신경정신루푸스의 조기진단을 위한 양성자 자기 공명분광 소견

배성권 ( Sung Kwon Bae ),송정수 ( Jung Soo Song ),박원 ( Won Park ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.4

Objective: To investigate the usefulness of 1H-magnetic resonance spectroscopy (1H-MRS) for the early diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE). Methods: Magnetic resonance image (MRI) and 1H-MRS were performed on fifteen normal volunteers (mean age, 29±6 years; age range, 24~40 years) and twenty seven patients with SLE: twelve (26±8 years; 16~42 years) with and fifteen (32±12 years; 13~57 years) without NPSLE. The localized 1H-MRS was performed by a GE 1.5T SIGNA MRI/MRS system (version 5.5) with active shielded gradients. For all spectra, a Stimulated Echo Acquisition Method (STEAM) localization sequence with three-pulse CHESS H2O suppression was used. The metabolite ratios of N-acetylaspartate (NAA) to creatine (Cr) and choline (Cho) to Cr measured on 1H-MRS of the basal ganglia (BG) and peritrigonal periventricular white matter (PWM). Results: The level of disease activity makers (anti-dsDNA, C3, C4, SLEDAI score), autoantibodies (lupus anticoagulant, anticardiolipin antibody, antiribosomal-P), and EEG did not showed significant difference between the patients without NPSLE and with NPSLE (p>0.05). Thirteen percent (2/15) of patients without NPSLE and fifty percent (6/12) of patient with the NPSLE showed abnormality in MRI. 1H-MRS showed significantly decreased NAA/Cr ratio in BG and increased Cho/Cr ratio in PWM for the patients with NPSLE compared to the patients without NPSLE and normal volunteers (p<0.05). No correlation was shown between the maker of disease activity and NAA/Cr in BG or Cho/Cr ratio in PWM in the SLE group (p>0.05). But negative correlation was shown between NAA/Cr in BG and Cho/Cr ratio in PWM (r=-0.58, p<0.05). Conclusion: NAA/Cr ratio in BG was decreased and Cho/Cr in PWM was increased in NPSLE. The neurometabolite ratio measured by 1H-MRS may be useful in the early detection of NPSLE.

류마티스 관절염과 동반된 골수섬유증

배성권 ( Sung Kwon Bae ),송정수 ( Jung Soo Song ),박원 ( Won Park ),오윤주 ( Yoon Ju Oh ),김성수 ( Sung Soo Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.2

Rheumatoid arthritis is thought to be a collagen disease induced by autoimmune mechanism of unknown etiology. Idiopathic myelofibrosis is a myeloproliferative disorder in which the large majority of patients is characterized by anemia, leucoerythroblastosis, splenomegaly, and bone marrow fibrosis with a predominance of megakaryocyte. In some patients autoimmune bone marrow damage has been claimed to he involved in the pathogenesis. A 76-year-old female patient was diagnosed to have rheumatoid arthritis 30 years ago and medicated intermittently. Three months ago, she started to take hydroxychloroquine 300mg/day, prednisolone 7.5mg/day and non-steroidal antiinflammatory drug. One month ago, white blood cell (WBC) count was 5,000/μL with the neutrophil count was 3000/μL, the hemoglobin (Hb) was 4.3g/dL, the platelet count was 95,000/μL and the reticulocyte count was 0.1%. The bone marrow biopsy had revealed hopercellular marrow with increased all hematopoietic element. At this time, the WBC count was 1,600/μL and the neutrophil count was 760/μL, the Hb was 2.7g/dL, the platelet count was 11,000/μL and the reticulocyte count was 0.2%. The bone marrow aspiration resulted in dry tap and the biopsy revealed fibrosis with marked degree of reticulin fibrosis and small numbers of hematopoietic cells.

고령사회에 대한 기독교 세계관적 이해

배성권 ( Sung Kwon Bae ) 통합연구학회 2006 통합연구 Vol.19 No.1

기독교세계관에서 본 한국 기독교병원의 방향

배성권(Bae Sung-Kwon),오창석(Oh Chang-Suk) 한국로고스경영학회 2006 로고스경영연구 Vol.4 No.2

종합병원 입원환자와 외래환자의 만족도 요인 분석 - 의료기관 서비스평가 자료를 활용한 실증 분석 -

배성권 ( Sung Kwon Bae ),남은우 ( Eun Woo Nam ),박재용 ( Jae Young Park ) 한국병원경영학회 2005 병원경영학회지 Vol.10 No.2

간염바이러스 감염 환자에서 나타나는 근골격계 증상과 치료시 간 기능에 영향을 주는 인자

배성권(Sung Kwon Bae),송정수(Jung Soo Song),박원(Won Park) 대한내과학회 2001 대한내과학회지 Vol.60 No.1

N/A Background : To investigate the musculoskeletal manifestations and factors aggravating hepatic enzyme in patients with hepatitis B (HBV) and C (HCV) viral infection. Methods : Eighty seven patients with HBV (72 patients) and HCV (15 patients) infection complaining of musculoskeletal symptoms were investigated retrospectively. Results : Extrahepatic manifestations of patients with hepatitis viral infection were arthralgia/ arthritis (77%/72%), dermatologic manifestations(16%), neurologic manifestations (11%), and constitutional symptoms (6%). The kinds and the incidence of extrahepatic symptoms were not different between two viral infections. The rheumatologic diagnosis of patients with hepatitis viral infection were RA (41%), fibromyalgia (13%), Sj gren's syndrome (7%), SLE (5%), sacroiliitis (5%), Behcet's disease (5%), carpal tunnel syndrome (3%), and unclassified arthritis (32%). The diagnosis were not different between the two groups. There was no association of the hepatitis viral infection with any specific rheumatic disease. The patterns of arthritis were polyarthritic (79%), oligoarthritic (16%), and monoarthritic (5%) and the involvement sites were peripheral (89%), root (38%), and axial(29%). The involvement of root joint in patients with HBV (41%) infection was more frequent than HCV (22%) infection (p<0.05). The involvement of axial and peripheral joint was not different between the two groups. The prevalence of rheumatoid factor and anti-nuclear antibody were 48% and 21% in patients with hepatitis viral infection respectively. Patients taking steroid, hydroxychloroquine, bucillamine, or combined disease modifying antirheumatic drugs (DMARDs) tended to have aggravated hepatic enzyme level (p<0.05). Conclusion : The patients with hepatitis viral infection showed various musculoskeletal manifestations without relation to any specific rheumatic disease. The patients with HBV infection had more involvement in root joint than HCV infection. The steroid, hydroxychloroquine, bucillamine, or combined DMARDs were related to aggravated hepatic enzyme.(Korean J Med 60:32-39, 2001)

류마티스 관절염에 동반된 빈혈에서 혈청 Transferrin 수용체 측정의 유용성: 골수 저장철과의 비교

김성수 ( Sung Soo Kim ),박원 ( Won Park ),배성권 ( Sung Kwon Bae ),이용환 ( Yong Hwan Lee ),송정수 ( Jung Soo Song ),최종원 ( Jong Weon Choi ),김순기 ( Sun Ki Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.4

Objective: This study was aimed at investigating the usefulness of serum transferrin receptor (sTfR) in anemic patients with rheumatoid arthritis (RA) compared with bone marrow storage iron and other tests for anemia. Methods: Fifty-five anemic RA patients were undergone anemia study including hematologic indices, iron panel, and sTfR. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured. Eighteen patients performed marrow iron stain. The sTfR and serum ferritin levels were compared with bone marrow iron store, hematologic values, iron batteries, and markers of the disease activity. Results: 1) Mean sTfR concentration was 2.68±1.29mg/L in all patients. 2) sTfR correlated significantly with hemoglobin concentration (r=-0.491; p<0.001), hematocrit (r=-0.348; p=0.009), MCV (r=-0.597; p<0.001), RDW (r=0.696; p<0.001), serum iron (r=-0.389; p=0.003), and transferrin saturation (r=-0.451; p=0.001) 3) Ferritin did not correlated significantly with hemoglobin, hematocrit, serum iron/TIBC, MCV and RDW, except reticulocyte count (r=0.295; p=0.032) and total iron binding capacity (TIBC) (r=-0.503; p<0.001). 4) sTfR showed no significant correlation with ESR and CRP, whereas ferritin correlated with CRP (r=0.342; p=0.019). 5) Among the patients who performed iron staining from bone marrow, sTfR was higher in iron-depleted group compared with iron replete group (p=0.040). Conclusion: This study suggests that measurement of sTfR may be useful assay for anemia and the possible substitute for invasive bone marrow study in differentiating iron deficiency anemia from anemia of chronic diseases in patients with RA.

류마티스 관절염에 동반된 양측성 화농성 슬관절염

김성수 ( Sung Soo Kim ),박원 ( Won Park ),배성권 ( Sung Kwon Bae ),송정수 ( Jeong Soo Song ),문경호 ( Kyung Ho Moon ),이정윤 ( Joung Yoon Lee ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.2

Septic arthritis is a disease that causes a rapid joint destruction by various kinds of bacteria such as Staphylococcus aureus. It affects more frequently the patients with rheumatoid arthritis, diabetes, immunocompromised patients, and chronic steroid users. In patients with rheumatoid arthritis, 1 to 12% of patients are affected by septic arthritis. In these patients, it is very difficult to distinguish between an acute exacerbation of rheumatoid arthritis and a development of septic arthritis if the latter affects more than one joint. Septic arthritis usually affects single joint, especially the knee joint. If the diagnosis and treatment are delayed, it would cause sepsis resulting in high mortality and morbidity. Thus early diagnosis by arthrocentesis, prompt drainage, and antibiotics therapy are essential. We experienced a 46 years-old woman with rheumatoid arthritis who abused the steroids for 10 years and complaining recent aggravation of bilateral knee joint swelling, warmth, and tenderness. Large amount of pus from both knees showed Gram positive cocci. The immediate open surgical drainage of both knees was done. The patient recovered from septic arthritis after 6 weeks of antibiotics therapy. The synovial fluid microbiology study should be done in all joints of the patients with the risk factors of joint infection.

학령후기 아동의 건강증진행위와 생활만족도의 관련성

이성한 ( Sung-han Lee ),배성권 ( Sung-kwon Bae ) 한국영유아아동정신건강학회 2009 영유아아동정신건강연구 Vol.2 No.2

본 연구는 학령후기 아동의 건강증진행위와 생활만족도의 관련성에 관해 알아본 것으로서 실태, 아동의 배경변인에 따른 건강증진행위 및 생활만족도 차이 및 건강생활이 아동의 생활만족도에 미치는 영향을 알아보기 위한 것이다. 연구대상은 부산지역 공립초등학교 4, 5, 6학년 아동 670명이며, 건강생활과 생활만족도 설문조사 기간은 2008년 6월 말경부터 7월 말까지 약 한달 간이었고, 최종 670부를 분석했다. 건강생활설문지는 김신정(2007)의 연구에서 사용된 것으로서 6개 영역 53개 문항 4점 척도이며, 생활 만족도는 이정미, 이양희(2007)의 한국판 아동용 다면적 생활만족도검사(K-MSLSS)로 5개 영역 34문항 6점 척도였다. t-test, one-way ANOVA, 상관분석 test 및 다중회귀분석을 실시했다. 연구결과는 다음과 같다. 학령후기 아동의 건강증진행위와 생활만족도와의 상관관계결과에서 질병예방은 식습관, 정신건강, 사고예방의 세항목과 상관이 있었다. 또한 정신건강은 개인위생, 식습관, 운동과 유의미한 상관이 있었다. 사고예방은 개인위생, 식습관, 운동, 정신건강과 유의미한 상관이 있었고 친구만족도는 정신건강과 상관이, 가족만족도는 정신건강, 질병예방, 사고예방, 학교만족도와 상관이, 환경만족도는 가족만족도와, 자아만족도는 질병예방, 친구만족도, 학교 및 가족만족도와 상관이 있었다. 그리고 중다 회귀분석 결과에서 아동의 정신건강증진행위는 아동의 친구만족도에 유의미한 영향을 미쳤으며 식습관, 정신건강, 질병예방의 세 항목은 학교만족도에 영향을, 운동, 정신건강, 사고예방의 세 항목은 가족만족도를, 정신건강은 환경만족도와 자아만족도에 매우 유의미한 영향력을 미쳤다. 결론적으로 운동, 정신건강, 사고예방의 세 항목은 아동의 생활 만족도를 설명하는데 통계적으로 매우 유의미한 영향을 미쳤다. The purpose of this study was to analysis relationship between the latter school age children's health promotion behavior and life satisfactions, to investigate children's variables which effect the latter school age children's health promotion behavior and the life satisfaction, and to study correlations between these variables. so we could helps children be able to carry on healthy, happy, and satisfied life. This study adopted questionnaire surveys for total 670 children, who are 4, 5, 6th grade at elementary public school age in Busan city, Health promotion behavior questionnaire and K-MSLSS, life satisfaction questionnaire. The following results were founded. First, the rank of health promotion behavior criterion of the children were Diseases Control>Personal Hygiene> Mental Health>Accident Prevention>Eating Habits=Exercise. Second, the rank of life satisfaction of the children were Family Satisfaction=Environment Satisfaction>Self Satisfaction>School Satisfaction. Third, children's health promoting behavior were different depending on children's gender, grades, family member, family traits, residing, father's education, mother's education, father's job, perceived child health state, school record, enrolled private institute number, and family socioeconomic states. Fourth, children's life satisfaction were different depending on children's background traits. Fifth, strong statistically significant correlations was founded at the correlation analysis of children's health promotion behavior and life satisfaction. Finally, Regression analysis results indicating statistically strong significant meaning which the health promotion behavior effecting on the children's life satisfaction. Exercise, mental health, and accident prevention were important elements promoting children's life satisfactions.

한국인에서 쇼그렌 증후군의 선별 및 추적검사로서 건빵 용해 검사의 개발

김성수 ( Sung Soo Kim ),송정수 ( Jung Soo Song ),박보형 ( Bo Hyoung Park ),이용환 ( Yong Hwan Lee ),배성권 ( Sung Kwon Bae ),박원 ( Won Park ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4

Objective: To investigate the usefulness of the Hardtack test to screen the Sjogren`s syndrome compared with non-stimulated whole salivary flow (NSWSF) and Schirmer-1 test. Methods: Fifty patients with RA and other connective tissue disease who had complained sicca symptoms (7 males and 43 females) and twenty healthy participant, were undergone the Hardtack test, NSWSF, and Schirmer-1 test. The Hardtrack test were compared with NSWSF and Schirmer-1 test for the screening of Sjogren`s syndrome. And the relationship between the tests were evaluated. Results: 1) The time of dissolution of the hardtack was 88.7sec (Max: 136, Min: 44) in healthy group, and 321 sec (Ma: 900, Min: 92) in patient group (p<0.001). 2) NSWSF was 0.6 ml/min (Max: 1.32, Min: 0.14) in healthy group, and 0.28 ml/min (Max: 0.8, Min: 0.01) in patient group (p<0.001). 3) The lacrimal flow in Schirmer-1 test was 22.0 mm (Max: 30, Min: 8) in healthy groups and 5.26 mm (Max: 21, Min: 0) in patient group (p<0.001). 4) The correlation coefficient between the hardtack test and NSWSF was -0.56 (p<0.001). The correlation coefficient between the hardtack test and Schirmer-1 test was -0.51 (p<0.001). NSWSF was correlated with Shirmer-1 test but not significantly (r=0.254, p=0.075). In the hardtack test, the best balance between sensitivity and specificity was seen with a cut-off value of 120 seconds. Conclusion: The Hardtack test is useful screening test to discriminate between subjects with normal and reduced salivary flow. The Hardtack test is easy to perform, inexpensive, imposes minimal discomfort on the subject with xerostomia and correlated well with the NSWSF and the Schirmer-1 test. So it can also be used as to monitor the Sjogren`s syndrome before the salivary flow measurement or Schirmer-1 test.