과학자 연구성과에 대한 젠더, 코호트, 조직적 요인 효과: 생화학자를 중심으로

박찬웅,Park, Chan-Ung 한국인구학회 2007 한국인구학 Vol.30 No.1

국내 생화학 분야 학자들의 연구성과에 영향을 주는 요인은 무엇인가? 특히 젠더는 연구성과에 어떤 영향을 주는가? 이 연구는 다음과 같은 항목에 초점을 두었다. 첫째 연구성과의 특징에 따른 차이를 보기 위해, 연구성과를 학술지 유형에 따라 SCI논문과 비SCI논문으로 구분해서 비교분석했다. 둘째, 교육기간부터 경력기간별로 연구성과에 미치는 요인이 변화할 가능성을 분석하기 위해, 연구성과를 종속변수로 하는 모델을 대학원 기간과 졸업 이후 경력 기간별로 구성했다. 셋째, 연구성과에 대한 이론적 요인으로서 사회인구학적 요인, 조직적 요인, 그리고 이전 연구업적의 누적효과를 음이항모델을 사용해서 분석했다. 연구 결과는 다음과 같다. 첫째, SCI논문성과의 경우 젠더 효과는 대학원 기간 동안에는 관찰되지 않았지만, 경력 초기부터 다음 기간 연구성과에 영향을 주는 것으로 나타났다. SCI학술지 연구성과의 경우 조직적 요인 중에서 외국 학위가 중요한 것으로 파악되었다. 이전 연구성과 역시 누적적으로 그 후 연구성과에 영향을 주었다. 비SCI논문 수를 분석한 결과, 대학원 기간과 졸업 후 3년간 기간에는 젠더 차이가 관찰되지 않았고, 졸업 후 3-6년 기간에 젠더 효과가 발견되었다. 또한 대학원 기간의 비SCI논문의 누적효과가 지속적으로 나타났다.

대학의 교육기부 - 대학의 사회적 책무로서 교육기부

박찬웅,Park, Chan-Ung 한국대학교육협의회 2013 大學敎育 Vol.182 No.-

종합 아미노산수액 투여에 의한 Nitrogen balance의 임상적 검토

박찬웅,임정규,이장규,이진오,박귀원,Park, C.W.,Lim, J.K.,Lee, J.K.,Lee, J.O.,Park, K.W. 대한약리학회 1977 대한약리학잡지 Vol.13 No.2

The nitrogen sparing effect of intravenous 3% amino acid solution was compared with 5% dextrose solution in 30 patients who were undergoing surgical operations or radiation therapy. Infusion of 3% amino acid solution or 5% dextrose solution was given before and immediately after operations or irradiation and continued for 6 days. Infusion of solutions through peripheral vein was well tolerated and not experienced any specific hematologic or blood chemistry change in all patients subjected throughout the experiment. The patients received 3% amino acid solution showed low blood glucose and insulin level, but significantly high blood urea nitrogen and ketone body. In patients receiving amino acids, as compared with those receiving dextrose, mean cumulative six day nitrogen losses were significantly lower($63.95{\pm}2.12$ Gm and $79.12{\pm}2.43Gm$ respectively). The nitrogen sparing effect of amino acids is probably due to decreased glucose and insulin levels allowing greater endogenous fat mobilization.

Ti-6Al-4V 합금 기지 위에 FGM 방식으로 적층제조 된 Inconel 718의 접합 특성 분석

박찬웅,박진웅,정기채,이세환,김성훈,김정한,Park, Chan Woong,Park, Jin Woong,Jung, Ki Chae,Lee, Se-Hwan,Kim, Sung-Hoon,Kim, Jeoung Han 한국분말재료학회 (*구 분말야금학회) 2021 한국분말재료학회지 (KPMI) Vol.28 No.5

In the present work, Inconel 718 alloy is additively manufactured on the Ti-6Al-4V alloy, and a functionally graded material is built between Inconel 718 and Ti-6Al-4V alloys. The vanadium interlayer is applied to prevent the formation of detrimental intermetallic compounds between Ti-6Al-4V and Inconel 718 by direct joining. The additive manufacturing of Inconel 718 alloy is performed by changing the laser power and scan speed. The microstructures of the joint interface are characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and micro X-ray diffraction. Additive manufacturing is successfully performed by changing the energy input. The micro Vickers hardness of the additive manufactured Inconel 718 dramatically increased owing to the presence of the Cr-oxide phase, which is formed by the difference in energy input.

골격근 Contractile Protein에 대한 $Ca^{++}$의 영향

박찬웅,정명희,오진섭,Park, C.W.,Chung, M.H.,Oh, J.S. 대한약리학회 1972 대한약리학잡지 Vol.8 No.2

Superprecipitation of actomyosin has been considered to be an in vitro model of the muscle contraction. The superprecipitation and ATPase activity (which supplies the energy for contraction) are influenced by several factors which are the large amount of changes in ionic strength, Mg and ATP concentrations. But those behaviors are found to be promptly influenced by the change in a small range of calcium concentration which can be controlled by the cellular function of muscle physiologically only in the presence of the modullatory proteins, tropomyosin and troponin. In order to elucidate the precise roles of calcium in the muscle contraction and relaxation, the effects of calcium on the actin- myosin interaction was observed in the presence of tropomyosin and troponin using the superprecipitation system. The results are summarized as follows: 1. EGTA (glycol ether diaminetetraacetic acid)prolonged the initiation of the superprecipitation of natural actomyosin. 2. Superprecipitation curve was declined by adding EGTA at the time when tile curve reached the half- maximum. The degree of declining was proportional to the amount of EGTA added. Especially, upon adding 0.25 mM EGTA the curve was lowered to the level before the protein superprecipitated. But addition of EGTA did not affect the curve after attaining the maximum. 3. Superprecipitation of Perry myosin B was not affected by EGTA added both before and during the course of the reaction. 4. Tropomyosin did not change the response of Perry myosin B to EGTA added at any time of the reaction. 5. Troponin also did not change the response of Perry myosin B to EGTA. 6. Both tropomyosin and troponin together rendered the Perry myosin B to obtain the same response as natural actomyosin to EGTA. 7. It was concluded that actin-myosin interaction was influenced by the minute change of calcium concentration only in the presence of both tropomyosin and troponin. We could reproduce the contraction and relaxation of the muscle in vitro under the presence of ATP by changing the calcium concentration.

남량특집 여름철의 건강관리-등산의 계획과 준비

박찬웅,Park, Chan-Ung 한국건강관리협회 1983 건강소식 Vol.7 No.7

Effect of Higenamine on Pulmonary Aorta of Rabbit

박찬웅,김봉기,최진석,임정규,Park, Chan-Woong,Kim, Bong-Gi,Choi, Jin-Suk,Lim, Jung-Kyoo The Korean Society of Pharmacology 1992 대한약리학잡지 Vol.28 No.1

Higenamine은 부자의 활성 성분의 하나로서 아드레나린성 beta-수용체를 통하여 강심효과를 나타내는 것으로 알려졌다. 본 연구는 norepinephrine 또는 potassium에 의한 토끼 페동맥의 수축에 미치는 Higenamine의 영향을 관찰한 것이다. 1. Norepinephrine으로 수축을 이르킨 폐동맥편은 higenamine의 전처치 또는 후처치로 용량의존적으로 이완되었다. 이같은 higenamine의 효과는 propranolol 전처치로 억제되었다. Higenamine의 propranolol에 대한 $pA_2$ 값은 8.25였다. 2. Higenamine의 페동맥편에 대한 효과는 phentolamine 전처치로 억제되지 않았다. 3. Isoproterenol도 norepinephrine에 의한 페동맥편 수축을 이완시켰으며 효력은 higenamine 보다 10배 켰다. 그러나 고농도$(3.3{\times}10^{-6})$의 isoproterenol은 내인성 활성을 보였다. 4. Higenamine과 isoproterenol은 potassium으로 유도된 페동맥편 수축에 대하여 이완효과를 나타내지 않았다. 이상의 결과로 미루어 higenamine은 혈관평활근에 대하여도 아드레나린성 beta-수용체를 통하여 이완효과를 나타낼 것으로 생각된다. Higenamine, which is one of active component of Aconiti tuber, has been known to have positive inotropic effect through adrenergic beta-receptor. The effect of higenamine on norepinepharine or potassium induced contraction of pulmonary aorta in rabbit were studies. 1. The contraction of aortic strips induced by norepinephrine was suppressec by pre-or post-treatment of higenamine dose dependently and those effects of higenamine were prevented by propranolol. The $pA_2$ value of higenamine against propranolol calculated as 8.25. 2. The effect of higenamine was not affected by phentolamine. 3. Isoprotrenol has shown 10 times stronger vasodiatory effect on norepinephrine induced cntracture than that of higenamine but high concentration $(3.3{\times}10^{-6}\;M)$ of isoproterenol produce intrinsic activity. 4. Vasodilatory effect of higenamine or isoproterenol was not observed in potassium induced contacture of pulmonary aortic strips. These results strongly suggest that higenamine dilated the pulmonary vascular smooth muscle through stimulation of adrenergic beta-receptor.

인삼(人蔘) Saponin 이 Morphine 에 의(依)한 Rat 대뇌피질절편(大腦皮質切片) 산소소비양(酸素消費量) 및 $Na^+$, $K^+$ 소장(消長)에 미치는 영향(影響)

박찬웅,Park, Chan-Woong 대한약리학회 1969 대한약리학잡지 Vol.5 No.1

The effects of Ginseng saponin on respiration and $Na^+$, $K^+$ content of rat cerebral cortex slices were investigated to determine the action of Ginseng saponin on brain cortex at cellular level. There are many reports for the study of Ginseng on central stimulatory action in experimental animals. The electrical stimulation of slices of cortex causes a loss of potassium. And the respiration is needed to maintain a supply of energy for active cation transport. The reduction in $Qo_2$ is a consequence of primary cessation of active cation transport. Ginseng saponin stimulated respiration which was depressed by Morphine. But there was no significant change of electrolyte. It is suggested that the Ginseng saponin act rather on metabolic process than neural excitatory mechanism in vitro.

흰쥐에서의 해당작용(解糖作用) Adrenergic Receptor에 대(對)한 검토(檢討)

박찬웅,차인준,Park, C.W.,Cha, I.J. 대한약리학회 1980 대한약리학잡지 Vol.16 No.1

To evaluate the adrenergic receptors for glycogenolytic responses to catecholamine, the blood glucose level, liver glycogen content and muscle glycogen level in rats were studied with treatment of epinephrine, norepinephrine and isoproterenol. In addition, to study the possibility of interconversion of adrenergic receptors, the effects of catecholamines in feeding animal were compared with those in fasting animal. The results are summarized as follow; 1) Epinephrine and norepinephine showed dose dependent increase of blood glucose level but the effect of isproterenol was not significant. 2) The prandial states of animal did not influence on effects of catecholamines on blood glucose level. 3) Liver glycogen contents were lowered by epinephrine or by norepinephrins but effect of isoproterenol was not significant. 4) Glycogen content of skeletal muscle was significantly lowered by isoproterenol and. epinephrine shifted the dose-response curve to right, but the effect of norepinephrine was not significant. 5) The effects of epinephrine and norepinephrine on blood glucose were significantly blocked by ergotamine but not by propranolol. These results indicate that the glycogenolytic response to adrenergic agents in rat is mediated by an alpha-receptor in liver and by a beta-receptor in skeletal muscle.

중엔트로피 합금 기지 위에 적층조형된 스테인리스강과 타이타늄 합금의 접합특성 분석

박찬웅,이민규,김정한,Park, Chan Woong,Adomako, Nana Kwabena,Lee, Min Gyu,Kim, Jeoung Han 한국분말야금학회 2019 한국분말재료학회지 (KPMI) Vol.26 No.4

Additive manufacturing (AM) is a highly innovative method for joining dissimilar materials for industrial applications. In the present work, AM of STS630 and Ti-6Al-4V powder alloys on medium entropy alloys (MEAs) NiCrCo and NiCrCoMn is studied. The STS630 and Ti64 powders are deposited on the MEAs. Joint delamination and cracks are observed after the deposition of Ti64 on the MEAs, whereas the deposition of STS630 on the MEAs is successful, without any cracks and joint delamination. The microstructure around the fusion zone interface is characterized by scanning electron microscopy and X-ray diffraction. Intermetallic compounds are formed at the interfacial regions of MEA-Ti64 samples. In addition, Vicker's hardness value increased dramatically at the joint interface between MEAs and Ti-6Al-4V compared to that between MEAs and STS630. This result is attributed to the brittle nature of the joint, which can lead to a decrease in the joint strength.