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이차성 부갑상선 기능 항진증을 가진 복막투석 환자에서 경구 칼시트리올 치료 반응에 관여하는 요인
강신욱(Shin Wook Kang),최규헌(Kyu Hun Choi),이호영(Ho Yung Lee),한대석(Dae Suk Han),신석균(Sug Kyun Shin),하성규(Sung Kyu Ha),노현진(Hyun Jin Noh),송현용(Hyun Yong Song),노현정(Hyun Jung Roh),유태현(Tae Hyun Yoo),황재하(Jae Ha Hwang) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.1
N/A Calcitriol therapy is an important treatment for the prevention and control of secondary hyperparathyroidism in continuous ambulatory peritoneal dialysis (CAPD) patients. However, this often has been limited by the associated hypercalcemia and hyperphosphatemia due to increase in intestinal calcium and phosphorus absorption. Many studies reported that these limitations could be avoided by changing routes, frequency and dose of calcitriol treatment. But, there are still controversy about each methods and the results on the PTH response to conventional calcitriol treatment in CAPD patients. This study was performed to evaluate the factors affecting the response to oral calcitriol in CAPD patients. A retrospective study was done in 92 CAPD patients with secondary hyperparathyroidism(intact PTH level >200pg/ml) on oral calcitriol treatment. After baseline study of serum calcium, phosphorus, alkaline phosphatase, BUN, creatinine and intact PTH, calcitriol therapy was begun via oral rou- te, daily. Serum calcium, phosphorus, alkaline phosphatase, BUN, creatinine, intact FI'H and other bio- chemical markers were checked at 3 month, 6 month after treatment. Parathyroid gland ultrasonography was performed to detect parathyroid hypertrophy and nodule and to measure the diameter of parathymid gland. All the patients were divided into two groups according to percent reduetion of i-PTH(initial PTH PTH after 3, 6 months)×100/initial PTH(%),△PTH during oral calcitriol therapy for 3 and 6 months(group I ; △PTH >30%, group II ; △PTH <30%). Result: 1) All 92 patients(mean age 46.5 11.3yr, M: F 45: 47, mean CAPD duration 51.3 39.4 months) were administered oral calcitriol, daily. Mean calcitriol dose during 3 month was 0.43 0.22μg and during 6month 0.43 0.24μg. 2) After 3-month treament, there were significant differences in initial i-PTH, the diameter of parathyroid gland, initial phosphorus, intial total alkaline phosphatase and duration of CAPD between group I and II(406.7±196.5 vs. 871.0±478Apglml, 6.2±2.6 vs. 13.1±5.2mm, 5.0±1.3 vs. 5.7±1.3mg/dl, 93.7±4L1 vs. 171.9±137.6IU/L, 40.1±34.9 vs. 73.5±37.8months, p< 0.05, respectively). 4) After 6-month treament, there were significant differences in initial i-PTH, the diameter of parathyroid gland, intial total alkaline phosphatase and duration of CAPD between group I and II(474.1±266.6 vs. 889.7±485.4pg/ml, 6.4±2.7 vs. 14.5±5.1mm, 107.9±80.1 vs. 180.7±121.5IU/L, 40.5± 32.9 vs. 81.8±35.3months, p<0.05, respectively). 5) The significant negative correlation was shown between △PTH and the duration of peritoneal dialysis, the diameter of parathyroid gland, initial PTH level and PTH response during 3-month and 6-month oral calcitriol treatment. The response to oral calcitriol was poor when i-PTH level more than 500pg/ml(kappa 0.429, p value <0.01), the diameter of parathyroid gland more than 10.0mm(kappa 0.641, p value<0.01), the duration of CAPD more than 55months(kappa 0.524, p value< 0.01). These data suggested that initial i-PTH level, the diameter of parathyroid gland size and the duration of CAPD were independent risk factors of the poor response to oral calcitriol therapy in CAPD patients with secondary hyperparathyroidism.
송현용(Hyun Yong Song),박영수(Young Soo Park),강신욱(Shin Wook Kang),최규헌(Kyu Hun Choi),하성규(Sung Kyu Ha),한대석(Dae Suk Han),이호영(Ho Yung Lee) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.4
목 적 : 의학의 발달과 노인 인구의 증가 등으로 말기신부전 환자의 수는 계속 증가하고 있으며 신대체 요법의 발달에 따른 환자의 삶의 질과 생존율은 계속 향상되고 있으나 말기신부전 환자의 사망률은 아직도 여전히 높은 편이다. 말기신부전 환자의 투석 방법에 따른 생존율의 차이에 대한 비교 연구와 장기간 투석을 시행받고 있는 환자의 예후에 대한 연구는 많으나 투석 개시 후 3개월 이내 사망한 조기 사망군에 대한 연구는 별로 없는 실정이다. 따라서 이들 조기 사망군의 특성을 이해하고 사망률을 낮춘다면 전체 말기신부전 환자의 생존율의 향상을 기대할 수 있다. 방 법 : 1994년 1월 1일부터 1999년 6월 30일까지 말기 신부전증으로 진단받고 처음 신대체 요법을 시행받은 환자 986명 중 투석 개시 후 90일 이내에 사망한 환자 66명과 투석 개시 후 1년 이상 생존한 환자 920명을 대상으로 하여 두 군간의 투석 개시시의 임상상, 동반질환, 생화학적 지표 및 사망 원인에 차이가 있는지 후향적으로 조사하였다. 결 과 : 전체 환자의 1년내 사망률은 10.4%였고 이중 조기 사망군의 사망률은 6.9%(1년내 사망 환자의 64.1%)였으며 평균 생존 기간은 28.9±23.0일이었다. 대상 환자의 평균 연령은 조기 사망군이 생존군에 비해 많았으며(47.6±15.1세 vs 64.7±13.8세, p<0.001) 남녀비는 조기 사망군 30 : 36, 생존 환자군 506 : 414로 조기 사망군에서 여성이 많았으나 통계적 유의성은 없었고 조기 사망군에서 신장내과 의사에게 투석전 적절한 전치료를 받은 조기의뢰군의 비율이 낮은 경향을 보였으나 통계적 유의성은 없었다. 투석 시작시 심전도 변화는 생존군의 경우 좌심실 비대 396예(43.0%), 허혈성변화 86예(9.3%), 부정맥 67예(7.3%), 정상 506예(55.0%)였으며 조기 사망군의 경우 좌심실 비대 24예(36.4%), 허혈성 변화 12예(18.2%), 부정맥 12예(18.2%), 정상 32예(48.5%)로 조기사망군의 경우 허혈성 변화와 부정맥의 빈도가 많았다(p<0.05). 조기 사망군의 동반 질환이 생존군에 비해 많았으며(2.7±1.4 vs 1.6±1.1, p<0.001) 특히 심혈관계 질환 및 악성종양의 동반이 통계적으로 유의하게 많았으나 당뇨 동반여부는 통계적 유의성이 없었다. 혈청 생화학적 검사상 조기 사망군의 경우 투석 전 백혈구의 증가와 림파구의 감소, 혈청 크레아티닌의 감소, 혈청 알부민의 감소, 총 콜레스테롤의 감소와 혈청 C-reactive protein(CRP)의 증가가 생존군에 비해 통계학적으로 유의한 차이를 보였다. 조기 사망군의 위험인자로 나이가 많을수록, 동반질환이 많을수록 특히 악성종양과 심부전이 동반되어 있는 경우, 혈청알부민이 저하 되어있는 경우 및 CRP가 증가되어있는 경우의 순으로 나타났으며 성별, 고혈압, 당뇨의 유무와는 상관관계가 없었다. 조기 사망군의 사망원인은 감염 32예(48.5%), 심혈관계 질환 28예(42.4%), 악성종양 4예(6.1%), 영양실조 2예(3.0%)였다. 결 론: 말기신부전 환자의 조기 사망은 투석 개시 전 감염증의 동반, 심혈관계 질환 및 악성 종양의 동반과 혈청 알부민의 저하, 총 콜레스테롤의 감소, 크레아티닌의 저하 등 영양 상태 불량과 심한 대사성 산증 및 고칼륨혈증 등 전신 상태가 나빠 응급 투석이 요하는 경우가 많으므 Background : Despite improvements in dialysis care, the mortality of patients with end-stage renal disease(ESRD) remains high. Patients who die within the first 90 days after beginning dialysis are not included in mortality rates and may be absent from incidence count. Therefore, the identification of modifiable characteristics associated with the risk of death during the first 90 days of treatment could lead to improved survival during this interval. Methods : We performed a retrospective analysis in 986 patients(at least 1 year survival from initiating dialysis were 920 patients, and 66 patients died within 90 days after dialysis) who were initiated renal replacement therapy first at Yonsei Medical Center from Jan 1994 to Jun 1999. Results : The 1 year mortality rate of total patients was 10.4%, and early death rate was 6.9%. The mean survival duration was 28.9±23.0 days. Characteristics independently associated with increased risk of early death included older age, inflammation, nutritional impairment, more comorbid condition and previous history of cardiovascular disease at starting dialysis. But Diabetes was not increased early death rate. By multivariate logistic regression analysis, old age, combined comorbid conditions, especially malignancy and congestive heart failure, low serum album and elevated C-reactive protein level were the independent risk factors affecting early death. Other variables such as sex, dyslipidemia, hypertension and diabetes mellitus were not significant risk factors. The leading cause of death in early death group was infection rather than cardiovascular accidents. Conclusion : Proper treatment of infection and improved nutritional status by adequate predialytic managements may contribute to their prolonged survival on dialysis patients.
[Ca<sub>1-x</sub>Sr<sub>x</sub>Al<sub>2</sub>O<sub>4</sub>:Eu<sup>2+</sup>] 형광체의 상전이 및 발광특성에 관한 연구
박윤진,송현돈,정상현,이지희,황민하,김영진,Park, Yun-Jin,Song, Hyun-Don,Jung, Sang-Hyun,Lee, Jee-Hee,Hwang, Min-Ha,Kim, Young-Jin 한국재료학회 2008 한국재료학회지 Vol.18 No.1
The phase transformations and luminescent properties of Eu-doped $Ca_{1-x}Sr_xAl_2O_4$ phosphors were investigated. $Ca_{1-x}Sr_xAl_2O_4:Eu^{2+}$ phosphors were synthesized by a solid-state reaction with a flux, $H_3BO_3$. A phase transformation from monoclinic $CaAl_2O_4$ to monoclinic $SrAl_2O_4$ was observed as the x values increased. A high-temperature hexagonal phase of $SrAl_2O_4$ was formed during this transformation as an intermediate phase under an $H_2$ atmosphere due to oxygen vacancies; this did not occur in an air atmosphere. Accordingly, the emission spectra shifted from a blue region to a green region as x increased.
수혜자의 슬픈 표정이 기부의도에 미치는 영향: 감정적 경로와 인지적 경로 고찰을 중심으로
박종철 ( Park Jong Chul ),송현아 ( Song Hyun A ),이가현 ( Lee Ha Hyun ),조서희 ( Jo Seo Hui ) 한국유통경영학회(구 한국유통정보학회) 2018 유통경영학회지 Vol.21 No.3
본 연구는 수혜자의 슬픈 표정과 기부의도 간의 관계에서 감정적 메커니즘(동정심과 감정적 염려)과 인지적 메커니즘(공정성 지각과 사회적 연결성)에 대한 심리적 기제를 고찰하였다. 수혜자의 슬픈 표정이 동정심, 감정적 염려, 공정성 지각, 사회적 연결성을 매개로 기부의도에 미치는 통합모델을 분석하기 위해 지방소재 학부생 304명을 대상으로 설문조사를 실시하였다. 분석결과, 수혜자의 슬픈 표정은 동정심, 감정적 염려, 공정성 지각, 그리고 사회적 연결성에 유의한 영향을 미치는 것으로 나타났다. 그리고 감정적 염려를 제외한, 동정심, 공정성 지각, 사회적 연결성 모두 기부의도에 유의한 영향을 미치는 것으로 나타났다. The aim of this research is to examined the psychological mechanism of 'both affective process(sympathy, emotional concern) and cognitive process(perceived fairness and social connectivity)' in the relationship between sad expression of donee and donation intention. A model integrating sad expression, sympathy, emotional concern, perceived fairness, social connectivity and donation intention was tested using the data of 304 undergraduate students. The results of the data analysis showed that the sad expression of donee positively influences on the sympathy, emotional concern, perceived fairness, and social connectivity. Also, sympathy has a significant impact on the donation intention. Finally, our results indicate that perceived fairness and social connectivity have a significant influence on the donation intention.
지리산둘레길에서 채집한 참진드기의 분포와 참진드기에서의 중증열성혈소판감소증후군바이러스 검출
송병준 ( Byung Joon Song ),임현철 ( Hyun Cheol Lim ),하태만 ( Tae Man Ha ),전두영 ( Doo Yung Jeon ),양수인 ( Soo In Yang ),송현제 ( Hyeon Je Song ) 한국가축위생학회 2016 韓國家畜衛生學會誌 Vol.39 No.2
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease characterized by fever and thrombocytopenia. Haemaphysalis longicornis ticks comprise the major population of ticks in the environment and have been considered as the main vector for SFTS virus (SFTSV). Here we investigated the distribution of ticks carrying SFTSV collected from the environment using the dragging or sweeping methods during April∼October 2015 in Jeollanam-do, Korea. Sampling was taken from Songjeong, Omi, Bangkwang, Sandong areas in Jiri walking trails. Among the total 3,869 ticks collected, 3,823 ticks (98.8%) were H. longicornis, 41 (1.1%) were Amblyomma testudinarium, and 5 (0.1%) were Ixodes nipponensis. Classification results by regional groups of H. longicornis indicated that 1,613 ticks were collected in Sandong, 1,190 ticks in Omi, 603 ticks in Bangkwang, and 417 ticks in Songjeong. In monthly distributional studies of H. longicornis based on the developmental stages, nymph (325 ticks) was collected from May to October, 94% of larvae from April to June, and 94% of adult from June to August. These results showed the different dominant stage of ticks according to seasons. However, no SFTSV-specific gene was detected in 3,823 ticks of H. longicornis, 41 of A. testudinarium and 5 of I. nipponensis.
분절화된 인간 배아에서 세포자연사와 Fas, Fas-ligand, Bax, Bcl-2 발현에 관한 연구
김종식,김명신,양현원,류재혁,윤용달,배인하,정병준,송현진,Kim, Jong-Sik,Kim, Myoung-Shin,Yang, Hyun-Won,Yu, Chai-Hyeock,Yoon, Yong-Dal,Bae, In-Ha,Jung, Byeong-Jun,Song, Hyun-Jin 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.3
Objective : The present study was performed to investigate whether apoptosis occur in human embryos by annexin staining and detect the expression of Fas, Fas-ligand (FasL), Bax, and Bcl-2 in human fragmented embryos derived from IVF-ET by immunofluorescence and Western blot analysis. Materials and Methods: Using annexin staining, immunofluorescence and Western blot analysis on normal and fragmented embryos, we were able to detect apoptotsis and apoptotic gene products in fragmented embryos. Result: Phosphatidylserine (PS) translocation, the marker for apoptosis, were detected frequently in fragmented embryos. Bcl-2 and Bax protein were detected in both fragmented and non-fragmented embryos. When fragmented embryos compared to normal embryos, immunofluorescent intensity of Bcl-2 tended to be lower in fragmented embryos. Bax gene expression increased in the fragmented embryos compared to the normal embryos. This result supports a model in which the molar ratio of Bcl-2 to Bax determines whether apoptosis induced or inhibited in human embryo. Fas was highly expressed in human preimplantation embryos but not FasL. It suggests that embryo may undergo apoptosis by binding with FasL produced by follicular or immune cells. Conclusion: The over expression of Bax and Fas will trigger apoptosis to lead embryo fragmentation and change embryo to be nonviable.