Expression of Clusterin in the Salivary Gland under Restraint Stress

박희경,전양현,홍정표,어규식,Park, Hee-Kyung,Chun, Yang-Hyun,Hong, Jung-Pyo,Auh, Q-Schick Korean Academy of Orofacial Pain and Oral Medicine 2008 Journal of Oral Medicine and Pain Vol.33 No.3

The belief that stress leads to illness has a long history. A number of the orofacial disease are also closely associated with stress. Despite research in the relationship of stress and the orofacial diseases leading to statistically significant correlations, the pathology remains vague. In the present study, the expression of clusterin, a stress protein responsible for antiapoptosis and cytoprotection, under restraint stress condition was observed in the submandibular gland, one of the major salivary glands. Sprague-Dawley rats were divided into 2 groups: normal group and restraint stress group. The rats of restraint stress group were placed in the stress cages and then sacrificed at day 0, 3 and 5 day of the experiment. After that, the submandibular glands of all the rats were excised immediately. The levels of clusterin proteins and mRNA in the tissues were measured by immunohistochemistry and Northern blot analyses, respectively. The results were as follows: 1. In the immunohistochemistry, clusterin protein was detected only immediately after the application of restraint stress. 2. In the restraint stress group, at day 3 and 5, histologically apoptosis was induced with karyorrhectic and pyknotic changes. 3. By the restraint stress, acinic cells were destructed earlier than ductal cells. 4. In the Northern blot, mRNA of clusterin was expressed only immediately after the application of restraint stress. The overall results suggest that as an early response to stress, clusterin is expressed in the glands to protect the glandular cells from the stress. But if stress is so strong and prolonged that it can exceed the stress adaptability of the cells, then the cells may undergo apoptosis instead of producing clusterin. An Epidemiologic Study of Symptoms of Temporomandibular Disorders in Korean College Students.

유량의 변화에 따른 탈산소계수 및 재폭기계수가 임계용존산소량에 주는 영향

박희경,남궁완 ( Hee Kyung Park,Wan Namkoong ) 한국물환경학회 1995 한국물환경학회지 Vol.11 No.4

Wasteload allocations(WLA) and total maximum daliy load(TMDL) determined with the lowest streaflow(e.g., 7Q10) may violate water quality standards as streamflow increases. Traditionally, streamflow increase is considered to monotonically improve the worst water quality (e.g., dissolved oxygen) which occurs at the lowest streamflow. This conventional worst case assumption might not be held because of parameter changes with streamflow increase which include increased non-point source discharges, varying decay (k₁ and reaeration (k₂ coefficients and reduced residence times. These parameter changes were hypothetically tested here to see the possible violation of the assumption. The results of this study indicate that unless the dependence of decay coefficient on streamflow is high and positive($gt;0.11), the worst case assumption will be valid in most natural channels. However, in highly regulated and polluted streams, the possibility of the violation was also observed. Since some of our major streams are well regulated for many purposes and sometimes observed highly polluted, the study results suggest that use of the lowest streamflow might be inappropriate for wasteload allocations. Rather, a trial and error approach is suggested. The approach develops wasteload allocation plans; tests them for a number of low streamflow conditions; and finds a best one. For this, computer models will be iteratively used.

The Application of the Forensic Dental Identification to Unidentified Individual Remains in Korea

박희경,Park, Hee-Kyung Korean Academy of Orofacial Pain and Oral Medicine 2006 Journal of Oral Medicine and Pain Vol.31 No.1

The cases of unidentified individual remains submitted to Forensic dentistry section in National Institute of Scientific Investigation, Korea were analyzed to study the application of forensic dental identification into individual identification in the period 2002-2005. The identification cases of unidentified remains were 405 out of 493, which accounted about 82% of whole cases. The incidence of submission of skeletons at least including the skull was increased from 58% in 2002 to 80% in 2005. The numbers of cases for the full examinations were 4 times more than that for age estimation in 2005. Twenty-four cases were submitted for skull to photographic superimposition and 15 out of 24 cases were examined, and the other 9 cases were examined by DNA analysis only. The submitted cases for dental comparison were 23 cases, 9 cases were positively identified, 4 cases were possible, 7 cases were excluded, and 3 cases ended up with insufficient evidences. The proportion of positive identification by dental methods was increased gradually from 9% in 2002 to 46% in 2005. Forensic dental identification has become important and useful because the availability of dental records and radiographs has been increasing. Compared to DNA analysis, forensic dental identification has several advantages such as no needs for high cost equipments and low expenses. And the interpretation of results is straightforward and speedy. These advantages are based on using primary their own dental records of the individuals rather than secondary DNA reference samples from family members. The application of the forensic dental identification to unidentified individual remains will be increased because the dental comparison can complement the limitation of DNA analysis and skull to photographic superimposition in many cases. In order to obtain positive identifications of unidentified remains, a close collaboration between the police and forensic scientists is important. The systemic approach including legislation to preserve dental records of unidentified remains and missing persons for the identification of unidentified remains should be needed.

복막투석 중인 소아에서 발생한 서혜부 탈장의 임상상

박희경,정규환,문석배,정성은,박귀원,Park, Hee-Kyung,Jung, Kyu-Whan,Moon, Suk-Bae,Jung, Sung-Eun,Park, Kwi-Won 대한소아외과학회 2009 소아외과 Vol.15 No.2

Peritoneal dialysis (PD) has been utilized for the children with end stage renal disease. Nevertheless, it is thought to promote inguinal hernia by increasing intraabdominal pressure. To investigate the clinical characteristics of inguinal hernia in children on PD, 155 cases of PD in children between January 1996 and June 2007 at Seoul National University Children's Hospital were reviewed retrospectively. Inguinal hernia developed in 16 cases (10.3 %, M:F=8:8). Hernia occurrence was not correlated to age. Eleven cases (69 %) of inguinal hernia developed in first 6 months after initiation of PD. All inguinal hernias were surgically repaired. No complications occurred related to inguinal hernia or surgery. Recurrent hernia developed in 1 patient (6.3 %) of 2 cases who had PD postoperatively on the day of surgery. In conclusion, inguinal hernia developed more frequently with children on PD than general population (3.5~5 %). The rate of hernia development was highest within the first 6 months following initiation of PD. After repair of hernia, we recommend to discontinue PD immediate postoperatively to prevent recurrence.

국내 식품가공공장 현장에서의 살균소독제 유효성 평가

박희경(Hee Kyung Park),박병규(Byung Kyu Park),신혜원(Hye Won Shin),박대우(Dae Woo Park),김용수(Yong-Su Kim),조양희(Yang Hee Cho),이광호(Kwang-Ho Lee),강길진(Kil-Jin Kang),전대훈(Dae-Hoon Jeon),박기환(Ki-Hwan Park),하상도(Sang-Do Ha) 한국식품과학회 2005 한국식품과학회지 Vol.37 No.6

대한상하수도학회 `99 정기총회 및 학술발표회 / 보고 및 논문 : 수도산업화의 민영화

박희경(Hee Kyung Park),최동진(Dong Jin Choi) 대한상하수도학회 1999 1999년도 정기총회 및 학술발표회 Vol.- No.-

일상의 발견

박희경(Park Hee-Kyung) 한국카프카학회 2007 카프카연구 Vol.0 No.18

패밀리 레스토랑의 Yield Management 측정 척도 개발

박희경(Park, Hee Kyung),손대현(Sohn, Dehyun),박준용(Park, Juneyong) 한국문화관광학회 2004 문화관광연구 Vol.6 No.1

The Purpose of this paper is to constuct a scale for yield management in family restaurant. 46 yield management items identified by literature reviews, web sites analysis, and interviews with family restaurant employees. Reliability was conducted in prestudy, 24 items selected as a result. The present study choose 5 factors and 15 items by conducting validity analysis, reliability analysis, and factor analysis. 5 factors are time factor, reservation factor, service factor, VIP factor, and waiting factor. This scale could help to make marketing strategies by segmenting customers. Socio-economic factors, personal characteristic factors, communication behavior factors have to be considered when segmenting customers.

International session : Effect of chemically tailored GAC on THMFP of humic acid and surface chemistry

박희경 ( Hee Kyung Park ),( Tayyab Ashfaq Butt ) 대한상하수도학회 2004 공동추계 학술발표회 논문집 Vol.2004 No.-

유아 행복의 차원 구조 및 원형 구조: 어머니의 인식을 중심으로

박희경 ( Hee-kyung Park ),정계숙 ( Kai-sook Chung ) 한국유아교육학회 2017 유아교육연구 Vol.37 No.3

본 연구는 다양한 요인들로 구성된 유아 행복의 개념의 속성과 요인들 간의 관계를 확인하기 위해 유아 행복의 차원 구조와 원형 구조를 도출하는 것을 목적으로 하였다. 이를 위해 본 연구는 3세-5세 유아 777명을 연구대상으로 하여 이들 어머니에게 유아 행복요인을 측정하고자 설문지를 실시하였다. 이론적으로 검토된 유아 행복요인은 유아의 배경변인과 함께 부모의 경제력, 사회교육문화 환경, 가족관계, 또래관계, 교사와의 관계, 외모, 여가, 건강, 긍정적 의사소통, 몰입, 긍정정서, 자기수용, 영성, 강점 발휘, 회복력 등 15개 요인이었다. 수집된 자료는 SPSS 18.0을 활용하여 다차원척도법으로 분석되어 차원 구조를 도출하였고, 원형 구조는 Browne이 개발한 CIRCUM 프로그램을 활용하여 분석되었다. 그 결과, 유아 행복의 차원 구조는 3차원 구조가 적합한 것으로 나타났으며, 각 차원의 요인 특성에 따라 가족환경-개인 심리 차원과 상호 관계-개인 역량 차원, 가족여가활동-사회적 발달·교육 자원 차원으로 명명하였다. 또한 유아 행복의 원형 구조는 원형 구조 내에서 긍정적 의사소통, 긍정정서, 영성 등의 개인 심리 특성을 보이는 요인들이 유사군집을 보였으며, 이러한 유사군집과 교사관계, 또래관계는 부모의 경제력과 사회교육문화 환경 등 유아의 환경적 요인들과 원형에서 정반대에 위치해 관련성이 낮은 것으로 나타났다. 가족관계는 정반대에 위치하는 요인이 없어 대부분의 요인들과 관련성이 있는 것으로 나타났다. 이를 통해 유아 행복에 관한 이해와 이를 바탕으로 유아 행복을 위한 교육적 시사점을 제시하였다. The purpose of this study was to derive the multi-dimensional and circumplex structure of the constructs of preschoolers` well-being to understand diverse aspects of preschoolers` well-being which is composed of various factors. For this purpose, a total of 777 children aged 3 to 5 years old were included in the study and a survey was conducted with their mothers to measure the constructs of preschoolers` well-being and the demographic variables of the preschoolers. The collected data were analyzed to determine the means and standard deviations for the constructs of preschoolers` well-being. The mean for the constructs of preschoolers` well-being were converted into standardized scores and multi-dimensional scaling analysis were conducted using SPSS 18.0. In addition, the circumplex model was based on the CIRCUM program developed by Browne. The results were: First, the result that dimensional structure of preschoolers` well- being was the three-dimensional structure was composed of the dimension of the family environment and individual psychology and dimension of interrelationship and individual competence, family leisure activity and social development-educational resources. Second, as a result of examining the circumplex structure of preschoolers` well-being after integrating the structure with the two-dimensional structure of preschoolers` well-being, the constructs of the quasi-cluster composed of positive communication, positive emotion, spirituality, self-acceptance, demonstration of character strengths, and resilience showed individual psychological characteristics. It was found that the quasi-cluster including positive communication, relationship with the teacher and peer relationship were not highly related to environmental factors such as parents` economic status and social-educational-cultural environment. In addition, it was found that although the family relationship was somewhat lowly related to the constructs such as the flow and parents` economic status, it was largely related to most of the constructs without any constructs in the opposite relation. Consequently, this study systematized preschoolers well being and identified its attributes. Based on this finding, implication was given for promoting preschoolers` well being in early childhood education.