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한국 자생식물 추출물의 항산화 및 Aldo-keto Reductase Family 1 B10 효소 억제 효과
판철호 ( Cheol Ho Pan ),이주영 ( Joo Young Lee ),송대근 ( Dae Geun Song ),김종환 ( Jong Hwan Kim ),안수용 ( Soo Young Ahn ),배덕성 ( Deok Sung Bae ),김영훈 ( Young Hoon Kim ),이재권 ( Jae Kwon Lee ) 한국응용생명화학회 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.4
측백의 aldo-keto reductase family 1 B10 효소 저해 효과
이주영 ( Joo Young Lee ),정우석 ( Woo Suk Jung ),송대근 ( Dae Geun Song ),이은하 ( Eun Ha Lee ),정상훈 ( Sang Hoon Jung ),이재권 ( Jae Kwon Lee ),판철호 ( Cheol Ho Pan ) 충북대학교 과학교육연구소 2014 과학교육연구논총 Vol.29 No.1
This study is to evaluate the inhibitory effect of Thuja orientalis leaves on aldo-keto reductase family 1 B10 (AKR1B10), a potential cancer therapeutic target. To identify the active compounds, seven compounds from the ethyl acetate fraction of T. orientalis were tested for their inhibitory effects on recombinant human AKR1B10 (rhAKR1B10). Among them, amentoflavone was the best inhibitor of rhAKR1B10. The inhibitory rate of amentoflavone against rhAKR1B10 was 81% at 1μM with an IC50 value of 0.86μM, and enzyme kinetic study revealed its inhibition mode to be mixed-competitive.
증례 : 신장 ; 피부병변과 고칼슘혈증, 신부전으로 발현한 유육종증 1예
민보영 ( Bo Young Min ),박원형 ( Won Hyeong Park ),송대근 ( Dae Geun Song ),김태균 ( Tae Gyun Kim ),박현경 ( Hyun Gyung Park ),김범 ( Beom Kim ),조영미 ( Yong Mee Cho ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S
본 증례는 유육종증이 피부와 신장을 동시에 침범하여, 특히 신장에서는 육아종성 간질성 신염에 의한 신부전까지 일으켰으나 고용량의 스테로이드에 좋은 치료 반응을 보인 예로써 신기능 저하와 고칼슘혈증이 동반된 환자에서 신장 유육종증은 주요 감별진단에 포함되어야 하겠다. Sarcoidosis is a granulomatous inflammatory disorder of unknown etiology. It can involve any organ and present in various clinical forms, but renal involvement is very unusual. We report on a 68-year-old man with renal sarcoidosis. He presented with unexplained renal impairment, hypercalcemia, and multiple light brown papules on the buttock and lower extremities. Non-caseating granulomas and interstitial nephritis were revealed in skin and kidney biopsies. The serum creatinine, hypercalcemia, and skin lesions rapidly improved on high-dose steroid therapy. One year later, the serum calcium level was normal, and serum creatinine was 1.3 mg/dL. (Korean J Med 77:S1226-S1230, 2009)