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난자공여 프로그램에서 난자수혜자의 연령이 임신율에 미치는 영향에 관한 연구
서창석,오선경,김석현,최영민,김정구,문신용,이진용,Suh, C.S.,Oh, S.K.,Kim, S.H.,Choi, Y.M.,Kim, J.G.,Moon, S.Y.,Lee, J.Y. 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.2
Oocyte donation program developed to reach the pregnancy in those patients suffering from premature ovarian failure or surgery induced menopause, particularly in their reproductive age. With technical advances and popularity of ART (assisted reproductive technology), the indication of oocyte donation program extended to low responders, and even to naturally menopaused patients that has led them quite successfully to getting in pregnancy. The purpose of this study was to evaluate which one is involved in the decline of fertility between the oocyte and uterine factor. One hundred five cycles of oocyte donation program were performed in 84 patients from Jan., 1993 to Dec., 1996. Oocytes were donated from healthy, young, fertile anonymous donors or relatives or infertile patients with supernumerary oocytes. The study population was divided into 3 groups according to the age of recipients. Group 1 was less than 35 years old, Group 2 was between 35 to 39 years old, and Group 3 was more than 39 years old. The results were as follows: The mean age of oocyte donor was $31.5{\pm}3.3$ (range; 25-36). The mean concentration of basal serum FSH and peak serum estradiol were not different among groups. The mean number of oocytes retrieved from donors, embryos transferred to recipients, and fertilization rate were not different among groups. The clinical pregnancy rate was 37.3% in Group 1, 31.6% in Group 2, and 31.6% in Group 3, respectively. The spontaneous abortion rate was 16.0% in Group 1, 16.7% in Group 2, and 16.7 in Group 3, respectively. The multiple pregnancy rate was 20.0% in Group 1, 16.7% in Group 2, 16,7% in Group 3, respectively, The implantation rate was 11.3% in Group 1, 10.3% in Group 2 and 10.0% in Group 3, respectively. All of the pregnancy outcomes were not different statistically among groups. In conclusion, endometrial receptivity does not seem to be impaired as age increases with transfer of good quality embryos and adequate endometrial preparation.
서창석,최훈,김선준,신용배,이대열 의과학연구소 1989 全北醫大論文集 Vol.13 No.1
The authers experienced a 12-year-old female patient with adrenogenitial syndrome(Nonsalt losing type). she was admitted with ambiguous genitalia and precocious puberty. Mean serum sodium and potassium concentrations were 145mEq/L and 3.9mEq/L, respectively. Urinary 17-Ketosteroid level was raised, 136mg/24hr. she was treated with oral prednisolone(7.5mg Bid, daily). Breat engorgement and menarche occurred after the steroid therapy for 8 weeks. The level of 17-ketosteroid in 24 urine was decreased to normal range after 4 잔 therapy. Clitoroplasty and vaginoplasty were not performed. She was considered to have 21-hedroxylation defect type in congenital adrenal hyperplasia on laboratory findings and clinical findings. We report this cas with review of references on adrenogenitial syndrome.