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배병기 ( Byung Gi Bae ),류동진 ( Dong Jin Ryu ),정기양 ( Kee Yang Chung ),김희정 ( Hee Jung Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6
Erosive pustular dermatosis of the scalp is a rare disorder of the elderly and it is characterized by pustular, erosive and crusted lesions of the scalp with progressive scarring alopecia. The predisposing factors have been reported to be trauma, including mechanical trauma, skin grafting, surgery and prolonged exposure of a bald scalp to UV light. Yet the laboratory data, the bacteriological and mycological investigations and the histopathologic findings of the previously reported cases were generally negative and not diagnostic. We herein present a case of erosive pustular dermatosis of the scalp that occurred after mechanical trauma on the previous skin graft site. This type of case has not been previously reported in the Korean dermatologic literature. (Korean J Dermatol 2009;47(6):702∼705)
외인성 아토피피부염과 내인성 아토피피부염 환자의 말초혈액 단핵세포와 피부 병변에서 IL-3와 FcεRI 발현의 차이
김산 ( Shan Jin ),노성민 ( Seong Min Noh ),배병기 ( Byung Gi Bae ),박창욱 ( Chang Ook Park ),이광훈 ( Kwang Hoon Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.6
Background: A small subgroup of atopic dermatitis (AD) patients show low total and allergen-specific immunoglobulin (IgE) levels. This subgroup has been termed ``intrinsic`` AD (IAD) as compared to its counterpart ``extrinsic`` AD (EAD). However, the difference of cytokine expression between IAD and EAD has not been fully understood. Objective: To compare the expression of various inflammatory cytokines in the peripheral blood mononuclear cells (PBMCs) and lesional skin of patients with IAD and EAD, which are known to be associated with AD pathophysiology. Methods: We assessed the protein levels of cytokines in the PBMCs and lesional skin. We evaluated the levels of IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, FcεRI and FcεRII from the PBMCs and lesional skin of patients with IAD and EAD. Results: The patients with EAD had elevated levels of the IL-3 expression in their PBMCs and elevated levels of FcεRI in their lesional skin compared to that of the patients with IAD. The expression of other cytokines did not differ in the PBMCs and lesional skin from the two subgroups. Conclusion: This study suggests that IL-3 could be associated with the pathophysiology of EAD as compared to that of IAD, along with FcεRI which was previously shown to be highly expressed in EAD patients. (Korean J Dermatol 2011;49(6):491∼498)
올브라이트 유전성 골이영양증의 진단에 실마리가 된 피부 골종
류동진 ( Dong Jin Ryu ),오상호 ( Sang Ho Oh ),한은천 ( Eun Chun Han ),배병기 ( Byung Gi Bae ),이주희 ( Ju Hee Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.4
Albright`s hereditary osteodystrophy (AHO) has a broad spectrum of physical findings, including short stature, flattened nasal bridge, round facies, obesity, skeletal anomalies of the hands with brachydactyly, osteoma cutis, mental retardation, dental defects, cataracts, and calcification in the basal ganglia. It also includes endocrinologic abnormalities such as pseudohypoparathyroidism and pseudopseudohypoparathyroidism. Primary osteoma cutis, which can precede other physical findings of AHO, might be a diagnostic clue for AHO. Therefore, close follow-up and regular laboratory tests should be done to detect the early development of AHO in young children with primary osteoma cutis. Early diagnosis and treatment of AHO can prevent irreversible mental retardation and developmental delay. (Korean J Dermatol 2009;47(4):435~438)