http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
세당환(世糖丸)이 Streptozotocin으로 유발된 흰쥐의 실험적 당뇨에 미치는 영향
배철호,소경순,정찬길,Bae, Chul-Ho,Soh, Kyeong-Sun,Jeong, Chan-Gil 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.1
Objectives : We performed this study in order to investigate the effects of Sedang-hwan(世糖丸) on the diabetes mellitus. Methods : We injected a vein with 65mg/kg of streptozotocin(STZ) on the rats. And then administered Sedang-hwan; 18.7mg/kg/day to sample groups and observed the weight and glucose level, insulin, C-peptide, triglyceride, albumin, T-protein, BUN(Blood Urea Nitrogen) and creatinine in blood. Results : 1. The sample groups showed a high suppressive effect of weight loss(P=0.002). 2. The sample groups' glucose level showed a effective in lowering level(P=0.001). 3. The sample groups showed a higher insulin level than control groups. 4. The sample groups showed a higher C-peptide level than control groups(P=0.001). 5. The sample groups' triglyceride level showed a effective in lowering level. 6. The sample groups showed a higher HDL-cholesterol level than control groups(P<0.001). 7. The sample groups showed a higher T-protein level than control groups(P=0.04). 8. The sample groups showed a higher albumin level than control groups(P<0.001). 9. The sample groups' creatinine level showed a effective in lowering level(P=0.04). 10. The sample groups' BUN level showed a effective in lowering level(P=0.03). Conclusions : Conclusively, Sedang-hwan was recognized to have decrease effect of serum glucose, triglyceride, creatinine, BUN of the diabetic rats induced by streptozotocin. It was suggested that Sedang-hwan can be used for effective diabetes mellitus medical treatment. It is also required to study further about detailed principles of blood-sugar dropping effect by Sedang-hwan, and recovery by diabetes mellitus.
익국환과 익국보화환의 실험적(實驗的) 간경변(肝硬變)에 대(對)한 효과(效果)
배철호,김성환,김강산,강병기,Bae Cheol-Ho,Kim Sung-Hwan,Kim Kang-San,Kang Byung-Ki 대한한의학방제학회 1998 大韓韓醫學方劑學會誌 Vol.6 No.1
간경변(肝硬變)은 각종(各種) 만성미만성간염(慢性彌滿性肝炎)이나 광범위(廣範圍)한 간장실질(肝臟實質)의 손상(損傷)이 계속적(繼續的)으로 발전(發展)하여 이루어진 결과(結果)이다. 주(主)된 병리적(病理的) 특징(特徵)은 간세포(肝細胞)의 변성(變成), 괴사(壞死) 후(後)에 나타나는 섬유조직(纖維組織)의 증식(增殖), 간세포(肝細胞)의 결절상(結節狀) 재생(再生), 가소엽(假小葉)의 형성(形成) 등(等)으로서, 이들 세가지의 변화(變化)가 뒤섞여 진행(進行) 되는 가운데, 간내(肝內) 혈관망(血管網)이 감소(減少)하거나 혈관망(血管網)에 이상(異狀) 함몰(陷沒)이 발생(發生)하는 것이다. 주(主)된 임상표현(臨床表現)은 간기능감퇴(肝機能減退)와 문맥압(門脈壓) 상승(上升)으로 인(因)한 비종대(脾腫大), 복수(腹水), 복벽정맥(腹壁靜脈)의 노장(怒張), 식도(食道)와 위저정맥(胃底靜脈)의 노장파열(怒張破裂), 간성혼수(肝性昏睡) 등(等)이 나타난다. 한의학(韓醫學)의 범주(範疇)로는 '적취(積聚), 징가, 황달(黃疸), 고창(鼓脹), 협통(脇痛), 단복창(單腹脹), 비괴' 등(等)에 해당(該當)되는 것으로 습열(濕熱)이 구울(久鬱)함에 따라 간(肝), 비(脾)가 손상(損傷)되고 이것이 더욱 오래되어 기체혈어(氣滯血瘀)로 발전(發展)하게 되는 병리변화(病理變化)를 갖는다. 이에 담도결찰(膽道結紮) 및 dimethylnitrosamine의 복강투여(腹腔投與)로 간경화(肝硬化)를 유발(誘發)하고, 울증(鬱證)에 다용하는 익국환과 익국보화환이 이러한 병증(病症)에 간기능보호작용(肝機能保護作用)이 있는가를 관찰(觀察)하고, 한의학적(韓醫學的) 병증(病症)의 분류(分類)에 따라 간질환(肝疾患)에 대(對)한 치료(治療)의 가능성(可能性)을 알아보고자 본(本) 실험(實驗)을 실시(實施)한 결과(結果), 유의성(有意性) 있는 결과(結果)를 얻었기에 보고(報告)하는 바이다. This study was to investigate the protective and effects of Ikgukwhan and Ikgukbowhawhan on the liver cirrhosis or fibrosis induced by prolonged bile duct ligation; a new experimental model for cirrhosis and the intraperitoneal injection of dimethylnitrosamine in the rat. The development of fibrosis or cirrhosis and its inhibition by the two prescriptions were examined by the chemical analysis of AST, ALT, and hydroxyproline. The results obtained were as follows. 1. The increase of serum asparate aminotransferase induced by bile ductligation was inhibited by the administration of Ikgukwhan and Ikgukbowhawn extract. 2. The increase of serum alanine aminotransferase induced by bile duct ligation was inhibited by the administration of Ikgukwhan and Ikgukbowhawhan extract. 3. The increase level of serum AST and ALT induced by the intraperitoneal injection of dimethylnitrosamine was inhibited by the administration of Ikgukwhan and Ikgukbowhawhan extract. 4. The increase level of hydroxyproline volume in the damaged liver tissues in the rat was decreased by the oral administration of Ikgukwhan and Ikgukbowhawhan extract. But there were no significant differences in the inhibition rate between the two experimental groups.
배철호(Bae Chulho),김정현(Kim Jeonghyun),우형민(Woo hyungmin),홍성호(Hong Seongho) 한국지반환경공학회 2008 한국지반환경공학회논문집 Vol.9 No.3
본 연구에서는 상수도 금속관의 공식특성에 따른 잔존 인장강도 예측모델을 제안하였다. 이들 모델중 회주철관에 대해서는 지수함수형 모델이 실측값에 대한 예측값의 상관성(R²)이 높게 나타났으며, 닥타일주철관과 강관 등은 선형함수인 공식특성에 따른 강도손실 모델이 더 예측력이 높은 것으로 나타났다. 국내에서 과거에 제조된 상수도 금속관의 파괴인성은 평균적으로 회주철관이 40.46kgf/㎟√㎜, 닥타일주철관이 85.27kgf/㎟√㎜, 그리고 강관이 97.27kgf/㎟√㎜로 나타났으며, 파괴인성을 이용한 잔존 인장강도 예측모델의 실측값에 대한 예측값의 상관성은 관종에 따라 다르나 0.44에서 0.86로 나타났다. 특히 이들 제안된 모델들을 새로운 지역에 매설된 상수관로에 대하여 적용한 결과, 결정계수가 0.76~0.78로 나타나 향후 노후 상수도 금속관의 잔존 강도를 예측하는데 활용됨으로서 합리적인 개대체 의사결정에도 도움을 줄 수 있을 것으로 판단된다. In this study, the residual strength prediction models were proposed by measuring various residual strength according to pit characteristics for metallic water pipes such as cast iron pipe (CIP), ductile iron pipe (DIP), and steel pipe (SP). The exponential prediction model was better fitted to measured residual tensile strength for CIP'. In case of DIP and SP, the prediction model using loss of strength was more exactly predicted compared with other model types. The fracture toughness were averagely 40.46kgf/㎟√㎜ for CIP, 85.27kgf/㎟√㎜ for DIP, and 97.27kgf/㎟√㎜ for SP, the determination coefficient (R²) of between measured residual tensile strength and predicted values for residual strength prediction models using fracture toughness was estimated from 0.44 to 0.86. Especially, the proposed residual tensile strength prediction models were applied for the verification and reliability to CIPs and DIPs at 14 sites. The determination coefficient (R²) between measured residual tensile strength and predicted values was estimated from 0.76 to 0.78. Therefore it was thought that the proposed residual tensile strength models could help to support resonable and economical decision of rehabilitation/replacement.