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Seong, Rho Hyun 가톨릭 의과학연구원 2001 가톨릭 의과학연구원 국제학술대회 Vol.5 No.-
Immature, double positive thymocytes are sensitive to glucocorticoid-induced apoptosis, while mature single positive T cells are relatively resistant. These double positive thymocytes seem to acquire resistance to glucocorticoids during differentiation into mature CD+4+ and CD^8+ single positive thymocytes. However, detailed knowledge concerning what determines the sensitivity of thymocytes to glucocorticoids and how glucocorticoid-sensitivity is regulated in thymocytes during development is lacking. We found that the expression level of SRG3 protein, which is a mouse homolog of yeast SWI3 and a component of SWI/SNF complex, determines the glucocorticoid-sensitivity of Tcells in mice.
이태수,정은환,성노현,안치석 대한부인종양 콜포스코피학회 1994 Journal of Gynecologic Oncology Vol.5 No.3
This study was performed 10 define the role of computerized quantitative analysis in evaluation for overexpression of p53 by immunohistochemistry. Total and labeled cells were counted automatically using commercially available software for color-image analysis. In 16 uterine cervical carcinomas, the p53 labeling index calculated by computerized quantitative analysis was 9.22%±8.70% and by visual analysis 5.90±6.51%. The present results suggest that the computerized quantitative analysis may be valuable in objective interpretation of immunohistochemical expression of p53 and reliable than conventional ways of visual analysis.
포유동물세포에 있어 자외선에 의한 절제회복에 미치는 수종 알킬화제의 영향
선우양일,박상대,홍승환,성노현 한국유전학회 1983 Genes & Genomics Vol.5 No.1
The present investigation determined how two different types of DNA damaging agents interact in inducing DNA single strand breaks and excision repair in CHO cells using UV-light and MMS. The results showed that strand breaks induced try UV-light were in low level when compared to those by MMS. Treatment with ara-C plus hydroxyurea, however, effectively accumulated DNA single strand breaks induced by UV-light, but not by MMS. When these cells were treated with UV-light and MMS concomitantly, UV-induced excision repair was inhibited by MMS, but the amounts of DNA single strand breaks were additive. These results suggested that a protein complex involved in UV-induced excision repair may be inactivated by MMS in excision-reinsertion step.