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이종간 원형질체 융합을 이용한 acetaminophen 생산균주 개량
손여원(Yeo Won Shon),정대영(Dae Young Jung),이상섭(Sang Sup Lee),민홍기(Hong Ki Min) 대한약학회 1994 약학회지 Vol.38 No.5
Acetaminophen, a widely used analgesic, can be formed by N-acetylation and p-hydroxylation of aniline. Interspecific protoplast fusion technique was used to get acetaminophen directly from aniline and to increase the productivity of acetaminophen. Three auxotrophic mutants were obtained from S. griseus(ATCC 13273) and S. hygroscopicus(KCTC 1089) by N-methyl-N''-nitro-N-nitrosoguanidine(NTG) treatment. Regeneration frequencies of S. griseus(his-), S. griseus(lys- ), S. hygroscopicus(arg-) were 42%, 45%, and 31%, respectively. Fusion of protoplasts carrying different auxotrophic markers was achieved by treatment with polyethylene glycol. When protoplasts were treated with 50% polyethylene glycol for 3 minutes, the fusion frequency between S. griseus(his- ) and S. hygroscopicus(arg-) was 3.8X10-5. The fusion frequency between S. griseus(lys-) and S. hygroscopicus(arg- ) was 5.6X10-4. When we checked the production of acetaminophen, thirty-four out of the fifty-six fusants produced larger amounts of acetaminophen than the parent strains did. Nine fusants produced twice more and twenty-five fusants produced one to two times more of acetaminophen than their parents.
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염산비퀴딜 캡슐 및 알리벤돌 정의 용출시험에 관한 연구
황정분(Joungboon Hwang),구은주(Eun Joo Koo),고서연(Seu Youn Go),조경철(Kyung Chul Cho),문현주(Hyun-Ju Moon),조수열(Soo Yeul Cho),강찬순(Chan Soon Kang),손여원(Yeo Won Shon),김영옥(Young Ok Kim),손경희(Kyung Hee Sohn),조대현(Dae Hyun 대한약학회 2010 약학회지 Vol.54 No.5
The dissolution test method and an analytical procedure by HPLC were developed and validated for viquidil hydrochloride capsules and alibendol tablets. These drugs were not yet characterized by the dissolution specifications in Korean Pharmaceutical Codex. So, with each reference and test drugs, we did the preliminary and standard experiments based on the Korean Pharmacopeia Guideline of dissolution testing for solid oral dosage forms. The dissolution test for viquidil hydrochloride capsules was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 50 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 30 min in this method. Also the dissolution test for alibendol tablets was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 100 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 45 min in this method. The dissolution samples were analyzed with a precise and accurate HPLC method. The developed dissolution test showed specificity, linearity, precision and accuracy within the acceptable range. The dissolution testing method described above was adequate for the purpose and may be proposed as a pharmacopeial standard to assess the performance of viquidil hydrochloride capsules and alibendol tablets.
ScienceON
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