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송필상 ( Pil Sang Song ),고광철 ( Kwang Cheol Koh ),유병철 ( Byung Chul Yoo ),백승운 ( Seung Woon Paik ),이준혁 ( Joon Hyoek Lee ),최문석 ( Moon Suk Choi ),류동열 ( Dong Ryeol Ryu ),이진영 ( Jin Young Lee ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.6
Hepatocellular carcinoma (HCC) is one of the most common malignancies. Many factors are considered to be etiology associated with HCC; the important factors are hepatitis B and C viruses and alcohol. Cirrhosis is present in the majority of patients with H
증례 : 심장을 침범한 Churg-Strauss 증후군 3예
이진영 ( Jin Young Lee ),송필상 ( Pil Sang Song ),오미정 ( Mi Jung Oh ),권남희 ( Nam Hee Kwon ),민태훈 ( Tae Hoon Min ),이병재 ( Byung Jae Lee ),최동철 ( Dong Chull Choi ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
저자들은 흉통과 호흡곤란으로 내원하여 심장을 침범한 Churg-Strauss 증후군으로 진단하고 치료한 3예를 경험하였기에 보고하는 바이다. Churg-Strauss syndrome (CSS) is a rare syndrome of unknown cause, which is characterized by systemic vasculitis, peripheral eosinophilia, extravascular granulomastosis and chronic atopic disease. Cardiovascular involvement is known to be the major cause of death in patients with CSS accounting for up to 48%. Few clinical records have determined on the cardiac manifestations of CSS, we reported three cases of CSS with cardiac involvement. Since delayed treatment could lead to intractable heart failure, we advocate that Churg-Strauss syndrome should be considered and evaluated for cardiac involvement in asthmatic patients with chronic dyspnea, neuropathy or eosinophilia.(Korean J Med 69:S979-S987, 2005)
증례 : Simvastatin 복용 중인 환자에서 Clopidogrel 병합요법 후 발생한 횡문근 융해증 1예
권용수 ( Yong Soo Kwon ),김승태 ( Seung Tai Kim ),송필상 ( Pil Sang Song ),류동열 ( Dong Ryeol Ryu ),최소연 ( So Yeon Choi ),이진영 ( Jin Young Lee ),김덕경 ( Duk Kyung Kim ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
Simvastatin은 HMG-CoA reductase 억제제로 혈중 지질을 개선해서 관상동맥 질환의 예방에 효과적이지만, 횡문근 융해증이란 중요한 합병증이 일어날 수 있다. 저자들은 simvastatin과 clopidogrel 병합 요법 후 횡문근 융해증이 발생하였고, 약물 중단 후 호전된 1예를 문헌 고찰과 함께 보고하며, simvastatin과 clopidogrel 병합 요법시 횡문근 융해증 발생에 대한 주의를 권유한다. Simvastatin, the 3-hydroxy-3methylglutaryl coenzyme (HMG-CoA) reductase inhibitor is effective in reduction the risk of coronary event and are generally well tolerated. Rhabdomyolysis is uncommon complication of this drug. We describe a case of rhabdomyolysis associated with concomitant use of simvastatin and clopidogrel. Rhabdomyolysis occurred 30 days after clopidogrel added to a chronic stable dose of simvastatin, and resolved after discontinuation of simvastatin and clopidogrel. We recommend careful monitoring when clopidogrel is given to patients receiving simvastatin. (Korean J Med 69:S906-S909, 2005)
증례 : 순환기 ; 비전형적 영상 소견을 보이는 악성 심낭 중피종 1예
천우정 ( Woo Jung Chun ),박용환 ( Yong Whan Park ),오주현 ( Ju Hyun Oh ),장성아 ( Seong A Jang ),송필상 ( Pil Sang Song ),류동열 ( Dong Ryeol Ryu ),강구현 ( Gu Hyun Kang ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
악성 심막 중피종은 예후가 매우 불량한 것으로 알려져 있으며 임상적으로 다른 양성 질환과의 감별이 어려운 경우도 있고, 여러 영상의학 검사 소견이 다양하며 심낭삼출액의 세포병리에서 암세포가 나오는 경우가 적기 때문에 진단하기가 쉽지 않다. 하지만 최근에는 항암 약물 치료로 효과를 본 증례들이 보고되고 있기 때문에 면역조직화학 검사를 시행하여 정확한 진단을 내리는 것이 환자의 예후에 중요하다고 할 수 있겠다. Primary malignant pericardial mesothelioma is a very rare and highly aggressive tumor with a poor prognosis. Here, we present the case of a 71-year-old man with symptoms of chest discomfort and exertional dyspnea starting 1 week prior to admission. We identified a pericardial mass using transthoracic echocardiography, but could not diagnose the patient using other multimodal imaging approaches and effusion cytology. Findings on contrast cardiac computed tomography (CT) and magnetic resonance imaging (MRI) were more consistent with angiosarcoma than malignant mesothelioma. Ultimately, the patient was diagnosed with malignant pericardial mesothelioma, based on immunohistochemical staining of the tumor tissue. In recent years, several cases have reported the efficacy of chemotherapy in malignant mesothelioma. Thus, we suggest that accurate diagnosis of pericardial tumors with pathology may have a profound impact on the final prognosis. (Korean J Med 2011;80:S161-S165)