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조유진 ( Eugene Cho ),김현우 ( Hyoun-woo Kim ),백효은 ( Hyo-eun Baek ),김현석 ( Hyeon-seok Kim ),조건웅 ( Geon-ung Jo ),박세이 ( Se-i Park ),오찬진 ( Chan-jin Oh ),오득실 ( Deuk-sil Oh ),김진 ( Jin Kim ) 조선대학교 공학기술연구원 2020 공학기술논문지 Vol.13 No.1
Ten species belonging to the genus Dicranopteris are distributed throughout the world and Dicranopteris pedeta (Houtt.) Nakaike is distributed in Korea. In this study, the antioxidant and anticancer activities of Dicranopteris pedeta aqueous extract was explored. Antioxidant activity of Dicranopteris pedeta aqueous extract was revealed with a range of 38% to 74% in the DPPH radicals test. The total polyphenols and flavonoids contents of aqueous extract were 92.5 ± 8.68 mg GAE/g and 28.04 ± 4.08 mg QE/g, respectively. Protocatechuic acid, gentisic acid, rutin, vanillic acid, hesperidin, oxyresveratrol, quercetin, and naringenin were detected by HPLC. Cytotoxicity test was conducted using MTT assay in normal cells 293T, cancer cells of YD-10B and HeLa. In the cytotoxicity test, aqueous extract did not show toxicity to normal cells but inhibited cancer cell proliferation. These results suggest that aqueous extracts of Dicroanopteris pedeta could potentially be developed as a functional cosmetics or anticancer agents.