FEM-FDM 격자 연합법을 이용한 복잡한 유동장의 효율적 수치해석

송창준(Chang-Joon Song),장근식(Keun-Shik Chang) 한국항공우주학회 1990 韓國航空宇宙學會誌 Vol.18 No.2

HILS를 위한 시뮬레이션 프로그램 설계 기법

박해리,전인수,송창준,Park, Haerhee,Jeon, In-Soo,Song, Chang-Joon 한국군사과학기술학회 2013 한국군사과학기술학회지 Vol.16 No.4

In this paper, a design method of the simulation program for HILS(Hardware-In-the-Loop Simulation) system is proposed. The present method consists of definition of requirements for HILS, development of specifications, and implementation of the program to satisfy the specifications. In the implementation of the program, the application of hardware interface and the concept of structural modularization are proposed to satisfy the specifications. The concepts of CSCI(Computer Software Configuration Item) and encapsulation are used for structural modularization. The proposed method was practically applied to the development of the simulation program for the efficient operation in HILS of an anti-ship missile system.

Multiple arc FSRT와 Conformal FSRT의 DVH 비교

김기환,김준상,장지영,김재성,김성호,송창준,박민규,존문준,Kim Ki-Hwan,Kim Jun-Sang,Jang JiYoung,Kim Jae-Sung,Kim Seong-Ho,Song Chang-Joon,Park Min-Kyu,Cho Moon-June 대한방사선종양학회 1999 Radiation Oncology Journal Vol.17 No.3

목적 : Multiple arc FSRT (fractionated stereotactic radiotherapy)와 conformal FSRT의 치료계획에 있어서 종양의 모양과 DVH (dose volume histogram)를 비교하여 두 기법간의 유용성에 대하여 논하고자 한다. 대상 및 방법 : 16명의 뇌종양 환자들을 대상으로 1997년 8월부터 1998년 12월까지 충남대학교병원 치료방사선과에서 112회의 FSRT를 실시하였다. 치료 전 모의치료에서 얻은 AP(Anterior-posterior), Lateral 필름상의 금속표지자의 좌표값을 ISOLOC프로그램에 입력하여 얻은 기준점과의 오차를 확인한 후 치료계획을 하였다. 치료계획은 종양용적과 종양표면적를 계산한 후 if (Irregular factor)를 고려하여 multiple arc FSRT 혹은 conformal FSRT를 선택하였다. Multiple arc FSRT는 종양의 IF값이 1-1.2인 경우에 고려하였고, conformal FSRT는 IF값이 1.3 이상인 경우에 고려한 후 종양용적에 대하여 처방선량 이상의 선량에 대한 DVH곡선에 의한 면적이 최소이면서 처방선량 이하의 선량에 대한 DVH곡선에 의한 면적이 최대가 되도록 하는 치료계획을 선택하여 평가하였다. 결과 : 치료전 모의치료에서 시행한 금속표지자의 좌표값을 ISOLOC프로그램에 입력하여 얻은 기준점과의 오차는 1 mm 이내였다. Huitlple arc FSRT는 누적DVH상에서 처방선량의 90, 91, 92, $93\%$에서 전체 종양용적을 포함하고 있었으며 평균값은 $90.6\%$이었고, conformal FSRT 는 누적DVH상에서 처방선량의 81, 85, 86, 87, $91\%$에서 전체 종양용적을 포함하고 있었으며 평균값은 $8\%$이었다. 두 방식 모두 결정장기들에는 최대선량의 $5\%$이하의 적은 선량이 조사되었다. 결론 : Multiple arc FSRT와 conformal FSRT를 IF를 기준으로 치료 계획하여 구형의 종양에 multiple arc FSRT를 시행하였으며, 불규칙한 모양의 종양에는 conformal FSRT를 시행하여 종양의 모양에 관계없이 적절한 FSRT치료계획을 수립할 수 있었다. Purpose : In FSRT (Fractionated stereotactic radiotherapy) planning, we studied the usefulness between multiple arc FSRT and conformal FSRT by comparing tumor shape and DVH (dose volume histogram). Materials and Methods In Chungnam Univ. hospital, we had treated the sixteen patients with FSRT from Aug. 1997 to Dec. 1998. In choosing multiple arc FSRT or conformal FSRT, we had considered If (irregular factor) after calculating tumor volume and surface area. We had considered multiple arc FSRT if tumor shape was similar to sphere or the value of If was less than 1.25, conformal FSRT if tumor shape was very irregular or If was more than 1.3. For evaluation of treatment planning, we had considered the appropriate DVH for tumor volume and for critical organs. Results : The errors between reference point and the coordinates point on AP, Lat radiography were less than 1 mm before treatment. We had planned $3\~$5 arcs for multiple arc FSRT, $5\~6$ports for conformal FSRT. The mean dose distribution of tumor volume of cumulative DVH between multiple arc FSRT and conformal FSRT was 90.6, 85%, respectively. The dose of critical organs irradiated was less than $5\%$ maximum dose of cumulative DVH. Conclusion : We had obtained the similar value between multiple arc FSRT and conformal FSRT, so that we had appropriate treatment planning of FSRT for multiple arc FSRT and conformal FSRT according to tumor shape and size.

방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험

조문준(Moon June Cho),김기환(Ki Hwan Kim),김병국(Byung Kook Kim),송창준(Chang Joon Song),김준상(Jun Sang Kim),김재성(Jae Sung Kim),장지영(Ji Young Jang) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.1

Objectives: We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods: A 64-year-old male patient was diagnosed with T4N0M0 supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2N0M0. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7x6.4to8x8cm 2, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results: In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion: Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

비인강암환자에서 시행한 3차원 입체조형 방사선치료의 조기 임상결과

장지영(Ji Young Jang),조문준(Moon June Cho),김기환(Ki Hwan Kim),송창준(Chang Joon Song),김병국(Byoung Kook Kim),김준상(Jun sang Kim),김재성(Jae sung Kim) 대한두경부종양학회 2000 대한두경부 종양학회지 Vol.16 No.2

Objectives: To improve local control and reduce toxicity, 3-D conformal radiotherapy was used as a boost the primary tumor site following fractionated radiotherapy in patients with nasopharyngeal carcinoma. Materials and Methods: Eight patients with previously untreated nasopharyngeal carcinomas were treated with 3-D conformal radiotherapy following fractionated radiotherapy from September 1998 to April 2000. All patients had biopsy confirmation of disease before radiation therapy. Stages were II in 1, III in 5, and IV in 2. Two patients received cisplatin based chemotherapy in addition to radiation therapy; induction chemotherapy in 1, concurrent chemoradiation in 1. 3-D conformal radiotherapy delivered using 6MV Linac as a boost(range 25.2-28.8Gy, median 25.7Gy) following conventionally fractionated radiotherapy(range 50.4Gy). Average total dose ranged from 75.6-79.2Gy(median 76Gy). Follow-up time was 4-21 months(median 9.6 months). Results: Seven of 8 patients were evaluated radiologically within 3 months after completion of radiation therapy. All 7 patients were seen complete remission. One of 7 patients had distant metastasis after 5 months and local failure after 7 months. The tree interval of local recurrence was ranged from 4 - 21 months(median 10.2 months). One patient without radiological evaluation got complete remission clinically. Treatment related toxicity was grade 1-3 xerostomia, dysphagia, and mucositis. During 3-D conformal radiotherapy, there was no aggravation of any toxicity. Conclusion: Although the number of patients was small and follow-up period was short, 3-D conformal radiotherapy following conventional radiotherapy improved tumor control and dose escalation without increased toxicity. Survival and late toxicity should be evaluated through long term follow-up. In addition, it is necessary to confirm the benefits of 3-D conformal radiotherapy in nasopharyngeal carcinoma with randomized trial.

비인강암의 방사선치료 성적

조문준(Moon-June Cho),장지영(Ji-Young Jang),김준상(Jun-Sang Kim),김병국(Byung-Kook Kim),송창준(Chang-Joon Song),김재성(Jae-Sung Kim) 대한방사선종양학회 2001 Radiation Oncology Journal Vol.19 No.1

목 적 :비인강암 환자의 방사선치료 성적을 후향적으로 분석하여 방사선치료의 효과와 예후인자를 분석하고자 하였다. 대상 및 방법 : 1989년 9월부터 1996년 10월까지 비인강암으로 진단받고 방사선치료를 받은 19명을 대상으로 하였다. 병기별로 보면 I 병기가 2명, II 병기가 6명, III 병기가 2명, IV 병기가 9명이었다. 병리조직학적으로 편평세포암이 5명, 미분화세포암이 14명이었다. 14명은 방사선치료만을 받았다. 5명은 항암제치료를 받았다. 추적 기간은 5개월에서 115개월이였으며 중앙값은 33개월이었다. 모든 환자에게서 추적이 가능하였다. 결 과 :방사선치료 후 15명(79%)에서 완전관해를 보였고 2명(10.5%)에서 부분관해를 보였으며 2명(10.5%)에서는 무반응을 보였다. 치료실패 양상은 국소 실패가 6명이었으며 원격전이가 4명에서 나타났다. 원격전이는 뼈, 간, 폐 등에서 관찰되었다. 전체 환자의 5년 생존율은 47.4%이었고 5년 무병 생존율은 48.1%였다. 병기, T 병기, N 병기, 뇌신경침윤 여부, 병리학적 유형, 활동지수, 반응도, 방사선량, 항암제 치료여부 등에 의한 생존율의 의미 있는 통계적 차이는 없었다. 결 론 :전체 환자의 5년 생존율은 47.4%이었고 5년 무병 생존율은 48.1%이었다. 치료 효과를 증가시키기 위하여 방사선치료 방법의 개선 및 항암제치료 방법에 대한 연구가 필요할 것으로 사료된다. Purpose :This is a retrospective study to evaluate the results of radiation therapy in nasopharyngeal carcinoma. Materials and Methods : From September 1989 to October 1996, 19 patients with nasopharyngeal ca rcinoma completed planned radiation therapy course. Stages were I in 2 patients, II in 6, III in 2 IV in 9 patients, respectively. Pathology was squamous cell carcinoma in 5 patients, undifferentiated cell carcinoma in 14 patients. Fourteen patients were treated with radiation therapy only. Five patients received chemotherapy. The follow- up period ranged from 5 months to 115 months with a median of 33 months. Follow- up was possible in all patients. Results : Responses to radiation therapy were complete response in 15 patients, partial response in 2, and no response in 2, respectively. Patterns of failure were as follows : locoregional recurrence in 6 patients and distant metastasis in 4 patients. The sites of distant metastasis were bone, liver and lung. Five year survival rate was 47.8% and five year disease free survival rate was 48.1%. Stage, T- stage, Nstage, central nervous system involvement, pathology type, performance status, response, radiation dose, chemotherapy were not significant prognostic factors. Conclusion :5- year survival rate was 47.8% and 5-yea r disease free survival rate was 48.1%. The advances in radiation therapy techniques and chemotherapy are needed.

지하철 신분당선 터널굴착에 따른 기존 지중전력구 구조물 및 케이블 안정성 확보방안

오장만(Jang-Man Oh),강원탁(Won-tag Kang),김재열(Jae-Youl Kim),최관익(Kawn-Ik Choi),송창준(chang-joon Song) 대한전기학회 2013 대한전기학회 학술대회 논문집 Vol.2013 No.7

Multiple are FSRT 와 Conformal FSRT의 DVH 비교

김기환(Ki-Hwan Kim),김준상(Jun-Sang Kim),장지영(Ji-Young Jang),김재성(Jae-Sung Kim),김성호(Seong-Ho Kim),송창준(Chang-Joon Song),박민규(Min-Kyu Park),조문준(Moon-June Cho) 대한방사선종양학회 1999 Radiation Oncology Journal Vol.17 No.3

목 적: Multiple are FSRT(fractionated stereotaerapy radiotherapy)와 conformal FSRT 의 계획에 있어서 종양의 모양과 DVH(dose volume histogram)를 비교하여 두 기법간의 유용성을 대하여 논하고자 한다 대 상 및 방법: 16명의 뇌종양 환자들을 대상으로 1997년 8월부터 1998년 12월까지 충남대학교의 치료방사선과에서 12회의 FSRT를 실시하였다.치료전 모의치료에서 얻은 AP(Anterior-posterior), lateral 필름상의 금속표지자의 좌표값을 ISOLOC프로그램에 입력하여 얻은 기준점과의 오차를 확인한 후 치료계획을 하였다. 치료계획은 종양용적과 종양표면적를 계산한후 IF (irregular factor)를 고려하여 multiple arc FSRT 혹은 conformal FSRT를 선택하였다. Multiple are FSRT 는 종양의 IF값이 1-1.2인 경우에 고려하였고, Conformal FSRT 는 IF값이 1.3이상인 경우에 고려한 후 종양용적에 대하여 처방선량 이상의 선량에 대한 DVH곡선에 의한 면적이 최소이면서 처방선량 이하의 선량에 대한 DVH곡선에 의한 면적이 최대가 되도록 하는 치료계획을 선택하여 평가하였다. 결 과: 치료전 모의치료에서 시행한 금속표지자의 좌표값을 ISOLOC프로그램에 입력하여 얻은 기준점과의 오차는 1mm이내였다. Multiple are FSRT는 누적 DVH상에서 처방선량의 90,91,92,93%에서 전체 종양용적을 포함하고 있었으며 평균값은 90.6%이였고, conformal FSRT는 누적 DVH상에서 처방선량의 81,85,87,91%에서 전체 종양용적을 포함하고 있었으며 평균값은 86%이었다. 두 방식 모두 결정장기들에는 최대선량의 5%이하의 적은 선량이 조사되었다. 결 론: Multiple are FSRT 와 conformal FSRT 를 IF를 기준으로 치료 계획하여 구형의 종양에 Multiple are FSRT를 시행하였으며, 불규칙한 모양의 종양에는 conformal FSRT를 시행하여 종양의 모양에 관계없이 적절한 FSRT치료계획을 수립할 수 있었다. Purpose:.In FSRT (Fractionated stereotactic radiotherapy) planning, we studied the usefulness between multiple arc FSRT and conformal FSRT by comparing tumor shape and DVH(dose volume histogram). Materials and Methods: In Chungnam Univ. hospital, we had treated the sixteen patients with FSRT from Aug. 1997 to Dec. 1998. In choosing multiple arc FSRT or conformal FSRT, we had considered multiple arc FSRT if tumor shape was similar to sphere or the value of IF was less than 1.25, conformal FSRT if tumor shape was very irregular or IF was more than 1.3. For evaluation of treatment planning, we had considered the appropriate DVH for tumor volume and for critical organs. Result: The errors between reference point and the coordinates point on AP, Lat radiography were less than 1 mm before treatment. We had planned 3~5 arcs for multiple arc FSRT, 5~6pots for conformal FSRT. The mean dose distribution of tumor volume of cumulative DVH between multiple arc FSRT and conformal FSRT was 90.6, 86%, respectively. The dose of critical organs irradiated was less than 5% maximum dose of cumulative DVH. Conclusion: We had obtained the similar value between multiple arc FSRT and conformal FSRT, so that we had appropriate treatment planning of FSRT for multiple arc FSRT and conformal FSRT according to tumor shape and size.

신 손상환자에서 혈관조영술의 역할

박청희,송창준,김종철 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

We analyzed angiographic findings of 18 patients with renal injury, and also excretory urography. Angiography is advocated for better definition of previously identified urographic abnormality and for assessment of active bleeding in patients with suspected damage to renal vessels. It also can be therapeutic as transcatheter embolization for control of hemorrhage.

방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.