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과민성 장 증후군 환자에서 세로토닌 수송 단백질 유전자의 다형성과 혈중 세로토닌치간의 연관 관계
박효진 ( Park Hyo Jin ),이덕용 ( Lee Deog Yong ),지상원 ( Ji Sang Won ),서윤주 ( Seo Yun Ju ),이상인 ( Lee Sang In ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
과민성 장 증후군의 발병 원인으로 최근에는 신경전달물질 중 세로토닌이 중요한 역할을 하는 것으로 생각되고 있다. 세로토닌이 과민성 장 증후군의 병태 생리에 관여하며 세로토닌 수송 단백질 유전자 조절부위의 유전자형이 과민성 장 증후군의 아형과 관련이 있음과 인종에 따른 차이가 보고되고 있으나 아직 명확하게 밝혀져 있지 않다. <목적> 본 연구에서는 한국인에서 세로토닌 수송 단백질의 유전자형과 과민성 장 증후군과의 연관 관계를 규명하고자 하였다. <대상 및
건강한 성인 및 과민성 장 증후군 환자에서 세로토닌 수송 단백질 유전자의 다형성
이덕용 ( Lee Deog Yong ),박효진 ( Park Hyo Jin ),김원호 ( Kim Won Ho ),이상인 ( Lee Sang In ),서윤주 ( Seo Yun Ju ),최영철 ( Choe Yeong Cheol ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.1
Background/Aims: Serotonin is thought to be an important neurotransmitter in the pathogenesis of irritable bowel syndrome (IBS). It is reported that functional polymorphism in the promotor region of the serotonin transporter gene is related with the subtypes of IBS and shows racial difference. However, a functional relation between polymorphism and IBS is not clear. The aim of this study was to investigate 5-hydroxytryptamine transporter (5-HTT) gene polymorphism in patients with IBS. Methods: For fifty-six healthy controls and 33 patients with IBS fulfilling Rome II criteria, 5`-flank promotor region of 5-HTT gene was analyzed by polymerase chain reaction. Results: The genotypes of healthy controls were S/S (57.1%), S/L (37.5%), and L/L (5.4%). Those of IBS patients were S/S (54.5%), S/L (36.4%), and L/L (9.1%). IBS patients were divided into three groups: diarrhea predominant (n=15; S/S, 40%; S/L, 53.3%; L/L, 6.7%), constipation predominant (n=12; S/S, 75.0%; S/L, 8.3%; L/L, 16.7%), diarrhea-constipation alternating type (n=6; S/S, 50%; S/L, 50%). There was no statistical difference in the 5-HTT gene polymorphism between patients and controls, and according to the subtypes of IBS patients (p=0.135). Conclusions: There was no relationship between serotonin transporter gene polymorphism and IBS. However, allele S/S genotype was most prominent genotype in both controls and patients. (Korean J Gastroenterol 2004;43:18-22)
복강경하 담낭절제술환자에서의 마취방법에 따른 수술 후 오심과 구토의 비교
서윤주,박효선,양인순 병원간호사회 2009 임상간호연구 Vol.15 No.2
Purpose: Postoperative nausea and vomiting(PONV) is a common problem after general anesthesia. The aim of this prospective, double-blind randomized study was to compare the effect of Propofol-Remifentanil vs. Sevoflurane inhalational anesthetics on PONV after laparoscopic cholecystectomy. Methods: Forty patients (ASA physical status 1, 2) scheduled for elective surgery participated in the study. Twenty of them received total intravenous anesthesia (TIVA group) with Propofol-Remifentanil, and the rest were given Sevoflurane inhalational anesthetics (inhalation group). The TIVA group was induced with Propofol 5mcg/ml and Remifentanil 3~4mcg/ml. The anesthesia was maintained with the continuous infusion of Propofol 2~3mcg/ml and Remifentanil 2~3mcg/ml IV. The inhalation group was induced with Pentotal Sodium 5mg/kg and 3~4mcg/kg/hr IV Remifentanil. Maintenance was obtained with 1.5~2.0 vol% Sevoflurane. Results: The subjects in TIVA group reported less PONV than those in Sevoflurane inhalation anesthesia group. Conclusion: Propofol-Remifentanil anesthesia (TIVA group) was considered a satisfactory anesthetic technique in reducing PONV in patients with laparoscopic cholecystectomy.