원발성 질암의 치험례

박재일(JI Park),박성기(SK Park) 대한산부인과학회 1961 Obstetrics & Gynecology Science Vol.4 No.2

희유한 원발성질암1치험예를 보고함과 동시에 본증에 관한 종설을 첨기하였다. 본증은 일반으로 그 예후가 불량한 점으로 보아 본증예에 대하여도 물론 앞으로 계속 주기적인 관찰을 행할 예정이다. Primary vaginal carcinoma is very rare in Korea. A 36 years-old, para-6, Korean house-wife with primary vaginal squamous cell carcinoma (about 3×3cm) near the introitus of the anterior vaginal wall was treated by deep X-ray therapy with the total dose of air roentgen 13,600r, tumor dosis 5,952r in a duration of ten weeks. The result is excellent for the moment as shown in the figures. Follow-up study of the patient will be made periodically. An atempt was made to summarize a brief review of literature.

( 난소 ) Arrhenoblastoma의 1예

박재일(JI Park) 대한산부인과학회 1961 Obstetrics & Gynecology Science Vol.4 No.2

1. 희유한 Arrhenoblastoma의 일치험예를 보고하는 동시에 그에 관한 문헌적고찰을 하였다. 2. 적출한 종양은 우측에 발생한 남성화난소종양이었으며 병리조직학적검사로써 중간형임을 알았다. 3. 본증환자에 있어서 수술후 2개월후에 다시 여성화증상을 볼 수 있었다. The author has submitted a case report of arrhenoblastoma of the ovary of a 36 year-old, married, nulliparous Korean woman. She complained of amenorrhea since 28 years of age, accompanied by atrophy of the breasts and external genitalia, and deepening of her voice. Her clitoris became hypertrophied. Hair growth of male type occured over the body and face. Although there was almost no change in her character, her libido was said to have been more active after cessation of her menstruation. Loss of weight and general weakness became gradually marked. She eventually felt abdominal fullness and discomfort. A tumor of the right ovary was treated by unilateral oophorectomy. Gross pathology of the tumor removed: Right solid ovarian tumor. Size; 5.5×8.0×10.0cm Weight; 200gm. Shape; oval-shaped. Capsule; well encapsulated with glastening, translucent and serous capsule with an irregular surface. Cut surface; pale yellow in general, grayish whitish in places. Consistence; rubbery, several fingertip-sized hard nodules could be palpated in the tumor. Microscopic findings of the tumor: The specimen showed a tubular and adenomatous pattern. The tubular formation in general was not perfect and not resemble testicular tubules. In some areas the tubular formation was difficult to identify. The spec imen was almost replaced by tumor cells. Under the high magnification the nuclei of the individual cells were large and hyper-and poly-chromatic and differed greatly in size. A great many vacuoles of various size in nuclei were noted. Microscopic diagnosis: Arrhenoblastoma, intermediate type. Two months following operation she showed refeminization. On arrhenoblastoma, historical considerations, histogenesis, pathology, clinical symptoms and signs, it`s relationship to pregnancy, malignity and recurrence, hereditary relationship, hormone, secretion of the tumor and it`s treatment were briefly discussed.

질트리코모나스 질염의 Tinidazole 1회 대량투여법의 치료성적

신순철(SC Shin),박재일(JI Park),나건영(KY Na) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.4

The purpose of this study was to access the effectiveness of single 2gm dose of Tinidazole a dertivative of imidazole, in 49 patients suffering from trichomonas vaginalis vaginitis. The aim of this study can be summarized as follows; 1. The inverstigate the safety and tolerance of tinidazole. 2. To determine the optimal dose and duration of therapy on trichomonas vaginalis vaginitis with tinidazole. In all patients the following laboratory tests were carried out ; SGOT, SGPT, alkaline phosphatase serum bilirubin, total and differential white cell count, and BUN for evaluation of drug toxicity. At the same time any side effect was observed. Results; In all patients and their husbands, tinidazole 2gm was administered at one time by mouth only, and wet smear and culture were conducted on 1wk and 4wks later for assesing the evidence of cure. 1. Side effects were appeared 11 cases (22.4%) such as abdominal discomfort, anorexia, dry mouth, verigo, and headache. But they were mild or moderate. 2. Toxicity ; only 2 cases (4.1%) were showed SGOT level increasing on post treatment 1wk, but they were returned normal level on post-treatment 4wks 3. Clinical symptoms and signs were imporved within post-treatment 1wk in 95%. 4. Cure rate ; post treatment 1wk ; 98% post treatment 4wks ; 92%

임산부의 임상통계적 관찰

신면우(MW Shin),박재일(JI Park),이동천(TK Lee),정좌구(JK Chung),김승경(SK Kim) 대한산부인과학회 1965 Obstetrics & Gynecology Science Vol.8 No.3

In spite of the significant progress of the obstetrical field in Korea during past two decades, studies in regard to the baseline of this field, presentes from fhis contry, are rarely found. Although the number of cases are fairly small, the principal purpose of the present investigation was to observe the general patterns of Korean women concerned to the child-bearing. This study is based on the retrospechic investigation of 1,384 grabides visited for their anteparum cares, 1,655 parturiants delivered in the wards, 65 gravidas and puerparas not delived but admitted for incidental complications, and babies born from those mothers, between April, 1962 and March, 1964 at the Seoul National University Hospital. Result obtained were as follows: 1) Obstetrical history (1) among the total number of 1,720 cases, 588 (34.18%) primigravidas, 1,127 (65.52%) multigravidas and the rest cases were. (2) There were 675(39.24%) primiparas an d 1,042 (60.58%) muttiparas. (3) Eighty-three (4.82%) cases had histories of premature delivery and 467 (27.15%) had abortion. (4) Seven hundres and twenty-five (42.15%) cases had no living child and 992 (57.67%) had one or more living children. 2) The antepartm cares were taken on 34.02% of admilted cases in 1962, while 44.02% in 1963. In the result, during these study years, the ratio of prenatally cared cases to the all admitted ones was 669:1,720(40.63%) and gradually increasing tendency was noticed. 3) The obstetrical complications occured more frquently in the non-registered group: (1) Of the 206 (11.97%of all admitted)cases of toxemias, 64 (9.15%) were in the registered group and 142 (13.90%) in the non-registered. (2) Severe complications during labor were developed mostly in the non-registered. 4) The average weight gain during the course of pregnancy was 8.33 kgm. 5) The mean hemoglobin value at term was 10.40gm% and increased to 10.90 gm% in labor. 6) The average value of hematocrits just before the labor was 32.85% but no conlcousive changes in relation to the various gestational months were found. 7) Leukocytosis was noted in both primiparas (11.500 per cmm) and multiparas (10,500) during labor. The mean balue was 10.900 per cmm. 8) The incidence of proteinuris was 61.40% in primiparas, 55.32% in multiparas and 57.51% of the all casas. 9) Positive cardiolipin microflocculation test (including±) was detected in 3.12% of all the examined. 10) One or more kinds of intestinal parasited were found in 995 (94.67%) out of 1,051 cases. 11) Deliveries ocucred in the daytime were 53.43% and in the night 46.56%. 12) The average durations of labor in primiparas: were 14.77 hours for the first stage, 48.99 minutes for the second and 11.76 minutes for the third. In multiparas, these were 8.66 hours, 31.33 minutes and 11.10 minutes respectivelu.

미니랩 난관불임술 2,256례에 대한 임상적 고찰

이승재(SJ Lee),백원영(WY Paik),박재일(JI Park),김승욱(SW Kim) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.10

Tubal sterilization is rapidly becoming one of the most important methods of family planning. Minilaparotomy is surgical entry into the lower abdominal cavity through a small transverse suprapubic incision for the purpose of tubal ligation. A clinical analysis has been made on 2,256 cases of minilaparotomy tubal sterilization which had been performed at the Dept. of Obstet. & Gynecol., Seoul National University Hospital from May 1976 to November 1982. The results were as follows: 1. The most common age group was 30 to 34 years of age and the mean age was 33.7. 2. Most of client had 2 or more living children and the mean parity was 2.7. 3. About two-thirds of the clients experienced 2 or more artificial abortions and the mean number of artificial abortion was 2.8. 4. The histories of previous laparatomy were in 1.2% but did not disturb the operative procedure. 5. Minilapatotomy tubal sterilizations were performed 4 years after delivery in about half of the clients. 6. Sterilization was performed at the time of abortion in about two thirds of the clients. 7. Most of procedures were successfully completed under the local anesthesia. 8. Most of procedures could be finished within 30 minutes and the mean operation time was 24.3 minutes. 9. Most of clients returned less than 6 hours after operation. 10. The operative complications were encountered i 1.7% but no intensive medical care were required for these complications. 11. The operative technical failure rate was 0.8% and the operative method failure rate was 0.04%. 12. Sterilization procedures were coincidentally performed with the salpingectomies(8 cases), ovarian cystectomies(7 cases), Adnexectomies(4 cases), parovarian cystectomies(4 cases), and biopsies(2 cases) through minilaparotomies. It is concluded that minilaparotomy tubal sterilization is simple, safe, acceptable, inexpensive, and widely applicable procedure for female sterilization.

한국 부인암 환자의 치료후 추적조사에 관한 연구

라건영(KY Rha),신면우(MW Shin),박재일(JI Park),장윤석(YS Chang),노형일(HI Noh) 대한산부인과학회 1980 Obstetrics & Gynecology Science Vol.23 No.1

1) 부인암등록환자수는 본대학 산부인과에서 입원치료를 받고 퇴원할 때 등록하는데 그 총 환자수는 1959년부터 1978년까지 만 20년간 1643예였고 그 중 자궁경암은 1305예(79.4%), 불모암은 228예(13.9%), 난소암은 73예(4.6%), 자궁체암은 22예(1.3%)였다. 2) 년평균치료환자수는 자궁경암이 65.3예, 불모암이 11.4예, 난소암이 3.8예, 자궁체암이 1.1예였으며 자궁두암은 연도에 따라 치료수가 뚜렷이 증가하였으나 다른 종류의 암에서는 특별한 증가나 감소의 현상을 볼 수 없었다. 3) 지역별분포는 모든 종류의 등록환자수는 서울시내가 지방보다 높은 분포를 보여 64.0%∼68.3%를 차지하고 있다. 4) 발병년령은 자궁경암과 난소암에서는 40세대에서 가장 높은 발생수를 보이고 있으나 불모암에서는 20세대, 자궁체암에서는 50세대에 가장 높은 발생빈도를 보여 주었다. 5) 분*과의 관계는 자궁경암과 자궁체암은 분*회수가 3∼4회인 경우에, 불모암에서는 분*회수가 1∼2회인 경우에, 또 난소암에 서는 분*회수가 미산부 또는 1∼2회 경산인 경우에 가장 높은 빈도를 보여 주었다. 6) 암의 치료시기로는 자궁경암에서 0기암이 10.7%, 제1기암이 43.2%로서 비교적 초기암이 반수이상이었으며, 자궁체암의 경우 도 제1기암이 77.3%였으나 난소암에서는 제3기암 및 제4기암이 각각 22.7%, 29.3%로서 말기암이 반수이상 차지하고 있다. 7) 병리조직학적분류로서는 자궁경암에서 편평상피세포암이 94.9%였고, 선암이 4.2%, adenoacanthoma가 0.9%였는데 자궁체암에 서는 전례가 자궁막선암이었으며 난소암에서는 장액성선암이 34.7%로서 가장 많은 높은 빈도를 나타냈다. 8) 타장기에의 전이는 자궁경암에서 제1기 및 제2기암의 경우 골반내 임파선전이는 각각 13.7%, 32,5%를 나타냈고, 불모암에서 는 폐장전이가 61.8%로 가장 높고, 질전이, 골반내전이, 뇌전이, 외음전이의 순으로 되어있다. 난소암에서는 인접부위로의 전 이가 5.3%, 복강내장기나 복강외부까지 침윤된 경우가 52.0%나 되었다. 9) 치료방법으로서는 자궁경암의 경우, 0기암은 수술요법, 제1기와 제2기암은 원칙적으로 병행요법, 제3기와 제4기암은 방사선 요법을 1978년까지는 시행하였다. 난소암과 자궁체암은 수술요법, 불모암은 화학요법을 시행했으나 환자의 년령, 건강상태 및 암의 진행상태에 따라 병행요법을 사용하기도 하였다. 10) 추적대상환자수는 전체등록환자수에서 외래로 5년이상 방문하므로써 추적된 환자와 치료후 5년이 경과하지 않은 환자 그리 고 주소가 불분명한 환자를 제외하고 조사대상으로 하였는데 질병별로는 자궁경암이 558예, 불모암이 106예, 난소암이 34예, 자 궁체암이 8예였으며 지역별로는 서울거주자가 414예, 지방거주자가 292예로 총 706를 추적대상으로 하였다. 11) 추적성적은 추적대상암등록자중 서울시내에서는 414예중 64예가 확인되어 15.5%의 확인율을 보였고, 지방의 경우에는 292예 중 123예가 확인되어 42.1%의 확인율을 보임으로서 지방의 경우가 추적성적이 훨씬 우수하였는데 이는 주소이동이 적고 인간관 계가 더 밀접한 것이 원인으로 생각된다. 12) 5년생존율은 외래 및 거주지 추적으로 확인된 각 질병별 5년생존율은 자궁경암에서 0기암은 100.0%, 제1기암은 92.4%, 제2 기암은 59.7%, 제3기암은 26.7%, 제4기암은 0%였고 불모암은 65.7%, 난소암은 33.3%, 자궁체암은 62.5로 나타났다. 조사원을 거주지파견시켜 생존 및 건강여부, 타질환으로 인한 사망여부를 추적확인한 자궁경암환 The main purpose of this study was to evaluate the five year survival rate and epidemiologic analysis of 1,643 gynecologic cancer patients treated at S.N.U.H from January, 1959 to December; 1978. The five tear survival rate was based on the confirmed patients by home visit. The rusult were as follow : 1.The total number of registered patients from 1959 to 1978 was 1,643 cases [cervical ca.:1,305(79.4%), chorio ca.:228(13.9%), ovarian ca.:75(4.6%), corpus ca.:22(1.3%)]. 2.The mean annual incidence of patients were 65.3 cases in cervical ca., 11.4 case in chorica., 3.7 casesin ovarianca., and 1.1 cases in corpus ca.. 3.The distribution of patients by residency showed thaat over sixty percent of patients located in Seoul city. 4.Age distribution of patients was concentrated on the age of 40-49 in the cerv- ical ca, and ovarian ca, 20-29 in the chorioca., 50-59 in the corpus ca.. 5.parity distribution of patients was concentrated on the parity 3-4 in the cer- vical ca, and corpus ca., 1-2 in the chorioca., 0 in the ovarian ca. 6.Histopathologic type of patients showed that 94.9% of cervical cancer patients belonged to the squamous cell ca., 4.2% to the adenoca., 0.9% to the adeno- acanthoma and all cases of corpus ca., and 32.5% in stage cerveal ca.. 7.The frequency of metastases was 13.7% in stage I cervcal ca., and 32.5% in stage cervcal ca., On the cheriocarcinoma, 61.8% of the cases was found to be metastasized and the most frequent site was the lung. 8.Seven hundred and six patients were the subject of the follow-up study by home visit, among whom 414 cases located in Seoul and 292 cases in local area. The percentile result of confirmation by home visit was 15.5% in Seoul and 42.1% in local area. 9.The five year survival rate of confirmed patients by home visit was 100% in stage 0, 89.5% in stage I, 52.0% in stage , 20.0% in stage III, 0% in stage IV of the cervical ca, of the uterus; 66.7% in corpus ca., 28.6% in ov- arian ca., and 55.0% in cgorioca.

EP(Engineering Plastic)를 적용한 스페리컬 받침의 개발

윤한울(Hanul Yun),지용수(Yongsu Ji),이유인(Youin Lee),임강섭(Kangsup Lim),박재일(Jaeil Park) 한국철도학회 2013 한국철도학회 학술발표대회논문집 Vol.2013 No.11

오늘날 교량받침으로 사용하고 있는 제품은 크게 고무받침, 포트받침, 우레탄받침 그리고 스페리컬 받침이다. 이중 철도교량으로 가장 많이 쓰이고 있는 제품으로는 고력황동 스페리컬 받침이 있다. 고력황동 스페리컬 받침은 다른 교량 받침에 비하여 큰 회전수용 능력, 연직 하중에 대한 작은 처짐량 그리고 부반력 기능을 가지고 있다. 하지만 오늘날 사용되고 있는 고력황동 스페리컬 받침은 1990년대 초에 일본에서 개발된 오래된 제품으로 다른 것들의 성능에 비하여 가격이 높고 그 크기가 크기 때문에 철도교량을 제외하고는 거의 사용되지 않고 있다. 또한 미끌림 요소인 STS 판과 고력황동은 모두 금속계열 재료이기 때문에 부식에 대한 위험성이 존재하고 있다. 따라서 이러한 단점을 보완하기 위하여, 고력황동이 아닌 Engineering Plastic을 사용하여 새로운 스페리컬 받침을 개발하였으며, 그 구조를 최적화 하여 Engineering Plastic Spherical Bearing(이하 ESB)을 실용화 하였다. Recently, bearings have been applied for the bridge are Rubber Bearing, Pot bearing, Urethane bearing and spherical bearing. Among them, High strength brass Spherical bearing has been predominantly used as a railway bridge bearing. High strength brass Spherical bearing has larger rotational capacity and lower deflection about the vertical load than other bearing’s and function to prevent negative reaction force. But High strength brass Spherical bearing developed in Japan in the early 1990s are not almost used in bridge except railway bridge because it has high price and big size comparing with the equivalent performance of others. It always exists dangerous about corrosion. Friction elements of STS plate and High strength brass are all metallic materials as well. Therefore the new spherical bearing was developed to improve its disadvantage with using not High strength brass but EP(Engineering Plastic). We optimized structural composition of the bearing and commercialized Engineering Plastic spherical Bearing(below called ESB).

나노스케일 3차원 프린팅 시스템

이현택(Hyun-Taek Lee),이길용(Gil-Yong Lee),김충수(Chung-Soo Kim),최정오(Jung-Oh Choi),박재일(Jae-Il Park),송지현(Ji-Hyun Song),장기환(Ki-Hwan Jang),이건우(Kun-Woo Lee),안성훈(Sung-Hoon Ahn) (사)한국CDE학회 2014 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2014 No.2

Fabrication of Micro/Nanostructures is come into the spotlight because of its potential at healthcare, electronic device and military related applications. However, existing fabrication processes contains limits in terms of rapid prototyping, due to its complicate manufacturing process, difficulties in achieving complex structure and limit of available materials. Herein, we developed novel nanoscale 3D printing system by integrating nanoparticle deposition system and focused ion beam.

2000년대 초에 유행한 Orientia tsutsugamushi에 의한 간염

박재일,한성희,조승철,조용현,홍상모,이학현,윤혜련,양선영,윤재훈,윤영섭,문지용,조경란,백상현,손주현,김태화,이동후 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3

목적: Orientia tsutsugamushi 감염은 삼림에 서식하는 매개충인 진드기(Leptotrombidium)의 유충이 우연히 사람의 피부를 통하여 전파되어 생기는 급성 발열 질환이다. 저자들은 지난 3년 동안 쯔쯔가무시병으로 진단된 환자들에서 간 기능 이상을 확인하고 가을철 간염환자의 감별진단 특히 non-A, non-B, non-C 간염의 진단에 주의를 환기하고자 관찰 결과를 보고하는 바이다. 대상과 방법: 한양대학교 서울병원과 구리병원에 2000년 10월부터 2002년 11월까지 hemagglutinin법으로 쯔쯔가무시병으로 진단된 환자 22명을 조사 대상으로 삼아 그 진료기록을 조사하였다. 결과: 남녀 비는 1:3.4로 여자가 많았다. 연령(범위 31-83세)은 56.4±2.6(평균±표준오차)세였다. 입원시기는 9월 23일부터 11월 15일 사이였고 10월 중순 이후 11월 상순 사이가 제일 많았다. 증상은 발열이 21예로 가장 많았고, 근육통 13예, 관절통 12예, 오한 6예, 피부발진 6예 순이었다. 잠복기는 7-9일이 10예로 가장 많았고 13-15일이 4예, 10-12일 3예, 3일 이내 3예, 4-6일 2예였다. ALT(범위 18-345 IU/L)는 93.2±17.3 IU/L(평균±표준오차)였고, AST(범위 34-255 IU/L)는 92.5±11.7 IU/L, GGTP (범위 19-251 IU/L)는 132.2±14.5 IU/L로 상승하였지만 혈중 총 빌리루빈은 정상이었다. 모든 환자들은 doxycycline 투여로 호전되었다. 결론: Orientia tsutsugamushi 감염은 대부분, 경도의 간 기능 이상을 동반하므로 특히 가을철 간 기능 이상을 보이는 열성 질환 환자들에게서 다른 간 질환과 감별해야 할 질환으로 인지하는 것이 중요하다. Background/Aims: Orientia -tsutsugamushi infection is an acute febrile disease due to the accidental transmission through human skin of forest dwelling vector Leptotrombidium larva. The authors observed liver dysfunctions in patients diagnosed with tsutsugamushi disease (Scrub typhus) in the past 3 years and report the data in the hope of bringing attention to this disease in the differential diagnosis of autumn-season hepatitis, especially of non-A, non-B and non-C hepatitis. Methods: Medical records of 22 patients diagnosed with tsutsugamushi disease by the hemagglutinin method between October 2000 and November 2002 were reviewed. Results: Female gender was dominant in the ratio of 3.4:1. Mean age was 56.4±2.6. Admission was between 23rd September and 15th November with the peak between mid October and early November. Fever, being the most common symptom, was observed in 21 cases, myalgia in 13, arthralgia in 12, chills in 6, and skin rash in 6. An incubation period of 7-9 days was most common (10 cases), 13-15 days (4), 10-12 days (3), within 3 days (3), and 4-6 days (2). Average ALT, AST and GGTP were increased to 93.2±17.3 IU/L (18±345 IU/L), 92.5±11.7 IU/L (34-255 IU/L) and 132.2±14.5 IU/L (19-251 IU/L), respectively, but total bilirubin was normal. All the patients improved with doxycycline therapy. Conclusions: since it usually shows liver dysfunction, it is important to take Orientia tsutsugamushi into consideration in differential diagnosis of autumn-season, febrile hepatic disease.(Korean J Hepatol 2003;9:198-204)