싸이토카인 유발 췌장 ${\beta}$세포 독성에 대한 천화분 추출물의 방어효과

송미영,김은경,송제호,Song, Mi-Young,Kim, Eun-Kyung,Song, Je-Ho 대한동의생리학회 2008 동의생리병리학회지 Vol.22 No.2

In this study, the preventive effects of Radix Trichosanthis extracts (RTE) against cytokine-induced ${\beta}-cell$ death were assessed. Cytokines generated by immune cells infiltrating pancreatic islets are crucial mediators of ${\beta}-cell$ destruction in insulin-dependent diabetes mellitus. The treatment of RIN cells with $interleukin-1{\beta}$ ($IL-1{\beta}$) and $interferon-{\gamma}$ ($IFN-{\gamma}$) resulted in a reduction of cell viability. RTE protected $IL-1{\beta}$ and $IFN-{\gamma}$-mediated viability reduction in a concentration-dependent manner. Incubation with RTE also induced a significant suppression of $IL-1{\beta}$ and $IFN-{\gamma}$-induced inducible nitric oxide synthase (iNOS) protein expression. The molecular mechanism by which RTE inhibited iNOS protein expression appeared to involve the inhibition of $NF{-\kappa}B$ activation. The $IL-1{\beta}$ and $IFN-{\gamma}$-stimulated RIN cells showed increases in $NF{-\kappa}B$ binding activityand $I{\kappa}B{\alpha}$ degradation in cytosol compared to unstimulated cells. However, pretreatment with RTE inhibited cytokines-induced $I{\kappa}B{\alpha}$ degradation and $NF{-\kappa}B$ activation in RINm5F cells. Furthermore, the protective effects of RTE were verified via protection of impairment in glucose-stimulated insulin secretions in $IL-1{\beta}$ and $IFN-{\gamma}$-treated islets.

다양한 지형에서의 걷기와 달리기 동작의 효율적 생성

송미영,조형제,Song Mi-Young,Cho Hyung-Je 한국정보처리학회 2006 정보처리학회논문지B Vol.13 No.2

대부분의 3차원 캐릭터 애니메이션에서는 모션 캡쳐 장비를 통해서 포착된 동작 데이터를 이용하여 다양한 지형상에서 캐릭터의 이동 동작을 표현한다. 이러한 동작 포착 데이터는 실제 사람과 같이 움직이는 동작들을 자연스럽게 표현할 수 있으나, 만약 다양한 지형에 대해 움직이는 동작을 표현할 경우, 지형의 유형에 따라 모든 동작을 캡쳐하여야 하고, 얻어진 동작 데이터를 다른 유형의 캐릭터에 적용할 경우 동작 데이터를 다시 얻거나 기존 동작 데이터를 재편집해야 하는 어려움이 있다. 따라서 본 연구에서는 평지면, 경사면, 계단면 그리고 굴곡면 등 다양한 지형에서의 적응적인 걷기, 달리기의 이동 동작을 생성하기 위한 통합적 생성 방법을 제안한다. 이 방법에서는 캐릭터의 신장이나 걷는 속도 걸음폭 등의 적은 매개변수들을 사용하여 이동 동작을 생성할 수 있다. 관절들의 위치나 각도는 역운동학(Inverse Kinematics)방법으로 계산하고, 골반과 이동하는 다리의 움직임 궤적 산출은 큐빅 스플라인 곡선을 활용한다. 또한 제안된 방법을 통해서 다양한 실제 캐릭터에 적용하여 이동 동작을 확인한다. In 3D animation most people adjust the moving motion of their characters on various terrains by using motion data acquired with the motion capture equipment. The motion data can be used to present real human motions naturally, but the data must be captured again to apply to the different terrains from those given at acquiring mode. In addition, there would be a difficulty when applying the data to other characters, in that case the motion data must be captured newly or the existing motion data must be heavily edited manually. In this paper we propose a unified method to generate human motions of walking and running for various terrains such as flat plane, inclined plane, stairway and irregular face. With these methods we are able to generate human motions controlled by the parameters : body height, moving speed, stride, etc. In the proposed methods, the positions and angles of joint can be calculated by using inverse kinematics, and we calculate the trajectory of the swing leg and pelvis according to the cubic spline. With these methods we were presented moving motions using a model of a human body.

국제특허분류를 중심으로 한 한의학 분야의 특허정보 분석 연구

송미영,김홍준,최환수,Song, Mi-Young,Kim, Hong-Jun,Choi, Hwan-Soo 한국한의학연구원 2005 한국한의학연구원논문집 Vol.11 No.2

This Study focused on IPC (International Patent Classification) for TKM (Traditional Korea Medicine) Paper. The results processed for 9,000 TKM paper by using 8th in IPC Classification. The name of Herbal Medicine assigned to IPC Classification, we assigned to two part for main-Classification(A61K) and sub-Classification (A61P). The results obtained about 77% for A61K and about 96% for A61K36 among them. And also analysed about 23% for sub-Classification(A61P) additionally. Main-Classification is distributed A61K > A61H37 > A61B5 > A61N > A61M1. Detailed Main-Classification for A61K is distributed A61K36 > A61K35 > A61K33 among Main-Classification. TKM Paper mainly analysed A61K36 and A61H37 in Main-Classification. According to the results. 'The Korean Journal of Herbology' has high-valued for Utilization as a Non Patent Document. we should constructed Database system for protection of intellectual property rights. And after We will registered minimum documentation of PCT.

필드와 모션벡터의 특징정보를 이용한 스포츠 뉴스 비디오의 장르 분류

송미영,장상현,조형제,Song, Mi-Young,Jang, Sang-Hyun,Cho, Hyung-Je 한국정보처리학회 2007 정보처리학회논문지B Vol.14 No.2

비디오와 브라우징, 검색, 조작을 위해서 비디오 내용을 기술하는 색인이 요구된다. 지금까지 색인의 구성은 대부분 비디오 내용에 제한된 키워드를 수작업으로 할당하는 전문가에 의해 수행되었는데 이는 비용과 시간을 소비하는 사업이므로 비디오 내용을 자동으로 분류하는 것이 필요하다. 이 연구는 축구, 골프, 야구, 농구, 배구 등 5종의 스포츠 뉴스 비디오의 분석과 요약을 위해서 자동적이고 효율적인 방법을 제안한다. 우선, 스포츠 뉴스 비디오를 앵커 장면과 스포츠 기사 장면으로 분류한다. 장면 분류는 앵커 장면의 영상 전처리와 색상 특정을 기반으로 한다. 그리고 필드의 우세색상과 모션 방향을 특징으로 이용하여 스포츠 장면을 5개의 장르로 분류한다. 241개의 스포츠 뉴스 장면에 대한 실험에서 75%의 정확도를 얻었다. 따라서 제안된 기법은 향후 개별 스포츠 뉴스와 스포츠 하이라이트를 위한 뉴스 비디오를 검색하는데 이용될 수 있을 것이다. For browsing, searching, and manipulating video documents, an indexing technique to describe video contents is required. Until now, the indexing process is mostly carried out by specialists who manually assign a few keywords to the video contents and thereby this work becomes an expensive and time consuming task. Therefore, automatic classification of video content is necessary. We propose a fully automatic and computationally efficient method for analysis and summarization of spots news video for 5 spots news video such as soccer, golf, baseball, basketball and volleyball. First of all, spots news videos are classified as anchor-person Shots, and the other shots are classified as news reports shots. Shot classification is based on image preprocessing and color features of the anchor-person shots. We then use the dominant color of the field and motion features for analysis of sports shots, Finally, sports shots are classified into five genre type. We achieved an overall average classification accuracy of 75% on sports news videos with 241 scenes. Therefore, the proposed method can be further used to search news video for individual sports news and sports highlights.

유리드믹스 리듬요소를 적용한 장애 청소년 융합학습지도방안 연구

송미영,남상문,Song, Mi Young,Nam, Sang Moon 국제문화기술진흥원 2021 The Journal of the Convergence on Culture Technolo Vol.7 No.3

장애 청소년은 부자연스러운 행동과 언어를 가지고 있어 부드럽고 유연한 언어와 행동이 어렵고, 학습의 경험이 부족하여 성숙한 행동과 의사소통이 자유롭지 못한 한계가 있다. 장애 청소년은 행동 변화를 가져오는 편안하고 창의적이며 독창적인 생각을 하도록 유리드믹스 음악적 리듬 요소를 시간과 공간, 힘과 무게 그리고 균형과 유동성으로 구분하여 교수학습에 반영하였다. 유리드믹스 리듬 요소를 적용한 학습지도안은 장애 청소년의 자아존중감, 의사 소통, 창의성이 향상되는 효과를 관찰하는 방향으로 교육의 효과를 높이기 위하여 음악교육, 미술교육, 체육교육에 융합하여 연구 참여자를 선정하여 인터뷰 질문지를 토대로 장애 청소년의 연구에 적합한 관찰 방법으로 진행하였다. 연구 결과, 음악, 미술, 체육(라인댄스, 플레이타임)을 융합하여 유리드믹스 리듬요소인 시간과 공간, 힘과 무게, 균형과 유동성을 적용하여 수업을 진행한 결과 장애 청소년 교육효과가 향상된 것을 관찰되었다. 따라서 이 학습 과정에서 한계점을 보완하고 장애 청소년 교육에 적용할 수 있는 다양한 교육방안과 유리드믹스의 신체 놀이를 통한 교육이 반영될 수 있는 지원제도, 그리고 다양한 학습 도구를 적절하게 구성하는 방안을 제시하고자 한다. Adolescents with disabilities have unnatural behavior and language, which makes it difficult to use soft and flexible language and behavior, and lack of learning experience has limitations in not being free in mature behavioral communication. Eurhythmics musical rhythm elements were divided into time and space, power and weight, and balance and fluidity and reflected in teaching and learning so that adolescents with disabilities could have comfortable, creative, and original thoughts that bring about changes in thawing. In order to increase the effectiveness of education in the direction of observing the effect of improving self-esteem, communication, and creativity of adolescents with disabilities, the study guide applying the Eurhythmics rhythm element was fused with music education, art education, and physical education, and interviewed by selecting research participants. Based on the questionnaire, an observation method suitable for the study of adolescents with disabilities was conducted. As a result of the study, it was observed that the educational effect of the disabled youth was improved as a result of conducting the class by applying the Eurhythmics rhythm elements time and space, force and weight, balance and fluidity by integrating music, art, and physical education(line dance, playtime). Therefore, to supplement the limitations in this learning process, various educational methods applicable to the education of youth with disabilities, a support system that can reflect Eurhythmics education through physical play, and a method to properly compose various learning tools do.

선행기술 조사를 통한 한의학 논문의 특허성 연구

송미영,이정화,안상우,Song, Mi-Young,Lee, Joung-Hwa,Ahn, Sang-Woo 한국한의학연구원 2005 한국한의학연구원논문집 Vol.11 No.2

This study is concerned with the patentability and protection of intellectual property rights in Traditional Korea Medicine Paper. The results analyzed significance of patentability by investigated for many kinds of Traditional Korea Medicine Paper. It provide extension of intellectual property rights protection and further research region of TKM field by analysing information of patentability. Recently, In the protection of intellectual property rights, the importance of traditional knowledge resource in many country is increased. It will predict the number of apply for the patent increased annually This study will be provide judging guideline and strategy of intellectual property rights protection by search to detect all existing similar patents in Patent Office (Korea, Japan, U.S.A. EPO) about Traditional Korea Medicine Paper. As a result, It can not be investigated about 33% because of paper research or theoretical study or question investigation etc. But the case of 'The Korea Association of Herbology' and 'The Korean Oriental Medical Ophthalmology & Otolaryngology & Dematology Society' have about 10% rate. If it will be constructed DB system, they will be protected by national treatment.

MBR의 비례 관계를 이용한 영상 보간이 적용된 뇌 MR 영상의 3차원 가시화

송미영,조형제,Song, Mi-Young,Cho, Hyung-Je 한국정보처리학회 2003 정보처리학회논문지B Vol.10 No.3

본 연구에서는 뇌 MR 영상의 3차원 가시화를 위해 여러 단면의 원영상을 사용하지 않고, 적은 수의 횡단면 영상만을 이용하여 보간 영상을 생성하는 방법에 대해 제안한다. 이 과정에서의 핵심인 영상 보간을 위해 우선 3차원으로 재구성하고자 하는 관심영역을 분할하고, 분할된 관심 영역들의 경계와 MBR(Minimum Bounding Rectangle) 정보를 추출한다. 그리고 보간하고자 하는 층의 영상 크기는 분할된 관심영역의 상ㆍ하층 각각 두 영상들의 MBR 크기 변화율로 결정하고, 이를 기반으로 분할된 관심 영역의 영상내에서 해당 화소를 찾고, 입방 보간법을 통해 검출된 각 화소의 명암 가중치를 부여하여 보간 영상의 화소 명암치를 산출한다. 최종적으로는 원영상에서 분할한 관심영역 및 생성된 관심영역의 보간 영상들에서 특징점 정보와 3차원 복셀을 추출하여 3차원으로 재구성한다. In this paper, we propose a new method in which interpolation images are created by using a small number of axiai T2-weighted images instead of using many sectional images for 3D visualization of brain MR images. For image Interpolation, an important part of this process, we first segment a region of interest (ROI) that we wish to apply 3D reconstruction and extract the boundaries of segmented ROIs and MBR information. After the image size of interpolation layer is determined according to the changing rate of MBR size between top slice and bottom slice of segmented ROI, we find the corresponding pixels in segmented ROI images. Then we calculate a pixel's intensity of interpolation image by assigning to each pixel intensity weights detected by cube interpolation method. Finally, 3D reconstruction is accomplished by exploiting feature points and 3D voxels in the created interpolation images.

고지방식이로 유도된 비만형 동물모델에서 부자 물추출물의 비만 및 당대사 개선 효능 평가

송미영,Song, Mi-Young 한방비만학회 2017 한방비만학회지 Vol.17 No.1

Objectives: This study investigated the effects of water extract of Aconitum carmichaeli Debx (ACD) on obesity and glucose tolerance in high fat diet induced obese mice. Methods: Five-week-old C5BL/6 mice were fed a high fat diet (HFD) containing or not containing ACD (100 or 300 mg/kg) for 16 weeks. Body weight, food intake, fasting blood glucose, and body temperature were checked every week and then organs, blood serums were collected after 16-week treatment. Furthermore oral glucose tolerance test (OGTT) was carried out after treatment. Results: ACD treated mice showed no significant decreases in body weight and adipose tissue weight as compared with HFD mice. Lipid accumulations in liver and serum lipid levels were not different between ACD treated and HFD mice. However, ACD extract administration significantly and dose-dependently reduced fasted plasma glucose and glucose tolerance as determined by OGTT. Conclusions: The present study demonstrates that ACD might prevent diet-induced glucose tolerance in mouse models of obesity.

성별에 따른 건강불평등 및 관련요인 연구

송미영 ( Mi Young Song ),임우연 ( Woo Youn Lim ),김증임 ( Jeung Im Kim ) 여성건강간호학회 2015 여성건강간호학회지 Vol.21 No.2

Purpose: This study was aimed to identify gender-based health inequality and explore impacting factors on health inequality in one province in Korea. Methods: This was an explanatory study using the secondary data on Chungnam province from the Fifth Community Health Survey from August 16 to Oct 31, 2012. Variables included in this analysis were education level, poverty, marital status, and residential community for socio-cultural characteristics and subjective health status as an indicator of health inequality. Data were analyzed by x2-test, t-test, ANOVA, and multiple linear regression. Results: There were gender inequalities and disparities in health, and these inequalities were greater in woman than in man (x2=161.8, p<.001). The impacting factors were education level, poverty, marital status, and residential community, which was accounted for 22.6% of variances of health inequality. Among these variables, gender showed the largest influence in health inequalities. Conclusion: To solve health inequalities, it should be considered gender differences based on social determinants of health. It is necessary to develop long term project based on these results and the social determinants model of World Health Organization.

과체중 및 비만 여성에서 한방비만변증에 따른 체성분 및 대사관련 지표의 상관성

송미영 ( Mi Young Song ),김호준 ( Ho Jun Kim ),이명조 ( Myeong Jong Lee ) 한방비만학회 2014 한방비만학회지 Vol.14 No.1

We conducted this study to analysis obesity pattern and obesity related blood parameters. Methods: A total of 64 overweight and obese (body mass index [BMI] ≥23 cm/kg2) women who had no other disease was recruited. Body composition and obesity related blood parameters were measured. Also subjects were given and filled out the Obesity pattern identification questi-onnaire. We analyzed the differences of body composition and blood parameters and measured correlations of BMI and blood parameters in each obesity pattern. Results: The distribution of obesity pattern was liver depression (35.6%), food accumulation (47.5%) and deficiency (pi and yang deficiency, 22.0%), in order. There were no significant differences age, body composition and obesity related blood parameters between obesity patterns. BMI and obesity related blood parameters, however, showed significant correlations depending on obesity patterns. Conclusions: We concluded that correlations between BMI and obesity related blood parameters were differed depending on obesity patterns.