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박상기(Sang Ki Park),김근화(Geun Hwa Kim),정성수(Seong Su Jeong),신경상(Kyoung Sang Shin),김애경(Ae Kyoung Kim),서지원(Jee Won Suhr),김재성(Jae Sung Kim),조문준(Moon June Cho),김주옥(Ju Ock Kim),김선영(Sun Young Kim) 대한내과학회 1997 대한내과학회지 Vol.53 No.6
N/A Background: The majority of patients with locally advanced, unresectable, non-small cell lung cancer(NSCLC) were treated with conventional thoracic radiation therapy Throcic radiation therapy produces tumor regression in most patients but few cures and dismal 5-year survival rate. Several randomized studies have demonstrated that systemic chemotherapy controls micrometastasis and improve survival ratNes for patients who have locally advanced NSCI.C. Hut the optimal frequency of chemotherapy and sequence for chemotherapy and radiotherapy are yet to be determined. In this study, we analyzed response rate, median survival time, side effects and prognostic variables according to the frequency of chemotheray in locally advanced NSCLC patients, Methods: We separated locally advanced, unresectable, NSCLC patients into two groups according to given number of chemotherapy cycles. Among 28 patients evaluated, eleven patients were classified to group A, receiving above 3 cycled chemotherapy and seventeen patients, classified to group B, receiving 3 cycled chemotherapy. In both groups, thoracic irradiation of 5940 cGy was given to all patients after chemotherapy. Results: 1) Median survival time was 12.9 months for group A, 12.8 months for group B but there was no statistically significant difference(P>0.05), 2) Overall response rates were not significantly different between two groups(P>0.05). 3) Frequency rate of local failure and distant metastasis were not significantly different between two groups (P>0.05). 4) The grade and frequency of toxicities during treatment were not significantly different between two groups (P>0.05). 5) Clinical stage was the only major prognostic factor for overall survival (P<0.05). Conclusion: Median survival time, response rate, toxicities and frequency of local failure and distant metastasis were not significantly different between two groups. So, when we treat locally advanced, unresectable, NSCLC patients in sequential combined treatement, we should consider planned therapy(limiting chemotherapy cycles given), because planned therapy reduces many troubles of patients, that is, economic loss and time consuming, psychiatric anxiety etc, during treatment period. The optimal frequency of chemotherapy is remained to be validated in large scale study in the future in the setting of combined treatment.
제한병기 소세포폐암에서 흉부 방사선 치료의 도입 시기에 따른 치료 효과의 비교 분석
박상기 ( Sang Ki Park ),김근화 ( Geun Hwa Kim ),정성수 ( Seong Su Jeong ),신경상 ( Kyoung Sang Shin ),김애경 ( Ae Kyoung Kim ),조해정 ( Hai Jeong Cho ),서지원 ( Jee Won Suhr ),김재성 ( Jae Sung Kim ),조문준 ( Moon June Cho ),김주 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.6
김선영(sun Young Kim),신경상(Kyoung Sang Shin),고동석(Dong Seok Ko),서재철(Jae Cheol Seo),김근화(Geun Hwa Kim),정성수(Seong Su Jeong),박상기(Sang Ki Park),김주옥(Ju lck Kim) 대한내과학회 1998 대한내과학회지 Vol.55 No.1
N/A Objectives : Tuberculous cervical lymphadenitis is one of the common cause of cervical mass in young adult in Korea. Sometimes it appears to be difficult in defining the role of surgery and duration of antituberculous treatment. To clarify the duration of medical treatment and to define the cause of prolonged treatment duration Methods : we analyzed the clinical data of 62 patients with tuberculous cervical lymphadenitis diagnosed at the Chungnam National University Hospital from Jan. 1994 to July 1996 and all patients were divided into two groups (standard and prolonged) by treatment duration. Results : The most prevalent age group was 20 to 39 years old (67%) and male to female ratio was 1:2.6 The most common physical finding was painless swelling on neck, standard group was 52%, prolonged group was 42%. The average size of lymph node was 2.7cm and 3.2cm, respectively (p<0.05). In prolonged group, incidence of associated pulmonary tuberculosis and previous antituberculous treatment history were higher than that in standard group (27%, 35% respectively). The most common affected site was right side of neck, whereas 19% of prolonged regimen group were involved in both side of neck. Bacteriological study from node aspirates showed relatively higher positivity in prolonged group (27%) than in standarded group (5%). The causes of prolonged treatment were increased mass(27%) or remnant mass(23%) and the develoment of new node formation and existing nodes after completion of treatment were found in both groups(10% of standard group, 19% of prolonged group). Conclusion : A new, prospective trial for proper regimens or duration of antituberculosis treatment is strongly needed.
폐암 환자에서 면역조직화학 염색을 통한 p53, erbB-2, CEA 종양단백 발현과 임상적 의의
강동원 ( Dong Won Kang ),이규승 ( Gyu Seung Lee ),김선영 ( Sun Young Kim ),김주옥 ( Ju Ock Kim ),정성수 ( Seong Su Jeong ),고동석 ( Dong Seok Ko ),서재철 ( Jae Chul Suh ),김근화 ( Geun Hwa Kim ),신경상 ( Kyoung Sang Shin ),송규상 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.4