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Tumor necrosis factor-alpha-308G/A의 유전적 다형성과 항결핵제 유발 반구진발진과의 연관성
서원용 ( Won Yong Suh ),김요한 ( Yo Han Kim ),주현돈 ( Hyun Don Joo ),박성준 ( Seong Jun Park ),류성혁 ( Sung Hyeok Ryuo ),최지성 ( Ji Sung Choi ),안선영 ( Sun Young Ann ),박창현 ( Chang Hyun Park ),김상훈 ( Sang Hoon Kim ),김상헌 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.2
Purpose: Adverse cutaneous reactions to antituberculous drugs (ATD), such as maculopapular eruption (MPE), are the most com¬mon causes of discontinuation of scheduled treatment of tuberculosis. We previously reported that tumor necrosis factor (TNF)-α genetic polymorphism -308G/A is significantly associated with ATD-induced hepatitis. This study aimed to investigate associations between TNF-α -308G/A and ATD-induced MPE. Methods: Patients with ATD-induced MPE and controls without any adverse reactions to ATD were recruited from the database of the Adverse Drug Reaction Pharmacogenomic Research Group database of Korea. We compared the genotype frequency of TNF-α -308G/A between patients with ATD-induced MPE and ATD-tolerant controls. Results: A total of 69 patients with ATD-induced MPE and 229 control subjects were enrolled for this study. There were no significant differences in genotype frequency between the patients and the controls, suggesting lack of associations between TNF-α -308G/A and ATD-induced MPE. Conclusion: The TNF-α genetic polymorphism -308G/A may not be related to the development of ATD-induced MPE, in contrast to ATD-induced hepatitis. These findings suggest that associations between TNF-α -308G/A and ATD-induced adverse reactions can be phenotype-specific.(Allergy Asthma Respir Dis 2015;3:124-127)
장용호 ( Yong Ho Jang ),임도형 ( Do Hyoung Lim ),김요한 ( Yo Han Kim ),서원용 ( Won Yong Suh ),박건우 ( Keon Woo Park ),송일한 ( Il Han Song ),이순일 ( Soon Il Lee ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.1
Skin metastasis from internal carcinoma rarely occurs and it has an incidence of 0.7% to 9%. Although the prognosis of the skin metastases varies considerably depending on the type of the primary malignancy, presence of metastatic skin cancer usually implies a widespread systemic disease and a high mortality. A 50-year-old Korean male patient visited Dankook University Hospital for evaluation of skin rash on his whole abdomen of about 1 month`s duration. He had undergone laparoscopy-assisted distal gastrectomy due to early gastric cancer about 3 months ago. He did not complain of any noticeable symptoms like febrile sense or pruritus. Skin biopsy was performed on the periumbilical area at previous port site and around the scar. Microscopic examination revealed multiple malignant cells in lymphatic spaces, consistent with metastatic carcinoma. He was therefore diagnosed with isolated skin metastasis from early gastic cancer. Because of patient`s poor liver function, systemic chemotherapy could not be performed and only best supportive care was provided. Herein, we report a rare case of cellulitis-like skin metastasis from early gastric cancer with a brief review of the literature. (Korean J Gastroenterol 2014;63:39-41)
즐례 : 복막전이를 동반한 그물막의 악성 혈관주위 상피모양세포 종양 1예
장석빈 ( Suk Bin Jang ),서원용 ( Won Yong Suh ),전지현 ( Ji Hyun Jeon ),박건우 ( Keon Woo Park ),임도형 ( Do Hyoung Lim ),남궁환 ( Hwan Namgung ),이순일 ( Soon Il Lee ) 대한내과학회 2014 대한내과학회지 Vol.86 No.1
혈관주위 상피모양세포 종양은 조직학적으로 HMB-45에 강한 양성을 보이는 상피 모양세포를 가지는 중간엽 종양의 한 범주를 총칭한다. 대개 양성경과를 보이며 진단 당시 전 이성 병변을 가지는 예는 흔치 않아 수술적 절제술이 일반 적인 치료로 선택된다. 그러나 양성과 악성의 조직학적 명확 한 경계가 없으며 재발에 대한 예측에 제한점이 많아 다양 한 치료 시도들이 지속되고 있다. 저자들은 좌상복부 거대 종괴 소견을 보인 환자를 대상으로 종괴제거 수술을 시행하 였고 복벽에 다수의 파종성 결절을 확인하였으며 절제된 종괴 및 결절조직의 면역 조직화학염색검사에서 HMB-45 강한 양성을 보여 복강으로 전이된 그물막의 악성 혈관주위 상피 모양세포 종양을 확진하였다. 환자는 더 이상의 추가적 치료를 원하지 않았으며 이후 7개월 만에 다발성 전이로 악화된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The World Health Organization (WHO) defines a perivascular epithelioid cell tumor (PEComa) as a mesenchymal neoplasia composed of perivascular epithelioid cells with characteristic morphological and immunohistochemical features. They are rarely malignant. Indeed, only a few cases have been reported in the English literature, and this is the first case of PEComa reported in Korea. A 64-year-old man presented with an abdominal mass and peritoneal seeding. The patient underwent mass excision with descending colon resection and anastomosis. The primary mass and peritoneal seeding was diagnosed as a PEComa histopathologically. Seven months later, he developed liver metastasis and aggravated peritoneal seeding. Here, we report a case of malignant PEComa of the omentum. (Korean J Med 2014;86:96-101)
권혁찬 ( Hyeok Chan Kwon ),김홍자 ( Hong Ja Kim ),장용호 ( Yong Ho Jang ),전지현 ( Ji Hyun Jeon ),김요한 ( Yo Han Kim ),서원용 ( Won Yong Suh ),장석빈 ( Suk Bin Jang ) 대한췌장담도학회 2014 대한췌담도학회지 Vol.19 No.1
A bezoar is a mass formed by the accumulation of digested food. A biliary bezoar, namely a bezoar formed in the bile duct, is rare, which occurs mostly in patients who formerly underwent cholecystectomy. It appears that incompetent sphincter produces occasional reverse flow of foreign bodies including undigested food from the alimentary canal into the bile tract. Surgical treatment is used for huge biliary bezoar which is too huge to be removed by nonsurgical treatment. Extracorporeal shock wave lithotripsy (ESWL) is mostly used to fragment renal or urinary calculi, but may be sparingly used against biliary calculi. This is to report the rare case of a patient with biliary bezoar who formerly underwent open cholecystectomy and choledocoduodenostomy. The patient`s huge biliary bezoar was removed by ESWL and the successive execution of endoscopic retrograde cholangio pancreatography (ERCP). ESWL is expected to be a comparatively safe and convenient solution to huge biliary bezoars. Korean J Pancreatobiliary 2014;19(1):37-41
골수 이형성 증후군에서 급성신손상을 동반한 Sweet 증후군의 치료 1예
김학수 ( Hak Soo Kim ),윤정아 ( Jung A Yoon ),이제환 ( Je Whan Lee ),장재원 ( Jai Won Chang ),서원용 ( Won Yong Suh ),이은경 ( Eun Kyoung Lee ) 대한내과학회 2020 대한내과학회지 Vol.95 No.5
저자들은 기저에 MDS가 있는 환자에서 발열과 다발성의 압통성 홍반이 발생하여 악성 질환 연관 SS로 의심하였다. 환자는 내원 시 급성신손상도 동반되어 있었다. 의심되는 SS에 대해 조기에 스테로이드를 투여함으로써 발열, 피부병변, 신기능이 완전히 회복된 증례를 경험하여 문헌고찰과 함께 보고하는 바이다. Sweet’s syndrome (SS) is an autoimmune-mediated acute febrile neutrophilic dermatosis with a number of possible etiologies, including infection, malignancy, and drug reactions. In contrast to its original description, it can rarely involve extracutaneous organs, including the central nervous system, cardiovascular system, lung, liver, gastrointestinal tract, spleen, and bone. To our knowledge, there have been only three cases of SS accompanied by acute kidney injury worldwide, and this is the first report in which the patient recovered completely from acute kidney injury as well as cutaneous lesions with early steroid administration. Here, we report a case of SS with acute kidney injury in a patient with myelodysplastic syndrome (MDS) whose skin lesions and renal function recovered fully with early diagnosis and steroid therapy along with a review of the relevant literature. (Korean J Med 2020;95:344 -348)