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감궁탕이 사람의 갑상선세포에서 Fas 매개성 apoptosis에 미치는 영향
남경수,손옥례,김미경,김철호,소명숙,전병훈,손윤희,Nam Kyung Soo,Son Ok Lye,Kim Mee Kyung,Kim Cheorl Ho,So Myung Suk,Jeon Byung Hun,Shon Yun Hee 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
Inflammatory cytokine, abundantly produced in Hashimoto's thyroiditis, induced Fas expression in normal thyrocytes. We determined that susceptibility to Fas-activated apoptosis could be influenced by inflammatory cytokine and investigated a potential role of Gamgung-tang (GGT, Glycyrrhizae Radix, black beans, Angelicae Radix and Cnidii Rhizoma) in the thyroid follicular cells. $IL-1\beta$ was able to induce Fas expression in normal thyrocytes. GGT inhibited $IL-1\beta-induced$ Fas expression. Thyroid follicular cells were found to undergo DNA fragmentation with the inflammatory cytokines. GGT inhibited DNA fragmentation in a dose-dependent manner. These results suggest that GGT inhibit Fas-mediated apoptosis in thyroid follicular cells, therefore, may have therapeutic potential in the treatment of autoimmune chronic thyroiditis.