강원지역 피부질환의 통계적 고찰(2000-2004)

박하나 ( Ha Na Bak ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2005 大韓皮膚科學會誌 Vol.43 No.9

피부장벽과 아토피 피부염

박하나 ( Ha Na Bak ) 한국피부장벽학회 2009 한국피부장벽학회지 Vol.11 No.1

아토피 피부염은 유전적 소인을 가진 만성 재발성 습진성 질환으로 아직 정확한 원인 및 발병기전이 밝혀져 있지 않다. 현재까지 알려진 고전적인 기전으로는 각종 흡입과 음식물 알러젠 및 포도상구균에 관한 면역학적 기전과 피부장벽 기능의 이상이 알려져 있다. 그 중에서도 피부장벽 기능의 이상과 관련하여 많은 연구가 진행되었는데 아토피 피부염 환자의 각질층에서 수분함량은 감소되어 있고 경표피수분소실은 증가되어 있으며 높은 산도가 병인과 관련됨이 잘 알려져 있다. 이외에도 LL-37, hBD-2,3, dermcidin 등의 피부표면의 antimicrobial peptide는 감소되어 있고 일부 psoriasin과 같은 antimicrobial peptide는 오히려 증가되어 있음이 새로 밝혀지고 있다. 최근에는 이런 고전적인 두 지 개념의 병태생리 기전이 시기별로 상호작용하여 아토피 피부염 발생을 설명하는 단일화된 가설의 새로운 패러다임을 제시하고 있다. 이러한 연구에 발맞추어 새로운 치료제도 개발되고 있는데 우선 고전적인 치료로는 악화 인자의 회피와 적절한 피부 보습 그리고 항히스타민제와 부신피질호르몬 경구복용 및 국소도포가 있고 최근 새로운 면역억제제 및 면역요법 등이 소개되고 있으며 그 외에도 probiotics 에 관련한 많은 연구들이 진행되고 있다.

테스토스테론이 피부장벽에 미치는 효과

박하나 ( Ha Na Bak ),최응호 ( Eung Ho Choi ),이광길 ( Kwang Gil Lee ),홍승필 ( Seung Phil Hong ),이승헌 ( Seung Hun Lee ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2005 대한피부과학회지 Vol.43 No.2

Skin Barrier and Moisturizer

박하나 ( Ha Na Bak ) 한국피부장벽학회 2010 한국피부장벽학회지 Vol.12 No.1

Moisturizers are substances designed to improve and maintain the skin barrier. They could include active ingredients that minimize dehydration, photoprotect, and provide antioxidant properties. Moisturizers are based on occlusive substances such as petrolatum and dimethicone, and humectant substances, such as glycerin, with a variety of sunscreens and botanicals for added functionality. Moisturizers prevent and treat dry skin, protect sensitive skin, improve skin tone and texture. Also, moisturizers can serve as important adjunctive therapeutic modalities for patients with various dermatologic disorders, including acne vulgaris, rosacea, retinoid-induced irritant dermatitis, atopic dermatitis, psoriasis, and the skin dryness that appears to occur with intrinsic and extrinsic aging. Therapeutic moisturizers, defined as those proven in clinical trials to be both compatible with topical therapies and biocompatible with the skin, not only improve the signs and symptoms of dry skin but also, as research has demonstrated, help maintain hydration and overall integrity of the stratum corneum. The type of humectants and emollients contained in a therapeutic moisturizer can affect the overall tolerability of the formulation. Dermatologists should recommend therapeutic moisturizers that are noncomedogenic, devoid of irritant ingredients, and compatible with many therapeutic regimens. But some factors have to be considered when assessing the safety of a moisturizer. We should consider harmful effects including allergenicity, irritation and carcinogenesis.

무모 생쥐에서 vinyl carbamate epoxide와 TPA로 유발된 종양과 비종양 병변의 표피지질 및 칼슘의 변화

안성구 ( Sung Ku Ahn ),박하나 ( Ha Na Bak ),천승현 ( Seung Hyun Chun ),전수영 ( Soo Young Jeon ),최응호 ( Eung Ho Choi ),이상주 ( Sang Joo Lee ),이승헌 ( Seung Hun Lee ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.10

독창 환아에서 발생한 결절홍반

안석용 ( Seok Yong Ahn ),박하나 ( Ha Na Bak ),최응호 ( Eung Ho Choi ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.10

A 7 year-old boy visited our hospital with a 2 week history of inflammatory, pustular, tender patches and plaques on the right scalp and face area. He had been treated with topical steroid and antibiotics in a private clinic. In a KOH smear mount, multiple hyphaes and spores appeared on stratum corneum of the outer root sheath layer of his hair. The diagnosis of kerion celsi induced by dermatophytes was made. The patient was treated with oral griseofulvin, and on the 2nd day after starting treatment, multiple erythematous and tendered subcutaneous nodules occurred on his shin. A photosensitive dermatitis like lesion also occurred on his periorbital area. Griseofulvin changed to terbinafine. On the 6th day after treatment, the skin lesions on his face and scalp had improved, as had his shin lesions. The interest of this case lies in the unusual association of kerion and erythema nodosum, of which only eleven cases have been reported in dermatologic literature, and all cases were kerion induced Trichophyton species. (Korean J Dermatol 2007;45(10):1101∼1104)

기미 병변에서 신경 펩티드와 그 수용체의 발현에 대한 연구

이현주 ( Hyun Ju Lee ),박하나 ( Ha Na Bak ),장성은 ( Sung Eun Chang ),최지호 ( Jee Ho Choi ),김명남 ( Myeung Nam Kim ),김범준 ( Beom Joon Kim ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.5

Background: The pathogenesis of melasma has not yet been clearly demonstrated. But, clinical manifestations such as remarkable lesional symmetry and the distribution related to trigeminal nerves, suggest that the neural system could play a pathogenic role in melasma. Objective: This study was carried out to examine the expression of some neuropeptides and their receptors, which are well known to be major contributors of neuroinflammation in many dermatoses, in melasma lesions. Methods: Skin biopsies were obtained from the lesional and non-lesional facial skin of 6 Korean women with melasma. Immunofluorecence staining and confocal laser scanning microscopy were performed. Results: In our results, no difference could be detected with regard to the intensity of immunoreactivity for vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP), calcitonin gene-related peptide receptor (CGRPR), substance P (SP), substance P receptor (SPR), somatostatin (SOM), pituitary adenylate cyclase activating peptide (PACAP) and pituitary adenylate cyclase activating peptide receptor (PACAPR) in the lesional skins compared with the non-lesional skins. Conclusion: These results suggest that neuroinflammation induced by neuropeptides such as substance P, calcitonin gene-related peptide, vasoactive intestinal peptide, and somatostatin and their receptors included in this study, are not directly associated with melasma pathogenesis. (Korean J Dermatol 2008;46(5):627∼632)

한랭이 피부장벽에 미치는 영향

김민정 ( Min Jeong Kim ),박하나 ( Ha Na Bak ),이상훈 ( Sang Hoon Lee ),이승헌 ( Seung Hun Lee ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.4

Background: Cold is considered an important environmental factor on the skin`s barrier function. It is also known that cold can disrupt the barrier`s permeability function. Historically irritant contact dermatitis develops frequently amongst fish pr℃essing workers. This means that cold may disrupt the skin barrier function. However, there are only a few studies of the effect of cold on the skin barrier. Objective: The aim of our study was to investigate the effects of exposure to the cold on the skin``s barrier permeability, calcium gradient and cornified enveloped proteins. Methods: Hairless mice were classified into four groups as follows; tape-stripping and exposure to cold (4℃) for 5 hours group (Group 1), exposure to cold (4℃) for 5 hours after tape-stripping and occlusion with Gore-Tex group (Group 2), exposure to cold (4℃) for 5 hours after tape-stripping and applying with petrolatum group (Group 3), and tape-stripping and exposure at room temperature (25℃) for 5 hours group (Group 4). Next, rate of barrier recovery was measured, and skin of cold exposure site was taken for immunohistochemistry of cornified enveloped protein, calcium inon capture chemistry and in situ hybridization. Results: Rate of barrier recovery of Group 1 was measured at -56.33%, the most delayed rate of all groups. Rate of barrier recovery of other groups were measured as follows; Group 2 (20%), Group 3 (55%) and Group 4 (41.78%). In calcium-ion capture cytochemistry, Group 1 appeared to absent calcium deposit in the entire epidermis. Group 3 appeared to the highest density of calcium in entire epidermis. In immunohistochemical staining of cornified enveloped proteins including involucrin, loricrin and filaggrin, Group 1 resulted in the lowest expression of cornified enveloped proteins. Of all groups, Group 3 appeared to have the highest expressionof cornified enveloped proteins. In situ hybridization of loricrin and filaggrin, expression were similar with results of immunohistochemical staining. Conclusion: Our results provide that cold impairs the skin`s barrier permeability by having a negative effect on recovery of calcium gradient and differentiation of cornifed enveloped proteins. But occlusion with vapor permeable membranes such as Gore-Tex or petrolatum could improve conditions of skin barrier impaired by cold by restoring the recovery rate of calcium gradient and differentiation of cornified enveloped protein. (Korean J Dermatol 2008; 46(4):437~445)

Collimated Low Fluence Q-switched Nd: YAG 레이저를 이용한 새로운 기미 치료법

정세영 ( Se Yeong Jeong ),장성은 ( Sung Eun Chang ),박하나 ( Ha Na Bak ),최지호 ( Jee Ho Choi ),김일환 ( Il Hwan Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.9

Background: Laser treatment in melasma has previously failed because of the resulting inflammation and consequent pigmentation and excessive thermal damage caused by the use of high fluence. Objective: This study is aimed at establishing the concept of the collimated low fluence Q-switched Nd: YAG laser as a treatment for melasma by investigating its therapeutic effects clinically as well as histopathologically. Methods: 27 patients were treated weekly with Q-switched Nd: YAG laser (1,064 nm wavelength, 7 mm spot size, 1.6~2.5 J/cm2 fluence) for 8 weeks. The results were evaluated based on standardized clinical images that used Robo skin analyzer, spectrophotometer, MASI score and general severity. Results: 17 (58.8%) patients showed GOOD (50~75% improvement) and no case of full recurrence was examined and partial recurrence was detected in 12/17 patients. Common adverse effects include pain, erythema, and temporary edema. Rarely partial hypopigmented macules and diffuse hyperpigmentation appeared. Additional studies, such as immunohistochemical examination and electron microscopic examination, are also currently in progress. Conclusion: The collimated low fluence Q-switched Nd: YAG Laser is effective in melasma treatment. This treatment method is a new concept that can be described as selective photothermolysis with minimal thermal damage and inflammation reaction to affected tissues by pigmentation. We consider this treatment method should be regarded as Minimized Selective Photothermolysis (MSP) that will provide a new effective treatment for melasma. (Korean J Dermatol 2008;46(9):1163~1170)

태닝 오일에 의한 모낭염

이성율 ( Sung Yul Lee ),지재홍 ( Jae Hong Ji ),박하나 ( Ha Na Bak ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.9

Folliculitis is an inflammatory disease that has various causes. It has been widely reported to be caused by exposure to industrial oil such as cutting oil and diesel oil. A 39-year-old man presented with multiple diffuse erythematous papules with a follicular distribution on the anterior chest, back and shoulder. The histopathologic findings of the papules showed follicular epithelial destruction and a perifollicular inflammatory cellular infiltration. He was diagnosed as having folliculitis. The distribution of lesions matched with the area of tanning oil application was identical to that of the patient`s applying tanning oil before the development of skin lesions. We report here on a case of folliculitis due to applying tanning oil. Tanning oil caused the follicular occlusion and dilatation in hairless mice in one experiment. (Korean J Dermatol 2010;48(9):780~782)