새로운 학부 의공학 교육과정의 일환으로 의공학 실험과목의 제안

박현진,지영준,서종범,Park, Hyun-Jin,Chee, Young-Joon,Seo, Jong-Bum 대한의용생체공학회 2011 의공학회지 Vol.32 No.4

Laboratory class is an integral part of biomedical engineering education. Current biomedical engineering curriculum in Korea mostly includes mandatory laboratory classes. Most of the Korean biomedical laboratory classes focus on electrical engineering aspects, while molecular/biological engineering aspects are neglected. Many leading universities in U.S.A. offer a more balanced laboratory class where both electrical engineering aspects and molecular/biological engineering aspects are considered. As a part of an effort to enhance undergraduate biomedical engineering education, a new biomedical engineering laboratory class is proposed to offer a more balanced laboratory learning experience.

국내 유통 중인 혼합채소샐러드 및 신선·냉동과일의 미생물 오염실태 조사

박현진,이정은,김솔아,심원보,Park, Hyun-Jin,Lee, Jeong-Eun,Kim, Sol-A,Shim, Won-Bo 한국식품위생안전성학회 2021 한국식품위생안전성학회지 Vol.36 No.4

국내에서 유통되고 있는 혼합채소샐러드류, 신선과일 및 냉동과일에 대해 미생물 오염 도를 식품군별, 지역별, 분기별로 비교 분석하였다. 식품군 별로 일반세균수는 혼합채소샐러드에서 가장 높은 6.48 log CFU/g, 신선과일은 5.07 log CFU/g, 냉동과일은3.78 log CFU/g 수준으로 나타났다. 분기별 일반세균수를 비교 분석한 결과에서는 1분기 오염도는 5.12 log CFU/g, 2분기는 6.26 log CFU/g, 3분기는 5.73 log CFU/g, 4분기는 4.42 log CFU/g으로 확인되어 외부온도가 높은 2,3분기에서 조금 더 높은 일반 세균수가 관찰되었다. 지역별 일반세균수의 오염은 5.26-5.47 log CFU/g으로 수준으로 지역별 차이는 확인되지 않았다. 대장균군의 경우 1.98-3.93 log CFU/g으로 나타났고, E. coli의 경우 혼합채소샐러드 27점 중 3점에서 평균 1.38 log CFU/g으로 검출되었다. 이러한 결과를 종합할 때 혼합채소샐러드와 신선과일은 Solberg 등이 제시한 비가열 식품의 일반세균 기준치(3 log CFU/g)를 초과한 것으로 확인되었고, 3점의 신선과일 시료에서 대장균이 검출되어 샐러드류 및 신선과일의 원료의 안전성과 제조 및 유통 단계에서의 위생관리가 보다 철저히 수행되어야 할 것으로 판단된다. In this study, the microbial levels on mixed vegetable salads, fresh fruits, and frozen fruits distributed in Korea were comparatively analyzed by food group, region, and quarter. Samples were collected from big markets in large cities from 2018 to 2019 and used for microbiological analysis. The levels of aerobic bacteria for mixed vegetable salads, fresh fruits, and frozen fruits were 6.48, 5.07, and 3.78 log CFU/g, respectively. As a result of analyzing the quarterly contamination levels of aerobic bacteria, the first quarter contamination level was 5.12 log CFU/g while the second quarter showed 6.26 log CFU/g, the third quarter 5.73 log CFU/g, and the fourth quarter 4.42 log CFU/g. A higher number of aerobic bacteria was observed in the second and third quarters when the temperature was higher. There was no difference in the number of bacteria by region. The levels of the coliform group were 1.98 - 3.93 log CFU/g in all samples, and Escherichia coli was detected at 1.38 log CFU/g in 3 out of 27 mixed vegetable salads. Since the mixed vegetable salad and fresh fruit used in this study exceeded the standard (3 log CFU/g) for unheated foods and E. coli was detected in three fresh fruits, stricter hygiene management in the manufacturing stage of salads and fresh fruit is required.

개선된 학부 의공학 소프트웨어 교육과정을 위한 새로운 과목의 제안

박현진,Park, Hyun-Jin 대한의용생체공학회 2011 의공학회지 Vol.32 No.4

Biomedical engineering is a discipline where engineering principles and techniques are applied to the medical field. Biomedical engineering lies between traditional engineering and medicine and is an inter-disciplinary field in its nature. Current Korean undergraduate biomedical engineering curriculum is a simple list of traditional engineering courses combined with basic medical/life science courses. There have been efforts to improve biomedical engineering education to reflect its inter-disciplinary nature. Enhanced software course for biomedical engineering is proposed as a part of effort to overhaul the undergraduate biomedical engineering curriculum. In this newly proposed course, students will learn MATLAB and LabVIEW, which are the most widely used software tools in biomedical engineering.

다차원 척도법(MDS)을 사용한 새로운 형태 정량화 기법

박현진,윤의중,서종범,Park, Hyun-Jin,Yoon, Uei-Joong,Seo, Jong-Bum 대한의용생체공학회 2010 의공학회지 Vol.31 No.2

Readily available high resolution brain MRI scans allow detailed visualization of the brain structures. Researchers have focused on developing methods to quantify shape differences specific to diseased scans. We have developed a novel method to quantify shape information for a specific population based on Multidimensional scaling(MDS). MDS is a well known tool in statistics and here we apply this classical tool to quantify shape change. Distance measures are required in MDS which are computed from pair-wise image registrations of the training set. Registration step establishes spatial correspondence among scans so that they can be compared in the same spatial framework. One benefit of our method is that it is quite robust to errors in registrations. Applying our method to 13 brain MRI showed clear separation between normal and diseased (Cushing's syndrome). Intentionally perturbing the image registration results did not significantly affect the separability of two clusters. We have developed a novel method to quantify shape based on MDS, which is robust to image mis-registration.

조립화된 분말식품의 인스탄트성질에 영향을 미치는 인자

박현진,이철,Park, Hyun-Jin,Rhee, Chul 한국식품과학회 1986 한국식품과학회지 Vol.18 No.1

본 연구는 유동층 조립기로 조립시킨 보리 미숫가루 입자들의 인스탄트 성질에 영향을 주는 인자들을 조사하였다. 조립에 사용된 바인더는 맥아당, 포도당, 젤라틴의 수용액과 물 이었으며 조립입자의 인스탄트 효과는 입자의 습윤성, 침강성, 분산성 및 용해성을 측정하여 결정하였다. 바인더의 종류별로 조립된 시료의 인스탄트 성질의 개선에 대한 기여도는 낮은 바인더 수용액에서 5%젤라틴수용액>5%맥아당수용액>5%포도당수용액의 순으로 나타났으며 물은 가장 낮은 인스탄트효과를 보였다. 바인더 용액의 농도증가에 따른 조립입자의 인스탄트성질은 포도당, 맥아당과 같은 당류의 경우 증가되었으나 젤라틴의 경우에는 이와 반대경향을 나타내었다. 조립입자의 크기가 인스탄트성질에 미치는 영향은 현저하였으며 입자의 크기가 $0.1{\sim}0.3mm$일 때, 시료의 인스탄트효과가 가장 좋았다. 조립입자의 건조온도($60^{\circ}C,\;70^{\circ}C,\;80^{\circ}C$)는 입자의 인스탄트효과에 거의 영향을 미치지 않았다. 바인더용액을 사용하여 조립한 미숫가루입자의 흡습속도는 각각의 상대습도(42%, 67%, 92%)에서 5%젤라틴수용액>5%맥아당수용액>5%포도당수용액의 순으로 빠르게 나타났으며 이러한 결과는 바인더 종류가 인스탄트 성질에 미치는 효과와 동일한 순서로 일치함을 보여주었다. Influencing factors on the instant properties of agglomerated parched barley powder prepared by fluidized bed agglomerator were investigated. Instant effect was measured by the determination of wettability, sinkability, dispersibility and solubility of agglomerated particles. Instant effect of agglomerated particle was influenced by sorts of binding materials, concentration of aqueous binder solution and agglomerated particle diameter. The binding materials for agglomerated process were water and aqueous solution of glucose, maltose and gelatin. Instant effect of agglomerated particles increased as the concentration of aqueous sugar solution increased. However, the effect of aqueous solution of gelatin on instant effect was inversely proportional to the concentration. The size of agglomerated particle had an outstanding effect on instant properties and the diameter of agglomerated particle ranging from 0.1 mm - 0.3 mm showed the excellent instant effect.

반복적인 모세기관지염, 과반응 기관지염을 보인 영유아의 임상양상, 치료와 자연경과

박현진,김주현,전윤홍,이수영,김상용,강진한,Park, Hyoun Jin,Kim, Joo Hyun,Chun, Yoon Hong,Lee, Soo Young,Kim, Sang Yong,Kang, Jin Han 대한소아감염학회 2014 Pediatric Infection and Vaccine Vol.21 No.1

목적: 영유아기 두 번 이상 반복된 모세기관지염, 즉 과반응 기관지염(RAD)을 보인 환아의 임상양상, 치료와 5년 후 자연경과를 조사하고자 연구를 계획하였다. 방법: 2007년 1월부터 12월까지 연구병원 소아청소년과에 모세기관지염으로 2회 이상 입원한 영유아를 대상으로 하였다. 의무기록을 후향적으로 조사하였고, 추가로 5년 후 2013년 현재의 의학적 상태를 보호자와 전화면담을 시행하여 문의하였다. 결과: 2007년 1년간 총 63명의 영유아들이 2회 이상 모세기관지염으로 입원하였다. 연구대상의 평균연령은 8.1개월이었고, 이들 중 남아는 44명(69.8%)이었다. 입원 중 흡입 스테로이드 치료를 받은 환아는 62명(98.4%), 기관지확장제 치료 53명(84.1%) 항생제 치료 40명(63.5%)이었다. 대상 환아 63명 중 45명과 전화면담이 가능하였고, 이들 중, 2013년 현재 38명(84.4%)은 더 이상 호흡장애가 없었고, 5명(11.1%)은 알레르기 비염, 2명(4.4%)은 천식으로 치료 중이었다. 결론: 영유아기 반복적인 쌕쌕거림을 보였던 RAD 환아들의 대부분은, 호흡기가 성숙된 5년 후에는 더 이상 호흡장애를 보이지 않았다. 모세기관지염에 대한 국내 치료지침이 제안되어야 할 것이고 RAD의 자연경과에 대한 좀더 체계적인 연구가 필요하다. Purpose: The purpose of this study was to investigate the clinical manifestations and 5-year natural course of recurrent bronchiolitis or reactive airways disease (RAD) in infants. Methods: We reviewed the medical records of infants with recurrent bronchiolitis from January 2007 to December 2007 at The Catholic University of Korea St. Mary's Hospital in Incheon, South Korea. Additionally, we telephoned their parents to confirm their present medical statuses. Results: Sixty-three subjects with recurrent bronchiolitis were identified. The mean age at admission was 8.1 months and the number of males was 44 (69.8%). Of the 63 infants with recurrent bronchiolitis, inhaled corticosteroids, bronchodilators, and antibiotics were given to 62 (98.4%), 53 (84.1%), and 40 (63.5%), respectively. Among the total 63 subjects, we were able to contact the parents of 45 children by telephone. None of these children had been hospitalized during the previous one year period due to respiratory infections or for other medical reasons. Of the 45 subjects we were able to contact, 38 (84.4%) had not experienced any further respiratory difficulties at all. Five (11.1%) had been diagnosed with allergic rhinitis while two (4.4%) were being managed for asthma. Conclusion: Most children who presented with recurrent episodes of bronchiolitis in infancy did not show any further respiratory difficulties after five years of age.

국방기술이전 성과영향요인에 관한 연구

박현진,이정동,정경인,이춘주,Park, Hyun-Jin,Lee, Jeong-Dong,Jung, Kyeong-In,Lee, Chun-Ju 한국국방경영분석학회 2006 한국국방경영분석학회지 Vol.32 No.1

본 연구는 전문가 설문기법으로 한국 군사기술의 상용이전에 영향을 미치는 주요한 요인들을 조사 분석하였다. 국방연구개발 투자의 효과로서 필요한 군사과학기술 개발과 더불어 군에서 민간부문으로의 기술이전을 통한 상용기술개발을 촉진하는 역할도 중요하게 여겨지고 있다. 군사선진국들은 국방기술개발에 대한 효과적이고 효율적인 투자의 중요성을 인식하고 자국의 특성을 고려하여 국가수준에서 연구개발투자의 효과를 극대화할 수 있는 최적의 기술이전 메커니즘을 적용하기 위해 노력하고 있다. 기술이전 메커니즘은 국가마다 다양하며 한국에서 효과적이고 효율적인 기술이전을 위한 영향요인은 무엇인지를 알아보는 것이 필요하다. 본 논문은 전문가 면담과 문헌연구를 통하여 고려대상 영향요인 19개를 식별하였으며 이중 11개가 기술이전활동에 유의한 영향을 미치는 것으로 나타났다. 정책적 함의로서 목표 지향적 투자, 기술이전 관련 규정의 검토, 그리고 기술이전 전문가 양성에 대한 필요성을 제기하고 있다. This study investigates key factors affecting the activity of defense technology transfer through the questionnaire survey in Korea. Defense R&D investment has played an important role in promoting the commercial technology development as well as the targeted defense sector through the spin-off mechanism as shown in many countries. Recognizing the importance of effective and efficient investment in defense technology development, the advanced countries in defense technology are trying to establish optimal technology transfer mechanism to maximize the effect of the invested R&D at the national level considering the idiosyncratic features of their own countries. Because the technology transfer mechanisms are very distinct from country to country, it is natural to question "what are the determinants of the effective and efficient technology transfer in Korea?" We tested 19 potential factors and identified 11 factors that are significantly important as the determinants of technology transfer. From the empirical findings, we discuss some policy implications to promote the technology transfer.

근린주거환경의 아동 놀이공간 유형 및 이동경로 특성에 관한 기초연구

박현진(Park, Hyun-Jin),박진희(Park, Jin-Hee),박소현(Park, So-Hyun) 대한건축학회 2016 대한건축학회논문집 Vol.32 No.2

Over time, children’s outdoor activities and opportunities for children to play, have continually declined. Such problems have led to increased interest in providing better physical environments for children’s active free play in residential neighborhoods. Previous research studies have generally focused on specific places (i.e. playgrounds and schoolyards) or types of buildings (i.e. apartment complexes). The primary goal of this paper is to identify the characteristics of neighborhood environments that are associated with play behavior by analyzing the types of children’s play spaces and their routes. Based on a week’s travel log and GPS data from 25 students who are in grades 1-3 in elementary school, this empirical study of Buk-chon, Seoul, demonstrates that children have used for their recreational use both ‘formal play spaces’, spaces specifically designed for recreational activities, and ‘informal play spaces’, spaces not intentionally designed for recreational activities. The results of analyzing children’s play behaviors and space conditions indicate certain environmental characteristics. Formal spaces include the following: 1) quality parks that are easily accessible, 2) schoolyards and small parks that are spacious yet close to residential areas, and 3) play spaces that are well connected with residential streets. Informal spaces include the following: 1) commercial facilities, bus-stop and alleys surrounding schools, 2) alleys near residences, and 3) streets(and their networks) within neighborhoods. Even without formal spaces, alleys around homes and schools and neighborhood streets have become ‘play routes’ for children in Buk-chon. Further research is needed to compare other residential areas, as well as the different types of buildings that exist in such areas, and identify the challenges between creating outdoor play spaces and maintaining residential neighborhoods’ characteristics.

랜덤포레스트와 다중회귀분석을 이용한 토양 EC1:5-ECe 환산 방법 개발

박현진 ( Hyun-jin Park ),백누리 ( Nuri Baek ),윤광식 ( Kwang-sik Yoon ),최우정 ( Woo-jung Choi ) 한국농공학회 2022 한국농공학회 학술대회초록집 Vol.2022 No.-

Measurement of electrical conductivity (EC) of saturated soil paste extracts (EC_e) is a standard method, but it is labor-intensive and time-consuming method. Therefore, conversion of EC of soil-water extract (EC_1:5) to ECe is necessary. However, the conversion factor varies widely being affected by many soil factors including soil texture and associated soil variables though such variation has rarely been investigated. This study was conducted to explore soil variables affecting EC conversion factor using random forest, and to develop conversion equations with soil variables through multiple regression analysis. Random forest model was built using the data of 16 variables (e.g., EC_1:5, sand, clay and organic matter contents, porosity, cation exchange capacity (CEC), exchangeable and soluble cation contents, sodium adsorption ratio (SAR), and exchangeable sodium and calcium percentage (ESP and ECP)) of soil samples (n=320) collected from 16 reclaimed tidelands located in the coastal areas of Korea. Majority (80%) of the data were trained to build the model, and 20% was used for model testing. The determination coefficient (r²) and root mean square error of the model were 0.43 and 1.6, respectively, and the difference between evaluated and predicted EC conversion factors was 14.7% on average. The contribution of the independent variables to the prediction of EC conversion factor using the model was the greatest (56.6%) for soil ESP, and followed by clay contents (20.0%), sand contents (7.4%), CEC (7.1%), and EC_1:5 (3.7%). A equation to derive conversion factor (y), y = 9.189 - 0.089 × Clay content + 0.041 × ESP (r²=0.31, P<0.001), was obtained through a multiple regression analysis. The ECe predicted using the conversion factors from the equation was highly correlated (r²=0.83, P<0.001, RMSE=2.3) with the measured EC_e. The equation presented in our study can be used for estimating EC_e using the soil data set.

췌관선암종이 동시에 동반된 췌장의 장액낭선종양 1예

박현진 ( Hyun Jin Park ),황준성 ( Jun Seong Hwang ),고성우 ( Sung Woo Ko ),소훈섭 ( Hoonsub So ),권재우 ( Jae Woo Kwon ),송태준 ( Tae Jun Song ) 대한췌장담도학회 2020 대한췌담도학회지 Vol.25 No.2

장액낭성종양(serous cystic neoplasm)은 1978년 Compagno와 Oertel에 의해 처음으로 분류되었으며, 췌장낭성종양(pancreatic cystic neoplasm) 중 10-16%의 빈도를 나타낸다. 장액낭성종양은 악성화의 위험성이 있는 점액낭성종양(mucinous cystic neoplasm)이나 췌관내유두상점액종양(intraductal papillary mucinous neoplasm, IPMN)과는 달리 악성화의 위험성이 거의 없다고 알려져 있다. 또한 장액낭성종양은 일반적으로 고립병터로 발견되며 췌장의 다른 낭성종양, 만성 췌장염, 췌장암과 같은 췌장 병변과 같이 존재하는 경우는 매우 드물다. 그중에서도 췌관선암종(pancreatic ductal adenocarcinoma)이동반되는 경우는 거의 없다고 알려져 있다. 이에 저자들은 고이형성 췌장상피내종양(pancreatic intraepithelial neoplasm, PanIN)이 동반된 장액낭성종양과 인접한 위치에 췌관선암종이 동시에 발견된 증례를 문헌고찰과 함께 보고하고자 한다. Serous cystic neoplasm (SCN) represents 10-16% of cystic pancreatic lesions, first classified by Compagno and Oertel at 1978. In contrast to mucinous cystic neoplasm or intraductal papillary mucinous neoplasm of pancreas which have malignant potential, SCN is thought to be exclusively benign as solitary lesion in nearly all cases. There has been rare reported association between the SCN and pancreatic ductal adenocarcinoma, and few cases were documented their coexistence. In this report, we present the case of SCN of the pancreas with literature review in which synchronous pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasm coexist together.