UBC 검사의 이상결과에 대한 연구

박준모,유혜정,김한철,한걸순,Park, Jun Mo,Yoo, Hye Jung,Kim, Han Chul,Han, Geul Soon 대한핵의학기술학회 2013 핵의학 기술 Vol.17 No.2

Purpose: As UBC IRMA is being tested, patients out of the reference value are reacting within the value again a few days later the urine collection tested, which causes the reliability of the test to decrease as a result. In this study, we can assume that the physiological changes in the factors would affect the results. The purpose of the study is to find out whether hematuria and proteinuria in the sample as well as the interval time (3 hours or more recommended) have affected the results. As a result, we could discover the changes in factors and increase the reliability of the test. Materials and Methods: 468 people (female: 249, male: 219) who came for the check-up were presented herein for medical examination from 2013.3.15 to 2013.1.2. Some people out of 468 who have reacted onto the reference value were divided into group low titer zone, ow-middle titer zone, and middle-high titer zone and tested for hematuria and proteinuria. During that period, 48 outpatients were asked to fill in a questionnaire regarding the urination interval time. The reagents used were (IDL Biotech AB, Sweden) and UBC IRMA. Results: Of the patients that are formed in the reference value of ($0.1-34.0{\mu}g/L$) turn out to be 52.7 years average age in their low concentration, ($mean{\pm}SD$) of the value of $0.10{\pm}0.02{\mu}g/L$. Among 80 people (50.8%, female: 49.2%), 16 patients (20%) have shown reaction to microscopic hematuria and 10 patients (12.5%) responded to proteinuria. In the average low concentration under 52.5 years of average age, 43 people (53%) have shown reaction to microscopic hematuria and 21 people (26.3%) are proteinuric patients out of 80 patients (male: 50.8%, female: 51.3%). In the middle high concentration of $11.8{\pm}4.82{\mu}g/L$ under the average age 51.7 years, 35 patients (53%) have responded to the microscopic hematuria and proteinuric patients are 26 people (39.3%) out of 66 people (men: 44%, women: 56%). In addition, in the concentration of $51.7{\pm}43.5{\mu}g/L$, some patients who get out of the reference value are observed as the average age of 52.0. 11 patients (78.6%) out of 14 (male: 35.7%, female: 64.3%) react to the microscopic hematuria. There show 6 people (42.8%) who turn out to be as proteinuric patients. As for the interval time, $1.67{\pm}3.71{\mu}g/L$ was the average value among 48 patients (female: 45.8%, male: 54.2%). Conclusion: We cannot see if proteinuria and hematuria directly affect abnormal results of inspection of 8,18 cytokeratin; however, we can find out that they statistically have an influence on highly generating UBC among several mechanisms. Also, although urination interval time was various every 15 minutes, we it does not affect these results.

The Proper Capacity of Anchorage in Ulsan Port with Reference to the Anchorage Operating Rate

박준모,윤귀호,전해동,공길영,Park, Jun-Mo,Yun, Gwi-Ho,Jeon, Hae-Dong,Kong, Gil-Young The Korean Society of Marine Environment and safet 2016 海洋環境安全學會誌 Vol.22 No.5

본 연구는 울산항의 정박지 규모의 적정성을 평가하기 위한 방법을 제시하고, 이를 통해 현재 뿐만 아니라 항만개발에 따른 미래의 정박지 규모의 적정성을 분석하는데 그 목적이 있다. 이를 위해 울산항의 정박지 적정성 평가를 위한 정박지 가동률 개념을 제시하였다. 그리고 이 가동률 개념을 울산항의 2014년 정박지에 적용하여 가동률을 계산한 결과 모든 정박지에서 가동률이 100 %를 넘지 않는 것으로 도출되어, 추가 정박지 지정이 필요하지 않은 것으로 분석되었다. 또한 울산항의 2020년 가동률을 추정한 결과 E1정박지가 168.3 %로 가장 높았으며, E3정박지가 131.1 %, E2정박지가 118.5 %, 그리고 M정박지가 108.7 %인 것으로 계산되어, 2020년에는 정박지가 부족할 것으로 판단된다. 따라서 울산항의 항만개발에 따른 정박지 가동률을 100 % 수준으로 낮추기 위해서는 E1정박지는 11척, E2정박지는 1척, E3정박지는 2척, M정박지는 1척이 추가적으로 정박할 수 있는 수역이 필요할 것으로 분석되었다. This study suggests methods to evaluate the availability of anchorage in Ulsan port and determine the proper capacity of future anchorage in accordance with port development. Accordingly, the concept of an Anchorage Operating Rate (AOR) is introduced to evaluate the capacity of anchorage that was available in Ulsan port in 2014. Calculations revealed that the operating rate of all anchorages in Ulsan port did not exceed 100 %. However, in 2020 it is estimated that the AOR at E1 anchorage will be the highest with a rate of 168.3 %, followed by E3 with 131.1 %, E2 with 118.5 % and M with 108.7%. These findings indicate a shortage of anchorage by 2020. In order to decrease the AOR to a level that will not exceed 100 %, in accordance with port development in Ulsan, areas to accommodate an additional 11 ships at E1 anchorage, 1 ship at E2 anchorage, 2 ships at E3 anchorage and 1 ship at M anchorage will be necessary.

Plasma renin activity(PRA) and Active renin concentration(ARC)비교를 통한 ARC 유용성 실험

박준모,김한철,최승원,Park, Jun Mo,Kim, Han Chul,Choi, Seung Won 대한핵의학기술학회 2018 핵의학 기술 Vol.22 No.1

Purpose Renin is a proteolytic enzyme synthesized and secreted from epidermal(juxtaglomerular) cells in kidney. Renin acts on the renin substrate angiotensinogen to produce angiotensin I, and then angiotensin II is produced by the action of angiotensin converting enzyme. This causes the adrenal glands to boost blood pressure (vasoconstriction) and promote aldosterone secretion. While Plasma renin activity (PRA) is to test angiotensin I, the active renin concentration (ARC) is a renin test directly. They have different test methods and their own substrates. However, these two methods are sometimes interpreted as the same as a result. The purpose of this study was to evaluate the usefulness of the ARC test by comparing the results between PRA and ARC. Materials and Methods For the diversity of the experiment, 26 samples were requested to test with PRA(TFB company) and ARC(Cisbio company) to other institution. We compared and analyzed PRA(Immunotech company) and ARC(Cisbio company) tests using 28 samples from September $15^{th}$ to October $13^{th}$ in 2017. The statistical analysis method for PRA/ARC evaluated the usefulness using Microsoft Excel program by verifying a correlation analysis of Aldosterone/PRA ratio and a correlation analysis of Aldosterone/ARC ratio and conducting T-test. Results The regression equation of the PRA(Immunotech company)/ARC(Cisbio company), which was tested in the department, was y = 0.0619x + 0.4615 and the correlation coefficient was 0.73. The regression equation of the PRA(TFB company)/ARC(Cisbio company), which was tested in the other institution, was y = 0.0888x + 0.3316 and the correlation coefficient was 0.91. In addition, The regression equation of Aldosterone / PRA ratio and Aldosterone / ARC ratio was y = 0.875x - 11.688 and the correlation coefficient was 0.87. Plus T - test showed no significant difference (P>0.05). Conclusion Both tests showed a strong positive correlation, but this only represents the strength and direction of the relationship between the two tests. Furthermore, the actual results showed somewhat differences. It is presumed that the measured value was influenced by the endogenous renin group mass in the plasma, the condition of the enzyme reaction and the kind of the inhibitor. When the active renin concentration (ARC) test is performed, it is useful to distinguish between the two tests as they are complementary.

세미나 - 수협 산지위판장의 포장규격화를 위한 연구

박준모,Park, Jun-Mo 한국포장협회 2014 包裝界 Vol. No.

각막지형도 검사를 이용한 전방각 비교 연구

박준모,이지은,이종수,Jun-Mo Park,Ji-Eun Lee,Jong-Soo Lee 대한안과학회 2005 대한안과학회지 Vol.46 No.5

Purpose: Iridocorneal angles measured by the OrbscanTM II z topography system (Bausch & Lomb) can be estimated using “plane” and “2D polynomial” modes. We compared the angle measurements between the two modes, and estimated the correlation of iridocorneal angles with other biometric measurements such as anterior chamber (A/C) depth, horizontal corneal diameter, and corneal thickness. Methods: This study comprised 100 normal eyes of 50 patients with refractive errors of -1.0 to +1.0 diopters. Iridocorneal angles were measured three times in eight meridians (0o, 45o, 90o, 135o, 180o, 225o, 270o and 315o) using both the “plane” and “2D polynomial” modes, by a single examiner. Results: Significant difference of the mean iridocorneal angles was found between the two reconstruction modes, which showed a correlation with each other. Angle measurement with the plane mode showed a significant correlation with A/C depth and horizontal corneal diameter measurement, but that with the polynomial mode showed no correlation with them. The highest reproducibility was shown at the superior location among the 8 locations. Conclusions: The iridocorneal angle, measured by the plane mode rather than the polynomial mode, especially at the superior location, should be useful for clinical application.

동결건조표준액의 안정성에 관한 보고

박준모,유혜정,김한철,한걸순,Park, Jun Mo,Yoo, Hye Jung,Kim, Han Chul,Han, Geul Soon 대한핵의학기술학회 2012 핵의학 기술 Vol.16 No.2

이 실험은 검사를 매일 실행하고, 동결건조된 표준액을 매번 녹여서 사용하는 검사실은 그 안정성에 대하여 고민을 할 필요는 없지만, 검사를 일주일에 한번 또는 두 번 정도 실행하는 검사실에 대한 보고라고 할 수도 있다. 동결 건조한 표준물질은 용해한 후 다시 동결을 할 경우 보통 $-20^{\circ}C$이하에서 유효기간까지 보관하라는 식으로만 표현 되어져 있고, 이는 몇 번을 녹인 후 재사용해도 안정한가에 대해서는 표현된 바가 없기에 이번 실험은 동결건조한 표준용액을 녹임과 동결을 여러 번 번복하였을 때와 냉장보관을 하였을 시에 표준용액의 변화도와 이것이 결과에 미치는 영향을 비교 평가하였다. 시판되고 있는 방사면역측정법을 이용한 체외진단키트 중 동결건조표준용액으로 되어진 부갑상선호르몬(PTH), 부신피지자극호르몬(ACTH), 황체형성호르몬(LH) kit를 같은Lot.NO.로 구성하였다. 이를 D.W.로 각 용량에 맞게 용해한 후 3개의 대조군으로 분리하였다. 제1대조군은 녹임, 동결을 번복하는 방법으로 하였고 제2대조군은 용해한 후 Test tube에 1회 사용할 만큼 분주하여 동결을 하였고 제3대조군은 냉장보관으로 하였다. 표준액과 환자농도값 날짜 별로 비교하였고, pH Test를 하였으며 날짜 별 단순회귀분석 및 결정계수 산출을 하였으며 Excel Paired t-Test (p-value)를 하여서 유의수준관계를 분석하였다. 위에서 실험한 ACTH, PTH, LH의 동결건조 표준액은 반드시 냉동보관을 할 것을 권고한다. 이는 다른 동결건조표준액도 같은 방법으로 보관을 해야 할 것이다. Purpose : Since standard solution is the one that knows its exact concentration, the curve of the dissolution has been determined according to the amount of the solution, compared to the amount of the unknown sample. Therefore, the antigen that makes up standard materials should be made in a pure form. The configuration of the standard substance solution in the kit we use is a freeze-dried material, or made and comes as a liquid. Lyophilized reference material is used after dissolving in usually D.W. (Distilled Water), and if the antigen to use is too sensitive, reagents should be freeze-dried. Furthermore, when freeze-dried reference has to be frozen again after being dissolved, it should be kept under $-20^{\circ}C$ until the expiration date according to the reports. Since it is not expressed in the experiment if it is safe or stable to reuse the solution which was dissolved a few times, thus, this time it is tested and evaluated that the changes of the standard solution by freezing and melting several times, and its results and the effectiveness of it were compared to the solution which was kept in a fridge. Materials and Methods : Among Vitro diagnostic kits on the market made by radioimmunoassay, parathyroid hormone (PTH), adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) are made of freeze-dried standard solution and all composed of the same Lot.NO. These hormones melted in D.W. and were separated into three groups. In the first group, melting and freezing were repeated, and in the second group, The solution only for one time use was put into a test tube after melting and freeze it. The third group was kept in the refrigerator. This experiment has been conducted from January to February in 2012. January to 2012. PH test was employed because ph is prone to changing depending on the change of protein. Each group of the standard solution, cpm (counter per minute), and the patient relative concentration values were compared by date, and Through the correlation coefficient and Paired t-test, the significant level of each group was analyzed. Results : ACTH, PTH, LH pH values were too subtle denaturation rather than numerical changes in the protein. In addition, when the standard solution of ACTH, PTH, LH was refrigerated, after 3 days and 7 days, there was a significant difference observed between the solution being kept in a refrigerator and a freezer within a significance level. Conclusion : Standard solution should be kept in a freezer, and being kept in a fridge, it is recommended to use the solution as soon as possible.

국내 건설사업관리(CM)의 제도개선 및 산업 진흥을 위한 방안

박준모,김옥규,김우영,전진구,Park, Jun-Mo,Kim, Ok-Gyu,Kim, U-Yeong,Jeon, Jin-Gu 한국건설관리학회 2015 건설관리 : 한국건설관리학회 학회지 Vol.16 No.5

정박지 점유율을 이용한 집단 정박지 면적 제시 방법 연구 - 울산항 E 정박지를 대상으로 시뮬레이션 -

박준모,Park, Jun-Mo 해양환경안전학회 2016 海洋環境安全學會誌 Vol.22 No.2

본 연구에서는 정박지 해상교통 환경을 재현한 시뮬레이션을 통하여 정박지의 적정 면적을 결정하기 위한 방법론을 제시하고, 이를 울산항 E정박지에 적용하여 울산항 정박지 면적의 적정성을 비교 분석하기 위한 목적이 있다. 이를 위해 정박지 사용현황에 따른 시간별 정박지 점유율과 필요 정박지 면적 계산식을 제시하였다. 시간별 정박지 점유율 분석을 위해 시뮬레이션 알고리즘을 구성하고, MATLAB 프로그램을 이용하여 모델링하였으며, 이를 울산항 E 정박지에 적용하여 시간별 정박지 점유율과 필요 정박지 면적을 도출하고 현재 울산항 E정박지 면적과 비교 분석하였다. 그 결과 E1 정박지의 필요 정박지 면적은 현재 정박지 면적의 1.41배, E2와 E3 정박지는 0.90배, 0.96배로 분석되었다. 본 연구에서 제시한 정박지 면적의 적정성 분석 결과를 정박지 설계기준에 반영할 경우 정박지를 이용하는 선박의 안전에 도움을 줄 수 있을 것으로 판단된다. This study aims to present methodology for determining the appropriate anchorage area through the simulation reproduces the maritime transport environment, and analysis of the adequacy of anchorage applied at Ulsan E anchorage, suggests the formula of anchorage occupancy rater per hour and necessary anchorage area for this purpose. And configured simulation algorithm and modeling using MATLAB program, and applied Ulsan E anchorage, compared anchorage area with anchorage occupancy rate per hour. As a result, E1 necessary anchorage is 1.41 times, E2 necessary anchorage is 0.90 times and E3 necessary anchorage is 0.96 times compared to total anchorage area. If the result of adequacy analysis of anchor area reflect anchorage design criteria, it is determined to be helpful for the safety of the vessel using the anchorage.

자동화장비 계측효율 관리적 측정방법 제안

박준모,김한철,최승원,Park, Jun Mo,Kim, Han Chul,Choi, Seung Won 대한핵의학기술학회 2018 핵의학 기술 Vol.22 No.2

Purpose Quality control of instrument takes up a large part in the Radioimmunoassays. The gamma-ray instrument, which is one of the important instruments in the laboratory, observes the condition and performance of instrument and performs quality control of the instrument by measuring the Normalization, Calibration, Background and etc. However, there are some automation instruments which can't measure the counting efficiency of gamma-ray meters, resulting in insufficient management in terms of performance evaluation of gamma-ray meters. Therefore, the purpose of this paper is to manage the quality control continuously and regularly by suggesting how to measure the counting efficiency of gamma-ray instruments. Materials and Methods In case of a comparative measurement method to a gamma-ray instrument dedicated to nuclear medical examination, the CPM and counting efficiency can be obtained after the measurement of normalization by inserting the I-125 $200{\mu}L$(CPM 50,000~500,000) into the test tube. With this CPM and counting efficiency values, it's possible to calculate the measurement of the DPM value and count the CPM from the automation instrument from the same source, and enter the DPM to calculate the counting efficiency using a comparative measurement method. Another method is to calculate the counting efficiency by estimating the half life using the radiation source information of the tracer in B test reagents of company A. Results According to the calculation formula using the DPM obtained by counting the normalization of gamma-ray meters, the detection efficiency was 75.16% for Detector 1, 76.88% for Detector 2, 77.13% for Detector 3, 75.36% for Detector 4 and 73.2% for Detector 5 respectively. Using another calculation formula estimated from the shelf life, the data of the detection efficiency from Detector 1 to Detector 5 were 74.9%, 75.1%, 76.5%, 74.9% and 73.2% respectively. Conclusion Although the accuracy of counting efficiencies of both methods are insufficient, this is considered to be useful for ongoing management of quality control if counting efficiency is managed after setting the acceptable ranges. For example, if the measurement efficiency is set to 70% or higher, the allowed %difference between measurements is within 3% and the %difference with the detector wall is set within 5%.

주택하자분쟁에 대한 국외 현황 및 관련 제도

박준모,최정현,Park, Jun-Mo,Choe, Jeong-Hyeon 한국건설관리학회 2010 한국건설관리학회 논문집 Vol.11 No.2