수소저장용 금속수소화물$(Mm(La_0.6-_0.8)Ni_4.0Co_0.6Mn_0.2Al_0.2)의 전열촉진

배상철(Bae, Sang-Chul),Yang, Yang,Masanori, Monde 한국신재생에너지학회 2006 신재생에너지 Vol.2 No.2

The effective thermal conductivities of Mm(La_{0.6-0.8})Ni_{4.0}Co_{0.6}Mn_{0.2}Al_{0.2} [TL-492] with hydrogen and helium have been examined. Experiment results show that pressure has great influence on effective thermal conductivity in low pressure range [below 0.5 MPa]. And that influence decreases rapidly with increase of gas pressure. The reason is at low pressure, the mean free path of gas becomes greater than effective thickness of gas film which is important to the heat transfer mechanism in this research. And, carbon fibers have been used to try to enhance the poor thermal conductivity of TL-492. Three types of carbon fibers and three mass fractions have been examined and compared. Naturally, the highest effective thermal conductivity has been reached with carbon fiber which has highest thermal conductivity, and highest mass fraction. This method has acquired 4.33 times higher thermal conductivity than pure metal hydrides with quite low quantity of additives, only 0.99 wt% of carbon fiber. This is a good result comparing to other method which can reach higher effective thermal conductivity but needs much higher mass fraction of additives too.

Human Adjuvant Disease 의 임상적 고찰

배상철(Sang Cheol Bae),이인홍(In Hong Lee),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),최희윤(Hee Youn Choi),주경빈(Kyung Bin Joo) 대한내과학회 1992 대한내과학회지 Vol.43 No.2

N/A Background: Human adjuvat disease means the autoimmune disease or autoimmune disease like syndrome developed after plastic surgery using foreign body implantation. After 1st report of HAD by Miyoshi at 1964, a number of cases have been reported especially from Japan. However, there has been no report regarding HAD in Korea. Authors report 12cases of HAD which were experienced recently, Methods: 12patients who represented autoimmune disease or autoimmune disease-like syndrome after plastic surgery using foreign body implantation were evaluated clinically. Results: 1) The mean interval from plastic surgery to onset of HAD was 14.9years. 2) Eight of tweleve patients had undergone rhinoplasty and paraffin was most frequently used. 3) Seven of our patients were given the diagnosis of rheumatoid arthritis and the others were unclassified HAD. 4) Five patients underwent the operation to remove foreign material, Only one was improved. Conclusion: In korea, there has been done a number of plastic surgery using paraffin or silicone, So we have to concern about HAD after plastic surgery using foreign body implantation.

전신성 류마티스 질환에서 항 ENA 항체에 관한 연구

배상철(Sang Cheol Bae),송관규(Gwan Gyu Song),이인홍(In Hong Lee),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),김신규(Thin Kyou Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.4

N/A Objectives: Among a variety of nuclear antigens, extractable nuclear antigens(ENA) which can be extracted from nuclei by homogenization in neutral saline contain ribonucleoprotin, Sm, SS-A/Ro, SS-B/La and other antigens. Characterization of anti-ENA anti-bodies provides information about nosology, subset definition within diseases, clinical activity, specific organ involvement and prognosis. Methods: Authors have used double immunodiffusion test to detect antibodies to ENAs and studied the frequencies of autoantibodies to these antigens and their correlation with clinical and laboratory features in systemic rheumatic diseases. Results: 1) 1,063 patients were investigated for the presence of serum antibodies to ENAs and 180 out of 1,063 patients (16.9%) had anti-ENA antibodies. 3,412 tests were performed for the presence of antibodies to Sm, RNP, Ro, La, Scl-70 and Jo-1 respectively and 230 out of 3,412 tests (6.7%) were positive. 2) The profiles of 137 patients who had anti-ENA antibodies are systemic lupus erythematosus (61), rheumatoid arthritis with secondary Sj6gren's syndrome (26) and without secondary Sjogren's syndrom (9), mixed connective tissue disease (18), scleroderma (10), polymyosits/dermatomyositis (6), undifferentiated connective tissue diease (4), gout (1), fibromyalgia syndrome (1) and Hashimoto's thyroiditis (1). 3) The frequencies of antibodes to ENAs were 73.5% in patiets with systemic lupus erythemtosus, 9.6% in rheumatoid arthritis, 100% in mixed connective tissue disease, 71.4% in scleroderma and 46.2% in polymyostis/dermatomyositis. 4) The frequencies of antibodies to Sm, RNP, Ro and La in patients with systemic lupus erythematosus were 18.1%, 41.5% 43.9% and 4.9% respectively. (1) Patients with anti-Sm antbodies had a higher incidence of pleuritis than those without anti-Sm antibodies(p=0.029). (2) Patients with anti-RNP anibodies had a higher incidence of Raynaud's phenomenon and pleuritis and a lower incidence of renal disease than those without anti-RNP antibodies (p=0.008, p=0.019, p=0.029). (3) Patients with anti-Ro antibodies had a higher incidence of thrombocytopenia than those without anti- Ro antibodies. (4) There were no clinical and laboratory differences between patients with anti-La antibodies and without anti-La antibodies. 5) In patients with rheumatoid arthritis, anti-Ro anti-body was likely to be associated wih secondary Sjogren syndrome, although statistically significant association was not found (p=0.063). Conclusions: These results showed that the detection of antibodies to ENAs by double immunodiffusion test was expected to be a useful diagnostic marker and predict some clinical features in systemic rheumatic diseases.

전신성 류마티스 질환에서 항인지질항체에 관한 연구

배상철(Sang Cheol Bae),정성수(Sung Soo Jung),송관규(Gwan Gyu Song),이인홍(In Hong Lee),장현규(Hyun Kyoo Jang),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),김신규(Think You Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.5

N/A Objectives: The antiphospholipid antibodies (APA) are associated with a clinical syndrome of vascular thrombosis, thrombocytopenia, recurrent fetal loss and neurological manifestations. This has been studied by several investigators for systemie lupus erythematosus but no systematic study has been reported for the correlation between a variety of systemic rheumatic diseases including rheumatoid arthritis and antiphospholipid antibodies in Korea. Methods: Authors have used enzyme-linked im-munosorbent assay (ELISA) to detect antibodies to phopholipids and studied the frequencies of antibodies to these antigens and their correlation with clinical and laboratory features in systemic rheumatic diseases. Resulta: 1) 206 patients were investigated for the presence of antibodies to phopholipids and 25 out of 206 patients (12. 1%) had antiphospholipid antibodies. 2) The frequencies of antibodies to phopholipids were 20.7% in patients with systemic lupus erythematosus, 12.3% in rheumatoid arthritis and 16.7% in mixed connective tissue dsease but antibodies to phospholipids were not detected in ankylosing spondylitis, polymyositis/ dermatomyositis, undifferentiated connective tissue disease and Behcet's disease. 3) In patients with systemic lupus erythematosus, no significant association was found between antiphos-pholipid antibodies and clinical and laboratory features except thrombocytopenia and anti-Ro antibody (p=0.003, p=0.036). But patients with antiphopholipid antibodies were likly to have a higher incidence of malar rash, photosensitivity, alopecia, neurologic manifestation, renal disorder, fetal loss and thrombosis than those without antiphospholipid antibodies. 4) In patients with rheumatoid arthritis, no significant association was found between antiphospholipid antibodies and clinical and laboratory features. Conclusions: These results showed that the detection of antibodies to phospholipids by ELISA was expected to be useful as a screening test and suggested that antiphospholipid antibody found in rheumatoid arthritis patients differed from that seen in systemic lupus eryth-ematosus patients. Further studies into the fine specificity of antiphospholipid antibody in various systemic rheumatic diseases are needed.

류마티스 관절염 환자에서 N-(2-Mercapto-2-methylpropionyl)- L-cysteine (SA96)의 임상시험

배상철 ( Bae Sang Cheol ),이인홍 ( Lee In Hong ),유대현 ( Yu Dae Hyeon ),김성윤 ( Kim Seong Yun ) 대한내과학회 1993 대한내과학회지 Vol.44 No.3

연구배경 : SA96은 D-penicillamine의 화학구조에서 thiol기를 변형시켜 일본에서 처음으로 개발된 새로운 DMARD의 일종으로, 한국인에 있어서 류마티스 관절염에 대한 SA96의 치료효과 및 안전성을 평가하기 위해 본 연구를 시행하였다. 방법 : 대상환자는 1987년 개정된 ACR 진단기준에 의거한 류마티스 관절염 환자 30명을 대상으로 SA96 100mg를 하루 3회, 총 16주간 투여하였다. 그리고 NSAID 및 경구용 스테로이드(prednisolone 환산량 1일 7.5mg 이하)의 병용요법은 허용하였으나, 관찰기간내 약제의 종류 및 용량은 변경하지 않았다. 결과 : 임상평가 항목 즉, Ritchie 지수, 동통 관절수, 종창 관절수, 아침 강직의 지속시가, 15m 보행시간 및 혈침속도는, 대부분 SA96투여 8주후부터 통계학적으로 유의한 변화를 보였다. 1) 최종 전반 개선도는, 중등도 개선이상을 나타낸 경우 13예(43%), 경도 개선이상을 나타낸 경우는 22예(73%)였다. 2) 개괄 안전도는, 부작용이 없었던 경우가 16예(53%), 약간의 부작용이 있었던 경우가 10예(33%)였다. 3) 유용성은 중등도 유용이상이 10예(34%), 경도유용이상은 16예(54%)였다. 결론 : 이상의 결과를 종합해 볼때, SA96은 류마티스 관절염 치료에 유용한 약물로 사료되나, 보다 광범위하고 장기적인 임상시험이 필요하다고 본다. Background : SA96 is a new antirheumatic drug which was developed in Japan. A number of clinical studies has been demonstrated that SA96 is effective and safe in the treatment of rheumatoid anthritis (RA) with mild adverse reactions. However, there has been no experience in SA96 on RA outside of Japan. This study was performed to evaluate the clinical efficacy and safety of SA96 in patients with RA in Korea. Methods : 30 patients with RA who fulfilled 1987 revised criteria of American College of Rheumatology (ACR) were selected and were given 300mg/day of SA96 for 16 weeks or longer by the non double blind method. And the daily dosage was allowed to change method. And the daily dosage was allowed to change within the range between 100 and 600 mg depending on patients` compliances. Every patient was allowed to take nonsteroidal antiinflammatory drug (NSAID) and/ or steroid (less than 7.5mg/day of prednisolone), provided that the dosage was kept constant for the duration of this clinical trial. Results : In the clinical evaluastion items, it showed statistically significant improvements in Ritchie index, the number of painful joints, the number of swollen joints, morning stiffness, 15m walking time and ESR by the 8th week of drug administration. 1) Final global improvement 4 patients (13%) were assessed as markedly improved, 9(30%) as moderately improved, 9(30%) as slightly improved and 8 (27%) as unchanged. An rating of slightly improved or better was seen in 22 patients (73%). 2) Overall safety Adverse reactions were experienced in 14 patients (47%), mild adverse reactions in 10 (33%), moderate adverse reactions in 2(7%) and severe adverse reactions in 2 (7%). 3) Usefulness Considering final global improvement and overall safety, 3 patients (10%) revealed markedly useful, 7 (24%) moderately useful, 6(20) slightly useful, 9 (30%) indecisive, 3(10%) slightly unfavorble, 1 (3%) moderately unfavorable and 1 (3%) markedly unfavorable. 54% (16 out of 30) revealed mild or better useful. Conclusion : SA96 is expected to be one of the useful DMARDs in the treatment of RA. However, further large scale, long-term follow up clinical trials are required.

부정경쟁방지법상 미등록 디자인 보호강화를 위한 개선방안

배상철(Bae, Sang Chul) 세창출판사 2009 창작과 권리 Vol.- No.55

The anti-counterfeiting provision in Korean Unfair Competition Prevention Act (hereinafter "Korean Act") as amended in 2004, which was intended to protect against dead copy of shape of goods, was enacted with reference to the anti-counterfeiting provision to protect against dead copy of shape of goods in Japanese Unfair Competition Provention Act (hereinafter "Japanese Act") as amended in 1993. After 12 years of the enforcement of the first anti-counterfeiting provision passed, Japan introduced dramatical changes on the Japanese Act, including clarification of the civil regulation and introduction of criminal penalties, reflecting discussions made among academia and in case laws. In this regards, this study proposes some amendments on the anti-counterfeiting provision against dead copy of shape of goods in the Korean Act, by analyzing key amendments in the Japanese Act and considering the Korean Act in light of the discussions made in academia and case laws since the Act's enactment four years ago. The proposed amendments in this study are based upon the problems and deficiencies necessary to be improved.

기술적 표장의 판단기준에 관한 판례분석

배상철(Sang-chul Bae) 세창출판사 2004 창작과 권리 Vol.- No.36

Whether the specific marks should have corresponded to the descriptive marks must be considered only conception of marks but also indication of figure. Therefore, this article tries to observe the judgement standards, for example judgement subject, degree, and method, etc. or whether it is described with commonly used methods in terms of judging the descriptive mark.

전신홍반루푸스 환자에서 발생한 피막성 경화복막염

배상철 ( Sang Chul Bae ),박주현 ( Joo Hyun Park ),장한얼 ( Han Eol Chang ),이주현 ( Joo Hyun Lee ),김유선 ( You Sun Kim ),나종천 ( Jong Chum Nah ),윤보영 ( Bo Young Yoon ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.1

Sclerosing encapsulating peritonitis (SEP) is characterized by peritoneal fibrosis and adhesion of the peritoneum with the loops of the small intestine. Although the prevalence is low, most cases are caused by peritoneal dialysis, infection, medication, systemic lupus erythematosus (SLE), and intra-abdominal neoplasm. We describe a 22-year old man who was presented with abdominal pain and distension, which were attributed to SLE with peritonitis. He had no specific history of previous medical illness and peritoneal dialysis. He was treated with intravenous high dose methylprednisolone 1 g/day for 3 days, followed by intravenous methylprednisolone 1 mg/kg daily and immunoglobulin. However, his symptoms did not improve. Eventually, a laparoscopic biopsy was performed for an accurate diagnosis. The histopathologic findings were presented in accordance to the typical characteristics of SEP. In spite of medical treatment, he did not show an improvement of clinical symptoms and radiologic findings. As a result, he died from nutritional deficiency, upper gastrointestinal bleeding, and congestive heart failure.

디자인보호법상 무심사등록제도의 문제점 및 개선방안

배상철 ( Bae Sang Chul ) 한국지식재산연구원 2007 지식재산연구 Vol.2 No.1

Under exam system, KIPO introduced a unexam system to get design-right earily in 1998. In present design-law, double track systems, which substantial exam system is primary and unexam system is secondary are formed. Class of B1, C1, F3, F4, M1 are the unexamined design's articles. Some of item included each class has been superfluous as a unexam design, and the article to specify a unexam design has been appered due to circumstance and technical change. To improve matters of unexam registration system and establish stablily, coordinating unexam design's article is a main subject. Therefore, a study will review the problem of unexam registration system and grope the revision.

국내 류마티스 질환의 유병률 조사 현황

배상철 ( Sang Cheol Bae ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.1