정신분열병 환자에서 G-protein β3 Subunit Gene (GNB3)의 C1429T 유전자의 다형성

서홍석(Hong-Seok Seo),이선우(Sun-Woo Lee),왕성근(Seong-Keun Wang),지익성(Ik-Seong Chee),김정란(Jeong-Lan Kim),윤지영(Ji-Young Yoon),이태경(Tea-Keong Lee) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.1

목적 : 본 연구는 정신 분열병과 관계있다고 알려진 GNB3 유전자 중, C1429T 유전자 다형성에 초점을 맞추어 정신분열병과 연관 관계를 알아보기 위하여 시행되었다. 방법 : DSM-IV 진단기준에 의해 진단된 정신분열병 환자군 100명과 정상 대조군 90명을 대상으로 하였다. C1429T 유전자형 판별을 위해 Restriction Fragment Length Enzyme(RFLP)을 이용한 Polymerase Chain Reaction(PCR)이 사용되었다. 결과 : 정신분열병 환자군에서 C1429T 유전자형의 분포는 CC 64(64.0%), CT 36(36.0%), TT 0(0.0%) 이었으며, 대립 유전자의 빈도는 C 164(82.0%), T 36(18.0%)이었다. 정상 대조군에서 C1429T 유전자형의 분포는 CC 60(66.7%), CT 24(26.7%), TT 6(6.7%) 이었으며 대립 유전자의 빈도는 C 144(80.0%), T 36(20.0%)이었다. 정신분열병 환자군과 대조군 간 C1429T 유전자형의 분포에서 통계적으로 의미 있는 차이를 보여주고 있었으나, 대립 유전자의 빈도에서는 차이는 유의미하지 않았다. 또한, 환자군을 성별, 정신과적 질병의 가족력, PANSS scale에 따른 증상 심각도 등의 변수에 따라 분류하였을 때도 유전자형의 분포와 대립 유전자의 빈도 차이는 유의미하지 않았다. 결론 : 이 연구의 결과는 한국인 정신분열병 환자들에서 GNB3/C1429T 유전자 다형성이 정신분열병의 병인과 관계가 있음을 보여준다. 가족-기초 비교 위험 연구와 정신분열병의 다른 임상적 변수들을 포함한 향후의 연구가 필요할 것이다. Objectives:This study aimed to investigate the association between polymorphisms of CNB3/C1429T and schizophrenia. Methods:100patients with schizophrenia and 90controls were enrolled in the study. A polymerase chain reaction( PCR) with restriction fragment length enzyme(RFLP) was used to genotype the C1429T polymorphisms. Results:1) In schizophrenic patients, genotype distributions of the GNB3/C1429T polymorphism were CC 64(64.0%), CT 36(36.0%) and TT 0(0.0%), and allele frequencies were C 164(82.0%), and T 36(18.0%). In normal control, genotype distributions of the GNB3/C1429T polymorphism were CC 60(66.7%), CT 24(26.7%) and TT 6(6.7%), and allele frequencies were C 144(80.0%), and T 36(20.0%). There were significant differences in the genotype frequencies of the GNB3/C1429T polymorphisms between the schizophrenia patients and the controls, while no significant differences in the alleic frequencies. 2) There were no difference in genotype distribution and allele frequencies of the GNB3/C1429T polymorphism, when patients were categorized by sex, family history of psychiatric disease, severity of symptom with PANSS scale. Conclusions:These results suggest a GNB3/C1429T polymorphism is causally related to the pathogenesis of schizophrenia in the Korean population. Further study of GNB3/C1429T polymorphism should be needed, including family based association study and other clinical variations of schizophrenia.

ST - 분절의 하강에 R - 파고의 변화를 추가한 운동부하 심전도 검사의 관상동맥 질환에 대한 진단적 가치

박성미(Seong Mi Park),노영무(Young Moo Ro),정성원(Seong Won Jeong),신정호(Jeong Ho Shin),김진석(Jin Seok Kim),이호준(Ho Joon Lee),송우혁(Woo Hyuk Song),박창규(Chang Kyu Park),김영훈(Young Hoon Kim),서홍석(Hong Seog Seo),심완주(Wan Jo 대한내과학회 2002 대한내과학회지 Vol.62 No.2

N/A Background: Exercise electrocardiogram is the most widely used non-invasive test in those patients suspected of having coronary artery disease. However, sensitivity and specificity of this test are not satisfactory, especially when the exercise induced ST-segment depression is used as a single criterion of myocardial ischemia. Although many investigators have tried to improve diagnostic accuracy with R-wave amplitude change in addition to ST-segment depression, controversy exists whether this new criteria improve the test accuracy for coronary artery disease or not. The purpose of this study is to determine the test accuracy of R-wave amplitude change induced by exercise combined with the conventional ST-segment criterion for myocardial ischemia. Methods: We reviewed our records of patients who visited to Korea University Anam Hospital with chest pain from January, 1998 to July, 1999. We included 130 patients with chest pain who had a tredmill test followed by a coronary angiography within 2 months. Patients with change in ST-segment depression (ΔSTD)≥1.00 mm and ΔSTD≥1.00 mm with R wave amplitude decrease (-ΔR)≥1.00 mm in the same lead in any of 12 leads and ΔSTD≥1.00 mm with R wave amplitude increase (+ΔR)≥1.00 mm in the same lead in any of 12 leads were compared. According to the findings of coronary angiograms, patients were divided into 4 groups ; normal coronary artery group, mild coronary artery stenosis group (≥30% to <50%), moderate coronary artery stenosis group (≥50% to <70%), severe coronary artery stenosis group (≥70%). Results: Fifty three patients (40.7%) had normal coronary angiograms and 77 patients (59.3%) had coronary artery stenosis. There was no significant difference in gender and age. But, patients with coronary artery stenosis had more diabetes mellitus, hyperlipidemia, smoking, previous myocardial infarction history and angina during exercise testing than those without coronary artery stenosis. The sensitivity of exercise EKG is significantly decreased when combined withΔR (ΔSTD, 74.0%, ΔSTD with -ΔR, 45.5%, ΔSTD with +ΔR, 30.0%, p<0.01), but the The test accuracy is ΔSTD; 73.7%, ΔSTD with -ΔR; 61.5%, ΔSTD with +ΔR; 57.7%. Conclusion: When ST-segment depression is combined with R-wave amplitude change as a marker for myocardial ischemia, the specificity is increased, but the test accuracy of exercise EKG is not improved.(Korean J Med 62:165-170, 2002)

마늘의 생육자료와 기상자료 기반으로 다층모형을 이용한 수확기 구중 추정

최성천(Seong Cheon Choi),김준기(Jun Ki Kim),서홍석(Hong Seok Seo) 한국원예학회 2021 원예과학기술지 Vol.39 No.4

마늘은 노지 작물로 기상에 따라 작황 변동성이 크기 때문에 생산량과 가격의 불안정성이 크다. 안정된 수급관리를 위하여 정확한 생산량 예측이 선제적으로 이루어져야 한다. 본 연구는 구 비대 초기의 마늘 생육과 기상자료를 기반으로 구중 추정모형을 개발함으로써 생산량 예측의 정확도 개선을 도모하였다. 분석은 개체단위인 4월 하순 지상부 생육자료와 필지단위인 4월 하순에서 수확기까지 기상 추정자료로 구성된 위계적자료 특성을 반영하여 2-수준 다층모형을 활용하였다. 분석결과 4월 하순 엽초경, 초장의 생육이 좋을수록 생구 무게가 증가하는 것으로 나타났다. 기상은 강수량, 강우일수는 구중에 감소효과를, 수확직전 강수량, 일조시간, 증발산량, 최적기온일수는 증가효과가 나타나 마늘 최종 구중에 유의한 요인으로 확인되었다. There is a large fluctuation in the production and price of garlic (Allium sativum L.) because it is grown mainly in the open field and is vulnerable to weather conditions. Accurate forecasting is needed to manage production. The purpose of this study was to improve the accuracy of production forecasting by developing a model that estimates the weight of garlic bulbs at harvest based on growth and meteorological data. For this study, a two-level multilevel model was used to reflect the hierarchical data characteristics consisting of individual unit data that represented the above-ground growth conditions at the end of April and the lot unit data that represented the meteorological conditions from the end of April to harvest time. It was determined that the weight of the garlic bulb increased as the growth of the sheath diameter and the plant height increased at the end of April. As for the meteorological factors, it was estimated that precipitation had negative effects on the garlic bulb weight, while the pre-harvest precipitation, duration of sunshine, evapotranspiration, and the optimal temperature days had positive effects on the weight.

Bcl-2 유전자 발현이 apolipoprotein E knockout mouse의 동맥경화병변에 미치는 영향

박상원 ( Park Sang Won ),서홍석 ( Seo Hong Seog ),신성희 ( Sin Seong Hui ),안정천 ( An Jeong Cheon ),박창규 ( Park Chang Gyu ),심완주 ( Sim Wan Ju ),오동주 ( O Dong Ju ),노영무 ( No Yeong Mu ) 한국지질동맥경화학회 ( 구 한국지질학회 ) 2003 춘계학술대회 Vol.- No.-

양파의 생육시기별 생육요인과 기상요인 간의 관계 탐색

김재휘 ( Jaehwi Kim ),최성천 ( Seong-cheon Choi ),김준기 ( Junki Kim ),서홍석 ( Hong-seok Seo ) 한국농림기상학회 2021 한국농림기상학회지 Vol.23 No.1

Onions are a representative produce that requires supply-demand control measures due to large fluctuations in production and price by growing season. Accurate forecasts of crop production can improve the effectiveness of such measures. However, it is challenging to obtain accurate estimates of crop productivity for onions because they are mainly grown on the open fields. The objective of this study was to perform the empirical analysis of the relationship between factors for crop growth and meteorological conditions, which can support the development of models to predict crop growth and production. The growth survey data were collected from open fields. The survey data included the weight of above ground organs as well as that of the bulbs. The estimates of meteorological data were also compiled for the given fields. Correlation analysis between these factors was performed. The random forest was also used to compare the importance of the meteorological factors by the growth stage. Our results indicated that insolation in early March had a positive effect on the growth of the above-ground. There was a negative correlation between precipitation and the growth of the above-ground at the end of March although it has been suggested that drought can deter the growth of onion. The negative effects of precipitation and daylight hours on the growth of the above-ground and under-ground were significant during the harvest period. These meteorological factors identified by growth stage can be used to develop models for onion growth and production forecast.

The First Total Syntheses of Prenyllicoflavone A and Licoflavone A and Biological Evaluation as Inhibitors of Bone Resorption Pits Formation

이성은,김재곤,이종건,이진수,임문정,정용호,송영옥,서홍석,Lee, Seong Eun,Kim, Jae Gon,Lee, Jong Geon,Lee, Jin Su,Im, Mun Jeong,Jeong, Yong Ho,Song, Yeong Ok,Seo, Hong Seok Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.12

Does Lipoprotein(a) act as the acute phase protein in patients with rheumatoid arthritis?

이영호 ( Young Ho Lee ),지종대 ( Jong Dae Ji ),최성재 ( Seong Jae Choi ),서홍석 ( Hong Seog Seo ),송관규 ( Gwan Gyu Song ) 대한내과학회 1998 대한내과학회 추계학술대회 Vol.1998 No.1

급성 심근경색 환자에서 재관류 후 운동부하 심전도에서 T파의정상화 소견과 심근기능 회복과의 관계

김경진(Kyung Jin Kim),심완주(Wan Joo Shim),정성원(Seong Won Jung),박희남(Hui Nam Pak),이수진(Soo Jin Lee),송우혁(Woo Hyuk Song),김영훈(Young Hoon Kim),서홍석(Hong Seog Seo),오동주(Dong Joo Oh),노영무(Young Moo Ro) 대한내과학회 2001 대한내과학회지 Vol.60 No.1

N/A Background : Several studies has been reported that T-wave normalization(TWN) in exercise ECG indicates the presence of viable myocardium. But the clinical implication of this phenomenon in patients with acute myocardial infarction who received proper revascularization therapy was not determined. The aim of this study was to investigate the relationship between TWN in exercise ECG and myocardial functional recovery after acute myocardial infarction. Methods : We studied 30 acute myocardial infarction patients with negative T waves in infarct related electrocardiographic leads and who received successful revascularization therapy. All patients performed exercise ECG, 10-14days after infarct onset using Naughton protocol. Patients were divided into 2 groups, according to presence (group I; n=14) or not (group II; n=16) of TWN in exercise ECG. Exercise parameters, coronary angiographic findings were compared between groups. Baseline and follow up (mean 11 months) regional and global left ventricular function was analyzed by echocardiography. Results : Exercise parameters was similar between groups. There were no difference in baseline ejection fraction and regional wall motion between group I and II (EF; 56±12% vs 52±11%, p=ns. WMS; 21±3 vs 23±4, p=ns) and it was improved at the tenth month by similar magnitude. (group I/group II, EF % change = 12±12% vs 7±6%, p=ns, WMS % change = 6±6% vs 7±5%, p=ns) The findings of no relation between TWN and functional recovery was observed also when the patients were analysed according to infarct location and presence of Q-waves. Conclusion : As the exercise induced TWN in patients with acute myocardial infarction was not related with better functional recovery of dysfunctional regional wall motion, TWN dose not appears to be a sign of myocardial viability.(Korean J Med 60:51-60, 2001)

Does lipoprotein ( a ) act as the acute phase protein in patients with rheumatoid arthritis ?

이영호(Young Ho Lee),지종대(Jong Dae Ji),최성재(Seong Jae Choi),서홍석(Hong Seog Seo),송관규(Gwan Gyu Song) 대한내과학회 1998 대한내과학회 추계학술대회 Vol.55 No.-

강직성 척추염과 비분류성 척추관절증 환자의 심장이상에 대한 연구

이영호 ( Young Ho Lee ),지종대 ( Jong Dai Ji ),진동규 ( Dong Kyu Jin ),박창규 ( Chang Gyu Park ),서홍석 ( Hong Seong Seo ),오동주 ( Dong Joo Oh ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.1

목적: 강직성 척추염과 비분류성 척추관절증 환자의 심장이상의 빈도, 종류 및 정도를 알아보고자 하였다. 방법: 강직성 척추염 환자 19명, 비분류성 척추관절증 환자 15명과 정상 대조군 21명을 대상으로 하여 문진, Schober 검사 및 흉곽 팽창 검사를 포함한 이학적 검사와 표준 심전도를 시행하였고 환자의 병력과 M-mode, 이면성 및 심초음파를 시행하였다. 결과: 1. 강직성 척추염 환자 19명중 8명(42.1%)에서 심장이상이 있었고 이들은 경증의 좌심실과 좌심방의 확대 1명, 미증의 삼첨판과 승모판의 폐쇄부전 1명, 미증의 승모판 폐쇄부전과 경증의 좌심실 확대 1명, 미증의 폐동맥판부전 1명, 경증의 삼첨판 폐쇄부전 2명과 동서맥 2명이었고 심장이상이 없는 환자에 비해 유병기간, HLA-B27 양성률, 부착부염과 포도막염이 더 많았으나 의의있는 차이는 아니었다. 2. 비분류성 척추관절증 환자 15명중 8명(53.3%)에서 심장이상이 있었고 이들은 경증의 승모판 폐쇄부전과 대동맥판 폐쇄부전 1명, 승모판과 대동맥판막의 경증의 비후 1명, 승모판 비후 1명, 미증의 폐동맥판 폐쇄부전 1명, 미증의 삼첨판 폐쇄부전 2명, 미증의 삼첨판 폐쇄부전과 폐고혈압(40㎜Hg) 1명이었고 심장이상이 없는 환자에 비해 HLA-B27 양성률과 건부착부염이 더많이 관찰되었으나 의의있는 차이는 아니었다. 3. 21명의 정상대조군에서는 심전도상 모두 정상소견을 보였고 심초음파상 1명(4.8%)에서 경증의 삼첨판 폐쇄부전이 관찰되었다. 4. 강직성 척추염이 환자의 부분류성 척추관절증 환자에서 심장이상의 빈도는 대조군에 비해 높았으나 강직성 척추염 환자와 비분류성 척추관절증 환자에서 심장이상의 빈도는 차이가 없었으며, 심장이상의 종류 및 정도도 유사한 양상을 보였다. 결론: 강직성 척추염 환자와 비분류성 척추관절증 환자에서 심장이상의 빈도는 대조군에 비해 높았으나 강직성 척추염 환자와 비분류성 척추관절증 환자에서 심장이상의 빈도는 차이가 없었으며, 심장이상의 종류 및 정도도 유사한 양상을 보였다. Objective: To investigate the frequency, type and severity of cardiac abnormalities in the patients with ankylosing spondylitis and undifferentiated spondyloarthopathy. Methods: A history, clinical examination, standard 12 lead electrocardiography, two dimensional, M mode, and Doppler echocardiographies were performed on 19 patients with ankylosing spondylitis, 15 patients with undifferentiated spondyloarthropathy and 21 normal controls. Results: 1) Cardiac abnormalities were detected in 8 patients(42.1%) with ankylosing spondylitis. 2) Cardiac abnormalities were detected in 8 patients (53.3%) with undifferentiated spondyloarthropathy including 2 patients with aortic valve abnormalities (mild aortic insufficiency, aortic valve thickening). 3) Cardiac abnormalities were detected in one (4.8%) among normal controls (mild tricuspid regurgitation). 4) There were sinus bradycardias on electrocardiography in 2 patients among patients witn ankylosing spond litis and in 1 patient among undifferentiated spondyloarthropathy. But there was no conduction disturbance in both groups. 5) The frequency of cardiac abnormality was higher in patients with ankylosing spondylitis and undifferentiated spondyloarthropathy than in normal controls. 6) The mean age, mean disease duration, presence of uveitis, peripheral arthritis, HLA-B27, enthesopathy, Schober test and chest expansion in the patients with ankylosing spondylitis and undifferentiated spondyloarthropathy with cardiac abnormalities were not different from those in the patients without cardiac abnormalities. Conclusion: The frequency of cardiac abnormality was higher in patients with ankylosing spondylitis and undifferentiated spondyloarthropathy than in normal controls. The frequency, type and severity of cardiac involvement in patients with ankylosing spondylitis were not different from those in patients with undifferentiated spondyloarthropathy.