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증례 : 류마티스 ; 루푸스 신염 환자에서 항인지질 항체와 연관된 감염 후 대칭적 말초 괴저
이재성 ( Jae Sung Lee ),성지석 ( Jee Seok Seong ),우용문 ( Yong Moon Woo ),조영준 ( Young Jun Cho ),정범진 ( Beom Jin Jeong ),강한나 ( Han Na Kang ),김수정 ( Su Jung Kim ) 대한내과학회 2014 대한내과학회지 Vol.87 No.3
Antiphospholipid syndrome (APS) is an autoimmune disease that involves vascular thrombosis and pregnancy morbidity associated with elevated titers of antiphospholipid antibodies. APS can affect any organ and has a variety of clinical manifestations. Infections can be associated with thrombotic events in APS, including the potentially fatal subset catastrophic APS. We report a case of extensive symmetrical peripheral gangrene complicating Escherichia coli sepsis associated with antiphospholipid antibodies in a patient with lupus nephritis. (Korean J Med 2014;87:379-382)
5-Fluorouracil을 투여한 대장암 환자에서 총정맥영양공급치료 중에 발생한 베르니케 뇌병증 2예
조경표 ( Kyung Pyo Cho ),이재성 ( Jae Sung Lee ),성지석 ( Ji Seok Seong ),우용문 ( Yong Moon Woo ),조영준 ( Young Jun Cho ),정범진 ( Beom Jin Jeong ),손지훈 ( Jee Hoon Sohn ),김수정 ( Su Jung Kim ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.3
Wernicke`s encephalopathy (WE) caused by thiamine deficiency is an acute neurological disorder. Clinically, the classic triad of WE consists of ophthalmoplegia, ataxia, and mental status changes. Thiamine deficiency is known to occur commonly in chronic alcoholic patients. Sometimes, it can occur in patients after gastrointestinal surgery and in those with malabsorption. In addition, patients undergoing renal dialysis, suffering from hyperemesis gravidarum, receiving total parenteral nutrition (TPN), and being treated with chemotherapeutic agents are also prone to develop thiamine deficiency. Herein, we report two cases of WE that developed following simultaneous 5-fluorouracil (5-FU) chemotherapy and TPN in colon cancer patients which was successfully treated with thiamine administration. (Korean J Gastroenterol 2014;64:158-163)