the Amorphous Silicon DR System and the Film-screen Systems

윤제웅,이형구,서태석,최보영,신경섭,문인기,김홍권,한용우,남승배,Youn, Je-Woong,Lee, Hyoung-Koo,Suh, Tae-Suk,Choe, Bo-Young,Shin, Kyung-Sub,Mun, In-K.,Kim, Hong-Kwon,Han, Yong-Woo,Nam, Seung-Bae Korean Association for Radiation Protection 1999 방사선방어학회지 Vol.24 No.3

비정질 실리콘 방사선 촬영기와 기존 X-ray filmrh과의 영상질 비교를 통하여 시스템의 성능을 평가하였다. 다양한 영상질 평가를 위하여 MTF (Modulation Transfer Function), NPS (Noise Power Spectrum), Contrast를 측정하여 계산하였다. 실험 결과 DR의 MTF는 기존 film-screen system과 유사하였다. Noise 특성은 두 시스템 모두 quantum noise가 주를 이뤘으며, 특히 DR 에서는 전기적인 noise가 발견되었다. 또한 우수한 sensitivity 특성과 영상처리를 통하여 DR 시스템이 기존의 film-screen 시스템보다 놀은 대조도를 보였다. 이와 같이 DR에서는 기존 film-screen 시스템과 유사한 해상도와 영상처리를 통해 같은 촬영조건에서도 향상된 대조도의 영상을 얻을 수 있었다. 본 연구를 통하여 의학적 활용과 관련된DR 시스템의성능에 대한 유용한 정보를 제공할 수 있으리라 기대한다. System performances in terms of image quality between an amorphous silicon DR system and a conventional film-screen system were evaluated. Various aspects of image quality MTF (modulation transfer function), NPS (noise power spectrum), SNR(signal-to-noise ratio) and contrast were measured and calculated. The MTF of the DR system was comparable to the film-screen systems. The noise was mainly dominated by the quantum mottle in both systems and the electronic noise was found in the DR system. The contrast of the DR system was better than the film-screen systems by virtue of high sensitivity and image processing. Compared to the film-screen systems in general radiography, the DR system had similar resolution and showed better contrast with the same exposure condition after contrast manipulation. The results of this study provide some useful information about the performance of the DR system in connection with medical applications.

Effects of Adjuvant Radiation Therapy and Chemotherapy Following Curative Surgery in Locally Advanced Rectal Cancer

강기문,최일봉,김인아,장지영,신경섭,장석균,이재학,김영하,원종만,최동환,김진승,박신희,Kang, Ki-Mun,Choi, Ihl-Bohng,Kim, In-Ah,Jang, Jee-Young,Shin, Kyung-Sub,Jang, Suck-Kyun,Lee, Jae-Hak,Kim, Young-Ha,Won, Chong-Man,Choi, Dong-Hwan,Kim, J The Korean Society for Radiation Oncology 1997 Radiation Oncology Journal Vol.15 No.2

목적 : 국소 진행된 직장암 환자에서 근치적 절제술후 방사선치료와 항암화학요법과의 병용치료를 시항하여 치료에 따른 합병증, 국소재발 그리고 생존율에 대한 그 효과를 알아보고자 하였다. 방법 : 1992년 9월부터 1995년 9월까지 직장암으로 진단받고 근치적 절제술후 방사선치료와 항암화학요법과의 병용치료를 받은 28명의 환자를 대상으로 하였다. 방사선치료는 근치적 절제술 후 4주에서 6주이내에 시행하였으며 선형가속기 6MV와 15MV X-ray를 이용하여 주 5회, 1회 180cGy로 5-6주간 총조사선량은 5040cGy-5580cGy까지 조사하였다. 항암화학요법은 방사선치료 시작 1주와 5주째 처음 제1일부터 제4일까지 4일간 5-FU는 체표면적 $m^2$당 400mg씩 그리고 Leucovorin은 체표면적 $m^2$당 20mg씩을 정맥주사로 4주간격으로 2회 시행하였다. 추적관찰기관은 2개월에서 42개월이었으며 중앙값은 24개월이었다. 결과 : 전체환자의 2년 생존율과 무병생존율은 각각 $78.6\%,\;70.8\%$였다. 병기에 있어 2년 생존율과 무병생존율은 $B_{2+3}$에서는 $93.0\%$와 $79.4\%,\;C_{2+3}$에서는 $76.2\%$와 $69.2\%$였다. 치료실패 양상은 국소재발이 $10.7\%$(3128), 원격전이가 $3.6\%$(1/28), 국소재발과 원격전이가 동시에 발생한 경우는 $7.1\%$(2/28)로 궁극적인 국소재발율이 $17.9\%$(5/28)였다. 병기에 따른 국소재발율은 $B_{2+3}$와 $C_{2+3}$의 각각 $13.3\%$(2/15)와 $23.1\%$(3/13)였다. 치료에 따른 합병증으로는 방사선 피부염은 $28.6\%$(8/28)로 가장 많이 발생하였고 혈액학적 부작용으로 백혈구감소증이 $21.4\%$(6/28)에서 발생하였으나 보조적인 치료후 모두 회복되었고 치료와 관련되어 사망한 경우도 없었다. 생존율, 무병 생존과 국소재발율은,.영향을 미치는 단변수분석에서는 조직학적 분화도에 있어 잘 분화된 선암이 분화도가 나쁜 선암보다 통계학적 유의성이 있었고(p=0.04, 0.05, 0.04) 그외에서는 초기병기일수록, 종양의 크기가 5cm 이하에서 좋은 결과를 보였지만 통계학적 유의성은 없었다. 결론 : 국소적으로 진행된 직장암의 경우 근치적 절제술후 방사선치료와 항암화학요법과의 병용치료가 비교적 안전하고 효과적인 방법이였다. 그러나 본 연구에서는 직장암이 국소적으로 진행된 대상환자의 수효가 적어 향후 좀 더 환자를 모으고 장기적인 추적 결과를 살펴보아야 근치적 절제술후 방사선치료와 항암화학요법과의 병용치료의 효율성을 보다 명확히 확인할 수 있으리라 생각된다. Purpose : To evaluate the effect of postoperative adjuvant radiation therapy and chemotherapy on the survival, pattern of failure and complication for locally advanced rectal carcinoma Materials and Methods : From October 1992 to September 1995, twenty eight patients with rectal carcinoma were treated by postoperative adjuvant radiation therapy and chemotherapy Radiation therapy was delivered with 6MV and 15MV linear accelerator, 180c0y fractions 5 day per week. Total radiation doses were 5040cGy in $B_{2+3}$ and 5580cGy in $C_{2+3}$. Within 4 weeks after radical surgery. 5-FU$(400mg/m^2/day)\;and\;Leucovorin(20mg/m^2/day)$ were administered by intravenous injection for 4 days during the first and fifth week of radiation therapy. The median follow up was 19 months with a range 2 to 47 months. Results : The 2 year overall survival and disease free survival rates were $78.6\%\;and\;70.8\%$, respectively. The 2 year overall survival was $93.0\%\;in\;B_{2+3}$ and $76.2\%\;in\;C_{2+3}$(p=0.11) The 2 year disease free survival was $79.4\%\;in\;B_{2+3}\;and\;69.2\%\;in\;C_{2+3}(p=0.13)$. The overall failure rate was $21.42\%$(6/28) including $10.72\%$(3/28) locoregional recurrence, $3.62\%$(1/28) distant metastasis and $7.12\%$(2/28) locoregional recurrence with distant metastasis. The overall locoregional recurrence rate was $17.92\%$(5/28). The 2 year locoregional recurrence rates were $13.32\%(2/15)\;and\;23.12\%$(3/13) for respectively for $B_{2+3}\;and\;C_{2+3}$ The difference between the locoregional recurrence of $B_{2+3}\;and\;C_{2+3}$ patients was not significant(p=0.07). Complications developed in 13 patients$(46.42\%)$, including 8 dermatitis, 7 loose stool, 6 leukopenia, 4 tenesmus, 2 diarrhea. In Univariate analysis, there was no statistically significant factor except for tumor grade in locoregional recurrence, disease free survival and overall survival rate(p=0.04, 0.05, 0.04). Conclusion : This study sugges1s that postoperative adjuvant radiation therapy and chemotherapy is effective in patients with locally advanced rectal cancer. Therefore these results need to be confirmed with a long term follow-up and larger number of patients with the further clinical trials including prospective controlled studies.

핵의학 영상의 정량적 분석을 통한 신장기능 평가 프로그램 개발

송주영(Ju Young Song),이형구(Hyoung Koo Lee),서태석(Tae Suk Suh),최보영(Bo Young Choe),신경섭(Kyung Sub Shin),정용안(Yong An Chung),김성훈(Sung Hoon Kim),정수교(Soo Kyo Chung) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.2

N/A Purpose: In this study, we developed a new software tool for the analysis of renal scintigraphy which can be modified more easily by a user who needs to study new clinical applications, and the appropriateness of the results from our program was studied. Materials and Methods: The analysis tool was programmed with IDL5.2 and designed for use on a personal computer running Windows. For testing the developed tool and studying the appropriateness of the calculated glomerular filtration rate (GFR), 99mTc-DTPA was administered to 10 adults in normal condition. In order to study the appropriateness of the calculated mean transit time (MTT), 99mTc-DTPA and 99mTc-MAG3 were administered to 11 adults in normal condition and 22 kidneys were analyzed. All the images were acquired with ORBITOR, the Siemens gamma camera. Results: With the developed tool, we could show dynamic renal images and time activity curve (TAC) in each ROI and calculate clinical parameters of renal function. The results calculated by the developed tool were not different statistically from the results obtained by the Siemens application program (Tmax: p=0.68, Relative Renal Function: p=1.0, GFR: p=0.25) and the developed program proved reasonable. The MTT calculation tool proved to be reasonable by the evaluation of the influence of hydration status on MTT. Conclusion: We have obtained reasonable clinical parameters for the evaluation of renal function with the software tool developed in this study. The developed tool could prove more practical than conventional, commercial programs. (Korean J Nucl Med 2001;35:89-99)

신장; 일측성 요로폐쇄 흰쥐 신장에서 암모니아 운반체의 발현

김승중 ( Seung Jung Kim ),김혜영 ( Hye Young Kim ),최재현 ( Jae Hyun Choi ),이동화 ( Dong Hwa Lee ),김경민 ( Kyung Min Kim ),김선문 ( Sun Moon Kim ),권순길 ( Soon Kil Kwon ),신경섭 ( Kyung Sub Shin ),김경숙 ( Kyung Sook Kim ) 대한내과학회 2014 대한내과학회지 Vol.86 No.4

목적: 일측 요로폐쇄는 요중 산배설이 감소하는 질환으로 대부분 요 암모니아 배설의 감소에 의한 것으로 알려져 있다. 본 연구는 일측 요로 폐쇄 흰쥐에서 산배설의 변화와 암모니아 운반체인 Rh C Glycoprotein (Rhcg)의 발현 변화를 확인하여 신세뇨관산증의 병인에 암모니아 운반체의 역할을규명하고자 하였다. 방법: Sprague-Dawley계 웅성 흰쥐를 사용하였으며, 실험군은 24시간 일측 요로폐쇄를 유발시켰다. 대조군과 실험군은 대사케이지에 mineral oil을 처리하여 24시간 동안 요를수집하였다. Rhcg의 면역조직화학염색을 시행하였고 세포크기, 총 Rhcg 발현, 자유세포면의 Rhcg 발현에 대하여 면역조직화학염색법을 정량화 분석하였다. 결과: 일측 요로폐쇄군에서 혈중 tCO2 농도는 대조군 27.5± 2.8 mEq/L에 비하여 실험군은 25.2 ± 1.0 mEq/L로 감소하였다(p < 0.05). 24시간 요 암모니아 배설은 대조군 0.38 ±0.08 mmol에 비하여 실험군에서 0.19 ± 0.03 mmol로 요 암모니아 배설이 감소하였으며(p < 0.05), Urine pH는 양 군 간에차이가 없어 일측성 요로폐쇄에 의해 신세뇨관산증이 유발되었음을 확인하였다. 반정량적 immunoblot 검사에서 Rhcg의 단백 발현은 양군 간에 유의한 차이가 없었다. 면역조직화학염색과 정량화 분석 결과 일측 요로폐쇄군에서 Rhcg의면역반응성은 비폐쇄부위 콩팥에서는 차이가 없었으나 폐쇄부위 콩팥에서는 감소하였다. 결론: 일측 요로폐쇄 흰쥐에서 암모니아 배설 감소와 폐쇄부위 콩팥에서 Rhcg의 면역반응성의 감소가 동반되었다. 따라서 일측 요로폐쇄의 산성화 장애 병인에 암모니아 운반체 Rhcg가 중요한 역할을 할 것으로 생각된다. Background/Aims: Urinary tract obstruction induces a form of renal tubular acidosis with a urinary acidification defect caused by decreasing net acid excretion, which is predominantly due to a decrease in urinary ammonia excretion. The present study examined whether this decrease is associated with changes in the renal expression of an ammonia transporter family member, Rh C glycoprotein (Rhcg), in rats with a unilateral ureteral obstruction. Methods: Male Sprague-Dawley rats underwent a 24-h unilateral ureteral obstruction. Rhcg expression was then evaluated by immunoblotting and immunohistochemistry. Cell height, total cellular expression, expression in the apical 25% of the cell, and % of total expression in the apical region were quantified by immunohistochemistry with quantitative morphometric analysis. Results: After 24 h of unilateral ureteral obstruction, the serum bicarbonate level and total urinary ammonia excretion were decreased. Both light microscopy and immunohistochemistry with quantitative morphometric analysis demonstrated that the total intensity of Rhcg expression was decreased in the obstructed kidneys, whereas Rhcg expression did not change in the cortical collecting duct (CCD) and outer medullary collecting duct (OMCD) of nonobstructed kidneys in rats with a 24-h unilateral ureteralobstruction. Conclusions: The rats with a unilateral ureteral obstruction showed decreased urinary ammonia excretion associated withdecreased Rhcg expression in the CCD and OMCD. These changes suggest that the ammonia transporter Rhcg mediates a urinaryacidification defect associated with unilateral ureteral obstruction. (Korean J Med 2014;86:444-452)

99mTc - HSA 신티그램을 이용한 쯔쯔가무시병에서의 장내단백소실 진단

박용휘(Yong Whee Bahk),김춘열(Choon Yul Kim),양우진(Woo Jin Yang),손형선(Hyung Sun Sohn),김성훈(Sung Hun Kim),신경섭(Kyung Sub Shin),김윤희(Yoon Hee Kim),정수교(Su Kyo Chung) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1

N/A N/A

99mTc - DISIDA 신티그래피를 이용한 간세포암 간외 전이의 진단 : 원발 간세포암과의 비교

박석희(Seog Hee Park),박용휘(Yong Whee Bahk),정수교(Soo Kyo Chung),김성훈(Sung Hoon Kim),백준현(Joon Hyun Baik),김영주(Young Joo Kim),천경아(Kyung Ah Chun),신경섭(Kyung Sub Shin) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.4

N/A It is well known that hepatobiliary agent are taken up by metastatic hepatocellular carcinoma(HCC) as well as primary HCC. But the reported cases of the extrahepatic metastasis of HCC diagnosed by hepatobiliary scintigraphy are for the most part hematogenous ones. The relation of the uptake pattern of hepatobiliary agent in the primary and metastatic HCC is also still remains unknown. So we undertook this study to evaluate the relation of the hepatobiliary scintigraphic patterns of primary and metastatic HCC with different metastiatic routes. Nine patients with primary HCC and twelve cases of metastaic HCC including four lung metastases, one bone metastasis, one right atrial metastasis, one peritoneal wall metastasis, and five lymph node metastases were studied with Tc-99m-DISIDA scintigraphy. The images were taken on 10, 30 minutes, 1, 2, 4-6 hours. The overall detection rates of hematogenous metastases(lung and bone) is 60%(3 of 5), direct metastasis(right atrium and peritoneal wall), 100%(2 of 2) and lymphatic metastases, 0%(0 of 5). In four of five metastatic cases demonstrated with hepatobiliary scintigraphy, biliary agent is also taken up by primary HCC lesions. And the appearing time of the radioactivity in the direct metastatic HCC lesion is same as that of primary HCC and in the cases of hematogenous metastasis, earlier than that of primary HCC. Hepatobiliary scintigraphy is more useful in the diagnosis of the metastatic HCC than primary HCC, in the cases of hematogenous and direct metastasis.

증례 : Cushing 증후군 20 예 - 감별진단 및 치료 상의 문제 분석

민병석 ( Byong Sok Min ),방병기 ( Byung Kee Bang ),손호영 ( Ho Young Son ),강성구 ( Sung Koo Kang ),이광우 ( Kwang Woo Lee ),임흥각 ( Heung Kark Lim ),신경섭 ( Kyung Sub Shin ) 대한내과학회 1983 대한내과학회지 Vol.26 No.4