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반하후박탕엑기스와 Tetracycline-HCl의 병용투여에 관한 연구 : 항균 및 항염 효과에 미치는 영향
손영상(Young Sang Sohn),김기호(Ki Ho Kim) 한국생약학회 1984 생약학회지 Vol.15 No.1
In this studies, the antimicrobial and anti-inflammatory effects of Banhahubak-Tang water extract (hereinafter, Banhahubak-Tang) were examined by administrating Banhahubak-Tang alone and concurrently with tetracycline-HCl in vitro and in vivo. In the antibacterial activities, Banhahubak-Tang ethanol extract showed tobe more effective than water extract against 6 Bacterial strains. The mixtures of tetracycline-HCl and Banhahubak-Tang showed 2 to 4 times as effective as Tetracycline-HCl or Banhahubak-Tang respectively. In the anti-inflammatory activities, all of the experimental groups showed significant effectiveness with exception of group administered in dose of BanhahubakTang 100㎎/㎏. After the combinistration of Banhahubak-Tang with tetracycline-HCl in dose of 400㎎/㎏ with 25㎎/㎏ respectively during 2, 5 days after infection with Staph. aureus, the most significant results were obtained as the values of the inhibitory rate, 58.37%, 53.84% as compared with 51.46%, 50.32% of tetracycline-HCl 50㎎/㎏ respectively.