임신기간 중에 진단된 악성 종양에서 모성 및 태아의 성적에 대한 임상적 고찰

서상수 ( Sang Soo Seo ),천은경 ( Eun Kyoung Chun ),김병재 ( Byoung Jae Kim ),김문홍 ( Moon Hong Kim ),노주원 ( Ju Won Roh ),김재원 ( Jae Won Kim ),박중신 ( Joong Shin Park ),전종관 ( Jong Kwan Jun ),박노현 ( Noh Hyun Park ),송용상 대한주산의학회 2000 大韓周産醫學會雜誌 Vol.11 No.4

신문(H7) 전침 자극이 EEG의 변화에 미치는 영향

서상수 ( Sang Soo Seo ),권순철 ( Sun Cheol Kwon ),이상룡 ( Sang Ryong Lee ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.21 No.1

Objectives: The aim of this study was to examine the effects of electroacupuncture(EA) at the H(7) (Shinmun) on normal humans using power spectral analysis. Methods: EEG power spectrum exhibit site-specific and state-related differences in specific frequency bands. In this study, power spectrum was used as a measure of complexity. 32 channel EEG study was carried out in 9 subjects (9 males; age=25,8 years). Results: In alpha band, the power values at Fp2 channels(p<0.05) during the H7-acupoint treatment significantly were decreased. In beta band, the power values at Fp1, Fp2 channels(p<0.05) during the H7-acupoint treatment significantly were decreased. In delta and theta band, the power values at the H7-acupoint treatment significantly was increased than the before-acupuncture treatment. Conclusions: This results suggest that electroacupuncture at the H7 is significantly in beta band of EEG.

신문$(H_7)$ 전침 자극이 EEG의 변화에 미치는 영향

서상수,권순철,이상룡,Seo, Sang-Soo,Kwon, Sun-Cheol,Lee, Sang-Ryong 경락경혈학회 2004 대한침구의학회지 Vol.21 No.1

Objectives : The aim of this study was to examine the effects of electroacupuncture(EA) at the $H_7$ (Shinmun) on normal humans using power spectral analysis. Methods : EEG power spectrum exhibit site-specific and state-related differences in specific frequency bands. In this study, power spectrum was used as a measure of complexity. 32 channel EEG study was carried out in 9 subjects (9 males; age=25,8 years). Results : In alpha band, the power values at Fp2 channels(p<0.05) during the $H_7-acupoint$ treatment significantly were decreased. In beta band, the power values at Fp1, Fp2 channels(p<0.05) during the $H_7-acupoint$ treatment significantly were decreased. In delta and theta band, the power values at the $H_7-acupoint$ treatment significantly was increased than the before-acupuncture treatment. Conclusions : This results suggest that electroacupuncture at the $H_7$ is significantly in beta band of EEG.

메스암페타민 사용자에서의 시점간 선택 특성 및 영향 요인

안상현(Sang-Hyun Ahn),김양태(Yang-Tae Kim),서상수(Sang-Soo Seo),신정욱(Jung-Uk Shin) 대한생물치료정신의학회 2017 생물치료정신의학 Vol.23 No.3

Objectives:The aims of this study were to investigate the characteristics of intertemporal choice in methamphetamine users and to examine the relationship among intertemporal choice, impulsivity and working memory. Methods:Methamphetamine users(n=37) and normal controls(n=41) were recruited. Intertemporal choice, working memory and impulsivity were assessed with the Delay Discounting Task(DDT), the Wisconsin Card Sorting Test (WCST), Barratt Impulsiveness scale(BIS). Results:The indifference point of DDT in methamphetamine users showed significant increase compared to the control group. Methamphetamine users showed higher total score on the BIS, non-planning and motor subscale and poor performance on the WCST. Statistical analysis showed no evidence of an association among value depreciation, working memory and impulsivity. Conclusion:Methamphetamine users showed delayed discounting at intertemporal choice. There was no significant correlation among delayed discounting, impaired working memory and self- report measure of impulsivity.

사회성 증진 프로그램이 감정표현불능증에 미치는 효과에 대한 예비연구

김민수(Min-Soo Kim),신정욱(Jung-Uk Shin),이영렬(Young-Ryeol Lee),이연우(Yeon-Woo Lee),정경애(Kyung-Ae Jung),정둘남(Dool-Nam Jung),박미리(Mi-Ri Park),송강식(Gang-Sik Song),서상수(Sang Soo Seo) 대한소아청소년정신의학회 2016 소아청소년정신의학 Vol.27 No.3

Objectives: The purposes of this study are to evaluate the effect of a school-based social skills training program on the emotional regulation of children and adolescents and to assess the plan for effective school-based mental health services. Methods: The Child and Adolescent Mental health promotion team of Bugok National Hospital conducted school-based social skills training (N=90, 7 sessions) for elementary and middle school students. Evaluations were conducted before and after the application of the program using a prosocial behavior questionnaire, a cohesiveness questionnaire, the Korean version of the 20-item Toronto Alexithymia Scale, a self-esteem scale, and the Novaco anger scale, in order to identify any changes. Results: The social skills training program increased the prosocial behavior and cohesiveness of the children and adolescents and decreased their alexithymic tendency and degree of anger, but did not significantly change their self-esteem. Conclusion: The social skills training program positively influences the emotional and behavioral levels of children and adolescents. The emotional regulation program based on a social skills training program is expected to have positive results in school-based mental health services. Future investigations are needed to validate the long term effects of this program.

SSR 해석을 위한 EMTDC 기반 테스트 시스템 구축

최승연(Sungyun Choi),서상수(Sang-Soo Seo),김태현(Tae-Hyun Kim),이수형(Soo-Hyung Lee),이종주(Jong-Joo Lee),최상봉(Sang-Bong Choi),문영환(Young-Hwan Moon),이정호(Jeong-Ho Lee) 대한전기학회 2015 대한전기학회 학술대회 논문집 Vol.2015 No.7

1, 2호 보호 처분 청소년의 정신의학적 특성 및 6개월 보호처분 후 추적조사

정운선(Un-Sun Chung),서상수(Sang Soo Seo),이승재(Seung Jae Lee),정성훈(Sung Hoon Jeong) 대한소아청소년정신의학회 2010 소아청소년정신의학 Vol.21 No.2

Objectives:This study investigated the differences between the psychiatric characteristics of minor juvenile offenders and normal adolescents as well as differences in psychiatric symptoms after a six month protective disposition. Further, the current study aimed at determining psychiatric screening methods for evaluating delinquent adolescents. Methods:The Latent Delinquency Questionnaire (LDQ), the Revised Children’s Manifest Anxiety Scale (RCMAS), the Children’s Depression Inventory (CDI), the Reynolds Suicidal Ideation Questionnaire (SIQ), the Piers-Harris Children’s Self Concept Inventory (SCI), and the Korean Youth Self Report (K-YSR) were administered to 134 normal adolescents (114 males) and 109 minor offenders (97 males) aged 12 to 16 years. After six months, 46 offenders (all males) completed the RCMAS, CDI, SIQ, and SCI again. Results:Adolescents with minor offenses had more delinquent, aggressive behavior and externalizing behavior problems, but were significantly less depressive, anxious, or suicidal than normal controls. Further, recidivists had more anxiety, depression, and delinquent behavior than non-recidivists. Minor offenders reported that their anxiety and depressive mood decreased after six months of protective disposition. Conclusion:Adolescents with minor offenses had more delinquent, aggressive behavior and externalizing behavior problems suggesting that psychiatric screening tools for minor offenders should measure disruptive behavior disorder.

사회성 증진 프로그램이 아동·청소년의 사회적 의사결정에 미치는 영향에 관한 예비연구

김민석(Min-Seok Kim),서상수(Sang-Soo Seo),김양태(Yang-Tae Kim) 대한생물치료정신의학회 2020 생물치료정신의학 Vol.26 No.2

Objectives:The purpose of this study is to evaluate the effect of a school-based social skills training program on the social decision-making of children and adolescents and to assess plan for effective school-based mental health services. Methods:It was performed school-based social skills training (n=46, 7 sessions) in elementary and middle school students. Evaluations were conducted before and after the application of the program using a ultimatum game and dictator game, in order to identify changes. Results:Before social skills training program (SSTP), the younger students showed higher acceptance rates of unfair offers than the older students in ultimatum game (UG) [at 9:1 offers 0.79±0.08>0.55±0.12 (p=0.001); at 8:2 offers 0.81±0.11>0.59±0.11 (p=0.001)]. the rejection rates of unfair offers in UG significantly increased after SSTP[at 9:1 offers 0.64±0.19→0.43±0.18 (p=0.001) ; at 8:2 offers 0.67±0.16→0.54±0.16 (p=0.046) ; at 7:3 offers 0.83±0.20→0.65±0.12 (p=0.001)]. the rejection rates of unfair offers in UG significantly increased at happy and at neutral facial expression of proposers after SSTP[happy facial expression condition, at 9:1 offers 0.89±0.12→0.68±0.19 (p=0.001) ; at 8:2 offers 0.82±0.19→0.72±0.14 (p=0.001) ; at 7:3 offers 0.99±0.07→0.92±0.17 (p=0.040] [neutral facial expression condition, at 9:1 offers 0.71±0.20→0.54±0.13 (p=0.001) ; at 8:2 offers 0.61±0.18→0.52±0.06 (p=0.001) ; at 7:3 offers 0.91±0.13→0.83±0.12 (p=0.001)]. the amount of money offered as a proposer in dictator game significantly increased after SSTP [3989.1±1952.3→4742.5±371.1, (p=0.012)]. Conclusion:The social skills training program positively influences the social decision-making. The school-based social skills training program can be expected to have positive results in school-based mental health services. Future investigation is needed to validate the long term effects of this program.

다태임신에서 질식 선택적 유산술 후의 임신 예후에 관한 연구

김석현(Seok Hyun Kim),서상수(Sang Soo Seo),임경실(Kyung Sil Lim),지병철(Byung Chul Jee),서창석(Chang Suk Suh),최영민(Young Min Choi),김정구(Jung Gu Kim),문신용(Shin Yong Moon),이진용(Jin Yong Lee) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.2

목적: 최근 보조생식술의 발달과 더불어 급증하고 있는 삼태아 이상의 다태임신 예에서 임신 초기에 질식 천자를 이용한 질식 선택적 유산술을 시행하여 합병증, 임신 결과 등의 시술 성적을 규명하고자 하였다. 연구방법: 1993년 7월부터 1998년 12월까지 서울대학교병원 산부인과 불임크리닉에서 과배란유도를 이용한 체외수정시술 등의 보조생식술을 시행받은 후 임신에 성공하였으나 삼태아 이상의 다태임신 환자 및 타병원 불임크리닉에서 보조생식술을 시행받은 후 삼태아 이상의 다태임신을 주소로 본원으로 전원된 환자, 총 70명에서 질식 천자를 이용한 질식 선택적 유산술을 시행하였다. 분만 후 추적 조사가 가능하였던 58명의 환자를 대상으로 의무기록의 후향적 분석을 실시하였다. 대상 환자 58명의 평균 연령은 30.9±2.7세 이었으며, 체외수정시술을 시행받은 환자가 51명(87.9%), 과배란유도 주기에서 인공수정을 시행받은 환자가 7명(12.1%) 이었다. 선택적 유산술 시술 전 삼태아는 37예(63.8%), 사태아는 14예(24.1%), 오태아는 5예(8.6%), 육태아는 2예(3.4%) 이었다. 결과: 선택적 유산술의 시술 시기는 평균 임신 8+3±1+3주 이었으며, 시술 횟수는 평균 1.3±0.6회 이었다. 선택적 유산술 시술 후 55예에서는 쌍태아, 3예에서는 단태아를 남겼다. 쌍태아를 남긴 55예 중 자궁내 일측 태아 사망이 4예(7.3%)에서 일어나 총 51예에서 쌍태아 임신이 유지되었으며, 임신 24주 전에 유산된 경우는 9예 이었고, 나머지 42예는 임신 24주 이후에 분만되었다. 쌍태아 임신 중 자연적인 태아 손실이 일어난 4예와 단태아를 남긴 3예를 합한 총 7예의 단태아 임신에서는 모두 임신 24주 이후에 분만되었다. 임신 24주 이후에 분만된 쌍태아 임신 42예 중 4예에서 심한 미숙으로 인하여 신생아가 모두 사망하였고, 단태아 임신 7예 중 1예에서 심한 미숙으로 신생아가 사망하였다. 출생된 83명의 신생아 중 1명은 무뇌증에 이환되어 곧 사망하였고, 나머지 82명은 출생 후 별다른 합병증 없이 생존하였다. 선택적 유산술 시술 후 4주일 이내에 패혈성 유산이 1예(1.7%)에서 발생하였으며, 임신 24주를 기준으로 한 지연 태아손실율은 13.8%(8/58) 이었다. 임신 24주 이후에 분만된 49예 중 신생아가 사망한 경우는 4예 이었으며, 따라서 선택적 유산술 시술 58예 중 13예에서 태아가 모두 유산되었거나 분만 후 사망하여 22.4%(13/58)의 태아손실율을 나타내었다. 결과적으로 선택적 유산술 시술 후 45예(77.6%)에서 적어도 1명 이상의 태아가 생존하였는데 이들의 평균 분만 주수는 36+3±2+0주 이었다. 태아의 자궁내 발육지연은 33.3%(15/45)에서 발생하였으며, 쌍태아 출산의 경우 두 신생아에서 출생시 체중 차이가 20% 이상되는 체중 불일치(discordancy)의 발생 빈도는 16.7%(6/36) 이었다. 주된 선천성 기형으로는 1예에서 무뇌증이 관찰되었다. 선택적 유산술 시술 전 태아의 수에 따른 태아손실율은 육태아에서 100.0%(2/2), 오태아에서 20.0%(1/5), 사태아에서 28.6%(4/14), 삼태아에서 16.2%(6/37)로서 유의한 차이는 없었다. 시술 전 사태아 이상 군과 삼태아군을 상호 비교한 결과 태아의 분만 주수 및 태아손실율은 각각 유의한 차이가 없었으며, 신생아의 출생 체중은 사태아 이상 군에서 유의하게 낮았다. 결론: 보조생식술시 다태임신을 완전히 예방할 수는 없으며, 특히 삼태아 이상의 다태임신은 모체 및 태아의 이환율 등을 증가시키므로 질식 선택적 유산술은 의학적 뿐만 아니라 사회적, 윤리적으로도 정당화될 수 있는 유용한 시술이라고 사료된다. Objective: To evaluate the maternal and fetal outcomes after transvaginal selective fetal reduction(SFR) in multifetal pregnancy. Materials and Methods: Transvaginal SFR using fetal intracardiac puncture with KCl injection and aspiration of amniotic fluid was performed in 58 multifetal pregnancies achieved after assisted reproductive technology(ART). After transvaginal SFR, 55 twin and 3 singleton pregnancies were evaluated and analyzed retrospectively with the medical records of mothers and babies. Results: Of 58 cases, abortion within 4 weeks after SFR occurred in 1 case(1.7%). Miscarriage of all fetuses occurred in 8 cases(13.8%) from 4 weeks after SFR until 24 weeks of gestation. Perinatal death occurred in 8 newborns from 5 mothers due to extreme prematurity in 7 cases and anencephaly in 1 case. Take-home baby rate, that is, discharge with at least 1 healthy baby, was 77.6%(45/58). Conclusion: Transvaginal SFR is an acceptable and effective management option in the cases of excessive multifetal pregnancy after infertility treatment. The ultimate successful outcomes of reduced multifetal pregnancy may be enhanced by more extensive experience with SFR.

상피성 난소암 진단에 있어서 Tissue Polypeptide Specific Antigen (TPS)과 CA 125의 임상적 유효성에 관한 연구

노재홍 ( Jae Hong No ),서상수 ( Sang Soo Seo ),김용범 ( Yong Bum Kim ),김재원 ( Jae Won Kim ),박노현 ( Noh Hyun Park ),송용상 ( Yong Sang Song ),강순범 ( Soon Beom Kang ),이효표 ( Hyo Pyo Lee ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12

목적 : 상피성 난소암을 진단하는데 있어 혈중 TPS 측정의 유용성을 CA 125와 비교 평가하고자 하였다. 연구 대상 및 방법 : 199년 1월부터 2000년 12월까지 난소 종양으로 개복 수술을 시행한 환자 93명으로 대상으로 하였다. 이들 중 51명은 경계성 종양 27명을 포함한 51명의 상피성 난소암 환자였으며 42명은 양성 난소 종양 환자였다. 모든 환자에서 수술 전에 채혈한 혈액을 이용하여 혈중 TPS 및 CA 125의 농도를 측정하였으며 후 Objective : The purpose of this study is to evaluate and compare the usefulness of the serum levels of tissue polypeptide specific antigen (TPS) and CA 125 for the diagnosis of epithelial ovarian cancer. Materials and Methods : A total of 93 patients were