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심활성도 압반사 제어 모델을 이용한 심혈관시스템 모델링 및 시뮬레이션
최병철,정도운,손정만,예수영,김호종,이현철,김윤진,정동근,이상훈,전계록,Choi Byeong Cheol,Jeong Do Un,Shon Jung Man,Yae Su Yung,Kim Ho Jong,Lee Hyun Cheol,Kim Yun Jin,Jung Dong keun,Yi Sang Hun,Jeon Gye Rok 대한의용생체공학회 2004 의공학회지 Vol.25 No.6
본 연구에서는 심혈관시스템 내의 압력 변화를 감지하는 압수용체 중 가장 대표적인 대동맥 압수용체의 시뮬레이션을 위한 심활성도 압반사 제어모델을 제안하였다. 그리고 제안된 모델은 압반사 조절, 시간지연을 포함한 전기회로 모델들로 구성하였으며, 대동맥동의 압반사 조절시 시간지연이 심주기와 일회 심박출량에 주는 영향을 관찰할 수 있도록 하였다. 심활성도 압수용체 제어 모델에서 시간지연의 기전은 대동맥동 압수용체에서 감지된 압력 정보가 구심성 신경으로 전달되고, 이 정보는 중추신경을 거쳐 원심성 신경으로 전달되어 제어 기능을 수행한다. 제안된 모델의 시뮬레이션 결과 시간지연에 따라 심혈관시스템 변이성의 세가지 패턴을 관찰할 수 있었다. 먼저 시간지연이 2.5초 이상일 경우에는 대동맥압, 일회심박출량, 심박동수가 비주기적으로 발생하고 불규칙인 것을 관찰할 수 있었고, 시간지연이 0.1초에서 2.5초 사이일 경우에는 주기적인 진동이 발생함을 관찰할 수 있었다. 그리고 시간지연이 0.1초 이하인 경우에는 심박동수와 동맥압-심박동수의 궤적은 안정상태를 유지함을 관찰할 수 있었다. In this paper, we proposed a heart activity control model for simulation of the aortic sinus baroreceptor, which was the most representative baroreceptor sensing the variance of pressure in the cardiovascular system. And then, the heart activity control model composed electric circuit model of the cardiovascular system with baroreflex control and time delay sub-model to observe the effect of time delay in heart period and stroke volume under the regulation of baroreflex in the aortic sinus. The mechanism of time delay in the heart activity baroreflex control model is as follows. A control function is conduct sensing pressure information in the aortic sinus baroreceptor to transmit the efferent nerve through central nervous system. As simulation results of the proposed model, we observed three patterns of the cardiovascular system variability by the time delay. First of all, if the time delay over 2.5 second, aortic pressure and stroke volume and heart rate was observed non-periodically and irregularly. However, if the time delay from 0.1 second to 0.25 second, the regular oscillation was observed. And then, if time delay under 0.1 second, then heart rate and aortic pressure-heart rate trajectory were maintained in stable state.
워그너_빌 분포 변환 기법을 이용한 마취단계별 심박변이율 신호 분석
전계록,김명철,유주연,이해림,박성민,손정만,예수영,노정훈,김길중,백승완,Jeon, Gye-Rok,Kim, Myung-Chul,Yoo, Ju-Yeon,Lee, Hae-Lim,Park, Seong-Min,Shon, Jung-Man,Ye, Soo-Young,Ro, Jung-Hoon,Kim, Gil-Jung,Baik, Seung-Wan 한국전기전자재료학회 2010 전기전자재료학회논문지 Vol.23 No.2
In this study, the heart rate variability(HRV) signal of operating patient was acquired according to anesthesia progress and identified to evaluation possibility of depth of anesthesia in each anesthesia stage. The HRV signal was analyzed time-frequency domain applied to Wigner-Ville distribution method, the characteristic parameters were extracted for evaluation of depth of anesthesia in each anesthesia stage. The progress of general anesthesia was divided into the states of pre-operation, induction of anesthesia, operation, awaking and post-operation.
커프 압력 조절에 따른 혈류량 변화 평가를 위한 임피던스법의 구현
정도운 ( Do Un Jeong ),배진우 ( Jin Woo Bae ),손정만 ( Jung Man Shon ),예수영 ( Su Yung Yae ),최병철 ( Byeong Cheol Choi ),남기곤 ( Ki Gon Nam ),김철한 ( Cheol Han Kim ),전계록 ( Gye Rok Jeon ) 한국센서학회 2004 센서학회지 Vol.13 No.6
N/A In this study, we measured the blood flow on arm by non-invasive method and implemented a system to measure variation of the blood flow by estimating bio-electrical impedance and arterial pressure according to cuff pressure. The implemented system measured impedance variation according to pressure variation applied by artificial cuff pressure on the measuring position. The system consisted of pressure measuring part and impedance measuring part using 4-electrode method. Pressure measuring part was composed of semiconductor pressure sensor and electronic circuit for signal processing of sensor output signal. In addition, impedance measuring part was composed of constant current source circuit and lock-in amplifier for detecting impedance signal. We conducted experiments of impedance measuring part using standard resistance for performance evaluation of the implemented system. In addition we experimented to estimate variation of the blood flow by measuring impedances of the experimental group. We estimated ratio of the blood flow resistance using mean arterial pressure and variation of the blood flow. As a result the ratio of the blood flow resistance and variation of blood flow were in an inverse relationship with each other and the correlation coefficient was -0.96776.
주기별 맥동파형의 절흔점 위치변화 특성을 이용한 혈압 추정
백승완 ( Seong Wan Baik ),박성민 ( Sung Min Park ),손정만 ( Jung Man Shon ),박근철 ( Geun Chul Park ),이상훈 ( Sang Hoon Lee ),장우영 ( Woo Young Jang ),전아영 ( Ah Young Jeon ),전계록 ( Gyerok Jeon ) 한국센서학회 2013 센서학회지 Vol.22 No.2
In the study, novel blood pressure estimation method was proposed to improve the accuracy of oscillometric method. The proposed algorithm estimated the blood pressure by comparing and analyzing the point variation aspect of dicrotic notch on pulsating waveform during each cardiac cycle. The waveforms of each cardiac cycle were extracted by maximum points. The extracted pulsating waveforms were applied by re-sampling, end-matching, and normalization. The systolic and diastolic blood pressures were estimated by point variation aspect of dicrotic notch. The blood pressures, which were estimated from proposed algorithm, were compared and analyzed by blood pressures from oscillometric methods and auscultation. The systolic blood pressure from oscillometric methods were +0.88 mmHg more than proposed algorithm, and 1.875 less than the diastolic blood pressures from proposed algorithm. The systolic and diastolic blood pressures from auscultation were 2.89 mmHg and 3.44 mmHg less than the blood pressures from proposed algorithm. As the errors between blood pressures from proposed algorithm, oscillometric method and auscultation were less than 5 mmHg, the proposed algorithm was effective.