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남기용(Nam, Kee-Yong),장신요(Chang, Shin-Yo),신동훈(Shin, Dong-Hoon),성낙응(Sung, Nak-Eung),엄륭의(Earm, Yung-E) 대한생리학회 1970 대한생리학회지 Vol.4 No.1
Studies on the analysis of walking were performed on 33 male subjects. A prescription of physical exercise (walking at a speed of greater than 6 km/hr for more than one hour daily) for the promotion of individual health is presented on the basis of walking analysis. Presumptions were made that adequate physical exercise does promote health and is beneficial for the healthy life and increases the life span. These presumptions were derived from the numerous experimental literatures. The literatures support indirectly the presumptions. The following results were obtained and prescription of physical exercise is presented. 1. Oxygen uptake in a walking on a treadmill at a speed of 4 km/hr was only 3 times of the resting oxygen uptake. This kind of moderate exercise did not stimulate the cardiopulmonary system adequately. Heart rate at a 4 km/hr walking was 101 beats/min in boys of less than 20 years old and 83 beats/min in adults. Oxygen uptake at a 6 km/hr walking exceeded 4 times of the resting oxygen uptake. It was interpreted that walking at 6 km/hr stimulated the cardiopulmonary system for the promotion of health. Heart rate at this speed was greater than 110 beats/min in boys and greater than 100 beats/min in adults. 2. Heart rates in a walking of 10 km/hr were 172 beats/min in boys, and 143 beats/min in adults, respectively. Maximal heart rates were 185 beats/min in boys, 180 in office clerks, and 168 beats/min in construction site laboreres. 3. The correlation between heart rate and oxygen uptake was high, namely, r>0.95. Subsequently heart rate could be used as a measure of degree of intensity of physical exercise instead of the cumbersome oxygen uptake measurement. 4. The prescription of physical exercise for the promotion of health is: Daily walking for more than one hour at a speed of greater than 6 km/hr. Bodily functions in this daily walking are in boys (body weight, 50 kg): heart rates of 110 beats/min; breathing frequency, 28/min; oxygen uptake, greater than 4 times of the resting uptake; pulmonary ventilation, 351/min; stride, 124 strides/min; cumulative number of strides for one hour, 7,440 strides, and energy expenditure of more than 300 kcal. In adults (body weight, 60 kg) the bodily functions are: heart rates of 100 beats/min, breathing frequency, 28/min; oxygen uptake, greater than 4 times of the resting uptake; Pulmonary ventilation, 301/min; stride, 127 strides/min; cumulative number of strides for one hour, 7,670 strides, and energy expenditure of more than 300 kcal.
산화방지제 BHT, BHA가 간세포내 Mixed Function Oxygenase 활성에 미치는 영향
성낙응 梨花女子大學校 醫科大學 醫科學硏究所 1989 EMJ (Ewha medical journal) Vol.12 No.1
To evaluate the effect of BHA and BHT on liver tissue, BHA and BHT, 100㎎ and 200㎎/㎏ B.W. respectively, were given to experimental animals for 4 months. Microsomal cytochrome P-450, cytochrome b_5, cytochrome C reductase activity and lipid peroxidation of liver tissue of experimental animal were measured. The results were as follow ; 1) Cytochrome P-450 increased significantly in experimental group given BHA but cytochrome b5 did not. 2) Cytochrome oxidnse activity increased moderately in BHA group but decreased in BHT group. From these finding, it can be assumed, that BHA and BHT has no great effect on human tissue.
수은이 Spironolactone 및 Canrenoate-K 전처치 흰쥐에서 Hepatic Cytochrome P-450과 Cytochrome b_5에 미치는 영향
成樂應,洪永淑,金福會 梨花女子大學校 韓國生活科學硏究院 1980 韓國生活科學硏究院 論叢 Vol.25 No.-
항 mineralocorticoid 제제인 spironolactone은 간조직내 약물대사효소의 기질 및 유고물 질로서 작용하며 생체내 투여 후 canrenone과 thioacetate로 biotransformation되고, 이sulfur moiety는 수은이온과 화합물을 형성하며 이 화합물은 체내에서 유기수은 화합물과 같이 분포한다. sulfur moiety가 있는 spironolactone 전처치후 염화수은을 투여했을 때 spironolactone에 의해서 유도되는 약물대사효소-cytochrome P-450과 cytochrome b_5의 함량이 감소되었으나 spironolactone의 대사산물인 sulfur moiety가 없는 canrenoate-K 전처치 후 염화수은을 투여했을 때는 이들 효소의 함량이 증가되었다. 또한 염화수은만을 투여했을 때도 이들 효소의 함량이 의의있게 증가됨을 관찰하였다. In well-fed normal male rats, either a single injection of spironolactone or its metabolite-canrenoate-K significant increments hepatic microsomal cytochrome P-450 and cytochrome b_5, canrenoate-K was increased more than spironolactone. In spironolactone treated rats, ad-ministration of mercuric chloride caused about 30-33% decrement in cytochrome p-450 and cytochrome b_5, while in canrenoate treated rats prcduced abcut 55% increment. This results suggested that sulfur moiety of spironolactone bind to mercury decreased substrate and in-ducer action of drug metabolizing enzymes of spironolactone. In normal, mercuric chloride administration increased microsomal cytochrome P-450 and cytochrome b_5.