식도 외 역류의 도그마

박일석,Park, Il-Seok 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

Laryngopharyngeal reflux (LPR) disease is an extraoesophageal variant of gastro-esophageal reflux disease that can affect the larynx and pharynx. LPR is associated with symptoms of laryngeal irritation such as throat clearing, coughing, and hoarseness. The main diagnostic methods currently used are laryngoscopy and pH monitoring. The most common laryngoscopic signs are redness and swelling of the throat. However, these findings are not specific of LPR and may be related to other causes or can even be found in healthy individuals. Furthermore, the role of pH monitoring in the diagnosis of LPR is controversial. A therapeutic trial with proton pump inhibitors (PPIs) has been suggested to be cost-effective and useful for the diagnosis of LPR. However, the recommendations of PPI therapy for patients with a suspicion of LPR are based on the results of uncontrolled studies, and high placebo response rates suggest a much more complex and multifactorial pathophysiology of LPR than simple acid reflux. Laryngoscopy and pH monitoring have failed as reliable tests for the diagnosis of LPR. Empirical therapy with PPIs is widely accepted as a diagnostic test and for the treatment of LPR. However, further research is needed to develop a definitive diagnostic test for LPR.

수평원관상의 LiBr-H$_{2}$O 액막흡수현상 해석

박일석,최도형,Park, Il-Seok,Choe, Do-Hyeong 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.2

A numerical study for vapor absorption into LiBr-H$_{2}$O solution film flowing over horizontal circular tubes has been carried out. The momentum, energy and diffusion equations, which are parabolized by the boundary- layer approximation, are solved simultaneously for various mass-flow rates and inlet conditions. The results for the velocity, temperature and concentration fields, as well as the heat and mass flux at the free surface are presented. The effects of inlet conditions, i.e., flow rate, temperature and concentration, on the absorption process are also examined and discussed.

흡인화상환자에서 발생하는 후두 및 기관 협착

박일석,장재혁,김범규,김용복,노영수,안회영,김종현,Park Il-Seok,Chang Jai-Hyuk,Kim Beom Gyu,Kim Yong Bok,Rho Young Soo,Ahn Hwoe Young,Kim Jong Hyun 대한기관식도과학회 2005 大韓氣管食道科學會誌 Vol.11 No.1

Background and Objectives : Laryngotracheal stenosis in bum patients with inhalation have features distinct from other stenosis after intubation or tracheostomy. However few studies have been reported and the incidence was reported variable. The purpose of this study is to evaluate the clinical manifestation and the incidence of laryngotracheal stenosis in bum patients with inhalation. Methods We retrospectively analyzed 138 bum Patients diagnosed inhalation injury who admitted to Hangang Sacred Heart Hospital from July 2002 to June 2004. Result : 5 patients were developed laryngotracheal stenosis. The incidence of Laryngotracheal stenosis in bum patients with inhalation was $3\%$. Symptom developed early in 2 patients, late in 3 patients.4 patients required trachostomy as initial airway support. The location of stenosis is subglottic region except 1 patient. Montgomery T-tube was inserted in 3 patients, and Single-stage laryngotracheal reconstruction was performed in 1 patient. Conclusion Incidence of laryngotracheal stenosis in our study is lower than other reports due to late presentation of symptom and early discharge after acute bum stage. Inhalation injury may lead to severe complication and sequelae, therefore physicians should be have a awareness for early diagnosis and all burn patients who have a history of inhalation injury should be followed closely.

노인성 후두의 조직병리학적, 생리학적 특성

박일석,Park, Il-Seok 대한후두음성언어의학회 2014 대한후두음성언어의학회지 Vol.25 No.1

Age-related changes in larynx can have a direct impact on voice quality and general comfort level. Observations of vocal aging have spanned perceptual, acoustic, aerodynamic, physical, electromyographic (EMG) and histological levels. Evidence of differential vocal aging in relation to gender and physical condition has been reported. Perceptual, acoustic, aerodynamic, kinematic, EMG and histological data document age-related changes in laryngeal structure and function with advancing age. These changes contribute to a functional age-related impact of vocal hypofunction or compensatory hyperfunction. This review will focus on the current understanding of the clinical and cellular changes in the larynx that lead to presbyphonia.

외이도진주종을 동반한 측두골골종

박일석(Il Seok Park),전승식(Seung Sik Jeon),심정원(Jung Weon Shim),홍석민(Seok Min Hong) 대한두경부종양학회 2015 대한두경부 종양학회지 Vol.31 No.1

An osteoma of the external auditory canal(EAC) is an uncommon benign tumor. If a canal obstruction occurs, ear fullness or conductive hearing loss can arise. But, the association of an osteoma with a cholesteatoma is ex-tremely rare. Therefore, we report a case of a 35-year-old female patient with osteoma of temporal bone that was complicated with EAC cholesteatoma.

제 4 새성 기형 1예

박일석(Il Seok Park),장재혁(Jai Hyuk Chang) 대한두경부종양학회 2005 대한두경부 종양학회지 Vol.21 No.1

The branchial anomaly is a lateral neck mass commonly seen by otolaryngologists. Depending on its anatomic location, branchial anomaly can be classified into first, second, third and fourth. The fourth branchial cleft anomaly is very rare entity and until now, only 35cases have been reported worldwide. It may present as neck cyst, recurrent neck abscess, thyroiditis. Combined with barium swallow esophagogram and computed tomography scan can aid in diagnosis of this rare disease entity. Complete excision of the entire epithelial tract combined with ipsilateral thyroid lobectomy remains the mainstay of treatment. Authors experienced a case of lateral neck mass which was anatomically presumed to be the fourth branchial cleft cyst. We report this case with the related literature.

양성자펌프억제제에 반응하지 않는 인두이물감 환자에서 "뮤코미스트Mucomyst^®" 객담제거 및 상기도 염증치료를 통한 증상개선효과 평가 다기관, 단일군, 전향적 관찰 연구

박한나,박일석,이상혁,이승원,이상준,이병주,천용일,박준욱,오경호,신유섭,Park, Hannah,Park, Il-Seok,Lee, Sang Hyuk,Lee, Seung-Won,Lee, Sang Joon,Lee, Byung-Joo,Cheon, Yong-Il,Park, Jun-Ook,Oh, Kyoung Ho,Shin, Yoo Seob 대한후두음성언어의학회 2022 대한후두음성언어의학회지 Vol.33 No.1

Background and Objectives Globus pharyngeus is one of the most common symptoms of patients visiting otorhinolaryngology out-patient clinic, and usually long-lasting, difficult to treat, and frequently recurrent. Mucomyst^®, N-acetyl cysteine is an inhalation agent mainly used for mucolysis and reducing inflammation in airway via antioxidative effect. The purpose of this study was to evaluate the efficacy of inhaled Mucomyst^® treatment in patients with globus pharyngeus refractory to proton pump inhibitor (PPI). Materials and Method We prospectively evaluated the efficacy of Mucomyst^® in relieving symptoms of globus pharyngeus refractory to PPI in nine medical centers. Three hundred and three patients enrolled and finally 229 patients finished the inhaled Mucomyst^® therapy for 8 weeks. We analyzed the change of Reflux Symptom Index (RSI), Reflux Finding Score (RFS), Visual Analogue Scale (VAS) for globus, and Globus Pharyngeus Symptom Scale (GPS) after use of Mucomyst^® for 4 and 8 weeks. Results The GPS, RSI, RFS, and VAS score significantly decreased serially in patients who finished 8 week-inhalation treatment. The GPS improvement gap was significantly correlated with initial GPS (p<0.001) in multiple regression analysis. Conclusion Inhaled Mucomyst^® therapy was effective for the reduction of both subjective and objective findings in refractory globus patients. This study might suggest new treatment option for patients with globus. However, further thorough studies would be needed to assess the real effect of inhaled Mucomyst^® treatment as a standard treatment for globus.

Acrylate를 결합제로 사용한 수계 테이프 캐스팅에서 알루미나 슬러리의 분산 및 점성 특성

조유정,박일석,문주호,김대준,Cho, Yu-Jeong,Park, Il-Seok,Moon, Joo-Ho,Kim, Dae-Joon 한국세라믹학회 2002 한국세라믹학회지 Vol.39 No.2

Acrylate 수계 결합제를 사용한 알루미나 테이프 캐스팅용 슬러리의 완전분산을 위한 최적의 분산제와 분산제량을 결정하기 위해 침강실험, 분말 함유량 실험, 점도 및 zeta 전위 측정을 행하였다. 알루미나 슬러리의 완전분산은 분산제를 polycarboxylic acid로 했을 때 얻어졌으며, 최적의 첨가량은 알루미나 100에 대하여 0.23∼0.24g 이었다. 분말에 대한 분산제량이 증가할수록 분산은 잘 이루어졌으나, 일정량 이상이 첨가되면 분산제가 용매 안에 과잉으로 존재하여 분산을 저해하는 요인으로 작용하였다. 테이프 캐스팅용 슬러리는 100g의 알루미나 분말에 0.2g의 polycarboxylic acid를 첨가하였을 때 분산 및 테이프 특성이 가장 우수하였고, 이 때 혼합한 결합제는 acrylate였고, 가소제는 Benzoflex를 사용하였다. 이 때 슬러리 최적 점도는 약 570 cps였고, 테이프 내 알루미나 량은 57 vol%이었다. Measurements of sedimentation, solid loading, zeta potential, and viscosity were employed to determine a proper dispersant and its amount for a well dispersed alumina powders in aqueous alumina tape casting using acrylate as a binder. Polycarboxylic acid was the most effective one among various dispersants considered in the present study and its amount was 0.23∼0.24 g per 100 g alumina for a dispersion. Better dispersion was obtained as an increase of dispersant addition. However, the dispersion was hindered as the amount of dispersant was higher than the optimum amount because of bridging or tangling of polymer chains. Excellent aqueous alumina tapes were prepared from the slurry containing the optimum amount of the polycarboxylic acid (0.2g), alumina powders(100 g), acrylate and Benzoflex as binder and plasticizer, respectively. The viscosity of the slurry was 570 cps and the alumina loading in the tape was 57 vol%.

하인두 악성종양: 수술적 치료 vs 항암화학방사선치료

노영수,박일석,김진환,Rho, Young-Soo,Park, Il-Seok,Kim, Jin-Hwan 대한기관식도과학회 2007 大韓氣管食道科學會誌 Vol.13 No.2

지르코니아/알루미나 복합체의 In-vitro Hertzian 피로거동

이득용,박일석,김대준,이세종,Lee, Deuk-Yong,Park, Il-Seok,Kim, Dae-Joon,Lee, Se-Jong 한국세라믹학회 2004 한국세라믹학회지 Vol.41 No.1

인공치아용 3Y-TZP와 (Y,Nb)-TZP/$Al_2O_3$ 복합체를 유사 구강분위기인 인공타액 하에서 500-3000N의 하중 조건으로 $10^6$ 횟수까지 헤르찌안 반복하중 피로특성을 조사하였다. 500N의 하중에서 $5{\times}10^5$까지 반복피로 실험결과, 강도 저하 및 균열 현상은 관찰되지 않았다. 피로특성은 SY-TZP가 (T,Nb)-TZP/$Al_2O_3$ 복합체보다 상전이에 의한 응역회복 때문에 우수하였다. 하중값이 증가함에 따라 링 균열에서 방사상 균열로 전이되었을 때 급격한 강도 저하 현상이 발생하였다. 강도 저하 현상은 유사 구강 분위기하에서 반복 하중 접촉 시 발생한 균열을 통해 침투한 인공타액의 화학적 침식으로 더욱 가속화 되었다. The degree of the indentation damage and strength degradation for 3Y-TZP ceramics and (Y,Nb)-TZP/$Al_2O_3$ dental implant composites was investigated under the Hertzian cyclic fatigue. Fatigue tests were conducted at contact loads of 500 to 3000 N and up to $10^6$ cycles in exact in vitro environments. At 500 N, no strength degradation and crack generation was observed up to $5{\times}10^5$ contact cycles. Fatigue properties of 3Y-TZP ceramics was superior to (Y,Nb)-TZP/ㅍ composites due to stress relief caused by the phase transformation from tettagonal to monoclinic phase. As contact load increased, the drastic reduction in strength was found when the damage transition from ring to radial crack occurred. The extent of strength degradation was more pronounced in vitro environments probably due to chemical corrosion of artificial saliva through cracks introduced during large numbers of contacts.