한국인 궤양성 대장염의 임상적 관찰

송인성(In Sung Song),최규완(Kyoo Wan Choi),백승운(Seung Woon Paik) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1

N/A The purpose of this study is to review the clinical and pathological features of the ulcerative colitis in Korea. A total of 39 cases of ulcerative colitis, experienced in the Seoul National University Hospital from June 1976 to January 1985, was analyzed in terms of incidence, symptomatology, laboratory findings, colonoscopic and barium enema findings, and consequence of treatment.1) The disease was most prevalent in the fourth decade with a slight preponderance on the female. 2) In 84.6% of the cases the duration of symptoms was less than 5 years. 2) The most common symptoms were hematochesia, bloody mucoid stool, low abdominal pain and the loss of weight in the order of frequency. 4) The laboratory findings were non-specific, including anemia, leukocytosis, increased erythrocyte sedimentation rate, electrolyte imbalance, hypoalbuminemia, increased serum alkaline phosphatase activity. 5) In terms of the anatomical distribution of the lesion, proctitis was shown in 15. 4% proctosigmoiditis in 10.3% the left-sided colitis in 33 .34% pancolitis in 20.5% ileitis in 10.3% 6) Colonoscopy revealed mucosal friability, diffuse hyperemia, diffuse erosion and ulceration, granularity and pseudopolyposis. 7) The barium enema showed no remarkable abnormality in 45.2% of the cases. But in the other cases granularity, loss of haustral marking, luminal narrowing, foreshortening, and pseudopolyps were noted. 8) The histopathologic examination showed non-specific inflammation in 56.4% of the cases. 9) With the medical treatment 92.1% of the cases showed initial improvement in the symptom. However 48.7% of the improved cases had recurrence in some time. 10) In 5 cases, who did not respond to the medical treatment, the involved segments of the colon were resected.

붉은 강낭콩에 의한 소장점막 손상후 재생에 과한 연구

송인성(In Sung Song),노임환(Im Hwan Roe),김정룡(Chung Young Kim) 대한내과학회 1991 대한내과학회지 Vol.40 No.3

N/A Red kidney bean (RKB) has been shown to cause toxic effct such as diarrhea, weight loss and failure of growth in animal and man. To investigate the reversibility of toxic effect of RKB, male adult rats weighing 140 gm were separated into 5 groups (n=10 in each group). Control group received a basic diet ad libitum for 3 weeks. Group I received the diet that crude RKB was added for 12% of the diet and were killed 1 week later. Group II received the RKB diet for 2 weeks. Group III received the RKB diet for 2 weeks and thereafter the basic ad libitum diet for 1 week, and Group IV received the RKB diet for 2 weeks following the ad libitum diet for next 2 weeks. During the period of RKB diet, progressive weight loss was found in each group. But after returning the basic diet progressive weight gain was noticed in group III and IV. During the period of RKR diet, villous height and crypt depth were increased progressively in each group. But they were almost same as those of the control after returning the basic ad libitum diet in group III and IV. And the mucosal enzymes activities such as sucrase, lactase, aminopeptidase and alkaline phosphatase were depressed on RKB diet and returned to control level after receiving the basic ad libitum diet for Z weeks. This study indicate that the toxic effect of RKB on small intestinal mucosa was completelv reversible.

위성자료를 이용한 환경보전적 계획기법에 관한 연구

송인성(Song In-Sung),문병채(Moon Byung-Chae) 대한공간정보학회 1997 대한공간정보학회지 Vol.5 No.1

예측 기반의 물류관리시스템 최적 저장위치 결정모형

송인성(In-Sung Song),조남욱(Nam-Wook Cho) 한국SCM학회 2015 한국SCM학회지 Vol.15 No.1

A Warehouse Management System(WMS) controls the movement and storage of materials within a warehouse and processes the material handling transactions. A WMS aims to increase efficiency and accuracy of the material handling processes. In spite of the benefits, implementing a WMS often provides challenges to a company, since it involves building stable interface with existing information systems and process reengineering of all associated processes, which incurs considerable cost and time. Thus, most companies focus on operational stability and, as a result, often neglect efficiency of a WMS. This paper provides a methodology that enhances the efficiency of inventory handling processes in a WMS. First, monthly stock and release data have been analyzed. Then the cell loading rule has been defined to minimize the travel distance of a Stacker Crane(SC). Based on real data of a pharmaceutical company, a time series analysis using an ARIMA model has been adopted to forecast demand. Simulations showed that the proposed method can reduce the travel distance of a S/C, thereby increasing efficiency of a WMS.

십이지장궤양의 치유에 있어 Famotidine 의 효과와 흡연 성별 및 연령의 영향

송인성(In Sung Song),정현채(Hyun Chae Jung),정영화(Young Wha Chung) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3

N/A 46 patients with duodenal ulcer proven by gastrofiberscopy were studied to assess the effect and safety of famotidine, a new, potent, long-acting H2 receptor antagonist and to evaluate the predictable value of smoking, sex and age on the healing of duodenal ulcer. The results were as followed. 1) Healing rate of duodenal ulcer with famotidine for 4 weeks was 76.1%. 2) Male patients with duodenal ulcer healed in 66.7%, whereas female patients 93.8%, so statisti- cally significant (p< 0.05). 3) Healing rate of duodenal ulcer in smoker was 69.6%, whereas in nonsmoker 82.6%, but statistically not significant. 4) Patients with duodenal ulcer aging more than 30 years old healed in 69.7%, whereas less than 30 years in 92.3%, but statistically not significant. 5) Neither abnormal laboratory test results including complete blood count, liver function test, urinalysis nor subjective complaints related to drug medication was being noted during 4 week trial. In conclusion, famotidine is effective and safe in the treatment of duodenal ulcer and female sex seems to increase ulcer healing with famotidine.

유당흡수장애자 및 염증성 장질환 환자에서의 우유섭취량에 따른 유당흡수능과 유당불내성 증상의 발현양상

송인성(In Sung Song),정현채(Hyun Chae Jung),김정룡(Chung Yong Kim),문선희(Sun Hi Moon),황진혁(Jin Hyok Hwang) 대한내과학회 1999 대한내과학회지 Vol.56 No.5

N/A Objective : To define whether lactase-deficient subjects are intolerable to even a pack of milk(200ml) and whether milk intolerance in the patients with IBD is only due to lactose malabsorption, we performed this study. Methods : We evaluated 32 healthy adults and 12 patients with active stage of inflammatory bowel disease(IBD) who had not received antibiotics therapy within the previous 3 weeks. Thirty-two healthy adults underwent H2-breath test with 200, 400, 600 and 800ml of milk at 1st, 2nd, 3rd and 4th day of study, respectively. We measured their end-expiratory hydrogen concentrations and asked them to record the gastrointestinal symptoms. Twelve patients with IBD were tested only with 200ml of milk. Lactose malabsorption was defined as the increase of 20ppm over basal H2 concentration and lactose intolerance as having two or more of the following symptoms; abdominal pain, diarrhea, borborygmus and flatus. Results : The prevalence of lactase deficiency was 72%(23 of 32 subjects) at 800ml of milk(lactose 40g). Among the lactase-deficient subjects, lactose intolerance at 200ml of milk(lactose 10g) was noticed only in 13%(3 of 23 subjects). In the patients with active stage of IBD, the frequency of milk intolerance at 200ml of milk was 50%(6 of 12 subjects), which was higher than in the healthy adults(9%). But the prevalence of lactose malabsorber in the patients with IBD at 200ml of milk(17%) was not higher than in the healthy adults(16%). Conclusion : Most of lactase-deficient subjects(87%) can ingest one pack of milk without lactose intolerance. The increased prevalence of lactose intolerance in the patients with IBD at 200ml of milk is not originated from lactose malabsorption, but probably from incomplete colonic compensation salvage.

정보통신과 지역발전 ; 전화 (電話)의 지역개발효과에 관한 연구 - 전남을 사례로 쇄신확산론적 (刷新擴散論的) 분석에 의하여 -

송인성(In Sung Song) 전남대학교 지역개발연구소 1986 지역개발연구 Vol.18 No.1

N/A N/A

독일연방공화국의 농촌공간재편성에 관한 소고

송인성(In-Sung Song) 대한국토·도시계획학회 1981 國土計劃 Vol.16 No.2

내시경적 (內視鏡的) 역행성 췌담관조영술의 (膵膽管造影術) 합병증에 (合倂症) 대한 Gabexate mesilate ( FOY ) 의 예방적 (豫防的) 효과

송인성(In Sung Song),김정용(Chung Yong Kim),윤영범(Yong Bum Yoon),배순기(Soon Kie Bae),송제일(Je Il Song) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.2

N/A The development and prevalence of endoscopic retrograde cholangiopancreatography(ERCP) has resulted in great progress in the diagnosis of the disease of the pancreas, and biliary tract. At the same time, however, the rise of serum amylase level has been often point out as the complication of ERCP. To assess the effect of synthetic protease inhibitor, Gabexate mesilate(FOY), in hyperamylasemia following ERCP, the authors carried out a controlled trial in 39 patients who were underwent ERCP under the impression of pancreatic or biliary system disease. Of them 20 patients were allocated to FOY@ treated group and 10 patients to control group. The following results were obtained: 1) There was no significant difference in serum amylase level between FOY treated group and control group before ERCP, however significant difference was observed in seram amylase level at 2 hour and 2 day after ERCP between FOY treated group and control group Before ERCP the serum amylase level was 107. 6 45. 1 I.U./dl in control group and 105. 7+-42.1 I.U./dl in FOY treated group.At 2hour after ERCP the serum amylase level was 186.7 +-150.1 I.U./dl in control group and 103.2+-47.9 I.U./dl in FOY treated group. On 2nd day after ERCP, the serum amylase level was 167.7+-84. 1 I.U,/dl in control group and 109.6+-59.1 I.U./dl in FOY treated group 2) The change in serum amylase levels at 2 hour and 2 day after ERCP by the extent of visualization showed a tendency that a greater extent of visualization was associated with a higher incidence of serum amylase levels. Such a tendency was more pronounced in control group and the mean serum amylase level was significantly higher in the control group. 3) FOY did not cause any serious side effect such as shock, fall of blood pressure, itching, eruption, chest pain etc. in all cases. 4) There was some report that FOY has a relaxant action on the Oddis sphincter and helps the cannulation to the opening of Papilla of Vater, however it more depended upon the skill of the endoscopist, anatomical variation of the Papilla of Vater and FOY did not give any great advantage to the cannulation.

Guinea Pig 에서 가수분해된 Carrageenan 으로 유발된 궤양성 대장염의 병태생리에 관한 연구

송인성(In Sung Song),김나영(Na Young Kim),정현채(Hyun Chae Jung),이효석(Hyo Suk Lee),윤용범(Yong Bum Yoon),김정룡(Chung Yong Kim),김우호(Woo Ho Kim) 대한내과학회 1992 대한내과학회지 Vol.43 No.3

N/A Background: Ulcerative colitis is a inflammatory bowel disease, of which characteristics are diarrhea, hematochezia, weight low, and the incidence of this disease is rising tendency in Korea, But the causes or pathophysiology of this disease have not been yet clear and the animal model has not been yet established. This paper is concerned with an experimentalnimal odel of ulcerative colitis wherein the ultimate goal is to study the causes and pathopohysiology of ulcerative colitis. Method: For the animal model, we use guinea pigs to observe whether the carrageenan extracted from the seaweed, causes the lesion to large and small intestine, and whether this lesionis similar to human ulcerative colitis clinically and anatomically. We classified the 82guinea pigs into three groups, the first group (the control group) which consisted of 11guinea pigs were given the tap water as drinking water, the 2nd group of 11 guinea pigs were given the 1.5% native carrageenan (1.5% NCG group) and the 3rd group of 60guinea pigs (1.5% HCG group) were given the 1.5% hydrolyzed carrageenan for 40days. In order to identify the pathophysiology of this lesion, we measured the PG4 and LTB4 at the cecal mucosa where the lesion existed. Xanthine oxidase, superoxide dismutase and catalase activity, all of which are closely related to superoxide radical system, were also measured, Results: 1) During experimental period of 40 days, the weight of 11 guinea pigs of the control group increased by 110g to 180g and the weight of 8guinea pig of the 1,5% native carrageenan group increased by 40g to 100g. However, the twenty eight guinea pigs of the 1.5% hydrolyzed carrageenan group lost 10g to 130g during experimental period. All of the 28guinea pigs of the 1.5% HCG group showed diarrhea and loose stools till the end of experiment, the fifty percent of 8 guinea pigs of the l. 5% NCG group showed loose stool, but none of the control group showed loose stool. All of the control group and the 1.5% NCG group showed negative occult blood when the hematest was taken at the end of experiment, but twenty seven guinea pigs (93.3%) of the 1.5% HCG group were positive and 12guinea pigs (43%) showed grossly hematochezia. By the way, the time of onset of clinical symptom in the 1.5% HCG group was very variable among the guinea pigs from 3weeks to 40days after the beginning of HCG intake. Moreover the guinea pig tended to die within 10days once the symptom developed. 2) There was no abnormal finding from the treiz ligament to the rectum in the control group but half of the 1.5% NCG group showed hemorrhagie erosions at the cecum and the twenty seven of 28 guinea pigs of l. 5% HCG group showed hemorrhagic erosions at the cecum. The two guinea pigs of the 1.5% HCG group showed 0.2×0.8cm and 0.3×1.0cm sized ulcerations grossly. 3) When the cecal mucosa was observed with light microscope, the six of the 8guinea pigs of the 1.5% NCG group showed mucosal atrophy and the four of these 6guinea pigs showed mild degree erosions and infiltration of inflammatory cells, but none of 1.5% NCG group showed metachromasia in the toludine blue stain. In the cecal mucosa of the twenty seven of the 28 guinea pigs of the 1.5% HCG group, multiple mucosal confined ulcerations from the shallow and small ulcerations to deep and broad ulcerations were found, and in the 2 of theae 27guinea pigs, the ulcerations were extended to submucosa though the muscularis mucosae. Inflammatory cells such as polymorphonuclear cells, machrophages, lymphocytes and plasma cells were found on the base and margin of the ulcers. Among these inflammatory cells, the infiltration of mechrophages was prominent and definite metachromasia in the toluidine blue stain was found in the machrophages. 4) The mean PGE2 level of the control group was 292.08pg/mg mucosa, and those of the 1.5% NCG group and the 1.5% HCG 281.25pg/mg mucosa, and 429.87pg/mg mucosa, respectively. The mean PGE2 value of 1.5% HCG group was highest among three