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성도환(Do Hwan Seong) 대한비뇨기종양학회 2011 대한비뇨기종양학회지 Vol.9 No.2
Androgen deprivation therapy (ADT) is the mainstay of systemic therapy for advanced or metastatic prostate cancer. The majority of 90% of patients respond to currently available first line ADT therapy. However, responses are transient and metastatic disease progresses as castration-resistant prostate cancer (CRPC). Traditional secondary hormonal manipulations can be of clinical benefit in some patients after primary ADT failure. Novel therapies for CRPC have demonstrated promising activity in many men with CRPC and may redefine the clinical management of these patients. This paper summarises the current clinical development of these agents as well as a brief review of hormonal strategies in CRPC.
근치적 전립선절제술 후 요실금 발생 환자에서의 항콜린제 처방에 대한 비뇨기과 의사의 실태조사
방우진(Woo Jin Bang),주관중(Kwan Joong Joo),조진선(Jin Seon Cho),전성수(Seong Soo Jeon),백성현(Sung Hyun Paick),성도환(Do Hwan Seong),김홍섭(Hong Sup Kim),함원식(Won Sik Ham),홍성준(Sung Joon Hong) 대한비뇨기종양학회 2012 대한비뇨기종양학회지 Vol.10 No.2
Purpose: We surveyed the actual use of anticholinergics for urinary incontinence after radical prostatectomy among the practicing urologists. Materials and Methods: 142 urologist members of the Korean Urological Oncology Society were given surveys through conventional mail and e-mail with 76 members returning responses. Answering for the number of radical prostatectomy performed each year, 21 urologists responded more than 50 cases, 37 responded 10 to 50 cases, 11 responded 5 to 10 cases, and 7 said 1 to 5 cases. Concerning primary approach, retropubic approach surgery, laparoscopic surgery, robotic surgery and perineal approach surgery each had 39, 19, 17, and 1, respectively. Results: Among 76 participants, 64 (84%) acknowledged prescribing anticholinergics after prostatectomy depending on symptoms. For post-op indication of anticholinergics, 43 members responded significant incontinence symptoms, while 19 answered frequent urination. Concerning the initiation of medication, 52 answered when symptoms arise after catheter removal. For duration of anticholinergics, less than 30 days, 31-60 days, 61-90 days, more than 90 days each received 8, 17, 24, and 15 votes from participants, respectively. Finally, 57 members thought the use of anticholinergics were beneficial in treating urinary incontinence after radical prostatectomy. Conclusions: Over 80% of survey participants acknowledged prescribing anticholinergics to urinary incontinence patients according to symptoms, and 75% concurred with their usefulness. But, there is no specified protocol of anticholinergics use for urinary incontinence after radical prostatectomy.