치자약침(梔子藥鍼)이 실험적(實驗的) 백서(白鼠)의 간손상(肝損傷)에 미치는 영향(影響)

박희수,박정현,Park, Hee-Soo,Park, Joung-Hyun 대한약침학회 2000 Journal of pharmacopuncture Vol.3 No.2

This is the study of the effects of Aqua-acupuncture with Gardeniae Fructus on thc recovery of rat's liver which was damaged by 0.3ml/ea of $CCI_4$. Rats were divided into 4 groups; Normal-group(None treated group), Control-group(Not treated after $CCI_4$-intoxicated), Exp. I(Treated with Saline Aqua-acupuncture after $CCI_4$-intoxicated) and Exp. ll(Treated with Gardeniae Fructus Aqua-acupuncture after $CCI_4$-intoxicated). Biochemical assays for each serum enzyme activities of AST, ALT, Albumin, LDH, ${\gamma}$-GT, TG and Total cholesterol were performed. The results were summarized as follows: 1. AST activities in serum significantly decreased in the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In companson with Saline-treated group after $CCI_4$-intoxicated, the Gardeniae Fructus Aqua-acupuncture treated group *The professor of Dept. of Acupuncture & Moxibustion, 2. At T activities in serum significantly decreased in the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In com pan son with Saline-treated group after $CCI_4$-intoxicated, the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated worked effectively to rat's damaged liver. 3. Albumin in serum increased in the Gardeniae Fructus Aqua- acupurkture treated group after $CCI_4$-intoxicated. 4. LDH in serum significantly decreased in the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In comparison with Saline-treated group after CClcintox icated, the Gardeniae Fructus Aqua acupuncture treated group after $CCI_4$-intoxicated worked highly effectively to rat's damaged liver. 5. ${\gamma}$-GT In serum significantly decreased In the Gardeniae Fructus Aqua-acupuncture trea ted group after $CCI_4$-intoxicated. In compan son with Saline-treated group after $CCI_4$-intoxicated, the Crardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated was not recognized significantly. 6. TG in serum significantly decreased in the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In comparison with Saline-treated group after $CCI_4$-intoxicated, the Gardeniae Fructus Aqua -acupuncture treated group after $CCI_4$-intoxicated worked highly effectively to rat's damaged liver. 7. Total cholesterol in serum decreased in the Gardenias Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In comparison with Saline-treated group after $CCI_4$-intoxicated, the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated worked highly effectively to rat's damaged liver. The results from ahove show that the Gardeniae Fructus Aqua- acupuncture has highly effects on the damaged liver caused by $CCI_4$. Therefore it is expected that the Gardeniae Fructus Aqua- acupuncture could be used to cure the damaged liver.

우슬(牛膝)의 관절염(關節炎) 치료(治療) 효능(效能)에 관(關)한 서지학적(書誌學的) 고찰(考察)

박희수,신선호,장통영,Park, Hee-Soo,Shin, Sun-Ho,Chang, Tong-Young 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.5

According to herbalogical bibligraphy and literature, therapeutic effects of Achyranthis Radix on arthritis was as follows, 1. Achyranthis Radix of Amaranthaceae is divided into five species-Achyranthes japonica, A. bidentata, A. longifolia, A. fauriei, Cyathula capitata, C. officialis and the characteristic, taste, channel entry, effects and main treatments were alike. 2. Winefrying stood for repairing treatement method for Achyranthis Radix Before repairing treatment method, Achyranthis Radix had three tastes(bitter, sour, and sweet) and calm and not poisoning characteristic. After repairing treatment method, the bitter taste was disappeared, and calm and not poisoning characteristic was changed into warm characteristic. 3. Effects of Achyranthis Radix were quicking the blood and dispelling stasis, liver-kidney supplement and strengthening musculo-skeletal system. Main treatments were relief of lumbar and knee joint pain, static menstrural block and wind-cold- damp impediment. 4. Contraindication of Achyranthis Radix was sympthom caused by spleen-kidney yang vacuity, upper burner disease and lower burner hemorrhage etc. Being used in pregnant woman, it could incur abortion. 5. Contraindication of Achyranthis Radix was beef, milk and mutton. It's fear was Radix Cynanchi Stauntonii and Semen Plantaginis. It's aversion was the firefly. Herba Taraxaci, Carapax Amydae, Carapax Testudinis and Radix Cynanchi Stauntonii. From above results, I suppose Achyranthis Radix has enough herbalogical foundation and could be used to treat arthritis and it is necessary to make a profound study of it.

적작약약침(赤芍藥藥鍼)이 Rat의 Adjuvant 관절염(關節炎)에 미치는 영향(影響)

박희수,손승현,Park, Hee-Soo,Sohn, Seong-Hyoun 대한침구의학회 2000 대한침구의학회지 Vol.17 No.1

To investigate effects of Paeonia Radix Rubra aqua-acupuncture on Adjuvant Athritis in rats, the edema rate, the number of WBC, the quantity of total protein, albumin and globuline in the blood serum were measured and histological test of the muscular tissue were done in the arthritis part. 1. After arthritis of Sprague dawley(SD) rats was induced by injecting Freund's complete adjuvant for 2 weeks, normal saline was injected for the Control group and Paeonia Radix Rubra acua-acupuncture was injected for the Exp. group during 30 days. Selected point was $D{\acute{u}}bf(ST_{35})$ in both groups. And then the inframmator volume of plantar were checked. The volume of the plantar was $0.84{\pm}0.14mm$ in Control group and $0.57{\pm}0.09mm$ in Exp. group, the swelling of plantar was restricted significanily in Exp, group(P<0.05). 2. The number of WBC was $10.34{\pm}0.14(10^3/ml)$ in normal group and $37.47{\pm}5.46(10^3/ml)$ in Control group. It was $25.21{\pm}3.45(10^3/ml)$ in Exp. group. This fact showed that Exp group. with Paeonia Radix Rubra acua-acupuncture was more effective than Control group in the treatment of arthritis(P<0.05). 3. The content of total protein in the blood serum were $6.14{\pm}0.43g/d{\ell}$ in normal group, $7.95{\pm}0.94g/d{\ell}$ in Control group, and $6.82{\pm}1.23g/d{\ell}$ in Exp. group. There was no significance in total protein between Exp. group and Control group from the statistical analysis. 4. The contents of albumin in the blood serum were $2.94{\pm}0.13g/d{\ell}$ in normal group, $2.01{\pm}0.48g/d{\ell}$ in Control group and $2.75{\pm}0.14g/d{\ell}$ in Exp, group. This fact showed that Exp. group had significant increase in the serum albumin from the statistical analysis, in comparison with Control group(P<0.05). 5. The contents of globulin in the blood serum were $3.19{\pm}0.48g/d{\ell}$ in normal group, $4.70{\pm}1.26g/d{\ell}$ in Control group and $3.58{\pm}0.73g/d{\ell}$ in Exp. group. There was no significance in the serum globulin between Exp. group and Control group from the statistical analysis. 6. In histological examinadon, because inflammatory reaction was active, remarkably irregular tissue and large amount of inflammatory cells were found in Control. group. But Exp. group showed that tissues were in some degree recovered, the number of inflamed cells was decreased and inflammation was restrained. From these results, it is shown Paeonia Radix Rubra aqua-acupuncture restrained inflammatory reaction and muscular tissue necrosis in SD rat's plantar was restrained by Freund's complete adjuvant.

전래(傳來) 한방(韓方) 경험방(經驗方) 및 가전(家傳) 비법(秘法) 수집

박희수,Park, Hee-Soo 대한약침학회 2004 Journal of pharmacopuncture Vol.7 No.3

Background & Objective : Through the long-term clinical examination experience, interesting informations have been found and passed on to future scholars, enabling research and development without going through the same lengthy procedure, hoarding these precious information to be discovered and preserved as a contribution to Oriental Medical Science. Methods : Personal interviews with seventy-years-old practicing oriental medicine doctors and herbalists with more than 30 years of practice in Gangwon-do, Chungcheongbuk-do, Chungcheongnam-do, and Daejeon area from September to December 2002

중완(中脘) 자침(刺鍼)이 indomethacin 유발 소화기 질환 SD-rat 뇌(腦)의 NADPH-diaphorase 신경세포에 미치는 영향

박희수,Park, Hee-Soo 대한약침학회 2003 Journal of pharmacopuncture Vol.6 No.2

Objective : This study was carried out to systemically investigate the effect of Joongwan(中脘; CV12) acupuncture in cerebrum and cerebellum of indomethacin-induced gastrointestinal disease in SD-rats. Method : 1. We induced gastrointestinal disease by indomethacin oral administration in SD-rats. 2. We selected Joongwan(中脘; CV12) acupuncture point that generally have been used to treat gastrointestinal disease. 3. We categorized SD-rats into three groups as followings. (1) Normal group : The group without any management (2) Control group : The group with indomethacin-induced gastrointestinal disease (3) Treated group : The group that Joongwan(中脘; CV12) acupuncture was performed after inducing gastrointestinal disease 4. We figured out the effect of acupuncture by analyzing staining degree of NADPH-diaphorase in cerebrum and cerebellum. Results : 1. Cerebrum (1) Normal group : The degree of staining was very low. (2) Control group : NADPH-diaphorase was mainly stained in cerebral cortex and the stained region was wider than Normal group. (3) Treated group : The degree and region of staining was higher and wider than the other goups. Sometimes the intensively stained regions were observed. 2. Cerebellum In both cases of Control group and Treated group, the regions in cortex were stained mainly. But, between Control group and Treated group, there was no remarkable difference. Conclusion : In case of cerebellum, there was no remarkable result. On the other hand, in case of cerebrum, there were certain differences among three groups. Through those results, we could conclude that Joongwan(中脘; CV12) acupuncture treatment was able to affect NADPH-diaphorase expression in the cerebrum of SD-rats that have gastrointestinal disease with indomethacin-inducing.

자침(刺鍼)이 마취(痲醉)에 미치는 작용기전(作用機轉) 연구(硏究) (제(第) 1 보(報)) - 뇌파를 중심으로 -

박희수,박경식,Park, Hee-soo,Park, Kyoung-sik 대한침구의학회 2002 대한침구의학회지 Vol.19 No.4

This study was carried to identify whether acupuncture at several meridian points can affect the human anesthesia or not using the EEG mapping. We observe the change in the brain wave patterns obtained by electroencephalogram after acupuncture. 1. It is concluded that the pattern of resting computerized EEG map in intact human is normal and acupunctuation at determined meridian points induced lesser narrow field of alpha activity, more extensive field of ${\delta}$, ${\theta}$ activity, father resulted in marked shift to cerebrofrontal dominance in field of ${\delta}$, ${\theta}$ activity by t-SPM. 2. It seems likely that acupunctuation at experimental meridian points acts on slight anesthesia or hypnosis.

Aspergillus spp.에서의 Velvet 조절자

박희수 ( Hee-soo Park ),유재혁 ( Jae-hyuk Yu ) 한국미생물생명공학회(구 한국산업미생물학회) 2016 한국미생물·생명공학회지 Vol.44 No.4

사상성 진균인 Aspergillus spp.은 환경 속에서 흔히 찾을 수 있는 진균으로 인류에 유익한 역할을 주기도 하지만 병원성을 일으키기도 한다. 대부분의 Aspergillus spp.는 무성 포자를 생성하여 번식을 하며 다양한 이차 대사 산물을 합성한다. 여러 연구에 따르면 Velvet 조절자들은 진균 특이적 전사 인자로 모델 진균인 Aspergillus nidulans의 성장, 분화 및 이차 대사산물 생성 등 다양 한 부분에서 중요한 역할을 한다고 보고되었다. 또한 Velvet 단백질들은 다양한 복합체를 형성하며, 이 복합체들은 Aspergillus nidulans에서 다양한 역할을 한다. 다른 Aspergillus spp.에서 Velvet 단백질들은 매우 유사한 구조를 가지며 진균의 무성 생식과 이차 대사를 조절한다. 이번 논문에는 Aspergillus spp.의 Velvet 단백질들의 기능에 대하여 요약하였다. Filamentous Aspergillus spp. are the most common fungi in our environment and can be beneficial and/or pathogenic to humans. Many Aspergillus spp. reproduce by forming asexual spores and can synthesize various secondary metabolites. A series of studies has revealed that Velvet regulators are fungus-specific transcription factors coordinating fungal growth, development, and secondary metabolism in the model fungus Aspergillus nidulans. Proteins of the Velvet family form various complexes that play diverse roles in the life cycle of A. nidulans. In other Aspergillus spp., proteins of this family are highly conserved and coordinate asexual development and secondary metabolism. This review summarizes the functions of Velvet proteins in Aspergillus spp.

도시정비사업에서 공공의 역할 강화요인의 중요도 평가

박희수(Park, Hee-Soo),송호창(Song, Ho-Chang),이주형(Lee, Joo-Hyung) 한국도시설계학회 2010 도시설계 : 한국도시설계학회지 Vol.11 No.2

본 연구는 최근 용산참사 사건 이후 도시정비사업 과정에서 발생하는 문제점과 갈등의 개선을 위해 사회적ㆍ제도적으로 공공의 책임 및 역할이 강조되고 있는 시점에서 향후 도시정비사업에 있어 공공부문의 역할을 강화하기 위한 방법과 우선적으로 개선할 부분에 대해 논의하였다. 연구방법은 크게 문헌조사와 전문가 브레인스토밍(brainstorming)과정 및 네트워크 분석적 의사결정(ANP)을 통해 이루어졌다. 연구결과, 향후 도시정비사업에서 공공의 역할을 강화하기 위해서는 사업의 공공성 확보 및 사업관리와 관련된 역할이 강화되어야 할 필요가 있는 것으로 나타났다. 세부적으로는 사업의 조정자(coordinator) 역할 강화, 사업성이 낮은 지역을 정비대상으로 강화, 표준 업무지침 및 가이드라인의 마련, 블록단위 정비추진, 지속적 운영관리, 세입자 대책강화, 초기 공공자금 투자 순으로 역할 강화방안의 중요도가 평가되었다. Recently, the responsibility and role of public sector are being emphasized to resolve the problems and conflicts, which were occurred in the Urban Redevelopment Project of Yongsan. This paper studied about the methods to intensify the role of public sector and improve the process of Urban Redevelopment Projects. The research methods consist of review of existing studies, brainstorming of experts and Analytic Network Process(ANP). The results show that the role of public sector concerning project management and public contribution must be strengthened in the Urban Redevelopment Projects. More specifically, the followings are suggested: reinforcement of public sector’s role as project coordinator, better management of projects with low economic feasibility, standardized guidelines and process, small unit redevelopment, consistent management of projects, better support for tenants, and the investment of public capitals in the early stage.

그람양성세균에 대한 새로운 퀴놀론계 항균제 Zabofloxacin의 항균력

박희수(Hee Soo Park),최동락(Dong-Rack Choi),정지웅(Ji-Woong Jeong),정성지(Sung Ji Jung),최응칠(Eung-Chil Choi),곽진환(Jin-Hwan Kwak),김효현(Hyo-Hyun Kim) 大韓藥學會 2011 약학회지 Vol.55 No.1

Zabofloxacin is a novel broad spectrum fluoroquinolone with excellent anti-pneumococcal activity. We investigated the in vitro activity of zabofloxacin against clinical isolates of gram-positive bacteria and the in vivo activity against systemic infection in mice. Zabofloxacin was very active against gram-positive bacteria except QRSA (Quinolone-resistant S. aureus) and VRE(Vancomycin-resistant Enterococci). Especially, zabofloxacin was extremely potent against clinical isolates of Streptococci. Zabofloxacin was as active as gemifloxacin against systemic infection in mice. In view of its improved antibacterial activities against gram-positive bacteria and good pharmacokinetic profiles in animals, the clinical usefulness of zabofloxacin should be established by further studies.

인지무선 시스템에서 아웃밴드 협력 스펙트럼 센싱

박희수(Hee-Soo Park),김양수(Yang-Soo Kim),우수민(Soo-Min Woo),반상우(Sang-Woo Ban),강법주(Bub-Joo Kang) 한국통신학회 2008 한국통신학회 학술대회논문집 Vol.2008 No.11