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- 저자 : 성용직 ( Young Jick Sung ) (검색결과 5 건)
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위장관 : Helicobacter pylori 제균 치료 1년 후 위 점막의 Cyclooxygenase-2 및 Inducible Nitric Oxide Synthase 발현 변화
김성수 ( Sung Soo Kim ),성용직 ( Young Jick Sung ),박민경 ( Min Kyoung Park ),임창훈 ( Chang Hoon Lim ),양홍준 ( Hong Jun Yang ),김태호 ( Tae Ho Kim ),김창환 ( Chang Whan Kim ),김진일 ( Jin Il Kim ),한석원 ( Sok Won Han ),정인식 ( 대한소화기학회 2008 대한소화기학회지 Vol.52 No.5
목적: H. pylori는 직접 혹은 간접적으로 위 점막의 COX-2와 iNOS 발현을 유도하며, H. pylori를 제균하면 이들 단백의 발현은 감소한다. 그러나 H. pylori 제균 치료 후에 COX-2와 iNOS 발현 변화에 대한 장기간의 관찰 보고는 없었다. 이에 저자는 만성위염 환자를 대상으로 H. pylori 제균치료 1년 후에 위 점막에서 COX-2와 iNOS 발현의 변화를 관찰하고자 하였다. 대상 및 방법: H. pylori 감염이 확인된 만성위염 환자 58명을 대상으로 하였으며, 45명에 제균 치료를 했다. H. pylori 제균 치료 전과 1년 후에 위전정부 점막 조직에서 면역화학 염색을 이용하여 COX-2와 iNOS 단백의 발현 강도 및 발현율 변화를 관찰하였다. 결과: COX-2와 iNOS 단백은 상피세포와 염증세포 및 점막근판의 평활근세포에서 발현되었다. 제균 치료에 성공한 38명에서 제균 치료 1년 후에 COX-2 및 iNOS의 발현율은 모두 유의하게 감소되는 것을 관찰할 수 있었다. 그러나 제균 치료에 실패하였거나 제균 치료를 받지 않아 H. pylori 감염이 있는 환자에서 COX-2 및 iNOS 발현은 변화가 없었다. COX-2의 발현율은 위 점막의 H. pylori 밀도, 중성백혈구 및 단핵구 침윤 정도와 유의한 상관관계를 보였으며, iNOS 발현율은 위 점막의 H. pylori 밀도와 중성백혈구의 침윤 정도와 유의한 상관관계를 보였다. 결론: H. pylori의 제균 치료는 COX-2와 iNOS의 발현을 장기간 억제할 수 있으며 이는 H. pylori 제균 및 이로 인한 위 염증 감소와 관련 있을 것으로 생각한다. Background/Aims: The cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), the proteins that have the role in the gastric carcinogenesis, are stimulated by H. pylori infection in the gastric mucosa. The aim of this study was to evaluate the expression of COX-2 and iNOS proteins one year after the eradication of H. pylori. Methods: Gastric antral mucosa from fifty eight patients with chronic gastritis who were all infected with H. pylori was examined for the expression of COX-2 and iNOS proteins before and one year after the eradication of H. pylori by immunohistochemical stain. Results: COX-2 and iNOS proteins were expressed in the epithelial cells and interstitial inflammatory cells of gastric mucosa. Percent expressions of COX-2 and iNOS were significantly decreased one year after the eradication in the patients with cured infection, but not in those having persistent H. pylori. COX-2 and iNOS expressions were well correlated with H. pylori density, acute and chronic inflammation of gastric mucosa. Conclusions: The eradication of H. pylori can decrease the expression of COX-2 and iNOS in the gastric mucosa in long-term period. This seems to be due to the removal of H. pylori itself and related regression of gastric inflammation. (Korean J Gastroenterol 2008;52:286-292)
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Ketoconazole 장기복용으로 발생한 간격막 섬유증 1 예
김영철,김진일,김용균,안병민,조재완,정규원,배시현,김부성,방춘상,선희식,박두호,성용직,강석진,고윤호,박영민 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.2
Ketoc onazole, an imidazole derivative, is a broad spectrum antifungal agent which has been used widely in the treatment of systemic or local fungal infections. Mild asymptomatic elevation of plasma transaminase activities occurs in approximately 6% to 17.5% of patients who have used ketoconazole. However, the incidence of symptomatic hepatic injury is low and overt hepatitis develops in about 5% of the patients. Nausea and vomiting are the most frequent side reactions. Histopathological features of the reported ketoconazole induced hepatotoxicity are massive or submassive hepatocellular necrosis involving the acinar zone 3, destroyed lobular architecture with bridging necrosis and inflammatory cell infiltration on portal tracts. However, hepatic septal fibrosis with liver cirrhosis has not been reported yet.We experienced a case of hepatic septal fibrosis that developed after 9 months of ketoconazole administration.(Korean J Hepatol 2000;6:241-245)
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이상훈,김진일,박선미,이광민,박영민,정규원,배시현,방춘상,선희식,장은덕,유수은,박두호,김동빈,성용직 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.3
Hepatocellular carcinoma (HCC) is one of the most common fatal malignancies worldwide, especially in Korea. The recent advances in diagnostic techniques, such as serum tumor marker assay, ultrasonography, computerized tomography (CT), magnetic resonance imaging (MRI), and angiography, allow us to detect HCC at early stage. Even though, it remains difficult to distinguish malignant nodules from benign space-occupying lesions of liver. Distinction of HCC from benign entities such as liver abscess is important because failure of prompt diagnosis could result in a missed opportunity for curative treatment. The differential diagnosis of HCC and liver abscess, especially HCC presenting as abscess, is sometimes very difficult. We report a case of HCC with liver abscess caused by secondary infection of CBD stone and cholangitis, that mimicked the dynamic CT findings of liver abscess, in an elderly patient with chronic hepatitis C virus infection. (Korean J Hepatol 1999;5:253-258)
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Hemoclip 접근이 어려운 소화성 궤양 출혈에서 EVL 용 투명캡의 사용
박수헌,김진일,정인식,김재광,정규원,성용직,한석원,김성수,방춘상,추교영,한준열,신희식 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.4
Background/Aims: There was some technical difficulty in applying the hemoclip on the posterior wall of the body, cardia of the stomach and posterior wall of duodenum because the angle of approach was tangential. Use of transparent cap on the tip of the endoscope could reduce some of these problems. The purpose of this study was to examine the efficacy of endoscopic hemoclipping using a transparent cap. Methods: From August 1997 to July 2000, 75 patients with bleeding peptic ulcer and stigmata of recent hemorrhage were treated with endoscopic hemoclipping. There was technical difficulty in applying the hemoclip in 18 patients and the transparent cap was used. Results: There was no statistically significant difference between the patients treated with cap and the patients treated withoup cap in initial hemostasis rate (91.1% vs 94.4%), rebleeding rate (11.8% vs 11.7%), and permanent hemostasis rate (92.9% vs 94.4%). Conclusions: Use of transparent cap on the tip of the endoscope was an efficient method when the angle of approach was tangential.
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김진일,정인식,유진영,선희식,박두호,성용직,한석원,김성수,송호진,방춘상 대한소화기학회 2001 대한소화기학회지 Vol.37 No.2
Background/Aims: Recent studies suggested that neutrophil and tumor necrosis factor-alpha (TNF-α) could play a significant role in NSAID-induced gastric mucosal damage. However, there is no data about the relationship between daily usual doses of NSAID and prostalglandin, neutrophil, or TNF-α. Methods: We divided mice into 3 groups and administered indomethacin (3 mg/kg, indomethacin group), NS-398 (3 mg/kg, NS-398 group) or vehicle alone (control group) orally to each mice group for 7 days. Then, we evaluated the concentrations of prostaglandin E2 (PGE2) and TNF-α, neutrophil infiltration and mucosal damage score for their gastric tissue. Results: Indomethacin group showed the lowest concentration of PGE2 and the highest values in TNF-α concentration, neutrophil infiltration and mucosal damage score (p$lt;0.01). NS-398 group showed a lower PGE2 concentration and a higher microscopic mucosal damage score than the control group (p$lt;0.01), but there were no differences in TNF-α concentration, neutrophil infiltn and gross mucosal damage scores. The PGE2 concentration was inversely related to TNF-α concentration (r=-0.768). Conclusions: We suggest that decrease of prostaglandin concentration and increase of TNF-α production and neutrophil infiltration play important roles in NSAID-induced gastric mucosal damage. Cyclooxygenase-2 (COX-2) selective inhibitors, which have less effect on prostaglandin and TNF-α concentration and neutrophil infiltration, can reduce the gastric mucosal damage, as compared with the conventional NSAID.
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