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      • GDC를 이용한 뇌 동맥류의 방사선학적 치료법

        설혜영,변홍식,최인섭 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.2

        A new method of the endovascular occlusion of the cerebral aneurysm using detachable coil called by GDC(Guglielmi detachable coil) has been developed by Guglielmi in 1991. The mechanisms of GDC treatment are the electrolysis and electrothrombosis. To evaluate the clinical results of GDC treatment, 45 cerebral aneurysms(9 small, 28 large, 8 giant aneurysms) in 42 patients(l0 males, 32 females) were analized. 1 Among total 45 cerebral aneurysms, anterior circulation aneurysms were 28 cases (62.2%) and posterior circulation aneurysms were 17 cases(37.8%). Most common site of cerebral aneurysms was the supraclinoid portion of internal carotid artery (15 cases, 33.3%). The second common site was the tip of basilar artery (6 cases, 13.3%) and the third, the cavernous portion of internal carotid artery(5 cases, 11.1%). 2. Among total 45 cerebral aneurysms, more than 90% occlusions of cerebral aneurysms with GDC were seen in 41 cases(91.1%). 3. Among total 42 patients, 3 patients(7.1%) had major complications by GDC treatment : death due to thrombosis, embolism. arterial dissection. And 3 patients(7.1%) showed temporary arterial occlusions. 4. Among 21 patients who had 6 months follow up study, 17 patients(81.0%) were successful for the treatment and 4 patients(l9.0%) were unsuccessful with coil packing or migration. Endovascular occlusion of cerebral aneurysm with GDC is the promising new technique. It had more advantages compared with the detachable ballon occlusion ; less stress to the wall of the aneurysm, more complete occlusion of the aneurysm lumen. It can be also an alternative or adjunct method to surgical clipping of the aneurysm.

      • 파노라마 촬영시 두개골위치에 따른 하악골의 수평 및 수직확대에 관한 연구

        설혜영,서원혁,신상완 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.3

        The Panoramic radiography is the most useful method for the delineation of the mandible and facial bones, because it converts easily the curved structures into the flat image. But the image of the panoramic radiogram causes the magnification and distortion of the anatomic structures. The most important point on the panoramic radiogram was the correct position of the head of the patient. The purpose of this study was to identify the horizontal and vortical magnification rates of the mandible examined on the standard position and the different changes of the horizontal and vertical magnifications of the mandible on the panoramic radiography according to the forward and backward frontal movements. After 2 midline and 8 bilateral locations on each sides were selected at a mandible of a dry skull, total 18 metal balls were attached correctly at the mandible. Total 8 dry skulls were prepared. Then 5 panoramic films per each dry skull (40 films per 8 dry skulls) were taken at the standard position and 4 moved positions (2 forward and 2 backward frontal movements on the sagittal axis with 1cm apart) The results were as follows: 1. On the standard position, total average horizontal magnification rate of the mandible was 110.6% and vertical magnification rate, 115.2%. The distribution of horizontal magnification rates at the 10 selected locations showed many varieties and vertical, little varieties. Most magnified location was the lower border of the mandible including the lower symphysis horizontally and the mandibular body vertically. The central incisor and the coronoid process were reduced in these horizontal diameters. 2. Both intercondylar distance was small as compared with both interangular distance on the forward frontal movement, and large on the backward frontal movement. 3. The magnification and distortion of the image on the backward frontal movement were more great as compared with the forward frontal movement. 4. The most changeable location of the magnification and distortion according to the frontal movements was the central incisor area. Because of the narrow focal trough (the area of sharpness) at the incisor area, the incisor showed the reduction in the horizontal diameter. The panoramic radiograms taken on the incorrect forward or backward frontal positions cause the prominent different changes of magnification and distortion of the mandible, so the correct position of the head is the most important point for the panoramic radiogram. And another important point was the recognition of the different magnification characteristics of each panoramic apparatus on each locations of the mandible.

      • 나선형 전산화단층촬영에서 대상구를 근거로 하는 대뇌 중심전회 및 중심후회의 식별

        설혜영,차상훈,이남준 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.2

        Cerebral precentral and postcentral gyri have the important functional areas; Brodmann's area 4(motor area) and 3, 1, 2(sensory area) each other. we can identify easily precentral and postcentral gyri on MR image because precentral, central and postcentral sulci are well visualized. Sometimes we have to investigate the brain anatomy on CT image when MR can't be examined due to the technical, economical causes. Total 100 brain images(58 males, 42 females) taken from spiral CT were investigated and analized; 1. On the basis of lateral sulci (precentral, central and postcentral sulci), precentral and postcentral gyri were easily identified on 61 subjects and poorly identified on 39 subjects. 2. On the basis of cingulate sulcus, precentral and postcentral gyri were easily identified on 91 subjects and poorly identified on 9 subjects. 3. On the basis of both lateral and cingulate sulci, precentral and postcentral gyri were easily identified on 95 subjects and poorly identified on 5 subjects. 4. Under 20 years old, lateral sulci were poorly visualized on 25 subjects and cingulate sulcus were poorly visualized on 8 subjects. 5. Precontrast and contrast CT images were taken on 78 subjects. Lateral and cingulate sulci were better visualized on noncontrast CT than on contrast CT on 16 subjects(20.5%), and they were better visualized on contrast CT than noncontrast CT on 5 subjects (6.4%). On 57 subjects(73.1%), no image difference for the visualizations of lateral and cingulate sulci was noted between noncontrast and contrast CT. In conclusion, precentral and postcentral gyri on the basis of cingulate sulcus can be better identified than on the basis of lateral sulci on spiral CT. The identifications of precentral and postcentral gyri are easier on the basis of both cingulate and lateral sulci.

      • 초음파를 이용한 표재성 신경초종의 분석 : 초음파기기 주파수 및 종양의 변성이 후방음파증강에 미치는 영향 The Influence of Sonographic Frequency and the Degenerative Change of Tumor on the Posterior Acoustic Enhancement

        차상훈,설혜영,정규병 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.2

        We retrospectively analyzed the sonographic findings of 18 pathologically proven superficial neurilemmomas in 17 patients during recent 5 years. We evaluated the contuor, size and internal echo pattern of the tumor, the presence of tumor capsule, and the degree of acoustic enhancement behind the tumor. We correlated the posterior acoustic enhancement with the pathologic features. Eighteen tumors showed oval or round in contuor and 9 tumors revealed hypoechoic pattern, 3 tumors revealed homogenously echogenic pattern and 6 tumors revealed heterogenously echogenic pattern. Sixteen tumors showed the capsule of tumor. Fourteen tumors showed posterior acoustic enhancement. Grade Ⅰ posterior acoustic enhancements were noted at 10 MHz transducer examination only and Grade Ⅱ posterior acoustic enhancements were noted at 5 MHz or 7.5 MHz tranducer examination. No definite correlation between hemorrhagic or cystic degenerations of superficial neurilemmomas and Grade Ⅱ posterior acoustic enhancements were noted. The mean size of hypoechoic superficial neurilemmoma was smallest and that of heterogenously echogenic superficial neurilemmoma was largest. We conclude that sonographic exammination was useful for evaluation of superficial neurilemmoma.

      • 高 에너지 放射線으로 單一照射한 家兎小腸의 病理組織學的 變化

        崔日淳,薛惠榮,徐源赫 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1

        When super-voltage cobalt 60 gamma ray treat many kinds of intra-abdominal tumors the small intestine is exposed to unwanted radiation effect and excessive amount of radiation dose is harmful for the small intestine. Author attempted the experimental study to search for maximum tolerable radiation dose of small intsetine. The pathological changes of small intestine of the rabbits following 1,500 rads, 2,500 rads and 3,500 rads single exposure of Cobalt 60 gamma ray have obtained with 80 experimental rabbits. The doses of 1,500 rads, 2,500 rads and 3,500 rads single exposures were equivalent of biologic effects of 4,500 rads in 4.5 weeks, 7,000 rads in 7 weeks and 9,000 rads in 9 weeks each other. Following 1,500 rads single exposure rabbits were terminated in 2 , 4 , 8 weeks intervals, 2,500 rads single exposure rabbits were terminated in 1, 2, 4 weeks intervals and 3,500 rads single exposure rabbits were terminated at two weeks period. And the small intestines were fixed to Formalin Solution immediately after dissection. The pathological changes were as follows: 1. Following 1,500 rads single exposure, 10%(3/30 ) of rabbits were dead by radiation and the small intestinal mucosa showed the necrosis of 100% in weeks subgroup and the inflammation of 73% and regeneration of 63% in 2.4% and 8 weeks subgroups. 2. Following 2,500 rads single exposure,57% (17/30) of rabbits were dead and the small intestinal mucosa showed the necrosis of 87%, inflammation of 89% and regeneration of 53% in 1 week, 2 weeks and 4 weeks subgroups. 3. Following 3,500 racs single exposure, 93%(14/15) of rabbits were dead and the small intestine showed necrosis of 100% and inflammation of 47% in 2 weeks subgroup. 4. 4 rabbits showed the metaplastic changes on small intestine in 1,500 rads and 2,500 rads single exposure groups. In conclusion, over 1,500 rads single exposure by using high energy radiation caused severe radiation effects and metaplastic changes on small intestines of rabbits.

      • Ultrasound Pattern of Abscess Asssociated with Bone Infection : Clinical Significance 임상적 의의

        Park, Cheol Min,Seol, Hae Young,Cha, Sang Hoon,Cha, In Ho,Suh, Won Hyuck 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.2

        화농성골감염 13예와 결핵성골감염 5예에서 동반된 연조직 농양을 초음파로 관찰하여 임상적 의의를 찾고자 하였다. 초음파 검사상 화농성 골감염 13예중 12예, 결핵성 5예중 4예에서 골병변과 붙어있는 농양을 관찰하였다. 농양의 두께는 급성화농성인 경우(0.4-0.6cm, 평균 0.5cm)에서 만성 화농성인 경우(0.4-3.6cm, 평균 1.5)나 결핵성인 경우(0.9-4.6cm, 평균 2.2cm)보다 작았다. 농양누공(n=4)과 부골(sequestrum)(n=3)은 만성화농성 골감염에서 관찰되었다. 결핵성인 경우에는 농양의 소방형성(n=2)과, 내부에 미세석회화를 포함하는 수지모양의 농양(n=1)이 보였다. 2예에서는 농양천자를, 1예에서는 골생검을 초음파유도하에 시행하여 세균학적, 병리조직학적 검사를 위한 가검물을 얻었다. 결론적으로, 초음파검사로 골병변과 접한 농양을 관찰함으로서 골감염을 조기에 진단할 수 있을 뿐아니라 화농성과 결핵성의 감별진단에도 도움이 될 수 있고, 초음파유도하 농향흡인이나 골생검을 시행하면 원인균의 규명과 병리학적진단을 위한 가검물을 채취할 수도 있다.

      • 침습성 뇌하수체선종의 MR 소견

        이남준,정환훈,설혜영,김정혁,정용구,이훈갑 고려대학교 의과대학 1997 고려대 의대 잡지 Vol.34 No.2

        Pituitary adenoma is usually confined in the sella or extends superiorly beyond the diaphragm sella. There are some cases that invade the adjacent perisellar structures, and then it is difficult to differentiate it from other juxtasellar tumors. The purpose of this study is to evaluate MR findings of the invasive pituitary adenoma. We evaluated the MR findings of 10 pathologically proven pituitary adenoma which invaded the cavernous sinuses. There were 4 males and 6 females. Average age was 41.5 years. Observation was made of the MR signal intensity, average size, degree and direction of tumor invasion, associated hydrocephalus, cystic or hemorrhagic changes in the tumor, and characteristic findings according to the secreting hormones. Average tumor size was 4.1 × 3.8 × 4.1 cm. Of the 10 tumors, 9 tumors extend superiorly, 5 tumors inferiorly, and 2 tumors posteriorly. 4 tumors had internal cystic changes, and 1 of these 4 tumors had combined hemorrhage. 6 tumors had no internal degeneration in the mass. Tumor signal intensities were similar to brain cortex on T1WI and T2WI, and all masses enhanced intensely. Prolactin secreting tumor frequently extended inferiorly (3/4), and nonsecreting tumor did not have internal degeneration(0/4). In conclusion, invasive pituitary adenoma was frequently noted as homogenous solid mass, especially nonsecreting tumor. There were some characteristic findings in internal degeneration and direction of invasion according to secreting hormons. Mode of tumor invasion would be helpful to differentiate pituitary adenoma from other juxtasellar tumors.

      • KCI등재후보

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