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당뇨병환자에서 동맥경화증의 병인에 관여하는 내피세포 및 혈소판의 기능에 관한 연구
우종욱(Chong Wook Woo),김현수(Hyun Soo Kim),홍대식(Dae Sik Hong),박희숙(Hee Sook Park),유명희(Myung Hi Yoo),김극배(Guk Bae Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A Atherosclerosis is well known as a major complication in diabetes. To investigate the role of platelet function, Factor VIII: vWF and prostacyclin in the pathogenesis of atherosclerosis in diabetes, we performed a platelet function test and measured PGF 1 which is a metabolite of prostacylin, Factor VIII: vWF and thromboxande B2 in 15 patients with diabetes and 10 normal controls. The platelet function test showed that ADP-induced platelet aggregation was significantly enhanced in diabetic patients with retinopathy (80.6±11. 45% vs 42.6±8.71%, p<0.05) compared with normal controls, but collagen induced platelet aggregation or platelet adhesiveness showed no significant difference between diabetic patients and normal controls. The plasma Factor VIII R: Ag level in diabetic patients as not signficantly different from normal controls while plasma Factor VIII: vWF in diabetic patients was significantly increased compared with normal controls (51.33±5.33% vs 27.50±6.71%, p<0.05) The prostaglandin F1α level was signficantly decrease in diabetic patients (2.01±0.32 pg/tube vs 3. 17±0.48pg/tube, p<0.05), while the plasma thromboxane B2 level showed no signficant difference between diabetic patients and normal controls. Our data showed that the increase plasma Factor VIII: vWF level and decrease PGF1α level as well as abnormal platelet function may contribute to the mechanism of atherosclerosis in diabetic patients.
朴姬淑,金重明 慶北大學校 醫科大學 1972 慶北醫大誌 Vol.13 No.2
In order to study inhibitory effects of DDS, Ciba 1906, INHA and SM in experimentally infected murine leprosy, 102 mice were used: two mice were used for control 50 mice were inoculated subcutaneously at the right side of the lower abdomen and were designated as the group A, another 50 mice were inoculated mycobacteria subcutaneously at the right side of the back and designated as the group B. Each group A and B were divided into 5 subgroups for the control, DDS, Ciba 1906, INAH and SM and were adminstered with respective drug to each subgroup. Group A was observed by spreading method and group B observed by the leprom size. The results were as follows; A. Results of spreading method: 1) The mycobacteria inoculated were observed in the monocytes and polymorphonuclear cells as fine masses on the next day of inoculation. 2) In the control group, the mycobacteria in the monocyte on the 2nd week of inoculation were more elongated and increased in number. There were much increase in number of moncytes and decreas of polymorphonuclear cells. The above feature was more clearly observed on the 4th week of inoculation. The preparation of the spreading method was impossible because of formation of the leprom. 3) Only the INAH was to seem to be effective on the 2nd and 3rd week and the DDS, Ciba 1906 and SM show no inhibitory effect, B.Results of the leprom formation: 1) In the control group, on the 4th week 3 mice began to form leprom and on the 6th week it was formed in all of the mice and on the 8th grow to 18th week, it to maximum size. There was ulcer formation in 5 mice. 2) In the DDS group, on the 4th week the leprom was observed only in one mouse on the 6th week the leprom was found in all of them and reached the maximum size, on the 6th to 16th week. The ulcer was observed only in one mouse. 3) In the Ciba 1906, on the 2nd week the leprom was found only in one mouse, and on the 4th week in 7 mice, and on 6th week it was found in all mice, of the group and reached to maximum size on the 16th week. 4) In the INAH group, on the 4th week the leprom was observed in one mouse but it disappeared on the 6th week and appeared again on the 8th to 10th week and disappeared again on the 12th week and reappeared on the 18th week. In one other mouse, small leprom was found on the 14th week and durated to the 18th week, in other 2 mice the leprom was found on the 18th week. 5) In the SM group, on the 6th week leprom was observed in 2 mice, and on the 10th week it was found in all mice, and they were grown gradually to maximum size in the 18th week. 6) In inhibitory effect of INAH against the experimental murine leprosy was the strongest among the drugs tested.
이성실,박희숙 한국아동교육학회 2004 아동교육 Vol.13 No.1
본 연구는 음악교육의 중요성이 부각되고 다양한 음악교육 과정의 개발과 교수법에 대한 관심이 증대함에 따라 유아교육현장에서 다루어지는 음악적 경험은 유아들의 지적 ? 정서적 측면의 발달에 대한 인식이 높아지고 있으므로, 유치원에서의 효과적인 유아음악교육의 방법을 제시하기 위해 첫째, 유아음악교육의 목적을 여러 측면에서 검토하였으며, 둘째, 유아음악교육의 내용에서 다루어야할 영역에 대해 살펴보았으며, 마지막으로 유치원현장에서 효과적으로 적용될 수 있는 생활주제별 음악 계획안을 제시하였다. In order to suggest an effective method of music education in kindergarten, this study investigated the aims of early music education, identified the scope of the content of early music education and thereby suggested effective means by which music can be taught as a life subject in kindergarten.